|
US913242A
(en)
|
1905-08-29 |
1909-02-23 |
Electrelle Company |
Automatic music-playing attachment for pianos.
|
|
US4391904A
(en)
|
1979-12-26 |
1983-07-05 |
Syva Company |
Test strip kits in immunoassays and compositions therein
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
US4978757A
(en)
|
1984-02-21 |
1990-12-18 |
The Upjohn Company |
1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
|
|
US4912227A
(en)
|
1984-02-21 |
1990-03-27 |
The Upjohn Company |
1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4954617A
(en)
|
1986-07-07 |
1990-09-04 |
Trustees Of Dartmouth College |
Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US5332837A
(en)
|
1986-12-19 |
1994-07-26 |
The Upjohn Company |
CC-1065 analogs
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5013653A
(en)
|
1987-03-20 |
1991-05-07 |
Creative Biomolecules, Inc. |
Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
WO1988009344A1
(en)
|
1987-05-21 |
1988-12-01 |
Creative Biomolecules, Inc. |
Targeted multifunctional proteins
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
US5773435A
(en)
|
1987-08-04 |
1998-06-30 |
Bristol-Myers Squibb Company |
Prodrugs for β-lactamase and uses thereof
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5162504A
(en)
*
|
1988-06-03 |
1992-11-10 |
Cytogen Corporation |
Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5084468A
(en)
|
1988-08-11 |
1992-01-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-88a derivatives
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
DE68913658T3
(de)
|
1988-11-11 |
2005-07-21 |
Stratagene, La Jolla |
Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
JP2598116B2
(ja)
|
1988-12-28 |
1997-04-09 |
協和醗酵工業株式会社 |
新規物質dc113
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5187186A
(en)
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
|
JP2510335B2
(ja)
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Dc―88a誘導体
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
SG48759A1
(en)
|
1990-01-12 |
2002-07-23 |
Abgenix Inc |
Generation of xenogenic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
AU648313B2
(en)
|
1990-04-25 |
1994-04-21 |
Pharmacia & Upjohn Company |
Novel CC-1065 analogs
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5763566A
(en)
|
1990-06-11 |
1998-06-09 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue SELEX
|
|
US5712375A
(en)
|
1990-06-11 |
1998-01-27 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6261774B1
(en)
|
1990-06-11 |
2001-07-17 |
Gilead Sciences, Inc. |
Truncation selex method
|
|
US5789157A
(en)
|
1990-06-11 |
1998-08-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US5864026A
(en)
|
1990-06-11 |
1999-01-26 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
GB9108652D0
(en)
|
1991-04-23 |
1991-06-12 |
Antisoma Ltd |
Immunoreactive compounds
|
|
JPH0597853A
(ja)
|
1991-10-07 |
1993-04-20 |
Kyowa Hakko Kogyo Co Ltd |
Dc−89誘導体の臭化水素酸塩
|
|
DK1024191T3
(da)
|
1991-12-02 |
2008-12-08 |
Medical Res Council |
Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker
|
|
JP3949712B2
(ja)
|
1991-12-02 |
2007-07-25 |
メディカル リサーチ カウンシル |
抗体セグメントレパートリー由来でファージに表示される抗自己抗体の産生
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
CA2076465C
(en)
*
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
GB9314960D0
(en)
|
1992-07-23 |
1993-09-01 |
Zeneca Ltd |
Chemical compounds
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US5573924A
(en)
*
|
1992-09-08 |
1996-11-12 |
Immunex Corporation |
CD27 ligand
|
|
ES2191016T3
(es)
|
1992-09-16 |
2003-09-01 |
Scripps Research Inst |
Anticuerpos monoclonales neutralizantes humanos para el virus respiratorio sincitial.
