ME01616B - Kinolinski derivati kao antibakterijski agensi - Google Patents
Kinolinski derivati kao antibakterijski agensiInfo
- Publication number
- ME01616B ME01616B MEP-2013-65A MEP6513A ME01616B ME 01616 B ME01616 B ME 01616B ME P6513 A MEP6513 A ME P6513A ME 01616 B ME01616 B ME 01616B
- Authority
- ME
- Montenegro
- Prior art keywords
- alkyl
- halo
- lil
- amino
- alkyloxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na upotrebu jedinjenja za proizvodnju leka za tretman ba kterijske infe kcije koja je uzrokovana sa Staphylococci , Enterococci ili Streptococci , pri čemu je spomenuto jedinjenje neko jedinjenje sa formulom (I) (I) neke njegov e farmaceutski prihvatljiv e kisel e ili bazn e adicion e so li , kvaternarn og amin a , stereohemijski izomern e forme , tautomer n e form e ili nek og njegov og N -o ksid a , gde : R 1 je vodonik , halo, halo alkil , cijano , hidroksi , Ar, Het, alkil , alkiloksi , alkiltio , alkiloksialkil , alkiltioalkil, Ar-alkil ili di(Ar)alkil ; p je celi broj jednak 1, 2 ili 3; s je celi broj jednak nuli , 1, 2, 3 ili 4; R 2 je vodonik ; halo; alkil ; hidroksi ; mer k apto; alkiloksi koji je ponekad supstituisan sa amino ili mono ili di( alkil )amino ili je radi k al sa formul om gde Z je CH 2 , CH-R 8 , O, S, N-R 8 , a t je celi broj koji je jednak 1 ili 2 , a tačkasta linija predstavlja neku moguću vezu ; alkiloksialkiloksi ; alkiltio ; mono ili di( alkil )amino gde alkil m ože ponekad da bude supstituisan sa jednim ili dva su pstituenta koja su nezavisno izabrana iz alkiloksi ili Ar ili Het ili morfolinila ili 2- oksopiro lidi nila ; Ar; Het ili neki radi k al sa formul om gde Z je CH 2 , CH-R 8 , O, S, N-R 8 ; t je celi broj jednak 1 ili 2; a tačkasta linija predstavlja moguću vezu ; R 3 je alkil , Ar, Ar- alkil , Het ili Het- alkil ; q je celi broj jednak nuli , 1, 2, 3 ili 4; R 4 i R 5 svaki nezavisno su vodonik , alkil ili benzil ; ili R 4 i R 5 zajedno i uključujući N na kojeg su spojeni mogu da formiraju radi k al koji je izabran iz grup e koja obuhvata piro lidi nil , 2- pirolinil , 3- pirolinil , piro lil , imidazolidi nil , pira zolidi nil , 2-imidazo linil , 2- pira zo linil , imidazo lil , pira zo lil , triazo lil , piperidi nil , piri di nil , piperazi nil , piri dazi nil , piri midi nil , pira zi nil , triazi nil , morfolinil i tio morfolinil , a svaki od pomenutih prstena je ponekad supstituisan sa alkil om , halo, halo alkil om , hidroksi , alkiloksi , amino, mono- ili di - alkil amino, alkiltio , alkiloksialkil om , alkiltioalkil om i piri midi nil om ; R 6 je vodonik , halo, halo alkil , hidroksi , Ar, alkil , alkiloksi , alkiltio , alkiloksialkil , alkiltioalkil , Ar- alkil ili di(Ar) alkil ; ili dva susedna R 6 radi kala mogu zajedno sa fenilnim prstenom na kojeg su spojeni da formiraju na f t i l; r je celi broj jednak 1, 2, 3, 4 ili 5; a R 7 je vodonik , alkil , Ar ili Het; R 8 je vodonik , alkil , hidroksi l, amino k arbo nil , mono- ili di( alkil )amino k arbo nil , Ar, Het, alkil su pstituisan sa jednim ili dva Het, alkil su pstituisan sa jednim ili dva Ar, Het-C(=O)- ili Ar-C(=O)-; alkil je ravan ili razgranat zasićeni ugljovodonički radi k al koji ima od 1 d o 6 atoma ugljenika ; ili je c iklički zasićeni ugljovodonički radi k al koji ima od 3 d o 6 atoma ugljenika ; ili je ciklički zasićeni ugljovodonički radi k al koji ima od 3 d o 6 atoma ugljenika koji su spojeni na ravni ili razgranati zasićeni ugljovodonički radi k al koji ima od 1 d o 6 atoma ugljenika ; gde svaki atom ugljenika može ponekad da bude supstituisan sa hidroksi , alkiloksi ili okso ; Ar je homoc ikal koji je izabran iz grup e koja obuhvata fenil , naftil , ace naftil , tetra hidro naftil , a svaki je ponekad supstituisan sa 1, 2 ili 3 su pstituenta , a svaki supstituent je nezavisno izabran iz grup e koja obuhvata hidroksi , halo, cijano , nitro, amino, mono- ili di alkil amino, alkil , halo alkil , alkiloksi , halo alkiloksi , k arb oksi l, alkiloksi k arbo nil , alkil k arbo nil , amino k arbo nil , morfolinil i mono- ili di alkil amino k arbo nil ; Het je monoc iklički heteroc ikal koji je izabran iz grup e