CN101277696A - 作为抗菌药物的喹啉衍生物 - Google Patents

作为抗菌药物的喹啉衍生物 Download PDF

Info

Publication number
CN101277696A
CN101277696A CNA2006800367512A CN200680036751A CN101277696A CN 101277696 A CN101277696 A CN 101277696A CN A2006800367512 A CNA2006800367512 A CN A2006800367512A CN 200680036751 A CN200680036751 A CN 200680036751A CN 101277696 A CN101277696 A CN 101277696A
Authority
CN
China
Prior art keywords
alkyl
group
formula
hydrogen
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2006800367512A
Other languages
English (en)
Chinese (zh)
Other versions
CN101277696B (zh
CN101277696B8 (zh
Inventor
J·E·G·吉尔蒙特
E·T·J·帕斯奎尔
D·F·A·兰科伊斯
K·J·L·M·安德里斯
A·考尔
L·J·J·巴克克斯
L·米尔波尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35744723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101277696(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN101277696A publication Critical patent/CN101277696A/zh
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA2006800367512A 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物 Granted CN101277696A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107164.5 2005-08-03
EP05107164 2005-08-03
PCT/EP2006/064858 WO2007014941A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (1)

Publication Number Publication Date
CN101277696A true CN101277696A (zh) 2008-10-01

Family

ID=35744723

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2006800367512A Granted CN101277696A (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物
CN200680036751.2D Expired - Fee Related CN101277696B8 (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200680036751.2D Expired - Fee Related CN101277696B8 (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物

Country Status (30)

Country Link
US (1) US8802671B2 (enExample)
EP (1) EP1912648B1 (enExample)
JP (1) JP5302680B2 (enExample)
KR (1) KR101413997B1 (enExample)
CN (2) CN101277696A (enExample)
AP (1) AP2654A (enExample)
AR (1) AR054890A1 (enExample)
AU (1) AU2006274880B2 (enExample)
BR (1) BRPI0614493B8 (enExample)
CA (1) CA2615903C (enExample)
CY (1) CY1114318T1 (enExample)
DK (1) DK1912648T3 (enExample)
EA (1) EA014833B1 (enExample)
ES (1) ES2414956T3 (enExample)
HR (1) HRP20130540T1 (enExample)
IL (1) IL189142A0 (enExample)
JO (1) JO2855B1 (enExample)
ME (1) ME01616B (enExample)
MX (1) MX2008001603A (enExample)
MY (1) MY159560A (enExample)
NO (1) NO341242B1 (enExample)
NZ (1) NZ565947A (enExample)
PL (1) PL1912648T3 (enExample)
PT (1) PT1912648E (enExample)
RS (1) RS52808B (enExample)
SI (1) SI1912648T1 (enExample)
TW (1) TWI422374B (enExample)
UA (1) UA95915C2 (enExample)
WO (1) WO2007014941A2 (enExample)
ZA (1) ZA200801110B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111397A (zh) * 2018-08-28 2019-01-01 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396A (zh) * 2018-08-28 2019-01-01 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN112079825A (zh) * 2020-10-09 2020-12-15 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用
CN112110907A (zh) * 2020-10-09 2020-12-22 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004186452A (ja) 2002-12-04 2004-07-02 Renesas Technology Corp 不揮発性半導体記憶装置およびその製造方法
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
PE20150778A1 (es) 2012-10-16 2015-05-23 Janssen Pharmaceutica Nv Moduladores de quinolinilo unidos a metileno de ror-gamma-t
PE20151203A1 (es) 2012-10-16 2015-08-31 Janssen Pharmaceutica Nv MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t
US9346782B2 (en) 2013-10-15 2016-05-24 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9624225B2 (en) 2013-10-15 2017-04-18 Janssen Pharmaceutica Nv Quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807750A (en) * 1956-06-15 1959-01-21 Rhone Poulenc Sa Improvements in or relating to piperazine derivatives
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
PL360102A3 (en) 2003-05-13 2004-11-15 "ENERGOMAR-NORD" Sp.z o.o. Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents
WO2005070430A1 (en) 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Quinoline derivatives and use thereof as mycobacterial inhibitors
WO2005070924A1 (en) 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Substituted quinolines and their use as mycobacterial inhibitors
ES2306098T3 (es) * 2004-01-29 2008-11-01 Janssen Pharmaceutica Nv Derivados de quinolina para uso como inhibidores de micobacterias.
EE05697B1 (et) 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
US20070018948A1 (en) 2005-07-22 2007-01-25 Elaine Chen Apparatus for stabilizing an electronic device during data input and device control

