JP2010523150A5 - - Google Patents
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- Publication number
- JP2010523150A5 JP2010523150A5 JP2010503081A JP2010503081A JP2010523150A5 JP 2010523150 A5 JP2010523150 A5 JP 2010523150A5 JP 2010503081 A JP2010503081 A JP 2010503081A JP 2010503081 A JP2010503081 A JP 2010503081A JP 2010523150 A5 JP2010523150 A5 JP 2010523150A5
- Authority
- JP
- Japan
- Prior art keywords
- fvii polypeptide
- modified fvii
- polypeptide
- modified
- modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92351207P | 2007-04-13 | 2007-04-13 | |
| US60/923,512 | 2007-04-13 | ||
| PCT/US2008/004795 WO2008127702A2 (en) | 2007-04-13 | 2008-04-11 | Modified factor vii polypetides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013220232A Division JP2014042523A (ja) | 2007-04-13 | 2013-10-23 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523150A JP2010523150A (ja) | 2010-07-15 |
| JP2010523150A5 true JP2010523150A5 (enExample) | 2011-07-07 |
| JP5761782B2 JP5761782B2 (ja) | 2015-08-12 |
Family
ID=39689319
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503081A Expired - Fee Related JP5761782B2 (ja) | 2007-04-13 | 2008-04-11 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
| JP2013220232A Withdrawn JP2014042523A (ja) | 2007-04-13 | 2013-10-23 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
| JP2016054083A Pending JP2016155836A (ja) | 2007-04-13 | 2016-03-17 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013220232A Withdrawn JP2014042523A (ja) | 2007-04-13 | 2013-10-23 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
| JP2016054083A Pending JP2016155836A (ja) | 2007-04-13 | 2016-03-17 | 改変第ｖｉｉ因子ポリペプチド及びその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20100166729A9 (enExample) |
| EP (2) | EP2481797A1 (enExample) |
| JP (3) | JP5761782B2 (enExample) |
| KR (2) | KR20100016462A (enExample) |
| CN (2) | CN101743309B (enExample) |
| AU (1) | AU2008239586B2 (enExample) |
| BR (1) | BRPI0810172A2 (enExample) |
| CA (1) | CA2683443A1 (enExample) |
| CO (1) | CO6231052A2 (enExample) |
| CR (1) | CR11058A (enExample) |
| DK (1) | DK2147096T3 (enExample) |
| EC (1) | ECSP099735A (enExample) |
| ES (1) | ES2537328T3 (enExample) |
| GT (1) | GT200900268A (enExample) |
| HN (1) | HN2009002098A (enExample) |
| IL (2) | IL201173A0 (enExample) |
| MX (1) | MX2009010997A (enExample) |
| NI (1) | NI200900187A (enExample) |
| NZ (2) | NZ579985A (enExample) |
| PH (1) | PH12014501960A1 (enExample) |
| PL (1) | PL2147096T3 (enExample) |
| PT (1) | PT2147096E (enExample) |
| RU (1) | RU2571931C2 (enExample) |
| SG (1) | SG174077A1 (enExample) |
| SI (1) | SI2147096T1 (enExample) |
| SV (1) | SV2009003393A (enExample) |
| UA (1) | UA101155C2 (enExample) |
| WO (1) | WO2008127702A2 (enExample) |
| ZA (2) | ZA200906854B (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700341B2 (en) | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| US7939304B2 (en) * | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
| JP5376747B2 (ja) * | 2002-10-02 | 2013-12-25 | カタリスト バイオサイエンシーズ， インコーポレイテッド | 改変された特異性を有するプロテアーゼを作製する方法およびスクリーニングする方法 |
| CA2562729C (en) * | 2004-04-12 | 2013-11-12 | Sandra Waugh Ruggles | Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1 |
| CN101340928B (zh) * | 2005-10-21 | 2011-12-21 | 催化剂生物科学公司 | 抑制补体激活的修饰的蛋白酶 |
| TW200804416A (en) * | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
| EP2402437B1 (en) | 2006-07-05 | 2016-06-01 | Catalyst Biosciences, Inc. | Protease screening methods and proteases identified thereby |
| PT2147096E (pt) * | 2007-04-13 | 2015-07-21 | Catalyst Biosciences Inc | Polipéptidos do factor vii modificados e suas utilizações |
| TWI465247B (zh) | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子ｖｉｉ多肽和其用途 |
| EP2177624A1 (en) * | 2008-10-02 | 2010-04-21 | Siemens Healthcare Diagnostics Products GmbH | Blood coagulation assays |
| BRPI1011244A2 (pt) | 2009-06-25 | 2016-03-22 | Univ North Carolina | método para tratar um distúrbio de hemorragia em um indivíduo, proteína de coagulação quimérica, molécula de ácido nucleico, vetor, e, célula |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| AU2011313505B2 (en) | 2010-10-06 | 2015-09-17 | Medimmune Limited | Factor II and fibrinogen for treatment of haemostatic disorders |
