|
US913242A
(en)
|
1905-08-29 |
1909-02-23 |
Electrelle Company |
Automatic music-playing attachment for pianos.
|
|
US4391904A
(en)
|
1979-12-26 |
1983-07-05 |
Syva Company |
Test strip kits in immunoassays and compositions therein
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
US4978757A
(en)
|
1984-02-21 |
1990-12-18 |
The Upjohn Company |
1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
|
|
US4912227A
(en)
|
1984-02-21 |
1990-03-27 |
The Upjohn Company |
1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4954617A
(en)
|
1986-07-07 |
1990-09-04 |
Trustees Of Dartmouth College |
Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5332837A
(en)
*
|
1986-12-19 |
1994-07-26 |
The Upjohn Company |
CC-1065 analogs
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
US5013653A
(en)
|
1987-03-20 |
1991-05-07 |
Creative Biomolecules, Inc. |
Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
DE3853515T3
(de)
|
1987-05-21 |
2005-08-25 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung.
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5773435A
(en)
|
1987-08-04 |
1998-06-30 |
Bristol-Myers Squibb Company |
Prodrugs for β-lactamase and uses thereof
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5162504A
(en)
*
|
1988-06-03 |
1992-11-10 |
Cytogen Corporation |
Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5084468A
(en)
|
1988-08-11 |
1992-01-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-88a derivatives
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
JP2598116B2
(ja)
|
1988-12-28 |
1997-04-09 |
協和醗酵工業株式会社 |
新規物質dc113
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5187186A
(en)
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
|
JP2510335B2
(ja)
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Dc―88a誘導体
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
KR100208957B1
(ko)
*
|
1990-04-25 |
1999-07-15 |
로렌스 티. 마이젠헬더 |
신규한 cc-1065 유사체
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5864026A
(en)
|
1990-06-11 |
1999-01-26 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US5712375A
(en)
|
1990-06-11 |
1998-01-27 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US5763566A
(en)
|
1990-06-11 |
1998-06-09 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue SELEX
|
|
US5789157A
(en)
|
1990-06-11 |
1998-08-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6261774B1
(en)
|
1990-06-11 |
2001-07-17 |
Gilead Sciences, Inc. |
Truncation selex method
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
WO1994025585A1
(en)
|
1993-04-26 |
1994-11-10 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
DK0546073T3
(da)
|
1990-08-29 |
1998-02-02 |
Genpharm Int |
Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
GB9108652D0
(en)
|
1991-04-23 |
1991-06-12 |
Antisoma Ltd |
Immunoreactive compounds
|
|
JPH0597853A
(ja)
|
1991-10-07 |
1993-04-20 |
Kyowa Hakko Kogyo Co Ltd |
Dc−89誘導体の臭化水素酸塩
|
|
DE69233408T2
(de)
|
1991-12-02 |
2005-09-22 |
Cambridge Antibody Technology Ltd., Melbourn |
Herstellung von Antikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken.
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
CA2076465C
(en)
*
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
GB9314960D0
(en)
|
1992-07-23 |
1993-09-01 |
Zeneca Ltd |
Chemical compounds
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US5573924A
(en)
*
|
1992-09-08 |
1996-11-12 |
Immunex Corporation |
CD27 ligand
|
|
US5762905A
(en)
|
1992-09-16 |
1998-06-09 |
The Scripps Research Institute |
Human neutralizing monoclonal antibodies to respiratory syncytial virus
|
|
GB9223377D0
(en)
|
1992-11-04 |
1992-12-23 |
Medarex Inc |
Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
|
|
EP0668777B2
(en)
*
|
1992-11-05 |
2011-02-09 |
Sloan-Kettering Institute For Cancer Research |
Prostate-specific membrane antigen
|
|
US7105159B1
(en)
*
|
1992-11-05 |
2006-09-12 |
Sloan-Kettering Institute For Cancer Research |
Antibodies to prostate-specific membrane antigen
|
|
JP3919830B2
(ja)
|
1992-11-28 |
2007-05-30 |
財団法人化学及血清療法研究所 |
抗ネコヘルペスウイルス−1組換え抗体および該抗体をコードする遺伝子断片
|
|
DE69427974T2
(de)
|
1993-04-29 |
2001-12-06 |
Unilever N.V., Rotterdam |
Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
|
EP0647450A1
(en)
*
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