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDRIES K. ET AL: "A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis", 《SCIENCE》 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111397A (zh) * 2018-08-28 2019-01-01 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396A (zh) * 2018-08-28 2019-01-01 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396B (zh) * 2018-08-28 2021-09-03 广东工业大学 一种喹啉芳香乙烯衍生物及其制备方法和应用
CN109111397B (zh) * 2018-08-28 2021-12-10 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN112079825A (zh) * 2020-10-09 2020-12-15 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用
CN112110907A (zh) * 2020-10-09 2020-12-22 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用
CN112110907B (zh) * 2020-10-09 2021-12-21 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用
CN112079825B (zh) * 2020-10-09 2021-12-21 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用

Also Published As

Publication number Publication date
EA200800508A1 (ru) 2008-06-30
BRPI0614493A2 (pt) 2011-03-29
IL189142A0 (en) 2008-08-07
RS52808B (sr) 2013-10-31
MX2008001603A (es) 2008-02-19
CA2615903C (en) 2016-08-30
TW200744595A (en) 2007-12-16
BRPI0614493B8 (pt) 2021-05-25
EA014833B1 (ru) 2011-02-28
AU2006274880B2 (en) 2012-12-13
NO20081026L (no) 2008-02-27
TWI422374B (zh) 2014-01-11
JO2855B1 (en) 2015-03-15
MY159560A (en) 2017-01-13
EP1912648A2 (en) 2008-04-23
ZA200801110B (en) 2011-10-26
AU2006274880A1 (en) 2007-02-08
AR054890A1 (es) 2007-07-25
WO2007014941A2 (en) 2007-02-08
US8802671B2 (en) 2014-08-12
SI1912648T1 (sl) 2013-07-31
HK1124234A1 (zh) 2009-07-10
CY1114318T1 (el) 2016-08-31
BRPI0614493B1 (pt) 2019-11-12
JP2009503025A (ja) 2009-01-29
CN101277696B (zh) 2015-09-02
DK1912648T3 (da) 2013-06-24
PL1912648T3 (pl) 2013-08-30
US20080207687A1 (en) 2008-08-28
ES2414956T3 (es) 2013-07-23
JP5302680B2 (ja) 2013-10-02
KR101413997B1 (ko) 2014-07-01
HRP20130540T1 (en) 2013-07-31
ME01616B (me) 2014-09-20
CA2615903A1 (en) 2007-02-08
EP1912648B1 (en) 2013-04-10
KR20080035666A (ko) 2008-04-23
NO341242B1 (no) 2017-09-25
WO2007014941A3 (en) 2007-03-29
PT1912648E (pt) 2013-06-27
WO2007014941A8 (en) 2007-05-31
CN101277696B8 (zh) 2016-07-06
NZ565947A (en) 2011-05-27
UA95915C2 (ru) 2011-09-26
AP2654A (en) 2013-04-25

Similar Documents

Publication Publication Date Title
EP2099758B1 (en) Antibacterial quinoline derivatives
CN101277696B (zh) 作为抗菌药物的喹啉衍生物
CN101547907B (zh) 抗菌的喹啉衍生物
NZ565283A (en) Quinoline derivatives as antibacterial agents
WO2006131519A1 (en) Quinoline derivatives as antibacterial agents
RU2446159C2 (ru) Антибактериальные производные хинолина
EP2099760B1 (en) Antibacterial quinoline derivatives
CN101277698B (zh) 作为抗菌剂的喹啉衍生物
CA2612614A1 (en) Quinoline derivatives as antibacterial agents
CA2612619C (en) Quinoline derivatives as antibacterial agents
WO2007000436A1 (en) Quinoline derivatives as antibacterial agents
HK1124234B (en) Quinoline derivatives as antibacterial agents
HK1124232B (en) Quinoline derivatives as antibacterial agents
HK1208437B (zh) 抗菌的喹啉衍生物
HK1124233B (en) Quinoline derivatives as antibacterical agents

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1124234

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
CI01 Publication of corrected invention patent application

Correction item: PCT international application published data

Correct: WO2007 / 0l4941 E N 2007.02.08

False: WO2007 / 014941 EN 2007.03.29

Number: 35

Volume: 31

CI03 Correction of invention patent

Correction item: PCT international application published data

Correct: WO2007 / 0l4941 E N 2007.02.08

False: WO2007 / 014941 EN 2007.03.29

Number: 35

Page: The title page

Volume: 31

ERR Gazette correction
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1124234

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150902