| US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| TWI557135B (zh) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| HRP20220036T1 (hr) | 2011-04-22 | 2022-04-01 | The Regents Of The University Of California | Virioni adeno-povezanog virusa s varijantom kapsida i postupci njihove upotrebe |
| WO2012149463A1 (en) * | 2011-04-29 | 2012-11-01 | The University Of North Carolina At Chapel Hill | Chimeric factor vii molecules with enhanced half life and methods of use |
| EP2554161A1 (en) | 2011-08-02 | 2013-02-06 | LFB Biotechnologies | Pharmaceutical composition comprising factor VII encapsulated in micelles |
| CN104271150A (zh) * | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
| NZ701205A (en) | 2012-04-16 | 2016-02-26 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| WO2013177584A2 (en) * | 2012-05-25 | 2013-11-28 | The Children's Hospital Of Philadelphia | FVIIa VARIANTS EXHIBITING ALTERED INTERACTION WITH ENDOTHELIAL PROTEIN C RECEPTOR (EPCR) AND METHODS OF USE THEREOF FOR MODULATING HEMOSTASIS |
| US8986991B2 (en) * | 2012-07-03 | 2015-03-24 | Expression Therapeutics, Llc | High yield suspension cell line, system and method for making same |
| BR112015001628A2 (pt) | 2012-07-25 | 2017-11-07 | Catalyst Biosciences Inc | polipeptídeos de fator x modificados e uso dos mesmos |
| WO2014060397A1 (en) | 2012-10-15 | 2014-04-24 | Novo Nordisk Health Care Ag | Factor vii conjugates |
| BR112015021866A2 (pt) * | 2013-03-15 | 2017-08-29 | Bayer Healthcare Llc | Domínios de gla como agentes direcionadores |
| CA2907799A1 (en) | 2013-05-31 | 2014-12-04 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| CN104774269B (zh) * | 2013-08-16 | 2016-02-24 | 安源生物科技(上海)有限公司 | 改良型人凝血因子FVII-Fc融合蛋白及其制备方法与用途 |
| WO2015055692A1 (en) | 2013-10-15 | 2015-04-23 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
| CN105793411B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
| KR102288849B1 (ko) | 2014-03-17 | 2021-08-12 | 애드베룸 바이오테크놀로지스, 인코포레이티드 | 원추세포에서 증강된 유전자 발현을 위한 조성물 및 방법 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| LT3149163T (lt) * | 2014-05-26 | 2020-09-25 | Academisch Ziekenhuis Leiden | Prohemostatiniai baltymai, skirti kraujavimo gydymui |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| CN114480502A (zh) | 2015-03-02 | 2022-05-13 | 阿德夫拉姆生物技术股份有限公司 | 用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法 |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| CN114672516B (zh) | 2016-07-29 | 2024-11-26 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体和其使用方法 |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| IL319473A (en) | 2016-12-02 | 2025-05-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11633504B2 (en) | 2017-05-09 | 2023-04-25 | Emory University | Nucleic acids encoding clotting factor variants and their use |
| WO2018222503A1 (en) * | 2017-05-31 | 2018-12-06 | The Regents Of The University Of California | Adeno-associated virus with variant capsid and methods of use thereof |
| KR102766238B1 (ko) | 2017-06-30 | 2025-02-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 보유한 아데노-부속 바이러스 비리온 및 이의 사용 방법 |
| AU2018324477A1 (en) | 2017-08-28 | 2019-10-17 | The Regents Of The University Of California | Adeno-associated virus capsid variants and methods of use thereof |
| US20200407421A1 (en) | 2017-09-05 | 2020-12-31 | GLAdiator Biosciences, Inc. | Delivery of payloads to stem cells |
| DK3793588T3 (da) | 2018-05-18 | 2025-06-16 | Bioverativ Therapeutics Inc | Fremgangsmåder til behandling af hæmofili a |
| EP3830273A4 (en) * | 2018-08-03 | 2022-05-18 | Duke University | PROTEIN C FACTOR VII CHIMERAS |
| WO2021030787A1 (en) | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| WO2024228958A2 (en) * | 2023-05-04 | 2024-11-07 | The Cleveland Clinic Foundation | Human factor vii deletion constructs for treating cancer |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| DK323587D0 (da) | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5033352A (en) | 1989-01-19 | 1991-07-23 | Yamaha Corporation | Electronic musical instrument with frequency modulation |
