JP2010516758A5 - - Google Patents
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- JP2010516758A5 JP2010516758A5 JP2009547177A JP2009547177A JP2010516758A5 JP 2010516758 A5 JP2010516758 A5 JP 2010516758A5 JP 2009547177 A JP2009547177 A JP 2009547177A JP 2009547177 A JP2009547177 A JP 2009547177A JP 2010516758 A5 JP2010516758 A5 JP 2010516758A5
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- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
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Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88706007P | 2007-01-29 | 2007-01-29 | |
| US60/887,060 | 2007-01-29 | ||
| PCT/KR2008/000525 WO2008093982A1 (en) | 2007-01-29 | 2008-01-29 | Novel macromolecule transduction domains and methods for identification and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013207349A Division JP2014057586A (ja) | 2007-01-29 | 2013-10-02 | 巨大分子伝達ドメインならびにその同定方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516758A JP2010516758A (ja) | 2010-05-20 |
| JP2010516758A5 true JP2010516758A5 (enExample) | 2011-04-21 |
| JP5518488B2 JP5518488B2 (ja) | 2014-06-11 |
Family
ID=39674245
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547177A Active JP5518488B2 (ja) | 2007-01-29 | 2008-01-29 | 巨大分子伝達ドメインならびにその同定方法および使用 |
| JP2013207349A Pending JP2014057586A (ja) | 2007-01-29 | 2013-10-02 | 巨大分子伝達ドメインならびにその同定方法および使用 |
| JP2015090144A Active JP6140759B2 (ja) | 2007-01-29 | 2015-04-27 | 巨大分子伝達ドメインならびにその同定方法および使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013207349A Pending JP2014057586A (ja) | 2007-01-29 | 2013-10-02 | 巨大分子伝達ドメインならびにその同定方法および使用 |
| JP2015090144A Active JP6140759B2 (ja) | 2007-01-29 | 2015-04-27 | 巨大分子伝達ドメインならびにその同定方法および使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8629097B2 (enExample) |
| EP (2) | EP2837636B1 (enExample) |
| JP (3) | JP5518488B2 (enExample) |
| KR (18) | KR20090103957A (enExample) |
| CN (1) | CN101616928B (enExample) |
| AU (1) | AU2008211854C1 (enExample) |
| CA (1) | CA2676797C (enExample) |
| WO (1) | WO2008093982A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2438962A3 (en) | 2006-02-13 | 2012-07-18 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| KR20090122946A (ko) | 2007-02-27 | 2009-12-01 | 주식회사 프로셀제약 | 줄기세포의 자가-재생을 촉진하고 분화를 억제하기 위한 세포투과성 ｎａｎｏｇ 및 ｏｃｔ４의 병합 용도 |
| CN101918556B (zh) * | 2007-09-04 | 2013-06-12 | 株式会社普罗赛尔制药 | 可穿透细胞的nm23重组蛋白、编码其的多核苷酸以及包含其的抗转移组合物 |
| KR100887266B1 (ko) * | 2007-09-04 | 2009-03-06 | 주식회사 프로셀제약 | 세포투과성 ｐ１８ 재조합 단백질, 이를 코딩하는폴리뉴클레오티드 및 이를 유효성분으로 함유하는 항암조성물 |
| EP2209892A2 (en) * | 2007-11-06 | 2010-07-28 | Procell Therapeutics Inc. | Cell permeable runx3 recombinant proteins, polynucleotides encoding the same, and anticancer compositions including the same |
| US8586544B2 (en) | 2008-04-04 | 2013-11-19 | Procell Therapeutics Inc. | Cell-permeable endostatin recombinant protein, a polynucleotide encoding the same, and an anti-cancer preparation containing the same as an active component |
| US20120095188A1 (en) | 2009-03-12 | 2012-04-19 | Procell Therapeutics Inc. | Establishment of induced pluripotent stem cell using cell-permeable reprogramming transcription factor for customized stem cell therapy |
| EP3252068B1 (en) | 2009-10-12 | 2025-07-02 | Larry J. Smith | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| TW201302800A (zh) * | 2011-06-10 | 2013-01-16 | 腫瘤療法 科學股份有限公司 | Ｓｅｍａ５ｂ胜肽及含其之疫苗 |
| US8859507B2 (en) | 2011-08-16 | 2014-10-14 | Samsung Electronics Co., Ltd. | Protein complex for intracellular delivery and uses thereof |
| KR101393397B1 (ko) * | 2011-11-23 | 2014-05-14 | 주식회사 프로셀제약 | 세포내 분자 전송 펩티드를 이용한 피부 생리 활성 분자의 경피 전달시스템 |
| ES2621337T3 (es) | 2011-11-23 | 2017-07-03 | Procell Therapeutics Inc. | Desarrollo de nuevo dominio de transducción macromolecular con mejor permeabilidad celular y método de uso del mismo |
| KR101258279B1 (ko) * | 2011-11-23 | 2013-04-25 | 주식회사 프로셀제약 | 세포 투과능을 개선한 개량형 신규 거대 분자 전달 도메인 개발 및 이의 이용방법 |
| JP6267190B2 (ja) | 2012-05-11 | 2018-01-24 | ジェムバックス アンド カエル カンパニー，リミティド | 悪液質の予防用または治療用組成物 |
| CN108949717B (zh) | 2012-05-11 | 2023-06-20 | 珍白斯凯尔有限公司 | 抗炎性肽及包含其的组合物 |
| WO2014005219A1 (en) * | 2012-07-02 | 2014-01-09 | Iprogen Biotech Inc. | Intracellular protein delivery |
