JP2010528122A5 - - Google Patents

Download PDF

Info

Publication number
JP2010528122A5
JP2010528122A5 JP2010507678A JP2010507678A JP2010528122A5 JP 2010528122 A5 JP2010528122 A5 JP 2010528122A5 JP 2010507678 A JP2010507678 A JP 2010507678A JP 2010507678 A JP2010507678 A JP 2010507678A JP 2010528122 A5 JP2010528122 A5 JP 2010528122A5
Authority
JP
Japan
Prior art keywords
group
polymer
polymer composite
groups containing
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010507678A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010528122A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/063128 external-priority patent/WO2008141111A2/en
Publication of JP2010528122A publication Critical patent/JP2010528122A/ja
Publication of JP2010528122A5 publication Critical patent/JP2010528122A5/ja
Pending legal-status Critical Current

Links

JP2010507678A 2007-05-09 2008-05-08 白金薬剤と結合されたポリマー Pending JP2010528122A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91685707P 2007-05-09 2007-05-09
PCT/US2008/063128 WO2008141111A2 (en) 2007-05-09 2008-05-08 Polymers conjugated with platinum drugs

Publications (2)

Publication Number Publication Date
JP2010528122A JP2010528122A (ja) 2010-08-19
JP2010528122A5 true JP2010528122A5 (enExample) 2011-06-16

Family

ID=39615788

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010507678A Pending JP2010528122A (ja) 2007-05-09 2008-05-08 白金薬剤と結合されたポリマー

Country Status (7)

Country Link
US (1) US20080279782A1 (enExample)
EP (1) EP2155254B1 (enExample)
JP (1) JP2010528122A (enExample)
CN (1) CN101730549B (enExample)
DK (1) DK2155254T3 (enExample)
TW (1) TW200906440A (enExample)
WO (1) WO2008141111A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
AU2006322254B2 (en) 2005-12-05 2012-08-02 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
WO2008141110A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
JP5341879B2 (ja) * 2007-05-09 2013-11-13 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
CN102176923A (zh) * 2008-10-15 2011-09-07 日东电工株式会社 制备聚谷氨酸酯结合物的方法
CA2751068A1 (en) * 2009-01-31 2010-08-05 Igf Oncology, Llc Anti-cancer protein-platinum conjugates
JP2013514443A (ja) * 2009-12-16 2013-04-25 日東電工株式会社 ポリグルタミン酸の制御された合成
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
US9884123B2 (en) 2012-01-03 2018-02-06 Invictus Oncology Pvt. Ltd. Ligand-targeted molecules and methods thereof
CN104582735B (zh) 2012-04-12 2019-01-11 日东电工株式会社 共聚物缀合物
WO2013169337A1 (en) 2012-05-07 2013-11-14 Nitto Denko Corporation Polymer conjugates with a linker