WO1995015969A1
(en)
|
1993-12-09 |
1995-06-15 |
Macquarie University |
Glycozylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and o-glycan removal
|
|
AU1866895A
(en)
|
1994-01-04 |
1995-08-01 |
Scripps Research Institute, The |
Human monoclonal antibodies to herpes simplex virus and methods therefor
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
EP0705833B1
(en)
|
1994-04-22 |
2004-07-21 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-89 derivative
|
|
JPH07309761A
(ja)
|
1994-05-20 |
1995-11-28 |
Kyowa Hakko Kogyo Co Ltd |
デュオカルマイシン誘導体の安定化法
|
|
EP0786252A4
(en)
|
1994-09-30 |
1998-01-07 |
Kyowa Hakko Kogyo Kk |
ANTI-TUMOR AGENT
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
CA2645735A1
(en)
|
1995-05-03 |
1996-11-07 |
Gilead Science, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6013443A
(en)
|
1995-05-03 |
2000-01-11 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue SELEX
|
|
JPH11513391A
(ja)
|
1995-10-03 |
1999-11-16 |
ザ スクリップス リサーチ インスティテュート |
Cc−1065 及びズオカーマイシンのcbi 類縁体
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
US6667156B2
(en)
*
|
1995-12-27 |
2003-12-23 |
Uab Research Foundation |
Diagnosis and treatment of neuroectodermal tumors
|
|
US5905027A
(en)
*
|
1995-12-27 |
1999-05-18 |
Uab Research Foundation |
Method of diagnosing and treating gliomas
|
|
US6107090A
(en)
*
|
1996-05-06 |
2000-08-22 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
|
|
US6136311A
(en)
*
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
|
US5843937A
(en)
*
|
1996-05-23 |
1998-12-01 |
Panorama Research, Inc. |
DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
|
|
EP0906271B1
(de)
*
|
1996-05-31 |
2002-02-06 |
Basf Aktiengesellschaft |
Carbamoylcarbonsäureamidoxime
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6132722A
(en)
|
1997-05-07 |
2000-10-17 |
Bristol-Myers Squibb Company |
Recombinant antibody-enzyme fusion proteins
|
|
WO1998052976A1
(en)
|
1997-05-21 |
1998-11-26 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
NZ500789A
(en)
|
1997-05-22 |
2002-05-31 |
Scripps Research Inst |
Analogs of duocarmycin and CC-1065
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6936249B1
(en)
|
1998-04-15 |
2005-08-30 |
Genencor International, Inc. |
Proteins producing an altered immunogenic response and methods of making and using the same
|
|
US6835550B1
(en)
|
1998-04-15 |
2004-12-28 |
Genencor International, Inc. |
Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
|
|
AU3657899A
(en)
|
1998-04-20 |
1999-11-08 |
James E. Bailey |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
|
GB9814383D0
(en)
|
1998-07-02 |
1998-09-02 |
Cambridge Antibody Tech |
Improvements relating to antibodies
|
|
EP1097172A1
(en)
|
1998-07-21 |
2001-05-09 |
Genmab A/S |
Anti hepatitis c virus antibody and uses thereof
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
EP1144011B1
(en)
|
1998-12-11 |
2010-03-10 |
Coulter Pharmaceutical, Inc. |
Prodrug compounds and process for preparation thereof
|
|
NZ539776A
(en)
|
1999-01-15 |
2006-12-22 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
EP2275540B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
EP1185559A2
(en)
*
|
1999-04-28 |
2002-03-13 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
US6387620B1
(en)
|
1999-07-28 |
2002-05-14 |
Gilead Sciences, Inc. |
Transcription-free selex
|
|
NZ517372A
(en)
|
1999-07-29 |
2004-04-30 |
Medarex Inc |
Human monoclonal antibodies to HER2/neu
|
|
JP4093757B2
(ja)
|
1999-08-24 |
2008-06-04 |
メダレックス, インコーポレイテッド |
ヒトctla−4抗体およびその使用
|
|
US6794132B2
(en)
|
1999-10-02 |
2004-09-21 |
Biosite, Inc. |
Human antibodies
|
|
JP2003531588A
(ja)
*
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
EP1294405A2
(en)
|
2000-06-14 |
2003-03-26 |
Corixa Corporation |
Prodrug compounds cleavable by thimet oligopeptidase
|
|
AU6685301A
(en)
|
2000-06-14 |
2001-12-24 |
Corixa Corp |
Prodrug compounds with isoleucine
|
|
AU2001275525B2
(en)
|
2000-06-14 |
2007-04-26 |
Medarex, Inc. |
Tripeptide prodrug compounds
|
|
AU2001288025A1
(en)
*
|
2000-09-05 |
2002-03-22 |
Biosight Ltd. |
Peptide conjugated anti-cancer prodrugs
|
|
ES2335861T3
(es)
|
2000-09-08 |
2010-04-06 |
Universitat Zurich |
Grupos de proteinas repetitivas que comprenden modulos repetitivos.
