JP2023036953A5 - - Google Patents
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- JP2023036953A5 JP2023036953A5 JP2023000606A JP2023000606A JP2023036953A5 JP 2023036953 A5 JP2023036953 A5 JP 2023036953A5 JP 2023000606 A JP2023000606 A JP 2023000606A JP 2023000606 A JP2023000606 A JP 2023000606A JP 2023036953 A5 JP2023036953 A5 JP 2023036953A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- protein
- carrier protein
- crm197
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 6
- 102000014914 Carrier Proteins Human genes 0.000 claims 3
- 108010078791 Carrier Proteins Proteins 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024084665A JP2024112952A (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463216P | 2017-02-24 | 2017-02-24 | |
| US62/463,216 | 2017-02-24 | ||
| US201762555444P | 2017-09-07 | 2017-09-07 | |
| US62/555,444 | 2017-09-07 | ||
| JP2019546002A JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| PCT/US2018/018729 WO2018156491A1 (en) | 2017-02-24 | 2018-02-20 | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Division JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084665A Division JP2024112952A (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023036953A JP2023036953A (ja) | 2023-03-14 |
| JP2023036953A5 true JP2023036953A5 (enExample) | 2023-05-25 |
Family
ID=63254065
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Active JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| JP2023000606A Pending JP2023036953A (ja) | 2017-02-24 | 2023-01-05 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| JP2024084665A Pending JP2024112952A (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Active JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084665A Pending JP2024112952A (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11090374B2 (enExample) |
| EP (1) | EP3589314A4 (enExample) |
| JP (3) | JP7680185B2 (enExample) |
| KR (2) | KR20190121330A (enExample) |
| CN (1) | CN110337307A (enExample) |
| AU (1) | AU2018225099B2 (enExample) |
| BR (1) | BR112019017560A2 (enExample) |
| CA (1) | CA3050120A1 (enExample) |
| MX (3) | MX2019009867A (enExample) |
| WO (1) | WO2018156491A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815327A (zh) * | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| BR112016015835B1 (pt) * | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR102800419B1 (ko) * | 2015-07-21 | 2025-04-25 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
| WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| BR112020004396A8 (pt) | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| AU2018328040B2 (en) | 2017-09-07 | 2025-01-16 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| MX2020005779A (es) | 2017-12-06 | 2020-10-28 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos. |
| JP7489324B2 (ja) | 2018-04-30 | 2024-05-23 | メルク・シャープ・アンド・ドーム・エルエルシー | リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法 |
| KR102827174B1 (ko) | 2018-04-30 | 2025-06-27 | 머크 샤프 앤드 돔 엘엘씨 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| CN113164581A (zh) * | 2018-09-23 | 2021-07-23 | 生物E有限公司 | 纯化的肺炎链球菌荚膜多糖 |
| KR20240169145A (ko) * | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| US20220184199A1 (en) * | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| BR112021024393A8 (pt) * | 2019-06-05 | 2023-01-31 | Merck Sharp & Dohme | Um conjugado de polissacarídeo-proteína pneumocócico de sorotipo 35b imunogênico e processo de conjugação para fabricar o mesmo |
| CN110804097B (zh) * | 2019-10-30 | 2021-02-26 | 云南沃森生物技术股份有限公司 | 一种同时制备两种单克隆抗体的方法 |
| EP4090364A4 (en) * | 2020-01-17 | 2024-02-21 | Inventprise, Inc. | MULTIVALENT STREPTOCOCCAL VACCINES |
| US12205148B2 (en) * | 2020-02-03 | 2025-01-21 | Anagog Ltd. | Distributed content serving |
| WO2021219530A1 (en) * | 2020-04-28 | 2021-11-04 | Janssen Pharmaceuticals, Inc. | Method for identification and quantification of polysaccharides in complex glycoconjugate compositions |
| CA3200968A1 (en) | 2020-11-10 | 2022-05-19 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2022249107A2 (en) * | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN114965784B (zh) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | 多糖活化度的测定方法 |
| WO2024059161A1 (en) * | 2022-09-16 | 2024-03-21 | Merck Sharp & Dohme Llc | Method for quantification of polysaccharide content in conjugate vaccines |
| IL321062A (en) | 2022-11-22 | 2025-07-01 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN121057590A (zh) | 2023-04-14 | 2025-12-02 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025219904A1 (en) * | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CN104815327A (zh) | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2006234984B2 (en) | 2005-04-08 | 2011-10-13 | Wyeth | Separation of contaminants from Streptococcus pneumoniae polysaccharide by pH manipulation |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| PT2074221E (pt) | 2006-10-10 | 2010-09-06 | Wyeth Llc | Métodos melhorados para a separação de polissacáridos tipo 3 de streptococcus pneumoniae |
| PT2129693T (pt) | 2007-03-23 | 2017-02-14 | Wyeth Llc | Processo de purificação abreviado para a produção de polissacáridos capsulares de streptococcus pneumoniae |
