RU2446159C2 - Антибактериальные производные хинолина - Google Patents

Антибактериальные производные хинолина Download PDF

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Publication number
RU2446159C2
RU2446159C2 RU2009125525/04A RU2009125525A RU2446159C2 RU 2446159 C2 RU2446159 C2 RU 2446159C2 RU 2009125525/04 A RU2009125525/04 A RU 2009125525/04A RU 2009125525 A RU2009125525 A RU 2009125525A RU 2446159 C2 RU2446159 C2 RU 2446159C2
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RU
Russia
Prior art keywords
alkyl
formula
compound
aryl
compounds
Prior art date
Application number
RU2009125525/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2009125525A (ru
Inventor
Жером Эмиль Жорж ГИЙЕМОН (FR)
Жером Эмиль Жорж Гийемон
Магали Мадлен Симон МОТТ (FR)
Магали Мадлен Симон Мотт
Кунрад Йозеф Лодевейк Марсель АНДРИС (BE)
Кунрад Йозеф Лодевейк Марсель Андрис
Анил КОУЛ (BE)
Анил Коул
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of RU2009125525A publication Critical patent/RU2009125525A/ru
Application granted granted Critical
Publication of RU2446159C2 publication Critical patent/RU2446159C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
RU2009125525/04A 2006-12-06 2007-12-04 Антибактериальные производные хинолина RU2446159C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125521.2 2006-12-06
EP06125521 2006-12-06

Publications (2)

Publication Number Publication Date
RU2009125525A RU2009125525A (ru) 2011-01-20
RU2446159C2 true RU2446159C2 (ru) 2012-03-27

Family

ID=37944337

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009125525/04A RU2446159C2 (ru) 2006-12-06 2007-12-04 Антибактериальные производные хинолина

Country Status (29)

Country Link
US (1) US7998979B2 (enExample)
EP (1) EP2086941B1 (enExample)
JP (1) JP5356245B2 (enExample)
KR (1) KR101490221B1 (enExample)
CN (1) CN101541752B (enExample)
AR (1) AR064150A1 (enExample)
AT (1) ATE465994T1 (enExample)
AU (1) AU2007328889B2 (enExample)
BR (1) BRPI0720251B8 (enExample)
CA (1) CA2668520C (enExample)
CL (1) CL2007003516A1 (enExample)
CY (1) CY1110706T1 (enExample)
DE (1) DE602007006231D1 (enExample)
DK (1) DK2086941T3 (enExample)
ES (1) ES2344535T3 (enExample)
HR (1) HRP20100384T1 (enExample)
IL (1) IL199081A (enExample)
JO (1) JO2685B1 (enExample)
ME (1) ME01073B (enExample)
MX (1) MX2009005980A (enExample)
NO (1) NO341995B1 (enExample)
NZ (1) NZ576673A (enExample)
PL (1) PL2086941T3 (enExample)
PT (1) PT2086941E (enExample)
RS (1) RS51390B (enExample)
RU (1) RU2446159C2 (enExample)
SI (1) SI2086941T1 (enExample)
TW (1) TWI412364B (enExample)
WO (1) WO2008068269A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
CN104650054B (zh) * 2013-11-25 2019-09-13 重庆医药工业研究院有限责任公司 一种抗结核菌的喹啉噻吩芳氧乙胺衍生物
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
US20250214980A1 (en) 2022-03-14 2025-07-03 Slap Pharmaceuticals Llc Multicyclic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1452455A3 (ru) * 1979-02-22 1989-01-15 Ниссан Кемикал Индастриз Лтд (Фирма) Гербицидна композици (ее варианты)
UA75691C2 (en) * 2001-07-31 2006-05-15 Univ Wayne State Quinoline derivatives, use thereof as antitumor drugs, composition based thereon and therapeutical method for treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965572A (en) 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
SI1527050T1 (sl) * 2002-07-25 2010-08-31 Janssen Pharmaceutica Nv Kinolinski derivati in njihova uporaba kot mikobakterijski inhibitorji
US7902225B2 (en) * 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
BRPI0507076B8 (pt) 2004-01-23 2021-05-25 Janssen Pharmaceutica Nv quinolinas substituídas, seu processo de preparação, composição farmacêutica que as compreende e seu uso como inibidores micobacterianos
UA83875C2 (ru) * 2004-01-29 2008-08-26 Янссен Фармацевтика Н.В. Производные хинолина для применения в качестве микобактериальных ингибиторов
MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
RS56357B1 (sr) 2004-09-28 2017-12-29 Janssen Pharmaceutica Nv Vezujući domen bakterijske atp sintaze

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1452455A3 (ru) * 1979-02-22 1989-01-15 Ниссан Кемикал Индастриз Лтд (Фирма) Гербицидна композици (ее варианты)
UA75691C2 (en) * 2001-07-31 2006-05-15 Univ Wayne State Quinoline derivatives, use thereof as antitumor drugs, composition based thereon and therapeutical method for treatment of cancer

Also Published As

Publication number Publication date
US7998979B2 (en) 2011-08-16
NO20092540L (no) 2009-09-07
EP2086941A1 (en) 2009-08-12
BRPI0720251A2 (pt) 2014-01-07
NO341995B1 (no) 2018-03-12
AU2007328889A1 (en) 2008-06-12
CA2668520A1 (en) 2008-06-12
BRPI0720251B1 (pt) 2020-10-06
TW200845987A (en) 2008-12-01
CL2007003516A1 (es) 2008-07-11
IL199081A (en) 2013-08-29
ATE465994T1 (de) 2010-05-15
KR20090087071A (ko) 2009-08-14
AR064150A1 (es) 2009-03-18
RU2009125525A (ru) 2011-01-20
EP2086941B1 (en) 2010-04-28
CN101541752A (zh) 2009-09-23
JO2685B1 (en) 2013-03-03
CY1110706T1 (el) 2015-06-10
JP5356245B2 (ja) 2013-12-04
CA2668520C (en) 2016-01-26
NZ576673A (en) 2011-09-30
HRP20100384T1 (hr) 2010-08-31
PL2086941T3 (pl) 2010-10-29
DK2086941T3 (da) 2010-08-09
CN101541752B (zh) 2013-07-17
HK1137428A1 (en) 2010-07-30
TWI412364B (zh) 2013-10-21
ME01073B (me) 2012-10-20
AU2007328889B2 (en) 2012-12-06
RS51390B (sr) 2011-02-28
WO2008068269A1 (en) 2008-06-12
US20100063061A1 (en) 2010-03-11
MX2009005980A (es) 2009-06-16
JP2010511670A (ja) 2010-04-15
ES2344535T3 (es) 2010-08-30
DE602007006231D1 (de) 2010-06-10
BRPI0720251B8 (pt) 2021-05-25
KR101490221B1 (ko) 2015-02-05
PT2086941E (pt) 2010-07-14
SI2086941T1 (sl) 2010-08-31

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