CN112156066B - 一种包含胶束的可注射复合水凝胶双载药系统的制备方法 - Google Patents
一种包含胶束的可注射复合水凝胶双载药系统的制备方法 Download PDFInfo
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- CN112156066B CN112156066B CN202011208146.7A CN202011208146A CN112156066B CN 112156066 B CN112156066 B CN 112156066B CN 202011208146 A CN202011208146 A CN 202011208146A CN 112156066 B CN112156066 B CN 112156066B
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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Priority Applications (1)
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CN202011208146.7A CN112156066B (zh) | 2020-11-03 | 2020-11-03 | 一种包含胶束的可注射复合水凝胶双载药系统的制备方法 |
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CN202011208146.7A CN112156066B (zh) | 2020-11-03 | 2020-11-03 | 一种包含胶束的可注射复合水凝胶双载药系统的制备方法 |
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CN112156066A CN112156066A (zh) | 2021-01-01 |
CN112156066B true CN112156066B (zh) | 2021-08-17 |
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CN202011208146.7A Active CN112156066B (zh) | 2020-11-03 | 2020-11-03 | 一种包含胶束的可注射复合水凝胶双载药系统的制备方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113952290A (zh) * | 2021-06-17 | 2022-01-21 | 四川省医学科学院·四川省人民医院 | 一种纳米制剂水凝胶的制备方法和应用 |
CN114404358A (zh) * | 2022-01-21 | 2022-04-29 | 吉林大学 | 一种用于治疗骨肉瘤的新型可注射载药水凝胶的制备方法 |
Citations (6)
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CN103897206A (zh) * | 2013-03-01 | 2014-07-02 | 四川大学 | N,o-羧甲基化壳聚糖-多醛基透明质酸凝胶及其用途 |
CN107550921A (zh) * | 2017-08-24 | 2018-01-09 | 南京邮电大学 | 一种纳米颗粒‑高分子可注射复合水凝胶双载药体系及其制备方法 |
WO2018088541A1 (ja) * | 2016-11-11 | 2018-05-17 | 国立大学法人北陸先端科学技術大学院大学 | 薬物放出制御用ハイドロゲル及びその製造方法 |
CN108619094A (zh) * | 2018-06-15 | 2018-10-09 | 四川省人民医院 | 一种抗癌天然产物藤黄酸的纳米制剂及其制备方法 |
CN111317709A (zh) * | 2020-03-20 | 2020-06-23 | 西安理工大学 | 一种可注射载双药物复合壳聚糖水凝胶及其制备方法 |
CN112089729A (zh) * | 2020-09-28 | 2020-12-18 | 四川大学华西医院 | 一种共载紫杉烷类胶束和铂类药物的可注射水凝胶及其制备方法和用途 |
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2020
- 2020-11-03 CN CN202011208146.7A patent/CN112156066B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103897206A (zh) * | 2013-03-01 | 2014-07-02 | 四川大学 | N,o-羧甲基化壳聚糖-多醛基透明质酸凝胶及其用途 |
WO2018088541A1 (ja) * | 2016-11-11 | 2018-05-17 | 国立大学法人北陸先端科学技術大学院大学 | 薬物放出制御用ハイドロゲル及びその製造方法 |
CN107550921A (zh) * | 2017-08-24 | 2018-01-09 | 南京邮电大学 | 一种纳米颗粒‑高分子可注射复合水凝胶双载药体系及其制备方法 |
CN108619094A (zh) * | 2018-06-15 | 2018-10-09 | 四川省人民医院 | 一种抗癌天然产物藤黄酸的纳米制剂及其制备方法 |
CN111317709A (zh) * | 2020-03-20 | 2020-06-23 | 西安理工大学 | 一种可注射载双药物复合壳聚糖水凝胶及其制备方法 |
CN112089729A (zh) * | 2020-09-28 | 2020-12-18 | 四川大学华西医院 | 一种共载紫杉烷类胶束和铂类药物的可注射水凝胶及其制备方法和用途 |
Non-Patent Citations (6)
Title |
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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing;Gong ChangYang,等;《BIOMATERIALS》;20130930;第43卷(第72期);第6377-6387页 * |
Gambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer;Yan Wang,等;《Chinese Chemical Letters》;20190228;第30卷(第4期);摘要,Supporting information部分第1页第2-3小节 * |
improving Anti-Tumor Activity of Curcumin by Polymeric Micelles in Thermosensitive Hydrogel System in Colorectal Peritoneal Carcinomatosis Model;Zhang, Wenli,等;《JOURNAL OF BIOMEDICAL NANOTECHNOLOGY》;20190331;第51卷(第3期);第236页 * |
Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration;Youming Deng,等;《Scientific Reports》;20170602;第7卷;第2页第2段、最后一段,第10页第3-4段 * |
Modulating biodegradation and biocompatibility of in situ crosslinked hydrogel by the integration of alginate into N,O-carboxylmethyl chitosan - aldehyde hyaluronic acid network;An Nguyen-My Le,等;《POLYMER DEGRADATION AND STABILITY》;20200703;第180卷;第1-8页 * |
Peritoneal adhesion prevention with a biodegradable and injectable N, O-carboxymethyl chitosan-aldehyde hyaluronic acid hydrogel in a rat repeated-injury model;Song Linjiang,等;《SCIENTIFIC REPORTS》;20161121;第6卷;第1-13页 * |
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Inventor after: Gong Changyang Inventor after: Luo Han Inventor after: Yang Qian Inventor after: Zhu Jingqiang Inventor after: Li Zhihui Inventor after: Tang Huairong Inventor before: Gong Changyang Inventor before: Luo Han Inventor before: Yang Qian Inventor before: Zhu Jingqiang Inventor before: Li Zhihui Inventor before: Tang Huairong |
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