JP2010533727A5 - - Google Patents
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- Publication number
- JP2010533727A5 JP2010533727A5 JP2010517123A JP2010517123A JP2010533727A5 JP 2010533727 A5 JP2010533727 A5 JP 2010533727A5 JP 2010517123 A JP2010517123 A JP 2010517123A JP 2010517123 A JP2010517123 A JP 2010517123A JP 2010533727 A5 JP2010533727 A5 JP 2010533727A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- aryl
- alkyl
- heteroaryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95016207P | 2007-07-17 | 2007-07-17 | |
| US60/950,162 | 2007-07-17 | ||
| PCT/US2008/070103 WO2009012277A1 (en) | 2007-07-17 | 2008-07-16 | Method for modulating gpr119 g protein-coupled receptor and selected compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533727A JP2010533727A (ja) | 2010-10-28 |
| JP2010533727A5 true JP2010533727A5 (OSRAM) | 2011-03-24 |
| JP5301539B2 JP5301539B2 (ja) | 2013-09-25 |
Family
ID=39864683
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517123A Expired - Fee Related JP5301539B2 (ja) | 2007-07-17 | 2008-07-16 | Ｇｐｒ１１９ｇタンパク質共役受容体の調節方法および選択された化合物 |
| JP2010517122A Expired - Fee Related JP5318867B2 (ja) | 2007-07-17 | 2008-07-16 | ピリドンｇｐｒ１１９ｇタンパク質共役受容体アゴニスト |
| JP2013144778A Withdrawn JP2013237680A (ja) | 2007-07-17 | 2013-07-10 | ピリドンｇｐｒ１１９ｇタンパク質共役受容体アゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517122A Expired - Fee Related JP5318867B2 (ja) | 2007-07-17 | 2008-07-16 | ピリドンｇｐｒ１１９ｇタンパク質共役受容体アゴニスト |
| JP2013144778A Withdrawn JP2013237680A (ja) | 2007-07-17 | 2013-07-10 | ピリドンｇｐｒ１１９ｇタンパク質共役受容体アゴニスト |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US7928230B2 (OSRAM) |
| EP (2) | EP2173737B1 (OSRAM) |
| JP (3) | JP5301539B2 (OSRAM) |
| KR (2) | KR20100051814A (OSRAM) |
| CN (3) | CN101801956B (OSRAM) |
| AR (2) | AR067568A1 (OSRAM) |
| AT (2) | ATE524460T1 (OSRAM) |
| AU (2) | AU2008276057B2 (OSRAM) |
| BR (2) | BRPI0814428A2 (OSRAM) |
| CA (2) | CA2693444A1 (OSRAM) |
| CL (2) | CL2008002110A1 (OSRAM) |
| CO (1) | CO6160315A2 (OSRAM) |
| CY (2) | CY1112151T1 (OSRAM) |
| DK (2) | DK2170864T3 (OSRAM) |
| EA (2) | EA016595B1 (OSRAM) |
| ES (2) | ES2371515T3 (OSRAM) |
| HR (2) | HRP20110806T1 (OSRAM) |
| IL (1) | IL228120A0 (OSRAM) |
| NZ (2) | NZ582664A (OSRAM) |
| PE (2) | PE20090888A1 (OSRAM) |
| PL (2) | PL2170864T3 (OSRAM) |
| PT (2) | PT2170864E (OSRAM) |
| SI (2) | SI2170864T1 (OSRAM) |
| TW (2) | TW200904440A (OSRAM) |
| WO (2) | WO2009012275A1 (OSRAM) |
| ZA (2) | ZA201000151B (OSRAM) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005310467B2 (en) * | 2004-12-01 | 2011-06-23 | Msd K.K. | Substituted pyridone derivative |
| US7910583B2 (en) | 2007-05-04 | 2011-03-22 | Bristol-Myers Squibb Company | [6,6] and [6,7]-bicyclic GPR119 G protein-coupled receptor agonists |
| CN101801956B (zh) | 2007-07-17 | 2013-11-20 | 百时美施贵宝公司 | 用于调节gpr119 g蛋白偶联受体的方法及所选化合物 |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| MX2011000664A (es) * | 2008-07-16 | 2011-02-24 | Schering Corp | Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119. |
| WO2010009208A1 (en) * | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| TW201006821A (en) * | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| GB0904287D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| CA2754523A1 (en) * | 2009-03-20 | 2010-09-23 | Pfizer Inc. | 3-oxa-7-azabicyclo[3.3.1]nonanes |
| TW201113269A (en) | 2009-06-24 | 2011-04-16 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
| TW201111361A (en) | 2009-06-24 | 2011-04-01 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2547339A1 (en) | 2010-03-18 | 2013-01-23 | Boehringer Ingelheim International GmbH | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
| WO2011127106A1 (en) | 2010-04-08 | 2011-10-13 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridinone analogues as gpr119 modulators |
| WO2011140161A1 (en) | 2010-05-06 | 2011-11-10 | Bristol-Myers Squibb Company | Benzofuranyl analogues as gpr119 modulators |
