JP2009503025A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009503025A5 JP2009503025A5 JP2008524509A JP2008524509A JP2009503025A5 JP 2009503025 A5 JP2009503025 A5 JP 2009503025A5 JP 2008524509 A JP2008524509 A JP 2008524509A JP 2008524509 A JP2008524509 A JP 2008524509A JP 2009503025 A5 JP2009503025 A5 JP 2009503025A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- use according
- hydrogen
- het
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 23
- -1 cyano, hydroxy Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 10
- 208000035143 Bacterial infection Diseases 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 208000022362 bacterial infectious disease Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 9
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 239000003242 anti bacterial agent Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 5
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 3
- 239000003926 antimycobacterial agent Substances 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229960003085 meticillin Drugs 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000004605 1,2,3,4-tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- 125000004364 3-pyrrolinyl group Chemical group [H]C1=C([H])C([H])([H])N(*)C1([H])[H] 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 206010062207 Mycobacterial infection Diseases 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000005476 oxopyrrolidinyl group Chemical group 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107164.5 | 2005-08-03 | ||
| EP05107164 | 2005-08-03 | ||
| PCT/EP2006/064858 WO2007014941A2 (en) | 2005-08-03 | 2006-07-31 | Quinoline derivatives as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009503025A JP2009503025A (ja) | 2009-01-29 |
| JP2009503025A5 true JP2009503025A5 (enExample) | 2009-09-17 |
| JP5302680B2 JP5302680B2 (ja) | 2013-10-02 |
Family
ID=35744723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524509A Expired - Fee Related JP5302680B2 (ja) | 2005-08-03 | 2006-07-31 | 抗バクテリア剤としてのキノリン誘導体 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8802671B2 (enExample) |
| EP (1) | EP1912648B1 (enExample) |
| JP (1) | JP5302680B2 (enExample) |
| KR (1) | KR101413997B1 (enExample) |
| CN (2) | CN101277696A (enExample) |
| AP (1) | AP2654A (enExample) |
| AR (1) | AR054890A1 (enExample) |
| AU (1) | AU2006274880B2 (enExample) |
| BR (1) | BRPI0614493B8 (enExample) |
| CA (1) | CA2615903C (enExample) |
| CY (1) | CY1114318T1 (enExample) |
| DK (1) | DK1912648T3 (enExample) |
| EA (1) | EA014833B1 (enExample) |
| ES (1) | ES2414956T3 (enExample) |
| HR (1) | HRP20130540T1 (enExample) |
| IL (1) | IL189142A0 (enExample) |
| JO (1) | JO2855B1 (enExample) |
| ME (1) | ME01616B (enExample) |
| MX (1) | MX2008001603A (enExample) |
| MY (1) | MY159560A (enExample) |
| NO (1) | NO341242B1 (enExample) |
| NZ (1) | NZ565947A (enExample) |
| PL (1) | PL1912648T3 (enExample) |
| PT (1) | PT1912648E (enExample) |
| RS (1) | RS52808B (enExample) |
| SI (1) | SI1912648T1 (enExample) |
| TW (1) | TWI422374B (enExample) |
| UA (1) | UA95915C2 (enExample) |
| WO (1) | WO2007014941A2 (enExample) |
| ZA (1) | ZA200801110B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004186452A (ja) | 2002-12-04 | 2004-07-02 | Renesas Technology Corp | 不揮発性半導体記憶装置およびその製造方法 |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2013254670B2 (en) | 2012-04-27 | 2017-03-30 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| KR20150070348A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| PE20150778A1 (es) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
| PE20151203A1 (es) | 2012-10-16 | 2015-08-31 | Janssen Pharmaceutica Nv | MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t |
| US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| CN109111397B (zh) * | 2018-08-28 | 2021-12-10 | 广东工业大学 | 一种喹啉芳香乙烯类衍生物及其制备方法和应用 |
| CN109111396B (zh) * | 2018-08-28 | 2021-09-03 | 广东工业大学 | 一种喹啉芳香乙烯衍生物及其制备方法和应用 |
| CN112079825B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用 |
| CN112110907B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB807750A (en) * | 1956-06-15 | 1959-01-21 | Rhone Poulenc Sa | Improvements in or relating to piperazine derivatives |