|
|
GB9223377D0
(en)
|
1992-11-04 |
1992-12-23 |
Medarex Inc |
Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
|
|
US7105159B1
(en)
*
|
1992-11-05 |
2006-09-12 |
Sloan-Kettering Institute For Cancer Research |
Antibodies to prostate-specific membrane antigen
|
|
JP4204642B2
(ja)
*
|
1992-11-05 |
2009-01-07 |
スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ |
前立腺に特異的な膜抗原
|
|
JP3919830B2
(ja)
|
1992-11-28 |
2007-05-30 |
財団法人化学及血清療法研究所 |
抗ネコヘルペスウイルス−1組換え抗体および該抗体をコードする遺伝子断片
|
|
EP0754225A4
(en)
|
1993-04-26 |
2001-01-31 |
Genpharm Int |
HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS
|
|
DK0698097T3
(da)
|
1993-04-29 |
2001-10-08 |
Unilever Nv |
Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
EP0647450A1
(en)
*
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
US5831077A
(en)
|
1993-12-09 |
1998-11-03 |
Redmond; John William |
Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal
|
|
WO1995018634A1
(en)
|
1994-01-04 |
1995-07-13 |
The Scripps Research Institute |
Human monoclonal antibodies to herpes simplex virus and methods therefor
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
PT705833E
(pt)
|
1994-04-22 |
2004-11-30 |
Kyowa Hakko Kogyo Kk |
Derivado de dc-89
|
|
JPH07309761A
(ja)
|
1994-05-20 |
1995-11-28 |
Kyowa Hakko Kogyo Co Ltd |
デュオカルマイシン誘導体の安定化法
|
|
AU3532895A
(en)
|
1994-09-30 |
1996-04-26 |
Kyowa Hakko Kogyo Co. Ltd. |
Antitumor agent
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
CA2219807C
(en)
|
1995-05-03 |
2008-12-30 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6013443A
(en)
|
1995-05-03 |
2000-01-11 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue SELEX
|
|
WO1997012862A1
(en)
|
1995-10-03 |
1997-04-10 |
The Scripps Research Institute |
Cbi analogs of cc-1065 and the duocarmycins
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
US6667156B2
(en)
*
|
1995-12-27 |
2003-12-23 |
Uab Research Foundation |
Diagnosis and treatment of neuroectodermal tumors
|
|
US5905027A
(en)
*
|
1995-12-27 |
1999-05-18 |
Uab Research Foundation |
Method of diagnosing and treating gliomas
|
|
US6136311A
(en)
*
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
|
US6107090A
(en)
*
|
1996-05-06 |
2000-08-22 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
|
|
US5843937A
(en)
*
|
1996-05-23 |
1998-12-01 |
Panorama Research, Inc. |
DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
|
|
DE59706319D1
(de)
*
|
1996-05-31 |
2002-03-21 |
Basf Ag |
Carbamoylcarbonsäureamidoxime
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
CA2289115A1
(en)
|
1997-05-07 |
1998-11-12 |
Bristol-Myers Squibb Company |
Recombinant antibody-enzyme fusion proteins
|
|
GB2339430A
(en)
|
1997-05-21 |
2000-01-26 |
Biovation Ltd |
Method for the production of non-immunogenic proteins
|
|
WO1998052925A1
(en)
|
1997-05-22 |
1998-11-26 |
The Scripps Research Institute |
Analogs of duocarmycin and cc-1065
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6835550B1
(en)
|
1998-04-15 |
2004-12-28 |
Genencor International, Inc. |
Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
|
|
US6936249B1
(en)
|
1998-04-15 |
2005-08-30 |
Genencor International, Inc. |
Proteins producing an altered immunogenic response and methods of making and using the same
|
|
PT2180007E
(pt)
|
1998-04-20 |
2013-11-25 |
Roche Glycart Ag |
Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
GB9814383D0
(en)
|
1998-07-02 |
1998-09-02 |
Cambridge Antibody Tech |
Improvements relating to antibodies
|
|
EP1097172A1
(en)
|
1998-07-21 |
2001-05-09 |
Genmab A/S |
Anti hepatitis c virus antibody and uses thereof
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
PT1144011E
(pt)
|
1998-12-11 |
2010-06-16 |
Coulter Pharm Inc |
Compostos pró-fármacos e processo para a sua preparação
|
|
KR20060067983A
(ko)
