DE69942128D1 - Prodrugs und verfahren zu deren herstellung - Google Patents

Prodrugs und verfahren zu deren herstellung

Info

Publication number
DE69942128D1
DE69942128D1 DE69942128T DE69942128T DE69942128D1 DE 69942128 D1 DE69942128 D1 DE 69942128D1 DE 69942128 T DE69942128 T DE 69942128T DE 69942128 T DE69942128 T DE 69942128T DE 69942128 D1 DE69942128 D1 DE 69942128D1
Authority
DE
Germany
Prior art keywords
leu
prodrug
prodrugs
therapeutic agent
ssala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69942128T
Other languages
English (en)
Inventor
Thomas J Lobl
Vincent Dubois
Anne-Marie Fernandez
Sanjeev Gangwar
Evan Lewis
Matthew H Nieder
Andre Trouet
Peter Viski
Geoffrey T Yarranton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
Coulter Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Pharmaceutical Inc filed Critical Coulter Pharmaceutical Inc
Application granted granted Critical
Publication of DE69942128D1 publication Critical patent/DE69942128D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
DE69942128T 1998-12-11 1999-12-10 Prodrugs und verfahren zu deren herstellung Expired - Lifetime DE69942128D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11179398P 1998-12-11 1998-12-11
US11931299P 1999-02-08 1999-02-08
PCT/US1999/030393 WO2000033888A2 (en) 1998-12-11 1999-12-10 Prodrug compounds and process for preparation thereof

Publications (1)

Publication Number Publication Date
DE69942128D1 true DE69942128D1 (de) 2010-04-22

Family

ID=26809248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69942128T Expired - Lifetime DE69942128D1 (de) 1998-12-11 1999-12-10 Prodrugs und verfahren zu deren herstellung

Country Status (14)

