JP2010511670A5 - - Google Patents
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- Publication number
- JP2010511670A5 JP2010511670A5 JP2009539740A JP2009539740A JP2010511670A5 JP 2010511670 A5 JP2010511670 A5 JP 2010511670A5 JP 2009539740 A JP2009539740 A JP 2009539740A JP 2009539740 A JP2009539740 A JP 2009539740A JP 2010511670 A5 JP2010511670 A5 JP 2010511670A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound according
- het
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 cyano, formyl Chemical group 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000005984 hexahydro-1H-1,4-diazepinyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 3
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 3
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000004306 triazinyl group Chemical group 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125521 | 2006-12-06 | ||
| EP06125521.2 | 2006-12-06 | ||
| PCT/EP2007/063315 WO2008068269A1 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511670A JP2010511670A (ja) | 2010-04-15 |
| JP2010511670A5 true JP2010511670A5 (enExample) | 2010-11-11 |
| JP5356245B2 JP5356245B2 (ja) | 2013-12-04 |
Family
ID=37944337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539740A Expired - Fee Related JP5356245B2 (ja) | 2006-12-06 | 2007-12-04 | 抗菌性キノリン誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7998979B2 (enExample) |
| EP (1) | EP2086941B1 (enExample) |
| JP (1) | JP5356245B2 (enExample) |
| KR (1) | KR101490221B1 (enExample) |
| CN (1) | CN101541752B (enExample) |
| AR (1) | AR064150A1 (enExample) |
| AT (1) | ATE465994T1 (enExample) |
| AU (1) | AU2007328889B2 (enExample) |
| BR (1) | BRPI0720251B8 (enExample) |
| CA (1) | CA2668520C (enExample) |
| CL (1) | CL2007003516A1 (enExample) |
| CY (1) | CY1110706T1 (enExample) |
| DE (1) | DE602007006231D1 (enExample) |
| DK (1) | DK2086941T3 (enExample) |
| ES (1) | ES2344535T3 (enExample) |
| HR (1) | HRP20100384T1 (enExample) |
| IL (1) | IL199081A (enExample) |
| JO (1) | JO2685B1 (enExample) |
| ME (1) | ME01073B (enExample) |
| MX (1) | MX2009005980A (enExample) |
| NO (1) | NO341995B1 (enExample) |
| NZ (1) | NZ576673A (enExample) |
| PL (1) | PL2086941T3 (enExample) |
| PT (1) | PT2086941E (enExample) |
| RS (1) | RS51390B (enExample) |
| RU (1) | RU2446159C2 (enExample) |
| SI (1) | SI2086941T1 (enExample) |
| TW (1) | TWI412364B (enExample) |
| WO (1) | WO2008068269A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2013254670B2 (en) | 2012-04-27 | 2017-03-30 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| CN104650054B (zh) * | 2013-11-25 | 2019-09-13 | 重庆医药工业研究院有限责任公司 | 一种抗结核菌的喹啉噻吩芳氧乙胺衍生物 |
| WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| JP2025510646A (ja) | 2022-03-14 | 2025-04-15 | スラップ ファーマシューティカルズ エルエルシー | 多環式化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6033389B2 (ja) * | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤 |
| WO1998018326A1 (en) | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| KR20040055774A (ko) * | 2001-07-31 | 2004-06-26 | 웨인 스테이트 유니버시티 | 퀴놀린 유도체 및 항종양제로서 그의 용도 |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| WO2005070430A1 (en) * | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
| WO2005070924A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Substituted quinolines and their use as mycobacterial inhibitors |
| ES2306098T3 (es) * | 2004-01-29 | 2008-11-01 | Janssen Pharmaceutica Nv | Derivados de quinolina para uso como inhibidores de micobacterias. |
| EP1753427B1 (en) * | 2004-05-28 | 2008-04-02 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| ME02935B (me) | 2004-09-28 | 2018-04-20 | Janssen Pharmaceutica Nv | Vezujući domen bakterijske atp sintaze |
-
2007
- 2007-11-29 JO JO2007507A patent/JO2685B1/en active
- 2007-12-04 RU RU2009125525/04A patent/RU2446159C2/ru active
- 2007-12-04 JP JP2009539740A patent/JP5356245B2/ja not_active Expired - Fee Related
- 2007-12-04 KR KR1020097012572A patent/KR101490221B1/ko not_active Expired - Fee Related
- 2007-12-04 AT AT07847813T patent/ATE465994T1/de active
- 2007-12-04 PT PT07847813T patent/PT2086941E/pt unknown
- 2007-12-04 DE DE602007006231T patent/DE602007006231D1/de active Active
- 2007-12-04 HR HR20100384T patent/HRP20100384T1/hr unknown
- 2007-12-04 AU AU2007328889A patent/AU2007328889B2/en not_active Ceased
- 2007-12-04 EP EP07847813A patent/EP2086941B1/en active Active
- 2007-12-04 SI SI200730286T patent/SI2086941T1/sl unknown
- 2007-12-04 CA CA2668520A patent/CA2668520C/en active Active
- 2007-12-04 US US12/516,370 patent/US7998979B2/en active Active
- 2007-12-04 PL PL07847813T patent/PL2086941T3/pl unknown
- 2007-12-04 CN CN2007800437666A patent/CN101541752B/zh not_active Expired - Fee Related
- 2007-12-04 ES ES07847813T patent/ES2344535T3/es active Active
- 2007-12-04 DK DK07847813.8T patent/DK2086941T3/da active
- 2007-12-04 NZ NZ576673A patent/NZ576673A/en not_active IP Right Cessation
- 2007-12-04 ME MEP-2010-111A patent/ME01073B/me unknown
- 2007-12-04 RS RSP-2010/0340A patent/RS51390B/sr unknown
- 2007-12-04 BR BRPI0720251A patent/BRPI0720251B8/pt not_active IP Right Cessation
- 2007-12-04 MX MX2009005980A patent/MX2009005980A/es active IP Right Grant
- 2007-12-04 WO PCT/EP2007/063315 patent/WO2008068269A1/en not_active Ceased
- 2007-12-05 TW TW096146213A patent/TWI412364B/zh not_active IP Right Cessation
- 2007-12-05 CL CL200703516A patent/CL2007003516A1/es unknown
- 2007-12-05 AR ARP070105443A patent/AR064150A1/es unknown
-
2009
- 2009-06-02 IL IL199081A patent/IL199081A/en active IP Right Grant
- 2009-07-06 NO NO20092540A patent/NO341995B1/no unknown
-
2010
- 2010-07-28 CY CY20101100708T patent/CY1110706T1/el unknown
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