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
WO1985000372A1 (fr) * 1983-07-01 1985-01-31 Battelle Memorial Institute Polypeptide biodegradable et son utilisation pour le relargage progressif de medicaments
US5385738A (en) * 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
CS254355B1 (en) * 1985-04-10 1988-01-15 Vladimir Saudek Soluble and biodegradatable copolymeres activated for bond of biologicaly active substances
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US6673347B1 (en) * 1986-04-30 2004-01-06 Gryphon Therapeutics Polypeptide and protein derivatives and process for their preparation
IN165717B (enExample) * 1986-08-07 1989-12-23 Battelle Memorial Institute
DE3806795A1 (de) * 1988-02-29 1989-09-07 Schering Ag Polymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6517824B1 (en) * 1990-05-14 2003-02-11 University Of Medicine & Denistry Of New Jersey Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
US5372807A (en) * 1990-05-14 1994-12-13 University Of Medicine And Dentistry Of New Jersey Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5660822A (en) * 1990-05-14 1997-08-26 University Of Medicine & Dentistry Of N.J. Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) * 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9120653D0 (en) * 1991-09-27 1991-11-06 Procter & Gamble Dispensing agent
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
FR2695563B1 (fr) * 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6749868B1 (en) * 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6753006B1 (en) * 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
AU673057B2 (en) * 1993-02-22 1996-10-24 Abraxis Bioscience, Llc Methods for (in vivo) delivery of biologics and compositionsuseful therefor
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
JPH09500411A (ja) * 1993-07-13 1997-01-14 アボツト・ラボラトリーズ 蛍光性ポリマー標識された接合体および中間体
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US6441026B1 (en) * 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
US6713045B1 (en) * 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US5762909A (en) * 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
DE19548114C2 (de) * 1995-12-21 2000-04-27 Deutsches Krebsforsch Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
SI0932399T1 (sl) * 1996-03-12 2006-10-31 Pg Txl Co Lp Vodotopna paklitakselna predzdravila
JPH09255590A (ja) * 1996-03-21 1997-09-30 Japan Synthetic Rubber Co Ltd 徐放性薬剤
US6030941A (en) * 1996-05-01 2000-02-29 Avi Biopharma, Inc. Polymer composition for delivering substances in living organisms
US5929198A (en) * 1996-07-16 1999-07-27 Nalco Chemical Company Biodegradable poly (amino acid)s, derivatized amino acid polymers and methods for making same
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5965118A (en) * 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US6251866B1 (en) * 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
US6229009B1 (en) * 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
US6528061B1 (en) * 1997-09-04 2003-03-04 Pasteur Institut Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
JP3390965B2 (ja) * 1997-09-12 2003-03-31 理化学研究所 糖結合スフィンゴシンを含有するポリマー化合物
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
WO2000038735A1 (fr) * 1998-12-24 2000-07-06 Kyowa Hakko Kogyo Co., Ltd. Preparation pharmaceutique
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20010041189A1 (en) * 1999-04-13 2001-11-15 Jingya Xu Poly(dipeptide) as a drug carrier
US20040121954A1 (en) * 1999-04-13 2004-06-24 Xu Wuhan Jingya Poly(dipeptide) as a drug carrier
AUPQ014799A0 (en) * 1999-05-04 1999-05-27 Access Pharmaceuticals Australia Pty Limited Amplification of folate-mediated targeting to tumor cells using polymers
US6600788B1 (en) * 1999-09-10 2003-07-29 Xilinx, Inc. Narrow-band filter including sigma-delta modulator implemented in a programmable logic device
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
NZ529789A (en) * 1999-10-12 2005-04-29 Cell Therapeutics Inc Manufacture of polyglutamate-20(S)-camptothecin conjugates
US6136846A (en) * 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
US6235264B1 (en) * 1999-12-01 2001-05-22 General Electric Company Medical imaging method for characterizing tumor angiogenesis using polymeric contrast agents
KR100729015B1 (ko) * 2000-01-04 2007-06-14 어섹스 팔마큐티칼스 인코포레이티드 Ｎ,ｏ-아미도말로네이트 백금 착화합물
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
SI21172A (sl) * 2000-03-17 2003-10-31 Cell Therapeutics, Inc. Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo
JP2004501875A (ja) * 2000-06-14 2004-01-22 メダレックス，インコーポレイティド トリペプチドプロドラッグ化合物
GB0018240D0 (en) * 2000-07-25 2000-09-13 Pharmacia & Upjohn Spa Polymeric conjugates of antitumor agents
EP1329221B1 (en) * 2000-09-26 2006-06-21 TOUDAI TLO, Ltd. Polymeric micelle containing cisplatin enclosed therein and use thereof
US7070797B2 (en) * 2000-11-07 2006-07-04 Dana Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers
RU2282641C2 (ru) * 2001-06-20 2006-08-27 Ниппон Каяку Кабусики Кайся Блок-сополимер с пониженным содержанием примесей, полимерный носитель, фармацевтические препараты в полимерной форме и способы их получения
US20030109432A1 (en) * 2001-12-10 2003-06-12 Zuo William W. Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same
US6939538B2 (en) * 2002-04-11 2005-09-06 Biomedical Research Models, Inc. Extended release analgesic for pain control
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
JP2004018494A (ja) * 2002-06-19 2004-01-22 Japan Science & Technology Corp ブロック共重合体−薬剤複合体の製造法
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
US6855695B2 (en) * 2003-06-13 2005-02-15 Vion Pharmaceuticals, Inc. Water-soluble SHPs as novel alkylating agents
WO2005035003A2 (en) * 2003-09-22 2005-04-21 Dihedron Corporation Compositions and methods for increasing drug efficiency
US20050118718A1 (en) * 2003-09-22 2005-06-02 University Of Utah Research Foundation Stabilization and controlled delivery of ionic biopharmaceuticals
CN100457185C (zh) * 2003-12-10 2009-02-04 株式会社东京大学Tlo 二氨基环己烷合铂(ⅱ)与含聚羧酸链段的嵌段共聚物的配位络合物、其抗肿瘤剂
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
KR20050104152A (ko) * 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
TW200616604A (en) * 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
TW200740460A (en) * 2005-07-12 2007-11-01 Sankyo Co Pharmaceutical composition containing PPAR γ agonist
AU2006322254B2 (en) * 2005-12-05 2012-08-02 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080051603A1 (en) * 2006-06-15 2008-02-28 Cell Therapeutics, Inc. Process for the preparation of poly-alpha-glutamic acid and derivatives thereof

Similar Documents

Publication Publication Date Title
JP2010528122A5 (enExample)
JP2010526917A5 (enExample)
Liang et al. Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers
Xia et al. pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy
Yu et al. Smart doxorubicin nanoparticles with high drug payload for enhanced chemotherapy against drug resistance and cancer diagnosis
Xu et al. Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid
Yin et al. Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid
Xia et al. Functionalized selenium nanoparticles for targeted delivery of doxorubicin to improve non-small-cell lung cancer therapy
Ernsting et al. Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models
Zhang et al. Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide
JP2010526829A5 (enExample)
Huang et al. Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment
CN106265510A (zh) 一种肿瘤细胞内pH触发式释药的多级靶向聚合物胶束及其制备方法
CN107660210B (zh) 基于硼替佐米的递送系统
TW201132357A (en) Carbohydrate-polyamino acid-drug conjugates
Guo et al. Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer
JP7164205B2 (ja) キナ酸修飾ナノ粒子およびその使用
EP2358396A2 (en) Method of preparing polyglutamate conjugates
Fu et al. A novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy
Zhong et al. αvβ3 integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo
Xu et al. Transferrin and tocopheryl-polyethylene glycol-succinate dual ligands decorated, cisplatin loaded nano-sized system for the treatment of lung cancer
Zhong et al. Co-delivery of sorafenib and crizotinib encapsulated with polymeric nanoparticles for the treatment of in vivo lung cancer animal model
Ma et al. ROS-responsive dimeric prodrug-based nanomedicine targeted therapy for gastric cancer
Liu et al. Platinum Drug‐Incorporating Polymeric Nanosystems for Precise Cancer Therapy
Kedar et al. Advances in dendritic systems and dendronized nanoparticles: paradigm shifts in cancer targeted therapy and diagnostics