Country Link
EP (1) EP1144011B1 (de)
JP (1) JP2003518000A (de)
AT (1) ATE460180T1 (de)
AU (1) AU773420B2 (de)
CA (1) CA2354766A1 (de)
CY (1) CY1111094T1 (de)
DE (1) DE69942128D1 (de)
DK (1) DK1144011T3 (de)
ES (1) ES2342637T3 (de)
HK (1) HK1039272A1 (de)
IL (2) IL143666A0 (de)
NZ (1) NZ512171A (de)
PT (1) PT1144011E (de)
WO (1) WO2000033888A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
PT1045897E (pt) 1998-01-23 2002-07-31 Newbiotics Inc Agentes terapeuticos por catalise enzimatica
DE69904831T2 (de) 1998-07-13 2003-11-06 Univ Texas Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
CA2370245A1 (en) 1999-05-14 2000-11-23 Boehringer Ingelheim Pharmaceuticals, Inc. Enzyme-activated anti-tumor prodrug compounds
US6613879B1 (en) 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
MXPA02000761A (es) * 1999-07-22 2002-08-12 Newbiotics Inc Agentes terapeuticos anti-infecciosos catalizados por enzima.
EP1200130A2 (de) * 1999-07-22 2002-05-02 Newbiotics, Inc. Vefahren zur behandlung von therapie-resistente tumoren
DE10018617A1 (de) * 2000-01-13 2001-10-31 Joerg G Moser Cyclodextrin-Dimere mit Peptid-Spacerstrukturen zur Entgiftung von pharmazeutischen Wirkstoffen hohen Nebenwirkungspotentials
SK12872002A3 (sk) 2000-03-15 2003-05-02 Bristol-Myers Squibb Pharma Company Cielené antineoplastické lieky a ich terapeutické použitie
AU7552501A (en) 2000-06-14 2002-01-08 Corixa Corp Tripeptide prodrug compounds
EP1294405A2 (de) * 2000-06-14 2003-03-26 Corixa Corporation Durch thimet oligopeptidase spaltbare prodrugs
AU2001266853B2 (en) * 2000-06-14 2005-02-17 Medarex, Inc. Prodrug compounds with an oligopeptide having an isoleucine residue
US7402556B2 (en) 2000-08-24 2008-07-22 Medarex, Inc. Prodrugs activated by plasmin and their use in cancer chemotherapy
MXPA03002882A (es) * 2000-10-27 2004-12-03 Aventis Pharma Sa Una combinacion que contiene camptotecina y un derivado de estilbeno para el tratamiento del cancer.
CA2428971A1 (en) * 2000-11-14 2003-05-01 New River Pharmaceuticals Inc. Conjugates of a therapeutic agent and a peptide carrier
WO2002060488A1 (en) * 2001-01-30 2002-08-08 Universite Catholique De Louvain Anti-tumor compounds
US6989452B2 (en) 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
ATE504315T1 (de) * 2001-06-11 2011-04-15 Medarex Inc Methode für die ausarbeitung von cd10-aktivierten prodrug-verbindungen
FR2825928B1 (fr) * 2001-06-18 2004-04-02 Ecole Norm Superieure Cachan Composition pharmaceutique pour le diagnostic, la prevention ou le traitement d'une pathologie tumorale, comprenant un agent modulateur de l'etat polymerisation de l'actine
EP1506221A2 (de) * 2002-05-10 2005-02-16 Boehringer Ingelheim Pharma GmbH & Co.KG Durch fap aktivierbare antitumorwirkstoffe
US7678386B2 (en) 2002-07-15 2010-03-16 Board Of Regents The University Of Texas Liposomes coated with selected antibodies that bind to aminophospholipids
US7879801B2 (en) * 2002-07-15 2011-02-01 Board Of Regents, The University Of Texas System Compositions comprising cell-impermeant duramycin derivatives
US7511124B2 (en) 2002-07-15 2009-03-31 Board Of Regents, The University Of Texas System Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents
US7378386B2 (en) 2002-07-15 2008-05-27 Board Of Regents, The University Of Texas System Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives
US7384909B2 (en) 2002-07-15 2008-06-10 Board Of Regents, The University Of Texas System Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents
US7053051B2 (en) 2003-10-28 2006-05-30 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
WO2005072061A2 (en) 2004-02-02 2005-08-11 Biosight Ltd. Conjugates for cancer therapy and diagnosis
WO2006095345A2 (en) 2005-03-08 2006-09-14 Ramot At Tel-Aviv University Ltd. Targeted drug-carrying bacteriophages
EP1993608A1 (de) * 2006-03-10 2008-11-26 Diatos Über einen enzym-spaltbaren linker an einen antikörper konjugierte arzneimittel gegen krebs
JP5398538B2 (ja) 2006-12-01 2014-01-29 メダレックス・リミテッド・ライアビリティ・カンパニー Ｃｄ２２に結合するヒト抗体およびその使用
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
AU2007333098A1 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind CD70 and uses thereof
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
US8664407B2 (en) 2007-02-21 2014-03-04 Medarex, LLC Chemical linkers with single amino acids and conjugates thereof
EP1977765A1 (de) * 2007-04-03 2008-10-08 Diatos Peptid-Prodrugs
AU2013243873B2 (en) 2012-04-04 2016-08-25 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
PL2938360T3 (pl) * 2012-12-28 2020-05-18 Cobiores Nv Minimalnie toksyczne proleki
CA2907521C (en) 2013-03-21 2021-04-13 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
HUE034308T2 (en) 2013-03-21 2018-02-28 Sanofi Aventis Deutschland Preparation of hydantoin-containing peptide products
US20140364368A1 (en) * 2013-06-06 2014-12-11 Massachusetts Institute Of Technology Stimulus responsive nanocomplexes and methods of use thereof
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
US12071450B2 (en) 2015-12-03 2024-08-27 Biosight Ltd. Salts of conjugates for cancer therapy
JP2018535987A (ja) 2015-12-03 2018-12-06 バイオサイト リミテッド 癌療法のためのコンジュゲートの塩
BR112018011177A2 (pt) 2015-12-03 2018-11-21 Biosight Ltd conjugados de citarabina para terapia de câncer
CN109021065B (zh) * 2017-06-08 2021-10-01 复旦大学 一种制备海兔毒素Dolastatin10的方法
CN116635054A (zh) 2020-12-22 2023-08-22 科比欧尔斯公司 包括四肽部分的化合物
WO2022167664A1 (en) 2021-02-07 2022-08-11 Cobiores Nv Compounds comprising a tetrapeptidic moiety

