JP2010528122A - 白金薬剤と結合されたポリマー - Google Patents

白金薬剤と結合されたポリマー Download PDF

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Publication number
JP2010528122A
JP2010528122A JP2010507678A JP2010507678A JP2010528122A JP 2010528122 A JP2010528122 A JP 2010528122A JP 2010507678 A JP2010507678 A JP 2010507678A JP 2010507678 A JP2010507678 A JP 2010507678A JP 2010528122 A JP2010528122 A JP 2010528122A
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JP
Japan
Prior art keywords
group
polymer
reactant
formula
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010507678A
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English (en)
Japanese (ja)
Other versions
JP2010528122A5 (enExample
Inventor
ヴァン、サン
ジャオ、ガン
ユ、レイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Publication of JP2010528122A publication Critical patent/JP2010528122A/ja
Publication of JP2010528122A5 publication Critical patent/JP2010528122A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
JP2010507678A 2007-05-09 2008-05-08 白金薬剤と結合されたポリマー Pending JP2010528122A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91685707P 2007-05-09 2007-05-09
PCT/US2008/063128 WO2008141111A2 (en) 2007-05-09 2008-05-08 Polymers conjugated with platinum drugs

Publications (2)

Publication Number Publication Date
JP2010528122A true JP2010528122A (ja) 2010-08-19
JP2010528122A5 JP2010528122A5 (enExample) 2011-06-16

Family

ID=39615788

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010507678A Pending JP2010528122A (ja) 2007-05-09 2008-05-08 白金薬剤と結合されたポリマー

Country Status (7)

Country Link
US (1) US20080279782A1 (enExample)
EP (1) EP2155254B1 (enExample)
JP (1) JP2010528122A (enExample)
CN (1) CN101730549B (enExample)
DK (1) DK2155254T3 (enExample)
TW (1) TW200906440A (enExample)
WO (1) WO2008141111A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010526829A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
JP2015503585A (ja) * 2012-01-03 2015-02-02 インビクタス オンコロジー プライベート リミテッド リガンド−標的指向分子およびその方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
WO2010045370A2 (en) * 2008-10-15 2010-04-22 Nitto Denko Corporation Method of preparing polyglutamate conjugates
CA2751068A1 (en) * 2009-01-31 2010-08-05 Igf Oncology, Llc Anti-cancer protein-platinum conjugates
CA2782410A1 (en) * 2009-12-16 2011-06-23 Nitto Denko Corporation Controlled synthesis of polyglutamic acid
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
ES2677478T3 (es) 2012-04-12 2018-08-02 Nitto Denko Corporation Conjugados de copolímero
US9078926B2 (en) 2012-05-07 2015-07-14 Nitto Denko Corporation Polymer conjugates with a linker
CN117327157A (zh) * 2023-09-12 2024-01-02 上海大学 一种多肽偶联药物及其制备方法和应用

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JP2003511349A (ja) * 1999-04-13 2003-03-25 ファニン バイオサイエンス、インク． 薬剤担体としてのポリ（ジペプチド）
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010526829A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
JP2015503585A (ja) * 2012-01-03 2015-02-02 インビクタス オンコロジー プライベート リミテッド リガンド−標的指向分子およびその方法

Also Published As

Publication number Publication date
DK2155254T3 (da) 2013-03-04
EP2155254B1 (en) 2012-11-28
TW200906440A (en) 2009-02-16
WO2008141111A3 (en) 2009-06-04
WO2008141111A2 (en) 2008-11-20
CN101730549B (zh) 2015-12-09
HK1141462A1 (en) 2010-11-12
US20080279782A1 (en) 2008-11-13
EP2155254A2 (en) 2010-02-24
CN101730549A (zh) 2010-06-09

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