CA3050120A1 - Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates - Google Patents
Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates Download PDFInfo
- Publication number
- CA3050120A1 CA3050120A1 CA3050120A CA3050120A CA3050120A1 CA 3050120 A1 CA3050120 A1 CA 3050120A1 CA 3050120 A CA3050120 A CA 3050120A CA 3050120 A CA3050120 A CA 3050120A CA 3050120 A1 CA3050120 A1 CA 3050120A1
- Authority
- CA
- Canada
- Prior art keywords
- polysaccharide
- protein
- serotypes
- prepared
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463216P | 2017-02-24 | 2017-02-24 | |
| US62/463,216 | 2017-02-24 | ||
| US201762555444P | 2017-09-07 | 2017-09-07 | |
| US62/555,444 | 2017-09-07 | ||
| PCT/US2018/018729 WO2018156491A1 (en) | 2017-02-24 | 2018-02-20 | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3050120A1 true CA3050120A1 (en) | 2018-08-30 |
Family
ID=63254065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3050120A Pending CA3050120A1 (en) | 2017-02-24 | 2018-02-20 | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11090374B2 (enExample) |
| EP (1) | EP3589314A4 (enExample) |
| JP (3) | JP7680185B2 (enExample) |
| KR (2) | KR20190121330A (enExample) |
| CN (1) | CN110337307A (enExample) |
| AU (1) | AU2018225099B2 (enExample) |
| BR (1) | BR112019017560A2 (enExample) |
| CA (1) | CA3050120A1 (enExample) |
| MX (3) | MX2019009867A (enExample) |
| WO (1) | WO2018156491A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815327A (zh) * | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| BR112016015835B1 (pt) * | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR102800419B1 (ko) * | 2015-07-21 | 2025-04-25 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
| WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| BR112020004396A8 (pt) | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| AU2018328040B2 (en) | 2017-09-07 | 2025-01-16 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| MX2020005779A (es) | 2017-12-06 | 2020-10-28 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos. |
| JP7489324B2 (ja) | 2018-04-30 | 2024-05-23 | メルク・シャープ・アンド・ドーム・エルエルシー | リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法 |
| KR102827174B1 (ko) | 2018-04-30 | 2025-06-27 | 머크 샤프 앤드 돔 엘엘씨 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| CN113164581A (zh) * | 2018-09-23 | 2021-07-23 | 生物E有限公司 | 纯化的肺炎链球菌荚膜多糖 |
| KR20240169145A (ko) * | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| US20220184199A1 (en) * | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| BR112021024393A8 (pt) * | 2019-06-05 | 2023-01-31 | Merck Sharp & Dohme | Um conjugado de polissacarídeo-proteína pneumocócico de sorotipo 35b imunogênico e processo de conjugação para fabricar o mesmo |
| CN110804097B (zh) * | 2019-10-30 | 2021-02-26 | 云南沃森生物技术股份有限公司 | 一种同时制备两种单克隆抗体的方法 |
| EP4090364A4 (en) * | 2020-01-17 | 2024-02-21 | Inventprise, Inc. | MULTIVALENT STREPTOCOCCAL VACCINES |
| US12205148B2 (en) * | 2020-02-03 | 2025-01-21 | Anagog Ltd. | Distributed content serving |
| WO2021219530A1 (en) * | 2020-04-28 | 2021-11-04 | Janssen Pharmaceuticals, Inc. | Method for identification and quantification of polysaccharides in complex glycoconjugate compositions |
| CA3200968A1 (en) | 2020-11-10 | 2022-05-19 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2022249107A2 (en) * | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN114965784B (zh) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | 多糖活化度的测定方法 |
| WO2024059161A1 (en) * | 2022-09-16 | 2024-03-21 | Merck Sharp & Dohme Llc | Method for quantification of polysaccharide content in conjugate vaccines |
| IL321062A (en) | 2022-11-22 | 2025-07-01 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN121057590A (zh) | 2023-04-14 | 2025-12-02 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025219904A1 (en) * | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