| GB9317491D0 (en) * | 1993-08-23 | 1993-10-06 | Fujisawa Pharmaceutical Co | New compound and a process for preparation thereof |
| WO1998018326A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| PL360102A3 (en) | 2003-05-13 | 2004-11-15 | "ENERGOMAR-NORD" Sp.z o.o. | Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents |
| WO2005070430A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
| WO2005070924A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Substituted quinolines and their use as mycobacterial inhibitors |
| ES2306098T3 (es) * | 2004-01-29 | 2008-11-01 | Janssen Pharmaceutica Nv | Derivados de quinolina para uso como inhibidores de micobacterias. |
| EE05697B1 (et) | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| US20070018948A1 (en) | 2005-07-22 | 2007-01-25 | Elaine Chen | Apparatus for stabilizing an electronic device during data input and device control |
-
2006
- 2006-07-18 JO JO2006232A patent/JO2855B1/en active
- 2006-07-31 NZ NZ565947A patent/NZ565947A/en not_active IP Right Cessation
- 2006-07-31 WO PCT/EP2006/064858 patent/WO2007014941A2/en not_active Ceased
- 2006-07-31 EP EP06778083.3A patent/EP1912648B1/en active Active
- 2006-07-31 SI SI200631602T patent/SI1912648T1/sl unknown
- 2006-07-31 US US11/997,173 patent/US8802671B2/en active Active
- 2006-07-31 KR KR1020087005071A patent/KR101413997B1/ko not_active Expired - Fee Related
- 2006-07-31 HR HRP20130540TT patent/HRP20130540T1/hr unknown
- 2006-07-31 EA EA200800508A patent/EA014833B1/ru unknown
- 2006-07-31 MX MX2008001603A patent/MX2008001603A/es active IP Right Grant
- 2006-07-31 CN CNA2006800367512A patent/CN101277696A/zh active Granted
- 2006-07-31 JP JP2008524509A patent/JP5302680B2/ja not_active Expired - Fee Related
- 2006-07-31 PL PL06778083T patent/PL1912648T3/pl unknown
- 2006-07-31 DK DK06778083.3T patent/DK1912648T3/da active
- 2006-07-31 ES ES06778083T patent/ES2414956T3/es active Active
- 2006-07-31 CN CN200680036751.2D patent/CN101277696B8/zh not_active Expired - Fee Related
- 2006-07-31 RS RS20130254A patent/RS52808B/sr unknown
- 2006-07-31 CA CA2615903A patent/CA2615903C/en active Active
- 2006-07-31 BR BRPI0614493A patent/BRPI0614493B8/pt not_active IP Right Cessation
- 2006-07-31 PT PT67780833T patent/PT1912648E/pt unknown
- 2006-07-31 UA UAA200801432A patent/UA95915C2/ru unknown
- 2006-07-31 ME MEP-2013-65A patent/ME01616B/me unknown
- 2006-07-31 AP AP2008004316A patent/AP2654A/xx active
- 2006-07-31 AU AU2006274880A patent/AU2006274880B2/en not_active Ceased
- 2006-08-01 MY MYPI20063727A patent/MY159560A/en unknown
- 2006-08-02 AR ARP060103372A patent/AR054890A1/es unknown
- 2006-08-02 TW TW095128224A patent/TWI422374B/zh not_active IP Right Cessation
-
2008
- 2008-01-31 IL IL189142A patent/IL189142A0/en active IP Right Grant
- 2008-02-01 ZA ZA2008/01110A patent/ZA200801110B/en unknown
- 2008-02-27 NO NO20081026A patent/NO341242B1/no not_active IP Right Cessation
-
2013
- 2013-07-09 CY CY20131100578T patent/CY1114318T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009503025A5 (enExample) | ||
| JP2009503024A5 (enExample) | ||
| EP2678336B1 (en) | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | |
| HRP20131116T1 (hr) | Derivati kinolina kao antibakterijska sredstva | |
| KR100423778B1 (ko) | 항미생물성 퀴놀론, 그의 조성물 및 용도 | |
| CA2553269A1 (en) | Quinoline derivatives and use thereof as mycobacterial inhibitors | |
| JP2006504658A5 (enExample) | ||
| CA2493225A1 (en) | Quinoline derivatives and their use as mycobacterial inhibitors | |
| CA2554049A1 (en) | Quinoline derivatives for use as mycobacterial inhibitors | |
| CA2566544A1 (en) | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases | |
| JP2008500992A5 (enExample) | ||
| JP2014527996A5 (enExample) | ||
| HRP20140206T1 (hr) | Derivati kinolina kao antibakterijska sredstva | |
| TW202317532A (zh) | Aak1抑制劑及其用途 | |
| KR20060113625A (ko) | 시클로프로필기 치환된 옥사졸리디논 항생제 및 그의유도체 | |
| JP2011509301A5 (enExample) | ||
| JP2017523213A (ja) | 抗菌薬としてのキノロン誘導体 | |
| JP2011517697A5 (enExample) | ||
| JP2013542267A5 (enExample) | ||
| AU2019200483A1 (en) | Methods of treating infections in overweight and obese patients using antibiotics | |
| JP2010507576A5 (enExample) | ||
| JP2018532786A5 (enExample) | ||
| JP2010511671A5 (enExample) | ||
| JP2009502869A5 (enExample) | ||
| JP2008546824A5 (enExample) |