|
|
US6818216B2
(en)
|
2000-11-28 |
2004-11-16 |
Medimmune, Inc. |
Anti-RSV antibodies
|
|
WO2002043478A2
(en)
|
2000-11-30 |
2002-06-06 |
Medarex, Inc. |
Transgenic transchromosomal rodents for making human antibodies
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
DE60227067D1
(de)
|
2001-05-11 |
2008-07-24 |
Kirin Pharma Kk |
Künstliches menschliches chromosom mit dem gen für die lambda-leichte kette menschlicher antikörper
|
|
ATE416235T1
(de)
*
|
2001-05-14 |
2008-12-15 |
Dow Corning Toray Co Ltd |
Wärmeleitende silikonzusammensetzung
|
|
JP2004532038A
(ja)
|
2001-05-17 |
2004-10-21 |
ディヴァーサ コーポレイション |
新規抗原結合分子の治療、診断、予防、酵素、産業ならびに農業各分野への応用とそのための新規抗原結合分子の作製とスクリーニングの方法
|
|
IL154183A0
(en)
|
2001-05-31 |
2003-07-31 |
Medarex Inc |
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
|
|
CA2450316A1
(en)
|
2001-06-11 |
2002-12-19 |
Medarex, Inc. |
Cd10-activated prodrug compounds
|
|
WO2004058821A2
(en)
|
2002-12-27 |
2004-07-15 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
AU2002319402B2
(en)
|
2001-06-28 |
2008-09-11 |
Domantis Limited |
Dual-specific ligand and its use
|
|
EP1423110A4
(en)
*
|
2001-09-07 |
2005-04-27 |
Scripps Research Inst |
CBI ANALOGUE OF CC-1065 AND DUOCARMYCINES
|
|
US7091186B2
(en)
*
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
MXPA04003798A
(es)
|
2001-10-25 |
2004-07-30 |
Genentech Inc |
Composiciones de glicoproteina.
|
|
US7261892B2
(en)
*
|
2001-11-27 |
2007-08-28 |
Celltech R&D Limited |
Methods for diagnosis and treatment of epithelial-derived cancers
|
|
US20060191026A1
(en)
|
2005-02-18 |
2006-08-24 |
Origen Therapeutics, Inc. |
Tissue specific expression of antibodies in chickens
|
|
US20070128593A1
(en)
*
|
2002-02-01 |
2007-06-07 |
Seattle Genetics, Inc. |
Sga-1m, a cancer associated antigen, and uses thereof
|
|
AU2003217782A1
(en)
*
|
2002-02-27 |
2003-09-09 |
The Government Of The United States Of America, Representated By The Secretary, Deparment Of Health |
Dna-binding polyamide drug conjugates
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US6534660B1
(en)
*
|
2002-04-05 |
2003-03-18 |
Immunogen, Inc. |
CC-1065 analog synthesis
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
PL373256A1
(en)
|
2002-04-09 |
2005-08-22 |
Kyowa Hakko Kogyo Co, Ltd. |
Cells with modified genome
|
|
WO2003097635A1
(en)
*
|
2002-05-17 |
2003-11-27 |
Auckland Uniservices Limited |
Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl(amine-derived)] compounds and analogues thereof, and to products obtained therefrom
|
|
EP1600459A3
(en)
|
2002-06-28 |
2005-12-07 |
Domantis Limited |
Ligand
|
|
US20040202665A1
(en)
*
|
2002-07-01 |
2004-10-14 |
Janette Lazarovits |
Compositions and methods for therapeutic treatment
|
|
DK1545613T3
(da)
*
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
WO2004016733A2
(en)
*
|
2002-08-16 |
2004-02-26 |
Agensys, Inc. |
Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
|
|
EP1558650A2
(en)
|
2002-11-08 |
2005-08-03 |
Ablynx N.V. |
Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders
|
|
US20080025989A1
(en)
*
|
2003-02-20 |
2008-01-31 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
WO2006113909A2
(en)
*
|
2005-04-19 |
2006-10-26 |