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| KR102800419B1 (ko) | 2015-07-21 | 2025-04-25 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
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| KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
| WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
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| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| PT3678654T (pt) * | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| BR112020004396A8 (pt) | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20200077538A (ko) | 2017-10-25 | 2020-06-30 | 머크 샤프 앤드 돔 코포레이션 | 아주반트 첨가된 백신 |
| MX2020005779A (es) | 2017-12-06 | 2020-10-28 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos. |
| KR102827174B1 (ko) | 2018-04-30 | 2025-06-27 | 머크 샤프 앤드 돔 엘엘씨 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| JP7489324B2 (ja) | 2018-04-30 | 2024-05-23 | メルク・シャープ・アンド・ドーム・エルエルシー | リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| WO2019236435A1 (en) | 2018-06-07 | 2019-12-12 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| KR20240169145A (ko) | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| KR20220016964A (ko) | 2019-06-05 | 2022-02-10 | 머크 샤프 앤드 돔 코포레이션 | 에스. 뉴모니아에 혈청형 29에 대해 보호하는 면역원성 조성물을 사용하여 환자를 치료하는 방법 |
| BR112021024393A8 (pt) | 2019-06-05 | 2023-01-31 | Merck Sharp & Dohme | Um conjugado de polissacarídeo-proteína pneumocócico de sorotipo 35b imunogênico e processo de conjugação para fabricar o mesmo |
-
2018
- 2018-02-20 BR BR112019017560A patent/BR112019017560A2/pt unknown
- 2018-02-20 WO PCT/US2018/018729 patent/WO2018156491A1/en not_active Ceased
- 2018-02-20 KR KR1020197027396A patent/KR20190121330A/ko not_active Ceased
- 2018-02-20 JP JP2019546002A patent/JP7680185B2/ja active Active
- 2018-02-20 US US16/487,550 patent/US11090374B2/en active Active
- 2018-02-20 MX MX2019009867A patent/MX2019009867A/es unknown
- 2018-02-20 EP EP18757315.9A patent/EP3589314A4/en active Pending
- 2018-02-20 CA CA3050120A patent/CA3050120A1/en active Pending
- 2018-02-20 AU AU2018225099A patent/AU2018225099B2/en active Active
- 2018-02-20 KR KR1020247001331A patent/KR20240011879A/ko active Pending
- 2018-02-20 CN CN201880013793.7A patent/CN110337307A/zh active Pending
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2019
- 2019-08-19 MX MX2023001948A patent/MX2023001948A/es unknown
- 2019-08-19 MX MX2023001947A patent/MX2023001947A/es unknown
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2021
- 2021-07-07 US US17/369,177 patent/US20210330777A1/en not_active Abandoned
- 2021-07-07 US US17/369,230 patent/US20210330778A1/en not_active Abandoned
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2023
- 2023-01-05 JP JP2023000606A patent/JP2023036953A/ja active Pending
- 2023-06-22 US US18/339,723 patent/US12295998B2/en active Active
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2024
- 2024-05-24 JP JP2024084665A patent/JP2024112952A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210330778A1 (en) | 2021-10-28 |
| KR20190121330A (ko) | 2019-10-25 |
| MX2023001948A (es) | 2023-03-14 |
| EP3589314A1 (en) | 2020-01-08 |
| US20240139303A1 (en) | 2024-05-02 |
| JP7680185B2 (ja) | 2025-05-20 |
| MX2019009867A (es) | 2019-10-02 |
| AU2018225099B2 (en) | 2024-08-22 |
| JP2023036953A (ja) | 2023-03-14 |
| JP2024112952A (ja) | 2024-08-21 |
| WO2018156491A1 (en) | 2018-08-30 |
| MX2023001947A (es) | 2023-03-14 |
| AU2018225099A1 (en) | 2019-07-25 |
| US20200054733A1 (en) | 2020-02-20 |
| RU2019129503A3 (enExample) | 2021-06-25 |
| KR20240011879A (ko) | 2024-01-26 |
| US11090374B2 (en) | 2021-08-17 |
| RU2019129503A (ru) | 2021-03-24 |
| JP2020514326A (ja) | 2020-05-21 |
| CN110337307A (zh) | 2019-10-15 |
| US20210330777A1 (en) | 2021-10-28 |
| BR112019017560A2 (pt) | 2020-04-07 |
| EP3589314A4 (en) | 2021-04-21 |
| US12295998B2 (en) | 2025-05-13 |
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