BRPI0409459A - novas composições imunogênicas para a prevenção e tratamento de doença meningocócica - Google Patents
novas composições imunogênicas para a prevenção e tratamento de doença meningocócicaInfo
- Publication number
- BRPI0409459A BRPI0409459A BRPI0409459-0A BRPI0409459A BRPI0409459A BR PI0409459 A BRPI0409459 A BR PI0409459A BR PI0409459 A BRPI0409459 A BR PI0409459A BR PI0409459 A BRPI0409459 A BR PI0409459A
- Authority
- BR
- Brazil
- Prior art keywords
- immunogenic compositions
- prevention
- treatment
- immunogenic
- meningococcal disease
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000037941 meningococcal disease Diseases 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000034762 Meningococcal Infections Diseases 0.000 abstract 1
- 241000588653 Neisseria Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"NOVAS COMPOSIçõES IMUNOGêNICAS PARA A PREVENçãO E TRATAMENTO DE DOENçA MENINGOCóCICA". A presente invenção se refere a proteínas de Neisseria ORF2086, proteínas imunogênicas de reação cruzada que podem ser isoladas de cepas nesserial ou preparadas recombinantemente, incluindo porções imunogênicas destas, equivalentes biológicos destas, anticorpos que se ligam imunoespecificamente às precedentes e seqüências de ácido nucléico que codificam cada uma das precedentes, bem como ao uso das mesmas em composições imunogênicas que são efetivas contra infecção por Neisseria meningitidis de grupo de soro B.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46316103P | 2003-04-16 | 2003-04-16 | |
PCT/US2004/011901 WO2004094596A2 (en) | 2003-04-16 | 2004-04-16 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0409459A true BRPI0409459A (pt) | 2006-05-02 |
Family
ID=33310752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409459-0A BRPI0409459A (pt) | 2003-04-16 | 2004-04-16 | novas composições imunogênicas para a prevenção e tratamento de doença meningocócica |
Country Status (11)
Country | Link |
---|---|
US (5) | US20070253964A1 (pt) |
EP (1) | EP1618185A4 (pt) |
JP (1) | JP2006525330A (pt) |
KR (1) | KR20060019515A (pt) |
CN (1) | CN1867354A (pt) |
AU (2) | AU2004233012A1 (pt) |
BR (1) | BRPI0409459A (pt) |
CA (1) | CA2522751A1 (pt) |
CO (1) | CO5700785A2 (pt) |
MX (1) | MXPA05011110A (pt) |
WO (1) | WO2004094596A2 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2261343A3 (en) | 1998-05-01 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
CA2929348A1 (en) | 1999-05-19 | 2000-11-30 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
ES2543736T3 (es) | 1999-10-29 | 2015-08-21 | Glaxosmithkline Biologicals Sa | Péptidos antigénicos de Neisseria |
PT2270030E (pt) | 2000-02-28 | 2012-07-24 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
IL308456A (en) | 2005-04-08 | 2024-01-01 | Wyeth Llc | A multivalent pneumomuroral protein-polysaccharide conjugate preparation |
EP1943269A2 (en) * | 2005-10-14 | 2008-07-16 | Intercell AG | Neisseria meningitidis antigens |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
SI2061897T1 (sl) | 2006-07-27 | 2020-07-31 | Wyeth Llc | Postopek fermentacije s tehniko dohranjevalne šarže za celice z visoko gostoto za proizvajanje rekombinantnega proteina |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
PL2411048T3 (pl) | 2009-03-24 | 2020-11-16 | Glaxosmithkline Biologicals Sa | Adjuwantowe meningokokowe białko wiążące czynnik h |
NZ598458A (en) | 2009-08-27 | 2014-03-28 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
JP5960055B2 (ja) * | 2009-10-27 | 2016-08-02 | ノバルティス アーゲー | 改変髄膜炎菌fHBPポリペプチド |
CA2792683A1 (en) * | 2010-03-10 | 2011-09-15 | Glaxosmithkline Biologicals S.A. | Neisserial fhbp vaccine composition |
RU2636455C2 (ru) * | 2010-05-14 | 2017-11-23 | Баксалта Инкорпорейтид, (US) | Химерные гены ospa, белки и способы их применения |
AU2011262346B2 (en) | 2010-06-04 | 2014-12-11 | Wyeth Llc | Streptococcus pneumoniae vaccine formulations |
EP2585106A1 (en) | 2010-06-25 | 2013-05-01 | Novartis AG | Combinations of meningococcal factor h binding proteins |
KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 rLP2086 항원의 안정한 제제 |
AU2011300409B2 (en) * | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
BR112014016223A8 (pt) | 2011-12-29 | 2017-07-04 | Novartis Ag | combinações adjuvantes de proteínas de ligação de fator h meningocócico |
KR101763625B1 (ko) | 2012-03-09 | 2017-08-01 | 화이자 인코포레이티드 | 수막염균 조성물 및 이의 사용 방법 |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
WO2013186753A1 (en) | 2012-06-14 | 2013-12-19 | Novartis Ag | Vaccines for serogroup x meningococcus |
AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
US9822150B2 (en) | 2013-09-08 | 2017-11-21 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
EP3782643A1 (en) | 2014-02-28 | 2021-02-24 | GlaxoSmithKline Biologicals SA | Modified meningococcal fhbp polypeptides |
KR20170103009A (ko) * | 2015-02-19 | 2017-09-12 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
GB202016604D0 (en) * | 2020-10-20 | 2020-12-02 | Univ Of Oxford | Compositions and methods for inducing an immune response |
CN113372571A (zh) * | 2021-07-05 | 2021-09-10 | 云南紫辰集团生物科技有限公司 | 黄腐酸钾干粉的生产工艺 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US466829A (en) * | 1892-01-12 | Carpet-stretcher | ||
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4650764A (en) * | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4980289A (en) * | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
US5124263A (en) * | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
WO1993007897A1 (en) * | 1991-10-21 | 1993-04-29 | Medimmune, Inc. | Bacterial expression vectors containing dna encoding secretion signals of lipoproteins |
FR2708622B1 (fr) * | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
DE19723095C2 (de) * | 1997-06-02 | 2001-08-23 | Siemens Ag | Bildrekonstruktionsverfahren für einen Computertomographen |
JP4290875B2 (ja) * | 1998-02-03 | 2009-07-08 | センター フォア ディズィーズ コントロール アンド プリヴェンション | 組換え脂質化PsaAタンパク質、調製法および使用 |
EP2261343A3 (en) * | 1998-05-01 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
DE69937571T2 (de) * | 1998-09-30 | 2008-09-04 | The Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences | Mutiertes cholera holotoxin als hilfsmittel |
CA2460546A1 (en) * | 2001-09-14 | 2003-03-27 | Invitrogen Corporation | Dna polymerases and mutants thereof |
MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
-
2004
- 2004-04-16 CA CA002522751A patent/CA2522751A1/en not_active Abandoned
- 2004-04-16 WO PCT/US2004/011901 patent/WO2004094596A2/en active Application Filing
- 2004-04-16 JP JP2006513095A patent/JP2006525330A/ja active Pending
- 2004-04-16 KR KR1020057019725A patent/KR20060019515A/ko not_active Application Discontinuation
- 2004-04-16 EP EP04759967A patent/EP1618185A4/en not_active Withdrawn
- 2004-04-16 AU AU2004233012A patent/AU2004233012A1/en not_active Abandoned
- 2004-04-16 BR BRPI0409459-0A patent/BRPI0409459A/pt not_active IP Right Cessation
- 2004-04-16 CN CNA2004800163535A patent/CN1867354A/zh active Pending
- 2004-04-16 US US10/553,670 patent/US20070253964A1/en not_active Abandoned
- 2004-04-16 MX MXPA05011110A patent/MXPA05011110A/es not_active Application Discontinuation
-
2005
- 2005-11-16 CO CO05116231A patent/CO5700785A2/es not_active Application Discontinuation
-
2006
- 2006-12-14 US US11/638,401 patent/US20070082866A1/en not_active Abandoned
- 2006-12-14 US US11/638,520 patent/US20070082007A1/en not_active Abandoned
- 2006-12-14 US US11/638,443 patent/US20070082006A1/en not_active Abandoned
-
2008
- 2008-06-16 US US12/214,043 patent/US20090202593A1/en not_active Abandoned
-
2010
- 2010-03-10 AU AU2010200892A patent/AU2010200892A1/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2522751A1 (en) | 2004-11-04 |
CO5700785A2 (es) | 2006-11-30 |
US20070082007A1 (en) | 2007-04-12 |
JP2006525330A (ja) | 2006-11-09 |
EP1618185A2 (en) | 2006-01-25 |
EP1618185A4 (en) | 2009-05-27 |
US20090202593A1 (en) | 2009-08-13 |
AU2010200892A1 (en) | 2010-04-01 |
WO2004094596A8 (en) | 2006-06-15 |
WO2004094596A2 (en) | 2004-11-04 |
AU2004233012A1 (en) | 2004-11-04 |
