MX2023001947A - Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. - Google Patents
Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae.Info
- Publication number
- MX2023001947A MX2023001947A MX2023001947A MX2023001947A MX2023001947A MX 2023001947 A MX2023001947 A MX 2023001947A MX 2023001947 A MX2023001947 A MX 2023001947A MX 2023001947 A MX2023001947 A MX 2023001947A MX 2023001947 A MX2023001947 A MX 2023001947A
- Authority
- MX
- Mexico
- Prior art keywords
- protein conjugates
- polysaccharide
- streptococcus pneumoniae
- protein
- pneumoniae polysaccharide
- Prior art date
Links
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 230000005847 immunogenicity Effects 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 6
- 150000004676 glycans Chemical class 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención proporciona composiciones inmunogénicas que tienen uno o más conjugados de polisacárido-proteína en los cuales uno o más polisacáridos de cápsulas bacterianas de Streptococcus pneumoniae se conjugan con una proteína vehículo en un solvente aprótico tal como dimetilsulfóxido (DMSO). La presente invención también proporciona métodos para proporcionar una respuesta inmunitaria mejorada a una vacuna de conjugado de polisacárido-proteína neumococo que comprende administrar a un sujeto humano una composición inmunogénica que comprende conjugados de polisacárido-proteína preparados en condiciones de DMSO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762463216P | 2017-02-24 | 2017-02-24 | |
US201762555444P | 2017-09-07 | 2017-09-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023001947A true MX2023001947A (es) | 2023-03-14 |
Family
ID=63254065
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009867A MX2019009867A (es) | 2017-02-24 | 2018-02-20 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
MX2023001948A MX2023001948A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
MX2023001947A MX2023001947A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009867A MX2019009867A (es) | 2017-02-24 | 2018-02-20 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
MX2023001948A MX2023001948A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
Country Status (10)
Country | Link |
---|---|
US (4) | US11090374B2 (es) |
EP (1) | EP3589314A4 (es) |
JP (2) | JP2020514326A (es) |
KR (2) | KR20240011879A (es) |
CN (1) | CN110337307A (es) |
AU (1) | AU2018225099A1 (es) |
BR (1) | BR112019017560A2 (es) |
CA (1) | CA3050120A1 (es) |
MX (3) | MX2019009867A (es) |
WO (1) | WO2018156491A1 (es) |
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US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
JP6612260B2 (ja) | 2014-01-21 | 2019-11-27 | ファイザー・インク | 肺炎連鎖球菌(Streptococcus pneumoniae)莢膜多糖およびそのコンジュゲート |
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CA3048981A1 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
CN110225757A (zh) * | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
US11491216B2 (en) | 2017-09-07 | 2022-11-08 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
JP7369123B2 (ja) | 2017-12-06 | 2023-10-25 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖類-タンパク質コンジュゲートを含む組成物およびその使用方法 |
KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
AU2019341723B2 (en) * | 2018-09-23 | 2024-03-21 | Biological E Limited | Purified capsular polysaccharides of Streptococcus pneumoniae |
MA54533A (fr) * | 2018-12-19 | 2022-03-30 | Merck Sharp & Dohme | Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation |
US20220184199A1 (en) * | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
MX2021014710A (es) * | 2019-06-05 | 2022-01-18 | Merck Sharp & Dohme Llc | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
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CN114965784B (zh) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | 多糖活化度的测定方法 |
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WO2024110839A2 (en) | 2022-11-22 | 2024-05-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
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MA54533A (fr) | 2018-12-19 | 2022-03-30 | Merck Sharp & Dohme | Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation |
US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
MX2021014710A (es) | 2019-06-05 | 2022-01-18 | Merck Sharp & Dohme Llc | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
JP2022535064A (ja) | 2019-06-05 | 2022-08-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 肺炎レンサ球菌血清型29から保護する免疫原性組成物で患者を治療する方法 |
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2018
- 2018-02-20 CN CN201880013793.7A patent/CN110337307A/zh active Pending
- 2018-02-20 WO PCT/US2018/018729 patent/WO2018156491A1/en unknown
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- 2018-02-20 JP JP2019546002A patent/JP2020514326A/ja active Pending
- 2018-02-20 KR KR1020197027396A patent/KR20190121330A/ko not_active Application Discontinuation
- 2018-02-20 MX MX2019009867A patent/MX2019009867A/es unknown
- 2018-02-20 EP EP18757315.9A patent/EP3589314A4/en active Pending
- 2018-02-20 AU AU2018225099A patent/AU2018225099A1/en active Pending
- 2018-02-20 US US16/487,550 patent/US11090374B2/en active Active
- 2018-02-20 BR BR112019017560A patent/BR112019017560A2/pt unknown
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2019
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US20200054733A1 (en) | 2020-02-20 |
MX2019009867A (es) | 2019-10-02 |
RU2019129503A3 (es) | 2021-06-25 |
US11090374B2 (en) | 2021-08-17 |
EP3589314A1 (en) | 2020-01-08 |
BR112019017560A2 (pt) | 2020-04-07 |
WO2018156491A1 (en) | 2018-08-30 |
US20210330778A1 (en) | 2021-10-28 |
JP2020514326A (ja) | 2020-05-21 |
KR20240011879A (ko) | 2024-01-26 |
MX2023001948A (es) | 2023-03-14 |
CA3050120A1 (en) | 2018-08-30 |
EP3589314A4 (en) | 2021-04-21 |
US20210330777A1 (en) | 2021-10-28 |
CN110337307A (zh) | 2019-10-15 |
JP2023036953A (ja) | 2023-03-14 |
KR20190121330A (ko) | 2019-10-25 |
AU2018225099A1 (en) | 2019-07-25 |
RU2019129503A (ru) | 2021-03-24 |
US20240139303A1 (en) | 2024-05-02 |
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