| US8540955B2 (en) | 2007-07-10 | 2013-09-24 | Wyeth Llc | Process for producing aluminum phosphate |
| HUE037465T2 (hu) | 2008-12-18 | 2018-09-28 | Wyeth Llc | Eljárás 19A szerotípusú streptococcus pneumoniae poliszacharidok molekulatömegének szabályozására |
| KR101307703B1 (ko) | 2008-12-18 | 2013-09-11 | 와이어쓰 엘엘씨 | 탄소를 사용하여 스트렙토코커스 뉴모니에 폴리사카라이드 분자량을 조절하는 방법 |
| EP3461496B1 (en) * | 2009-06-22 | 2023-08-23 | Wyeth LLC | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| ES2614807T3 (es) | 2010-06-04 | 2017-06-02 | Wyeth Llc | Formulaciones vacunales |
| US20130273098A1 (en) | 2010-12-10 | 2013-10-17 | Jeffrey T. Blue | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN104870463B (zh) | 2012-12-20 | 2018-09-28 | 辉瑞公司 | 糖缀合方法 |
| KR20220080201A (ko) | 2014-01-21 | 2022-06-14 | 화이자 인코포레이티드 | 접합된 캡슐 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
| BR112016015835B1 (pt) * | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| CA2937190A1 (en) * | 2014-01-21 | 2015-07-30 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
| SG11201700325SA (en) * | 2014-08-08 | 2017-02-27 | Glycovaxyn Ag | Modified host cells and hybrid oligosaccharides for use in bioconjugate production |
| DK3244917T5 (da) * | 2015-01-15 | 2024-10-14 | Pfizer | Immunogene sammensætninger til anvendelse i pneumokokvacciner |
| IL255106B2 (en) | 2015-05-04 | 2023-04-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses |
| KR102800419B1 (ko) | 2015-07-21 | 2025-04-25 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| HK1259103A1 (zh) | 2015-11-17 | 2019-11-22 | Pfizer Inc. | 用於在细菌细胞培养物中生产多糖的培养基和发酵方法 |
| CA3005524C (en) | 2015-11-20 | 2023-10-10 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20190103256A (ko) * | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MX392525B (es) | 2017-01-20 | 2025-03-12 | Pfizer | Composiciones inmunogenicas para su uso en vacunas neumococicas |
| KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
| WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| WO2018156465A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier |
| AU2018225083B2 (en) | 2017-02-24 | 2023-06-01 | Merck Sharp & Dohme Llc | Pneumococcal conjugate vaccine formulations |
| WO2018156467A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
| US20200360500A1 (en) | 2017-08-16 | 2020-11-19 | Merck Sharp & Dohme Corp. | Pneumococcal conjugate vaccine formulations |
| AU2018328040B2 (en) * | 2017-09-07 | 2025-01-16 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| PT3678654T (pt) * | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| BR112020004396A8 (pt) | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20200077538A (ko) | 2017-10-25 | 2020-06-30 | 머크 샤프 앤드 돔 코포레이션 | 아주반트 첨가된 백신 |
| MX2020005779A (es) | 2017-12-06 | 2020-10-28 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos. |
| KR102827174B1 (ko) | 2018-04-30 | 2025-06-27 | 머크 샤프 앤드 돔 엘엘씨 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| JP7489324B2 (ja) | 2018-04-30 | 2024-05-23 | メルク・シャープ・アンド・ドーム・エルエルシー | リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| WO2019236435A1 (en) | 2018-06-07 | 2019-12-12 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| KR20240169145A (ko) | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| KR20220016964A (ko) | 2019-06-05 | 2022-02-10 | 머크 샤프 앤드 돔 코포레이션 | 에스. 뉴모니아에 혈청형 29에 대해 보호하는 면역원성 조성물을 사용하여 환자를 치료하는 방법 |
| BR112021024393A8 (pt) | 2019-06-05 | 2023-01-31 | Merck Sharp & Dohme | Um conjugado de polissacarídeo-proteína pneumocócico de sorotipo 35b imunogênico e processo de conjugação para fabricar o mesmo |
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2018
- 2018-02-20 BR BR112019017560A patent/BR112019017560A2/pt unknown
- 2018-02-20 WO PCT/US2018/018729 patent/WO2018156491A1/en not_active Ceased
- 2018-02-20 KR KR1020197027396A patent/KR20190121330A/ko not_active Ceased
- 2018-02-20 JP JP2019546002A patent/JP7680185B2/ja active Active
- 2018-02-20 US US16/487,550 patent/US11090374B2/en active Active
- 2018-02-20 MX MX2019009867A patent/MX2019009867A/es unknown
- 2018-02-20 EP EP18757315.9A patent/EP3589314A4/en active Pending
- 2018-02-20 CA CA3050120A patent/CA3050120A1/en active Pending
- 2018-02-20 AU AU2018225099A patent/AU2018225099B2/en active Active
- 2018-02-20 KR KR1020247001331A patent/KR20240011879A/ko active Pending
- 2018-02-20 CN CN201880013793.7A patent/CN110337307A/zh active Pending
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2019
- 2019-08-19 MX MX2023001948A patent/MX2023001948A/es unknown
- 2019-08-19 MX MX2023001947A patent/MX2023001947A/es unknown
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2021
- 2021-07-07 US US17/369,177 patent/US20210330777A1/en not_active Abandoned
- 2021-07-07 US US17/369,230 patent/US20210330778A1/en not_active Abandoned
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2023
- 2023-01-05 JP JP2023000606A patent/JP2023036953A/ja active Pending
- 2023-06-22 US US18/339,723 patent/US12295998B2/en active Active
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2024
- 2024-05-24 JP JP2024084665A patent/JP2024112952A/ja active Pending
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