|
1999-01-15 |
2006-06-20 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
EP2275540B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
US6416758B1
(en)
*
|
1999-04-28 |
2002-07-09 |
Board Of Regents, The University Of Texax System |
Antibody conjugate kits for selectively inhibiting VEGF
|
|
US6387620B1
(en)
|
1999-07-28 |
2002-05-14 |
Gilead Sciences, Inc. |
Transcription-free selex
|
|
DE60037896D1
(de)
|
1999-07-29 |
2008-03-13 |
Medarex Inc |
Menschliche antikörper gegen her2/neu
|
|
CA2589418A1
(en)
|
1999-08-24 |
2001-03-01 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US6794132B2
(en)
|
1999-10-02 |
2004-09-21 |
Biosite, Inc. |
Human antibodies
|
|
AU4761601A
(en)
*
|
2000-04-11 |
2001-10-23 |
Genentech Inc |
Multivalent antibodies and uses therefor
|
|
US7214663B2
(en)
|
2000-06-14 |
2007-05-08 |
Medarex, Inc. |
Tripeptide prodrug compounds
|
|
AU6685301A
(en)
|
2000-06-14 |
2001-12-24 |
Corixa Corp |
Prodrug compounds with isoleucine
|
|
AU7130101A
(en)
|
2000-06-14 |
2001-12-24 |
Corixa Corp |
Enzyme-cleavable prodrug compounds
|
|
IL154696A
(en)
*
|
2000-09-05 |
2008-11-03 |
Biosight Ltd |
Peptide conjugated anti-cancer prodrugs
|
|
US7417130B2
(en)
|
2000-09-08 |
2008-08-26 |
University Of Zurich |
Collection of repeat proteins comprising repeat modules
|
|
US6818216B2
(en)
|
2000-11-28 |
2004-11-16 |
Medimmune, Inc. |
Anti-RSV antibodies
|
|
ATE378403T1
(de)
|
2000-11-30 |
2007-11-15 |
Medarex Inc |
Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
|
|
EP1243276A1
(en)
*
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
CA2508763C
(en)
|
2001-05-11 |
2012-01-24 |
Kirin Beer Kabushiki Kaisha |
Human antibody producing mouse and method for producing human antibody using the same
|
|
DE60230142D1
(de)
*
|
2001-05-14 |
2009-01-15 |
Dow Corning Toray Co Ltd |
Wärmeleitende silikonzusammensetzung
|
|
JP2004532038A
(ja)
|
2001-05-17 |
2004-10-21 |
ディヴァーサ コーポレイション |
新規抗原結合分子の治療、診断、予防、酵素、産業ならびに農業各分野への応用とそのための新規抗原結合分子の作製とスクリーニングの方法
|
|
CA2448319C
(en)
*
|
2001-05-31 |
2010-07-27 |
Medarex, Inc. |
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
|
|
WO2002100353A2
(en)
|
2001-06-11 |
2002-12-19 |
Medarex, Inc. |
Cd10-activated prodrug compounds
|
|
ATE477280T1
(de)
|
2001-06-28 |
2010-08-15 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
|
JP2005502703A
(ja)
|
2001-09-07 |
2005-01-27 |
ザ スクリプス リサーチ インスティテュート |
Cc−1065およびデュオカルマイシンのcbi類似体
|
|
US7091186B2
(en)
*
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
EP1443961B1
(en)
|
2001-10-25 |
2009-05-06 |
Genentech, Inc. |
Glycoprotein compositions
|
|
US7261892B2
(en)
*
|
2001-11-27 |
2007-08-28 |
Celltech R&D Limited |
Methods for diagnosis and treatment of epithelial-derived cancers
|
|
US20060191026A1
(en)
|
2005-02-18 |
2006-08-24 |
Origen Therapeutics, Inc. |
Tissue specific expression of antibodies in chickens
|
|
AU2003219696A1
(en)
*
|
2002-02-01 |
2003-09-02 |
Seattle Genetics, Inc. |
Sga-1m, a cancer associated antigen, and uses thereof
|
|
AU2003217782A1
(en)
*
|
2002-02-27 |
2003-09-09 |
The Government Of The United States Of America, Representated By The Secretary, Deparment Of Health |
Dna-binding polyamide drug conjugates
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US6534660B1
(en)
*
|
2002-04-05 |
2003-03-18 |
Immunogen, Inc. |
CC-1065 analog synthesis
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
EA200401325A1
(ru)
|
2002-04-09 |
2005-04-28 |
Киова Хакко Когио Ко., Лтд. |
Клетки с модифицированным геномом
|
|
US7235578B2
(en)
*
|
2002-05-17 |
2007-06-26 |
Auckland Uniservices Limited |
Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom
|
|
CA2492092A1
(en)
|
2002-06-28 |
2004-01-08 |
Greg Winter |
Immunoglobin single variant antigen-binding domains and dual-specific constructs
|
|