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037388B1 (de) * 1980-03-31 1984-12-12 Institut International De Pathologie Cellulaire Et Moleculaire Pharmazeutische Stoffe, deren Herstellung und Präparate in denen diese enthalten sind
US5155210A (en) * 1990-09-11 1992-10-13 Brunswick Corporation Methods of conjugating actinomycin d
ES2149867T3 (es) * 1993-02-26 2000-11-16 Drug Delivery System Inst Ltd Derivados de polisacaridos y soportes para farmacos.
WO1996005863A1 (fr) * 1994-08-19 1996-02-29 La Region Wallonne Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
CA2265476A1 (en) * 1996-09-12 1998-03-19 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
HRP970566A2 (en) * 1996-10-30 1998-08-31 Jones Deborah Defeo Conjugates useful in the treatment of prostate canser
AU7582298A (en) * 1997-05-19 1998-12-11 Johns Hopkins University School Of Medicine, The Tissue specific prodrug
CA2295860A1 (en) * 1997-07-10 1999-01-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
PL197006B1 (pl) * 1997-12-02 2008-02-29 Merck & Co Inc Koniugat do leczenia raka prostaty, zawierająca go kompozycja farmaceutyczna i jej zastosowanie

Also Published As

Publication number Publication date
NZ512171A (en) 2004-07-30
PT1144011E (pt) 2010-06-16
AU773420B2 (en) 2004-05-27
AU2373300A (en) 2000-06-26
WO2000033888A3 (en) 2001-11-08
ES2342637T3 (es) 2010-07-09
CY1111094T1 (el) 2015-10-07
IL143666A0 (en) 2002-04-21
CA2354766A1 (en) 2000-06-15
EP1144011A2 (de) 2001-10-17
ATE460180T1 (de) 2010-03-15
IL143666A (en) 2009-02-11
WO2000033888A2 (en) 2000-06-15
WO2000033888A9 (en) 2001-05-10
JP2003518000A (ja) 2003-06-03
DK1144011T3 (da) 2010-07-05
EP1144011B1 (de) 2010-03-10
HK1039272A1 (en) 2002-04-19

Similar Documents

Publication Publication Date Title
DE69942128D1 (de) Prodrugs und verfahren zu deren herstellung
US7442386B2 (en) Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies
DE69833798T2 (de) Trialkyl-blockierung-vereinfachte polymerische medikamentenvorstufen von aminogruppen enthaltenden bioaktiven substanzen
EP0781778B1 (de) Paclitaxel Prodrogen, Verfahren zur Herstellung und ihre Verwendung zur selektiven Chemotherapie
US20050271615A1 (en) Self-immolative dendrimers releasing many active moieties upon a single activating event
CA2478066A1 (en) Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting
AU2002324723A1 (en) Synthesis and use of reagents for improved DNA lipofection and/or slow release pro-drug and drug therapies
DE102009051799B4 (de) Bifunktionale Prodrugs und Drugs
JP2016538281A (ja) 血液脳関門を通過するタンパク質ホスファターゼ阻害剤
WO2005016867A3 (en) Anthranilic acid derivatives and their use as activators of the hm74a receptor
JP2003528851A (ja) セラミド誘導体と使用方法
WO2014013995A1 (ja) KRAS遺伝子発現抑制RNAi医薬組成物
DE69917281T2 (de) Coumarin und damit verwandte aromatische polymere prodrugs
JP2013544289A (ja) ６−シクロヘキシル−１−ヒドロキシ−４−メチルピリジン−２（１ｈ）−オンのプロドラッグおよびその誘導体
US20200277251A1 (en) Novel antibacterial compounds and methods of making and using same
EP3791897A1 (de) Hsp9-inhibitor-wirkstoff-konjugate
KR102490825B1 (ko) 상피 기능장애 치료에서의 아델미드롤의 용도
WO2015186770A1 (ja) ＣＫＡＰ５遺伝子発現抑制ＲＮＡｉ医薬組成物
JP6774965B2 (ja) カチオン性脂質としての化合物
JP2019535824A (ja) 胃腸ポリープの処置のための組成物及び方法
CN103183722A (zh) 一种乙二醛酶ⅰ抑制剂及其制备方法和医药用途
JPS6317840B2 (de)
RU2724882C1 (ru) 1,1'-(Гексан-1,6-диил)бис(3-(((1R,4aS,10aR)-7-изопропил-1,4а-диметил-1,2,3,4,4а,9,10,10а-октагидрофенантрен-1-ил)метил)мочевина, проявляющая ингибирующее действие в отношении фермента тирозил-ДНК-фосфодиэстеразы 1 человека и увеличивающая активность темозоломида в отношении клеток глиобластомы
WO2023101993A3 (en) Segmented nucleic acids
EP1933820A2 (de) Auf palmarumycin basierende hemmer von thioredoxin und anwendungsverfahren

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MEDAREX INC., PRINCETON, N.J., US

8364 No opposition during term of opposition