Seattle Genetics, Inc. |
Humanized anti-cd70 binding agents and uses thereof
|
|
ATE472338T1
(de)
*
|
2003-02-20 |
2010-07-15 |
Seattle Genetics Inc |
Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
|
|
JP4889493B2
(ja)
|
2003-05-14 |
2012-03-07 |
ドマンティス リミテッド |
ポリペプチドレパートリーから可逆的にアンフォールドするポリペプチドを回収するための方法
|
|
EP1639011B1
(en)
|
2003-06-30 |
2008-11-12 |
Domantis Limited |
Pegylated single domain antibodies (dAb)
|
|
EP1648512A4
(en)
*
|
2003-07-31 |
2009-01-21 |
Immunomedics Inc |
ANTI-CD19 ANTIBODIES
|
|
US20050282168A1
(en)
*
|
2003-09-29 |
2005-12-22 |
Wyeth |
Cell surface molecules as markers and therapeutic agents against kidney cancers
|
|
PL2489364T3
(pl)
*
|
2003-11-06 |
2015-06-30 |
Seattle Genetics Inc |
Związki monometylowaliny zdolne do sprzęgania do przeciwciał
|
|
NZ547499A
(en)
*
|
2003-12-10 |
2009-04-30 |
Medarex Inc |
IP-10 antibodies and their uses
|
|
WO2005070457A1
(en)
*
|
2004-01-23 |
2005-08-04 |
Seattle Genetics, Inc. |
Melphalan prodrugs
|
|
US7615211B2
(en)
*
|
2004-02-09 |
2009-11-10 |
Cbr Institute For Biomedical Research, Inc. |
CD70 inhibition for the treatment and prevention of inflammatory bowel disease
|
|
RU2402548C2
(ru)
*
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
CA2570887C
(en)
*
|
2004-06-18 |
2014-09-16 |
Genentech, Inc. |
Tumor treatment
|
|
WO2006002895A2
(en)
*
|
2004-06-30 |
2006-01-12 |
Novartis Ag |
Conjugates of antibody and duoarmycin derivatives as antitumor agents
|
|
WO2006044643A2
(en)
*
|
2004-10-15 |
2006-04-27 |
Seattle Genetics, Inc. |
Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
US7641903B2
(en)
*
|
2004-10-15 |
2010-01-05 |
Seattle Genetics, Inc. |
Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
WO2006079372A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
CA2597924C
(en)
*
|
2005-02-15 |
2018-10-02 |
Duke University |
Anti-cd19 antibodies and uses in oncology
|
|
JP2008538365A
(ja)
*
|
2005-04-15 |
2008-10-23 |
イミュノジェン・インコーポレーテッド |
腫瘍内の不均一または混合細胞集団を排除する方法
|
|
US20060257317A1
(en)
*
|
2005-05-04 |
2006-11-16 |
Duke University |
Combination therapy in the treatment of cancer
|
|
KR20080026562A
(ko)
*
|
2005-06-02 |
2008-03-25 |
갤럭시 바이오테크, 엘엘씨 |
항체를 이용한 뇌종양 치료 방법
|
|
US8008453B2
(en)
*
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
EA016186B1
(ru)
*
|
2005-09-26 |
2012-03-30 |
Медарекс, Инк. |
Человеческие моноклональные антитела к cd70 и их применение
|
|
NZ566982A
(en)
*
|
2005-09-26 |
2011-06-30 |
Medarex Inc |
Duocarmycin drug conjugates
|
|
EP1957099B1
(en)
|
2005-11-07 |
2015-03-25 |
The Rockefeller University |
Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
BRPI0619056A2
(pt)
|
2005-11-28 |
2011-09-20 |
Genmab As |
anticorpo monovalente, método para preparar e produzir um antcorpo monovalente, construção de ácido nucleico, célula hospedeira, imunoconjugado, uso de um anticorpo monovalente, e, composição farmacêutica
|
|
EP1974040B1
(en)
|
2006-01-17 |
2012-10-03 |
Biolex Therapeutics, Inc. |
Compositions and methods for humanization and optimization of N-glycans in plants
|
|
US20080131428A1
(en)
*
|
2006-02-24 |
2008-06-05 |
Arius Research, Inc. |
Cytotoxicity mediation of cells evidencing surface expression of TROP-2
|