koja obuhvata N- f en oksi piperidi nil , piperidi nil , piro lil , pira zo lil , imidazo lil , fura nil , tie nil , oksa zo lil , izoksa zo lil , tia zo lil , izotia zo lil , triazo lil , piri di nil , piri midi nil , pira zi nil i piri dazi nil ; ili je bic iklički heteroc ikal koji je izabran iz grup e kino linil a , izokino linil a , 1,2,3,4-tetra hidro izokino linil a , kinoksa linil a , indo lil a , indazo lil a , benzimidazo lil a , benz oksa zo lil a , benz izoksa zo lil a , benzo tia zo lil a , benz izotia zo lil a , benzofura nil a , benzo tie nil a , 2,3-di hidro benzo[1,4]di oksi nil a ili benzo[1,3]di okso lil a ; a svaki monoc iklički i bic iklički heteroc ikal može ponekad da bude supstituisan na atomu ugljenika sa 1, 2 ili 3 su pstituenta , a svaki su pstituent je nezavisno izabran iz grup e halo, hidroksi , alkil a ili alkiloksi ; halo je su pstituent koji je izabran iz grup e fluoro, hloro , bromo i jodo i halo alkil je ravan ili razgranat zasićen ugljovodonički r adi k al koji ima od 1 d o 6 atoma ugljenika ili je c iklički zasićeni ugljovodonički radikal koji ima od 3 d o 6 atoma ugljenika ili je c iklički zasićeni ugljovodonički radi k al koji ima od 3 d o 6 atoma ugljenika koji je spojen na ravan ili razgranat ugljovodonički r adi k al koji ima od 1 d o 6 atoma ugljenika ; gde je jedan ili više atoma ugljenika supstituisano sa jednim ili više halo atoma; p od uslovom da kada radi k al se nalazi na poziciji 3 u kinolinskom ostatku ; R 7 se nalazi na poziciji 4 u kinolin skom ostatku, a R 2 se nalazi na poziciji 2 u kinolin skom ostatku i predstavlja vodonik , hidroksi , mer k apto, alkiloksi , alkiloksialkiloksi , alkiltio , mono ili di( alkil )amino ili radi k al sa formul om gde Y je CH 2 , O, S, NH ili N- alkil ; a tada s je 1, 2, 3 ili 4 .
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05107164 | 2005-08-03 | ||
EP06778083.3A EP1912648B1 (en) | 2005-08-03 | 2006-07-31 | Quinoline derivatives as antibacterial agents |
PCT/EP2006/064858 WO2007014941A2 (en) | 2005-08-03 | 2006-07-31 | Quinoline derivatives as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ME01616B true ME01616B (me) | 2014-09-20 |
Family
ID=35744723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2013-65A ME01616B (me) | 2005-08-03 | 2006-07-31 | Kinolinski derivati kao antibakterijski agensi |
Country Status (31)
Country | Link |
---|---|
US (1) | US8802671B2 (me) |
EP (1) | EP1912648B1 (me) |
JP (1) | JP5302680B2 (me) |
KR (1) | KR101413997B1 (me) |
CN (2) | CN101277696B8 (me) |
AP (1) | AP2654A (me) |
AR (1) | AR054890A1 (me) |
AU (1) | AU2006274880B2 (me) |
BR (1) | BRPI0614493B8 (me) |
CA (1) | CA2615903C (me) |
CY (1) | CY1114318T1 (me) |
DK (1) | DK1912648T3 (me) |
EA (1) | EA014833B1 (me) |
ES (1) | ES2414956T3 (me) |
HK (1) | HK1124234A1 (me) |
HR (1) | HRP20130540T1 (me) |
IL (1) | IL189142A0 (me) |
JO (1) | JO2855B1 (me) |
ME (1) | ME01616B (me) |
MX (1) | MX2008001603A (me) |
MY (1) | MY159560A (me) |
NO (1) | NO341242B1 (me) |
NZ (1) | NZ565947A (me) |
PL (1) | PL1912648T3 (me) |
PT (1) | PT1912648E (me) |
RS (1) | RS52808B (me) |
SI (1) | SI1912648T1 (me) |
TW (1) | TWI422374B (me) |
UA (1) | UA95915C2 (me) |
WO (1) | WO2007014941A2 (me) |
ZA (1) | ZA200801110B (me) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004186452A (ja) | 2002-12-04 | 2004-07-02 | Renesas Technology Corp | 不揮発性半導体記憶装置およびその製造方法 |
JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
WO2013160431A1 (en) | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
EP2841425B1 (en) | 2012-04-27 | 2016-03-23 | Janssen Pharmaceutica, N.V. | Antibacterial quinoline derivatives |
EP2909192B1 (en) | 2012-10-16 | 2017-05-17 | Janssen Pharmaceutica NV | Methylene linked quinolinyl modulators of ror-gamma-t |
CN105073729A (zh) | 2012-10-16 | 2015-11-18 | 詹森药业有限公司 | RORγt的苯基连接的喹啉基调节剂 |
JP6250686B2 (ja) | 2012-10-16 | 2017-12-20 | ヤンセン ファーマシューティカ エヌ.ベー. | Rorγtのヘテロアリール結合させたキノリニルモジュレータ |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
CA2926339A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of roryt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