US20040202665A1
(en)
*
|
2002-07-01 |
2004-10-14 |
Janette Lazarovits |
Compositions and methods for therapeutic treatment
|
|
ES2544527T3
(es)
*
|
2002-07-31 |
2015-09-01 |
Seattle Genetics, Inc. |
Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
|
|
US20040081653A1
(en)
*
|
2002-08-16 |
2004-04-29 |
Raitano Arthur B. |
Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
|
|
AU2003286002B2
(en)
|
2002-11-08 |
2011-06-16 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP1578801A2
(en)
|
2002-12-27 |
2005-09-28 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
JP5356648B2
(ja)
*
|
2003-02-20 |
2013-12-04 |
シアトル ジェネティックス, インコーポレイテッド |
抗cd70抗体−医薬結合体、ならびに癌および免疫障害の処置のためのそれらの使用
|
|
US20080025989A1
(en)
*
|
2003-02-20 |
2008-01-31 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
WO2006113909A2
(en)
*
|
2005-04-19 |
2006-10-26 |
Seattle Genetics, Inc. |
Humanized anti-cd70 binding agents and uses thereof
|
|
EP2357237A1
(en)
|
2003-05-14 |
2011-08-17 |
Domantis Limited |
A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
|
|
PT1639011E
(pt)
|
2003-06-30 |
2009-01-20 |
Domantis Ltd |
Anticorpos (dab) de domínio único peguilados
|
|
JP4733635B2
(ja)
*
|
2003-07-31 |
2011-07-27 |
イミューノメディクス、インコーポレイテッド |
抗cd19抗体
|
|
US20050282168A1
(en)
*
|
2003-09-29 |
2005-12-22 |
Wyeth |
Cell surface molecules as markers and therapeutic agents against kidney cancers
|
|
CN103394083B
(zh)
*
|
2003-11-06 |
2017-07-18 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
RS53984B1
(sr)
*
|
2003-12-10 |
2015-10-30 |
E. R. Squibb & Sons L.L.C. |
Ip-10 antitela i njihove upotrebe
|
|
US20050214310A1
(en)
*
|
2004-01-23 |
2005-09-29 |
Seattle Genetics, Inc. |
Melphalan prodrugs
|
|
WO2005077462A2
(en)
*
|
2004-02-09 |
2005-08-25 |
The Cbr Institute For Biomedical Research, Inc. |
Cd70 inhibition for the treatment and prevention of inflammatory bowel disease
|
|
RU2402548C2
(ru)
*
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
US8147827B2
(en)
*
|
2004-06-18 |
2012-04-03 |
Genentech, Inc. |
Tumor treatment
|
|
CN101010106A
(zh)
*
|
2004-06-30 |
2007-08-01 |
诺瓦提斯公司 |
抗体和Duocarmycin衍生物的缀合物作为抗肿瘤剂
|
|
US7641903B2
(en)
*
|
2004-10-15 |
2010-01-05 |
Seattle Genetics, Inc. |
Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
AU2005295595C1
(en)
*
|
2004-10-15 |
2012-06-21 |
Seattle Genetics, Inc. |
Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
JP2008528010A
(ja)
|
2005-01-31 |
2008-07-31 |
アブリンクス ナームローゼ フェンノートシャップ |
重鎖抗体の可変ドメイン配列を作出する方法
|
|
CN105535967B
(zh)
*
|
2005-02-15 |
2022-05-03 |
杜克大学 |
抗cd19抗体及其在肿瘤学中的应用
|
|
AU2006236489C1
(en)
*
|
2005-04-15 |
2012-04-12 |
Immunogen, Inc. |
Elimination of heterogeneous or mixed cell population in tumors
|
|
US20060257317A1
(en)
*
|
2005-05-04 |
2006-11-16 |
Duke University |
Combination therapy in the treatment of cancer
|
|
RU2007146986A
(ru)
*
|
2005-06-02 |
2009-06-27 |
ГЭЛЭКСИ БАЙОТЕК, ЭлЭлСи (US) |
Способы лечения опухолей головного мозга с использованием антител
|
|
US8008453B2
(en)
*
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
EP1934261B1
(en)
*
|
2005-09-26 |
2014-10-29 |
Medarex, L.L.C. |
Human monoclonal antibodies to cd70
|
|
ES2416136T3
(es)
*
|
2005-09-26 |
2013-07-30 |
Medarex, Inc. |
Conjugados de anticuerpo-fármaco y su uso
|
|
EP2455100A3
(en)
|
2005-11-07 |
2012-11-07 |
The Rockefeller University |
Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
EA016609B1
(ru)
|
2005-11-28 |
2012-06-29 |
Генмаб А/С |
Рекомбинантные моновалентные антитела и способы их получения
|
|
AU2007205935B2
(en)
|
2006-01-17 |
2013-07-11 |
Synthon Biopharmaceuticals B.V. |
Compositions and methods for humanization and optimization of N-glycans in plants
|
|
US20080131428A1
(en)
*
|
2006-02-24 |
2008-06-05 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of TROP-2
|