| US10967000B2 (en) | 2012-07-11 | 2021-04-06 | Gemvax & Kael Co., Ltd. | Cell-penetrating peptide, conjugate comprising same and composition comprising same |
| CA2928851A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| WO2014046490A1 (ko) * | 2012-09-19 | 2014-03-27 | 주식회사 카엘젬백스 | 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 |
| JP6510410B2 (ja) | 2012-09-19 | 2019-05-08 | ジェムバックス アンド カエル カンパニー，リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
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| EP4063863A1 (en) | 2013-06-07 | 2022-09-28 | Gemvax & Kael Co., Ltd. | Gv1001, gemcitabine and capecitabine for use in the treatment of pancreatic cancer in high eotaxin baseline level patients |
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| GB201315321D0 (en) | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| CN105899224B (zh) | 2013-10-23 | 2019-12-13 | 珍白斯凯尔有限公司 | 用于治疗和预防良性前列腺增生的组合物 |
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| JP6243577B2 (ja) * | 2014-05-29 | 2017-12-06 | プロセル セラピューティックス インコーポレーティッド | 新規な細胞透過性ペプチド及びこれとボツリヌストキシン結合体、およびこれらの用途 |
| CA2957501C (en) * | 2014-08-17 | 2020-08-11 | Cellivery Therapeutics, Inc. | Advanced macromolecule transduction domain (amtd) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of amtds comprising the same, method to develop the amtd sequences comprising the same |
| US20160060310A1 (en) | 2014-08-27 | 2016-03-03 | Daewoong Jo | Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Hepatocellular Carcinoma Effect - Improved Cell-Permeable Suppressor of Cytokine Signaling (iCP-SOCS3) Proteins, Polynucleotides Encoding the Same, and Anti-Hepatocellular Carcinoma Compositions Comprising the Same |
| CN104548073B (zh) * | 2014-12-12 | 2017-08-11 | 浙江大学 | Prx I重组蛋白在制备抗细菌性败血症药物中的应用 |
| US20170369529A1 (en) * | 2014-12-22 | 2017-12-28 | Hoffmann-La Roche Inc. | Cell penetrating peptides |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
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| US20170029798A1 (en) | 2015-07-27 | 2017-02-02 | Cellivery Therapeutics, Inc. | Development of Improved Cell-Permeable (iCP) Parkin Recombinant Protein as a Protein-Based Anti-Neurodegenerative Agent for the Treatment of Parkinson's Disease-Associated Phenotypes by Utilizing BBB-Penetrating Protein Delivery System MITT, Enabled by Advanced Macromolecule Transduction Domain (aMTD) |
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| KR101800407B1 (ko) * | 2016-04-04 | 2017-11-22 | 건국대학교 산학협력단 | 비단뱀으로부터 분리한 신규한 항균 펩타이드 및 이의 발굴 방법 |
| US10898540B2 (en) | 2016-04-07 | 2021-01-26 | Gem Vax & KAEL Co., Ltd. | Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same |
| CN118909050A (zh) * | 2016-10-12 | 2024-11-08 | 费尔丹生物公司 | 用于将多肽负荷递送至靶真核细胞的合理设计的合成肽穿梭剂，其用途、方法和试剂盒 |
| JP7062595B2 (ja) * | 2016-10-23 | 2022-05-06 | デンカ株式会社 | 複合ポリペプチド単量体、細胞浸透機能を有する当該複合ポリペプチドの単量体の会合体、及び、当該会合体を有効成分とする皮下、皮内、経皮又は筋肉内投与用ノロウイルスコンポーネントワクチン |
| CN106831957B (zh) * | 2017-04-17 | 2019-12-03 | 扬州大学 | 一种源于鸡传染性贫血病毒VP1-aa 1-19多肽作为高效细胞穿膜肽的应用 |
| CN106995487B (zh) * | 2017-04-17 | 2019-12-03 | 扬州大学 | 源于鸡传染性贫血病毒VP1-aa 23-43多肽作为高效细胞穿膜肽的应用 |
| CN111465611B (zh) | 2017-12-01 | 2024-10-11 | 古德T细胞有限公司 | 预防或治疗脱发的组合物 |
Family Cites Families (10)
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| CN1031959C (zh) * | 1991-04-11 | 1996-06-05 | 住友电气工业株式会社 | 测量涂层状态的方法和设备 |
| US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
| US6248558B1 (en) * | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| CN1309417C (zh) | 2001-02-15 | 2007-04-11 | 王荣福 | 穿细胞肽在产生抗肿瘤免疫力上的用途 |
| EP1495045B1 (en) * | 2002-03-29 | 2009-09-02 | Creagene, Inc. | Cytoplasmic transduction peptides and uses thereof |
| US6835810B2 (en) * | 2002-05-13 | 2004-12-28 | Geneshuttle Biopharma, Inc. | Fusion protein for use as vector |
| SE0201863D0 (en) * | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| US20070154437A1 (en) | 2002-09-03 | 2007-07-05 | Pingfan Rao | Peptide-tagged proteins and methods of making and using thereof |
| US20040043463A1 (en) * | 2002-09-03 | 2004-03-04 | Pingfan Rao | Peptide-tagged proteins and compositions for regulating features of the skin or hair; methods of making, and methods of using thereof |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
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