KR20060019515A (ko) | 2006-03-03 |
US20070253964A1 (en) | 2007-11-01 |
MXPA05011110A (es) | 2006-01-24 |
US20070082006A1 (en) | 2007-04-12 |
US20070082866A1 (en) | 2007-04-12 |
CN1867354A (zh) | 2006-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0409459A (pt) | novas composições imunogênicas para a prevenção e tratamento de doença meningocócica | |
BR0212999A (pt) | novas composições imunogênicas para a prevenção e tratamento de doença meningocócica | |
MX2009006760A (es) | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedades meningococicas. | |
BR0311777A (pt) | Composição de vesìcula meningocócica multivalente, vacina para o tratamento de doença neisserial, métodos para fabricação de composição de vesìcula meningocócica multivalente e para prevenção ou tratamento de doença neisserial, e, uso de uma quantidade imunologicamente eficaz da vacina | |
NZ601538A (en) | Vaccine compositions comprising a mutated factor h binding protein | |
BR0210804A (pt) | Vacinação de dose única com mycoplásma hyopneumoniae | |
BR9914374A (pt) | Sequências genÈmicas de neisseria e métodos para seu uso | |
JP2024511179A (ja) | 百日咳ワクチン | |
WO2005116270A3 (en) | Influenza virus vaccine composition and method of use | |
BRPI0612655A8 (pt) | composição imunogênica, vacina, kit de vacina para a administração seqüencial ou concomitante, processo para a produção da vacina, método de imunização de um hospedeiro humano contra doença causada por infecção de neisseria meningitidis, e, uso da composição imunogênica. | |
CN102580072A (zh) | 组合式奈瑟球菌组合物 | |
BRPI0416796A (pt) | compostos orgánicos | |
EA200900024A1 (ru) | Противогриппозная вакцина | |
BRPI0508365A (pt) | composições imunogênicas para chlamydia pneumoniae | |
BRPI0314373B8 (pt) | produto imunogênico estável para a indução de anticorpos contra uma ou várias proteínas antigênicas em um indivíduo, composições farmacêutica, imunogênica e de vacina e processo de preparação de um produto imunogênico | |
EA200800397A1 (ru) | Композиции тизанидина и способы лечения с применением композиций | |
BRPI0411875A (pt) | método de imunização contra os sorogrupos a e c de neisseria meningitidis | |
UA107177C2 (uk) | Імуногенна композиція цвс2 та спосіб приготування такої композиції | |
DE60035485D1 (de) | IDENTIFIZIERUNG VON SPEZIFISCHEN DIFFERENZIELL EXPRIMIERTEN ANTIGENEN AUS MYCOBACTERIUM UND MEDIZINISCHE VERWENDUNG DER MYCOBAKTERIUMPROTEINE Rv0068 UND Rv3407 | |
NZ591738A (en) | Non-typhoidal salmonella vaccines comprising a polypeptide which is an outer membrane protein d of non typoidal salmonella | |
WO2005117956A3 (en) | Neisserial vaccines | |
BRPI0412419A (pt) | proteìna de babésia, ácido nucleico, fragmento de cdna, molécula de dna recombinante, veìculo recombinante vivo, célula hospedeira, vacina, método para a preparação de uma vacina, uso de uma proteìna ou um fragmento imunogênico de referida proteìna, e, testes diagnósticos para a detecção de um ácido nucleico associado com, para a detecção de anticorpos contra, e para a detecção de material antigênico de um organismo da famìlia babesiidae | |
MA32080B1 (fr) | Vaccin comprenant un extrait de protéine ribosomale (rpe) et facultativement un adjuvant promouvant la réponse th1 | |
BR0110791A (pt) | Composição, métodos para induzir uma resposta imune em um indivìduo contra um imunogene, para modular o sistema imune de um indivìduo e para imunizar um indivìduo contra um patógeno, vacina recombinante, e patógeno atenuado vivo | |
BR0313100A (pt) | Composição imunogênica, composição imunogênica isolada, vacina, método de tratamento ou prevenção de doença bacteriana gram-negativa, uso da vacina, cepa bacteriana gram-negativa geneticamente manipulada, método para preparar a composição imunogênica, método para preparar a vacina, método de preparar uma imunoglobulina para uso na prevenção ou tratamento de infecção neisserial, preparação de imunoglobulina, preparação farmacêutica, e, uso da preparação farmacêutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2206 DE 16/04/2013. |