| US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
| EP0521873B1 (en) * | 1990-01-29 | 1999-06-02 | Zymogenetics, Inc. | Anticoagulant proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| US5817788A (en) * | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
| US5861374A (en) * | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
| US20040087498A1 (en) * | 1991-02-28 | 2004-05-06 | Novo Nordisk Health Care Ag | Modified factor VII |
| US5788965A (en) * | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| ATE363532T1 (de) | 1991-03-01 | 2007-06-15 | Dyax Corp | Verfahren zur herstellung bindender miniproteine |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| AU735463B2 (en) | 1997-02-14 | 2001-07-12 | American Red Cross | Expression of active human factor IX in mammary tissue of transgenic animals |
| US20050032690A1 (en) * | 1997-09-10 | 2005-02-10 | Rojkjaer Lisa Payne | Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia |
| US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7247708B2 (en) * | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6017882A (en) | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6537749B2 (en) | 1998-04-03 | 2003-03-25 | Phylos, Inc. | Addressable protein arrays |
| DE19937219A1 (de) | 1999-08-06 | 2001-02-08 | Aventis Behring Gmbh | Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie |
| WO2001032711A2 (en) | 1999-10-21 | 2001-05-10 | Board Of Trustees Of The University Of Arkansas | Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| NZ521257A (en) * | 2000-02-11 | 2004-10-29 | Maxygen Aps | Factor VII or VIIa-like molecules |
| WO2001083725A1 (en) | 2000-05-03 | 2001-11-08 | Novo Nordisk A/S | Human coagulation factor vii variants |
| US6905683B2 (en) * | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| CZ20023667A3 (cs) * | 2000-05-10 | 2003-04-16 | Novo Nordisk A/S | Farmaceutický prostředek obsahující VIIA a XIII faktory |
| ES2429523T3 (es) * | 2000-09-13 | 2013-11-15 | Novo Nordisk Health Care Ag | Variantes del factor VII de coagulación humana |
| EP2253703A1 (en) | 2000-09-13 | 2010-11-24 | Novo Nordisk Health Care AG | Human coagulation factor VII variants |
| IL154879A0 (en) * | 2000-10-02 | 2003-10-31 | Novo Nordisk As | Factor vii glycoforms |
| US7173000B2 (en) * | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
| ATE538380T1 (de) | 2001-01-23 | 2012-01-15 | Harvard College | Nukleinsäure-programmierbare protein-arrays |
| US20040133930A1 (en) | 2002-03-11 | 2004-07-08 | Cooper Julian D. | Production of high levels of transgenic factor ix without gene rescue, and its therapeutic uses |
| US7235638B2 (en) * | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
| AU2002249096B2 (en) | 2001-03-22 | 2007-06-28 | Novo Nordisk Health Care Ag | Coagulation factor VII derivatives |
| US20030134298A1 (en) * | 2001-07-03 | 2003-07-17 | Madison Edwin L. | Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon |
| US7419949B2 (en) * | 2001-07-16 | 2008-09-02 | Novo Noridsk Healthcare A/G | Single-dose administration of factor VIIa |
| US6882883B2 (en) * | 2001-08-31 | 2005-04-19 | Medtronic, Inc. | Implantable medical device (IMD) system configurable to subject a patient to a stress test and to detect myocardial ischemia within the patient |
| WO2003027147A2 (en) | 2001-09-27 | 2003-04-03 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
| US7052868B2 (en) * | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| HUP0402158A2 (hu) * | 2001-10-02 | 2005-01-28 | Novo Nordisk Health Care Ag | Rekombináns fehérjék előállítási eljárása eukarióta sejtekben |
| US20030143219A1 (en) * | 2001-10-09 | 2003-07-31 | Madison Edwin L | Nucleic acid molecules encoding a transmembrane serine protease 25, the encoded polypeptides and methods based thereon |
| JP3862996B2 (ja) | 2001-10-31 | 2006-12-27 | 帝人ファイバー株式会社 | ポリトリメチレンテレフタレートフィラメント糸およびその製造方法 |
| US6960657B2 (en) * | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| US7291587B2 (en) * | 2001-11-09 | 2007-11-06 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides |
| WO2003044179A2 (en) * | 2001-11-20 | 2003-05-30 | Dendreon San Diego Llc | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
| CN1606452A (zh) * | 2001-12-21 | 2005-04-13 | 诺沃娜第克公司 | 修饰的因子ⅶ多肽的液体组合物 |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| WO2003093465A1 (en) * | 2002-04-30 | 2003-11-13 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa POLYPEPTIDE VARIANTS |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| US20040001801A1 (en) * | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
| DE60336555D1 (de) * | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
| WO2004005471A2 (en) * | 2002-07-02 | 2004-01-15 | Dendreon Corporation | Serine protease 16 |
| DE60330923D1 (de) | 2002-09-25 | 2010-02-25 | Novo Nordisk Healthcare Ag | Menschliche Koagulationsfaktor VII Polypeptide |
| US6911323B2 (en) * | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| EP1549677B1 (en) * | 2002-09-30 | 2011-04-13 | Bayer HealthCare LLC | FVII OR FVIIa VARIANTS HAVING INCREASED CLOTTING ACTIVITY |
| JP5376747B2 (ja) * | 2002-10-02 | 2013-12-25 | カタリスト バイオサイエンシーズ， インコーポレイテッド | 改変された特異性を有するプロテアーゼを作製する方法およびスクリーニングする方法 |
| DK1608745T3 (da) * | 2003-03-20 | 2009-06-15 | Bayer Healthcare Llc | FVII eller FVIIa-Varianter |
| FI20030413L (fi) | 2003-03-20 | 2004-09-21 | Suomen Intech Oy | Kaasulaakerointi |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| WO2004087933A2 (en) | 2003-03-28 | 2004-10-14 | The Regents Of The University Of California | A novel encoding method for 'one-bead one-compound' combinatorial libraries |
| WO2004108763A2 (en) | 2003-06-05 | 2004-12-16 | Canadian Blood Services | Mutants of the factor vii epidermal growth factor domain |
| US20060116324A1 (en) * | 2003-06-13 | 2006-06-01 | Novo Nordisk Healthcare A/G | Novel formulations |
| DK1644504T3 (da) | 2003-06-19 | 2010-05-25 | Bayer Healthcare Llc | Faktor VII- eller -VIIA-Gla-domænevarianter |
| ATE547519T1 (de) * | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
| WO2005032581A2 (en) * | 2003-10-07 | 2005-04-14 | Novo Nordisk Health Care Ag | Hybrid molecules having factor vii/viia activity |
| US20070072271A1 (en) * | 2004-01-07 | 2007-03-29 | Novo Nordisk Healthcare A/G | Method for the production of recombinant proteins |
| EP1713906A2 (en) | 2004-02-03 | 2006-10-25 | Novo Nordisk Health Care AG | Coagulation factor vii/viia variants lacking functional lipid membrane binding domain |
| CA2562729C (en) * | 2004-04-12 | 2013-11-12 | Sandra Waugh Ruggles | Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1 |
| US20080058255A1 (en) * | 2004-06-21 | 2008-03-06 | Novo Nordisk Healthcare A/G | Glycosylation-Disrupted Factor VII Variants |
| WO2006014253A2 (en) * | 2004-07-02 | 2006-02-09 | Genentech, Inc. | Factor viia variants |
| WO2006114105A2 (en) * | 2005-04-26 | 2006-11-02 | Maxygen Holdings Ltd. | Use of modified factor vii for treating bleeding |
| JP5690047B2 (ja) * | 2005-09-14 | 2015-03-25 | ノボ ノルディスク ヘルス ケア アーゲー | ヒト凝固第ｖｉｉ因子ポリペプチド |
| WO2007039475A1 (en) * | 2005-09-21 | 2007-04-12 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
| CN101340928B (zh) * | 2005-10-21 | 2011-12-21 | 催化剂生物科学公司 | 抑制补体激活的修饰的蛋白酶 |
| TW200804416A (en) * | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
| EP2402437B1 (en) * | 2006-07-05 | 2016-06-01 | Catalyst Biosciences, Inc. | Protease screening methods and proteases identified thereby |
| PT2147096E (pt) * | 2007-04-13 | 2015-07-21 | Catalyst Biosciences Inc | Polipéptidos do factor vii modificados e suas utilizações |
| TWI465247B (zh) * | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子ｖｉｉ多肽和其用途 |
| BRPI1011244A2 (pt) * | 2009-06-25 | 2016-03-22 | Univ North Carolina | método para tratar um distúrbio de hemorragia em um indivíduo, proteína de coagulação quimérica, molécula de ácido nucleico, vetor, e, célula |
| TWI557135B (zh) * | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| BR112015001628A2 (pt) * | 2012-07-25 | 2017-11-07 | Catalyst Biosciences Inc | polipeptídeos de fator x modificados e uso dos mesmos |
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