EP3057422B1 (en) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Quinolinyl modulators of ror(gamma)t |
CN109111396B (zh) * | 2018-08-28 | 2021-09-03 | 广东工业大学 | 一种喹啉芳香乙烯衍生物及其制备方法和应用 |
CN109111397B (zh) * | 2018-08-28 | 2021-12-10 | 广东工业大学 | 一种喹啉芳香乙烯类衍生物及其制备方法和应用 |
CN112110907B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 一种含1,4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用 |
CN112079825B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 含1,3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB807750A (en) * | 1956-06-15 | 1959-01-21 | Rhone Poulenc Sa | Improvements in or relating to piperazine derivatives |
GB9317491D0 (en) * | 1993-08-23 | 1993-10-06 | Fujisawa Pharmaceutical Co | New compound and a process for preparation thereof |
US5965572A (en) * | 1996-10-28 | 1999-10-12 | The United States Of America As Respresented By The Secretary Of The Army | Methods for treating antibiotic-resistant infections |
US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
CN1325475C (zh) * | 2002-07-25 | 2007-07-11 | 詹森药业有限公司 | 喹啉衍生物及其作为分枝杆菌抑制剂的应用 |
PL360102A3 (en) | 2003-05-13 | 2004-11-15 | "ENERGOMAR-NORD" Sp.z o.o. | Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents |
WO2005070430A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
BRPI0507076B8 (pt) | 2004-01-23 | 2021-05-25 | Janssen Pharmaceutica Nv | quinolinas substituídas, seu processo de preparação, composição farmacêutica que as compreende e seu uso como inibidores micobacterianos |
EP1713776B1 (en) * | 2004-01-29 | 2008-05-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
US20070018948A1 (en) | 2005-07-22 | 2007-01-25 | Elaine Chen | Apparatus for stabilizing an electronic device during data input and device control |
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2006
- 2006-07-18 JO JO2006232A patent/JO2855B1/en active
- 2006-07-31 CN CN200680036751.2D patent/CN101277696B8/zh not_active Expired - Fee Related
- 2006-07-31 AP AP2008004316A patent/AP2654A/xx active
- 2006-07-31 MX MX2008001603A patent/MX2008001603A/es active IP Right Grant
- 2006-07-31 BR BRPI0614493A patent/BRPI0614493B8/pt not_active IP Right Cessation
- 2006-07-31 EP EP06778083.3A patent/EP1912648B1/en active Active
- 2006-07-31 US US11/997,173 patent/US8802671B2/en active Active
- 2006-07-31 RS RS20130254A patent/RS52808B/en unknown
- 2006-07-31 KR KR1020087005071A patent/KR101413997B1/ko active IP Right Grant
- 2006-07-31 UA UAA200801432A patent/UA95915C2/ru unknown
- 2006-07-31 ES ES06778083T patent/ES2414956T3/es active Active
- 2006-07-31 JP JP2008524509A patent/JP5302680B2/ja active Active
- 2006-07-31 NZ NZ565947A patent/NZ565947A/en not_active IP Right Cessation
- 2006-07-31 ME MEP-2013-65A patent/ME01616B/me unknown
- 2006-07-31 DK DK06778083.3T patent/DK1912648T3/da active
- 2006-07-31 CN CNA2006800367512A patent/CN101277696A/zh active Granted
- 2006-07-31 PT PT67780833T patent/PT1912648E/pt unknown
- 2006-07-31 WO PCT/EP2006/064858 patent/WO2007014941A2/en active Application Filing
- 2006-07-31 AU AU2006274880A patent/AU2006274880B2/en not_active Ceased
- 2006-07-31 PL PL06778083T patent/PL1912648T3/pl unknown
- 2006-07-31 SI SI200631602T patent/SI1912648T1/sl unknown
- 2006-07-31 EA EA200800508A patent/EA014833B1/ru unknown
- 2006-07-31 CA CA2615903A patent/CA2615903C/en active Active
- 2006-08-01 MY MYPI20063727A patent/MY159560A/en unknown
- 2006-08-02 AR ARP060103372A patent/AR054890A1/es unknown
- 2006-08-02 TW TW095128224A patent/TWI422374B/zh active
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2008
- 2008-01-31 IL IL189142A patent/IL189142A0/en active IP Right Grant
- 2008-02-01 ZA ZA2008/01110A patent/ZA200801110B/en unknown
- 2008-02-27 NO NO20081026A patent/NO341242B1/no not_active IP Right Cessation
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2009
- 2009-02-05 HK HK09101045.4A patent/HK1124234A1/zh not_active IP Right Cessation
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2013
- 2013-06-14 HR HRP20130540TT patent/HRP20130540T1/hr unknown
- 2013-07-09 CY CY20131100578T patent/CY1114318T1/el unknown
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