| US8940716B2 (en) | 2010-05-06 | 2015-01-27 | Bristol-Myers Squibb Company | Bicyclic heteroaryl compounds as GPR119 modulators |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| KR101563793B1 (ko) | 2010-10-08 | 2015-10-27 | 카딜라 핼쓰캐어 리미티드 | 신규한 ｇｐｒ 119 작용물질 |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| EP2648516B1 (en) | 2010-12-06 | 2018-09-05 | Aclaris Therapeutics, Inc. | Substituted pyridinone-pyridinyl compounds |
| WO2012123449A1 (en) * | 2011-03-14 | 2012-09-20 | Boehringer Ingelheim International Gmbh | N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators |
| US9181214B2 (en) | 2011-06-09 | 2015-11-10 | Rhizen Pharmaceuticals Sa | Bicyclic compounds as modulators of GPR-119 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013173198A1 (en) | 2012-05-16 | 2013-11-21 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2921489B1 (en) * | 2012-11-13 | 2017-09-06 | Nissan Chemical Industries, Ltd. | 2-pyridone compound |
| CN102993088A (zh) * | 2012-12-31 | 2013-03-27 | 东华大学 | 一种4-羟基-2-吡啶酮的制备方法 |
| TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
| TW201444821A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代之哌啶化合物及其作為食慾素受體調節劑之用途 |
| TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途 |
| WO2014197846A1 (en) | 2013-06-07 | 2014-12-11 | Confluence Life Sciences, Inc. | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| EP3010889B1 (de) | 2013-06-20 | 2018-10-03 | Bayer CropScience Aktiengesellschaft | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| BR112015031291A2 (pt) | 2013-06-20 | 2017-07-25 | Bayer Cropscience Ag | derivados de sulfureto de arila e derivados de arilalquil sulfóxido como acaricidas e inseticidas |
| WO2015004028A1 (de) | 2013-07-08 | 2015-01-15 | Bayer Cropscience Ag | Sechsgliedrige c-n-verknüpfte arylsulfid- und arylsulfoxid- derivate als schädlingsbekämpfungsmittel |
| WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| BR112017004742B1 (pt) | 2014-09-11 | 2022-11-29 | Janssen Pharmaceutica Nv | 2-azabiciclos substituídos e seu uso como moduladores de receptor de orexina |
| WO2016130652A1 (en) | 2015-02-10 | 2016-08-18 | Vanderbilt University | Negative allosteric modulators of metabotropic glutamate receptor 3 |
| JP6578116B2 (ja) * | 2015-03-25 | 2019-09-18 | 公益財団法人相模中央化学研究所 | 一置換（フルオロアルキル）エチレン類及びその製造方法 |
| US10865194B2 (en) | 2017-11-03 | 2020-12-15 | Fondazione Istituto Italiano Di Tecnologia | Therapeutically active bicyclic-sulphonamides and pharmaceutical compositions |
| CN115667277A (zh) | 2020-02-28 | 2023-01-31 | 卡尔优普公司 | Gpr40激动剂 |
| IL296054A (en) | 2020-03-27 | 2022-10-01 | Aclaris Therapeutics Inc | Oral preparations of the mk2 pathway inhibitor for the treatment of immune conditions |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| AU2021297323A1 (en) | 2020-06-26 | 2023-02-16 | Kallyope, Inc. | AMPK activators |
| WO2022081573A1 (en) * | 2020-10-12 | 2022-04-21 | University Of Tennessee Research Foundation | Transient receptor potential canonical 3 inhibitors and methods of use thereof |
| CN115504927A (zh) * | 2022-08-15 | 2022-12-23 | 广西中医药大学 | 4-甲基-2-对甲苯基-6-羰基吡啶-3-甲酸及其制备方法和用途 |
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| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5488064A (en) * | 1994-05-02 | 1996-01-30 | Bristol-Myers Squibb Company | Benzo 1,3 dioxole derivatives |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
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| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
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| UA57811C2 (uk) | 1997-11-21 | 2003-07-15 | Пфайзер Продактс Інк. | Фармацевтична композиція, що містить інгібітор альдозоредуктази та інгібітор глікогенфосфорилази (варіанти), комплект, який її включає, та способи лікування ссавців зі станом інсулінорезистентності |
| PL201048B1 (pl) | 1998-07-06 | 2009-03-31 | Bristol Myers Squibb Co | Bifenylosulfonamid jako dualny antagonista receptorów angiotensyny i endoteliny oraz jego zastosowanie |
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| CN101801956B (zh) * | 2007-07-17 | 2013-11-20 | 百时美施贵宝公司 | 用于调节gpr119 g蛋白偶联受体的方法及所选化合物 |
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2008
