TW200906440A - Polymers conjugated with platinum drugs - Google Patents
Polymers conjugated with platinum drugs Download PDFInfo
- Publication number
- TW200906440A TW200906440A TW097117163A TW97117163A TW200906440A TW 200906440 A TW200906440 A TW 200906440A TW 097117163 A TW097117163 A TW 097117163A TW 97117163 A TW97117163 A TW 97117163A TW 200906440 A TW200906440 A TW 200906440A
- Authority
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- Taiwan
- Prior art keywords
- polymer
- group
- polymer conjugate
- reactant
- platinum
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 125000004952 trihaloalkoxy group Chemical group 0.000 description 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US91685707P | 2007-05-09 | 2007-05-09 |
Publications (1)
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| TW200906440A true TW200906440A (en) | 2009-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097117163A TW200906440A (en) | 2007-05-09 | 2008-05-09 | Polymers conjugated with platinum drugs |
Country Status (7)
| Country | Link |
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| US (1) | US20080279782A1 (enExample) |
| EP (1) | EP2155254B1 (enExample) |
| JP (1) | JP2010528122A (enExample) |
| CN (1) | CN101730549B (enExample) |
| DK (1) | DK2155254T3 (enExample) |
| TW (1) | TW200906440A (enExample) |
| WO (1) | WO2008141111A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9393315B2 (en) | 2011-06-08 | 2016-07-19 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing siRNA activity |
| DE602006013893D1 (de) | 2005-12-05 | 2010-06-02 | Nitto Denko Corp | Polyglutamat-Aminosäure-Konjugate und Verfahren |
| WO2008141110A2 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
| EP2155255B1 (en) | 2007-05-09 | 2013-08-14 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
| US20100093935A1 (en) * | 2008-10-15 | 2010-04-15 | Nitto Denko Corporation | Method of preparing polyglutamate conjugates |
| KR20110126644A (ko) * | 2009-01-31 | 2011-11-23 | 아이쥐에프 온콜로지, 엘엘씨 | 항암 단백질-백금 결합체 |
| BR112012013305A2 (pt) * | 2009-12-16 | 2016-03-01 | Nitto Denko Corp | processos para a preparação de ácido poliglutâmico |
| US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
| EP2800586A1 (en) * | 2012-01-03 | 2014-11-12 | Invictus Oncology Pvt. Ltd. | Ligand-targeted molecules and methods thereof |
| US9295728B2 (en) | 2012-04-12 | 2016-03-29 | Nitto Denko Corporation | Co-polymer conjugates |
| JP6262209B2 (ja) | 2012-05-07 | 2018-01-17 | 日東電工株式会社 | リンカーを有するポリマー結合体 |
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| DE3806795A1 (de) * | 1988-02-29 | 1989-09-07 | Schering Ag | Polymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| JP2517760B2 (ja) * | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
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| DE602006013893D1 (de) * | 2005-12-05 | 2010-06-02 | Nitto Denko Corp | Polyglutamat-Aminosäure-Konjugate und Verfahren |
| US20080051603A1 (en) * | 2006-06-15 | 2008-02-28 | Cell Therapeutics, Inc. | Process for the preparation of poly-alpha-glutamic acid and derivatives thereof |
-
2008
- 2008-05-08 JP JP2010507678A patent/JP2010528122A/ja active Pending
- 2008-05-08 US US12/117,604 patent/US20080279782A1/en not_active Abandoned
- 2008-05-08 CN CN200880020323.XA patent/CN101730549B/zh not_active Expired - Fee Related
- 2008-05-08 EP EP08769347A patent/EP2155254B1/en not_active Not-in-force
- 2008-05-08 DK DK08769347.9T patent/DK2155254T3/da active
- 2008-05-08 WO PCT/US2008/063128 patent/WO2008141111A2/en not_active Ceased
- 2008-05-09 TW TW097117163A patent/TW200906440A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008141111A2 (en) | 2008-11-20 |
| WO2008141111A3 (en) | 2009-06-04 |
| CN101730549B (zh) | 2015-12-09 |
| HK1141462A1 (en) | 2010-11-12 |
| DK2155254T3 (da) | 2013-03-04 |
| CN101730549A (zh) | 2010-06-09 |
| US20080279782A1 (en) | 2008-11-13 |
| EP2155254A2 (en) | 2010-02-24 |
| JP2010528122A (ja) | 2010-08-19 |
| EP2155254B1 (en) | 2012-11-28 |
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