JP2010513549A5 - - Google Patents
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- Publication number
- JP2010513549A5 JP2010513549A5 JP2009543052A JP2009543052A JP2010513549A5 JP 2010513549 A5 JP2010513549 A5 JP 2010513549A5 JP 2009543052 A JP2009543052 A JP 2009543052A JP 2009543052 A JP2009543052 A JP 2009543052A JP 2010513549 A5 JP2010513549 A5 JP 2010513549A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- serotype
- carrier protein
- conjugate
- activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical group 0.000 claims 73
- 229920001282 polysaccharide Polymers 0.000 claims 73
- 239000005017 polysaccharide Substances 0.000 claims 73
- 102000014914 Carrier Proteins Human genes 0.000 claims 39
- 108010078791 Carrier Proteins Proteins 0.000 claims 39
- 230000002163 immunogen Effects 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 17
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 5
- 150000001768 cations Chemical class 0.000 claims 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000007800 oxidant agent Substances 0.000 claims 5
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical group OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 4
- 239000012279 sodium borohydride Substances 0.000 claims 4
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 4
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical group [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims 3
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/644,924 US7709001B2 (en) | 2005-04-08 | 2006-12-22 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11/644,924 | 2006-12-22 | ||
| PCT/US2007/086941 WO2008143709A2 (en) | 2006-12-22 | 2007-12-10 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513549A JP2010513549A (ja) | 2010-04-30 |
| JP2010513549A5 true JP2010513549A5 (enExample) | 2011-02-17 |
| JP5523836B2 JP5523836B2 (ja) | 2014-06-18 |
Family
ID=39876611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543052A Active JP5523836B2 (ja) | 2006-12-22 | 2007-12-10 | 多価肺炎球菌多糖−タンパク質コンジュゲート組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7709001B2 (enExample) |
| EP (2) | EP2417983B1 (enExample) |
| JP (1) | JP5523836B2 (enExample) |
| KR (3) | KR20140130567A (enExample) |
| CN (2) | CN101610785B (enExample) |
| AT (1) | ATE545431T1 (enExample) |
| AU (1) | AU2007353769B2 (enExample) |
| BR (1) | BRPI0720624A2 (enExample) |
| CA (1) | CA2673477C (enExample) |
| CL (2) | CL2007003782A1 (enExample) |
| DK (2) | DK2417983T3 (enExample) |
| ES (2) | ES2424940T3 (enExample) |
| IL (2) | IL199350A (enExample) |
| MX (1) | MX2009006705A (enExample) |
| PL (2) | PL2417983T3 (enExample) |
| PT (2) | PT2094298E (enExample) |
| RU (1) | RU2493870C2 (enExample) |
| SI (2) | SI2094298T1 (enExample) |
| WO (1) | WO2008143709A2 (enExample) |
| ZA (1) | ZA200904760B (enExample) |
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