- 2008-07-16 CN CN2008801081672A patent/CN101801956B/zh not_active Expired - Fee Related
- 2008-07-16 DK DK08781867.0T patent/DK2170864T3/da active
- 2008-07-16 SI SI200830464T patent/SI2170864T1/sl unknown
- 2008-07-16 CA CA2693444A patent/CA2693444A1/en not_active Abandoned
- 2008-07-16 ES ES08781867T patent/ES2371515T3/es active Active
- 2008-07-16 EP EP08781868A patent/EP2173737B1/en not_active Not-in-force
- 2008-07-16 AU AU2008276057A patent/AU2008276057B2/en not_active Ceased
- 2008-07-16 JP JP2010517123A patent/JP5301539B2/ja not_active Expired - Fee Related
- 2008-07-16 AR ARP080103060A patent/AR067568A1/es unknown
- 2008-07-16 US US12/173,864 patent/US7928230B2/en active Active
- 2008-07-16 WO PCT/US2008/070101 patent/WO2009012275A1/en not_active Ceased
- 2008-07-16 EA EA201000211A patent/EA016595B1/ru not_active IP Right Cessation
- 2008-07-16 BR BRPI0814428-1A2A patent/BRPI0814428A2/pt not_active IP Right Cessation
- 2008-07-16 AT AT08781867T patent/ATE524460T1/de active
- 2008-07-16 PL PL08781867T patent/PL2170864T3/pl unknown
- 2008-07-16 NZ NZ582664A patent/NZ582664A/en not_active IP Right Cessation
- 2008-07-16 AU AU2008276055A patent/AU2008276055B2/en not_active Ceased
- 2008-07-16 BR BRPI0815097A patent/BRPI0815097A2/pt not_active IP Right Cessation
- 2008-07-16 PE PE2008001196A patent/PE20090888A1/es not_active Application Discontinuation
- 2008-07-16 SI SI200830592T patent/SI2173737T1/sl unknown
- 2008-07-16 NZ NZ582661A patent/NZ582661A/en not_active IP Right Cessation
- 2008-07-16 KR KR1020107003333A patent/KR20100051814A/ko not_active Withdrawn
- 2008-07-16 AT AT08781868T patent/ATE540945T1/de active
- 2008-07-16 AR ARP080103061A patent/AR067569A1/es not_active Application Discontinuation
- 2008-07-16 US US12/173,856 patent/US8003796B2/en active Active
- 2008-07-16 EP EP08781867A patent/EP2170864B1/en not_active Not-in-force
- 2008-07-16 HR HR20110806T patent/HRP20110806T1/hr unknown
- 2008-07-16 HR HR20120221T patent/HRP20120221T1/hr unknown
- 2008-07-16 WO PCT/US2008/070103 patent/WO2009012277A1/en not_active Ceased
- 2008-07-16 CN CN201310495045.6A patent/CN103550218A/zh active Pending
- 2008-07-16 CA CA2693439A patent/CA2693439A1/en not_active Abandoned
- 2008-07-16 TW TW097127046A patent/TW200904440A/zh unknown
- 2008-07-16 PL PL08781868T patent/PL2173737T3/pl unknown
- 2008-07-16 KR KR1020107003332A patent/KR20100045471A/ko not_active Withdrawn
- 2008-07-16 PT PT08781867T patent/PT2170864E/pt unknown
- 2008-07-16 DK DK08781868.8T patent/DK2173737T3/da active
- 2008-07-16 CN CN200880108168A patent/CN101801957A/zh active Pending
- 2008-07-16 EA EA201000210A patent/EA018709B1/ru not_active IP Right Cessation
- 2008-07-16 TW TW097127045A patent/TW200904439A/zh unknown
- 2008-07-16 PT PT08781868T patent/PT2173737E/pt unknown
- 2008-07-16 ES ES08781868T patent/ES2378914T3/es active Active
- 2008-07-16 JP JP2010517122A patent/JP5318867B2/ja not_active Expired - Fee Related
- 2008-07-16 PE PE2008001197A patent/PE20090449A1/es not_active Application Discontinuation
- 2008-07-17 CL CL200802110A patent/CL2008002110A1/es unknown
- 2008-07-17 CL CL200802111A patent/CL2008002111A1/es unknown
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2010
- 2010-01-08 ZA ZA2010/00151A patent/ZA201000151B/en unknown
- 2010-01-15 CO CO10003756A patent/CO6160315A2/es unknown
- 2010-01-15 ZA ZA2010/00326A patent/ZA201000326B/en unknown
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2011
- 2011-03-07 US US13/041,564 patent/US8178561B2/en active Active
- 2011-06-14 US US13/159,497 patent/US8232404B2/en active Active
- 2011-12-14 CY CY20111101241T patent/CY1112151T1/el unknown
-
2012
- 2012-04-09 CY CY20121100343T patent/CY1112751T1/el unknown
- 2012-04-24 US US13/454,789 patent/US20120232048A1/en not_active Abandoned
- 2012-06-12 US US13/494,489 patent/US8513424B2/en active Active
-
2013
- 2013-07-10 JP JP2013144778A patent/JP2013237680A/ja not_active Withdrawn
- 2013-08-26 IL IL228120A patent/IL228120A0/en unknown
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