EA200800508A1 - Производные хинолина в качестве антибактериальных средств - Google Patents

Производные хинолина в качестве антибактериальных средств

Info

Publication number
EA200800508A1
EA200800508A1 EA200800508A EA200800508A EA200800508A1 EA 200800508 A1 EA200800508 A1 EA 200800508A1 EA 200800508 A EA200800508 A EA 200800508A EA 200800508 A EA200800508 A EA 200800508A EA 200800508 A1 EA200800508 A1 EA 200800508A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
het
hydrogen
substituted
hydroxy
Prior art date
Application number
EA200800508A
Other languages
English (en)
Other versions
EA014833B1 (ru
Inventor
Жером Эмиль Жорж Гийемон
Элизабет Терез Жанн Паскье
Давид Франсис Ален Лансуа
Кунрад Йозеф Лодевейк Марсель Андрис
Анил Коул
Лео Якобус Йозеф Бакс
Ливен Мерпул
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35744723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800508(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200800508A1 publication Critical patent/EA200800508A1/ru
Publication of EA014833B1 publication Critical patent/EA014833B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Применение соединения для приготовления лекарственного средства для лечения бактериальной инфекции, при условии, что бактериальная инфекция является иной, чем микобактериальная инфекция, причем указанное соединение является соединением формулы (I), его фармацевтически приемлемой кислотно-аддитивной солью или аддитивной солью с основанием, четвертичным амином, стереохимической изомерной формой, таутомерной формой или N-оксидной формой, где Rпредставляет собой водород, галоген, галогеналкил, циано, гидрокси, Ar, Het, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar)алкил; р равно 1-3, s равно 0-4; Rпредставляет собой водород; галоген; алкил; гидрокси; меркапто; необязательно замещенная алкилокси; алкилоксиалкилокси, алкилтио, моно- или ди(алкил)аминогруппу, где алкил может быть необязательно замещен; Ar, Het или радикал формулы (II), Rпредставляет собой алкил, Ar, Ar-алкил, Het, Het-алкил; q равно 0-4; Rи R,каждый независимо, представляет собой водород, алкил или бензил; или Rи Rмогут быть взяты вместе, включая N, к которому они присоединены; Rпредставляет собой водород, галоген, галогеналкил, гидрокси, Ar, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar)алкил; или два смежных радикала Rмогут быть взяты вместе с образованием, вместе с фенильным кольцом, к которому они присоединены, нафтила; r равно 1-5; Rпредставляет собой водород, алкил, Ar или Het; Rпредставляет собой водород, алкил, гидроксил, аминокарбонил, моно- или ди(алкил)аминокарбонил, Ar, Het, алкил, замещенный одним или двумя Het, алкил, замещенный одним или двумя Ar, Het-C(=O)- или Ar-С(=O)-, при условии, что когда радикал, имеющий R, находится в положении 3 хинолинового фрагмента молекулы, Rнаходится в положении 4 и Rнаходится в положении 2 и
EA200800508A 2005-08-03 2006-07-31 Производные хинолина в качестве антибактериальных средств EA014833B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05107164 2005-08-03
PCT/EP2006/064858 WO2007014941A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
EA200800508A1 true EA200800508A1 (ru) 2008-06-30
EA014833B1 EA014833B1 (ru) 2011-02-28

Family

ID=35744723

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800508A EA014833B1 (ru) 2005-08-03 2006-07-31 Производные хинолина в качестве антибактериальных средств

Country Status (31)

Country Link
US (1) US8802671B2 (ru)
EP (1) EP1912648B1 (ru)
JP (1) JP5302680B2 (ru)
KR (1) KR101413997B1 (ru)
CN (2) CN101277696A (ru)
AP (1) AP2654A (ru)
AR (1) AR054890A1 (ru)
AU (1) AU2006274880B2 (ru)
BR (1) BRPI0614493B8 (ru)
CA (1) CA2615903C (ru)
CY (1) CY1114318T1 (ru)
DK (1) DK1912648T3 (ru)
EA (1) EA014833B1 (ru)
ES (1) ES2414956T3 (ru)
HK (1) HK1124234A1 (ru)
HR (1) HRP20130540T1 (ru)
IL (1) IL189142A0 (ru)
JO (1) JO2855B1 (ru)
ME (1) ME01616B (ru)
MX (1) MX2008001603A (ru)
MY (1) MY159560A (ru)
NO (1) NO341242B1 (ru)
NZ (1) NZ565947A (ru)
PL (1) PL1912648T3 (ru)
PT (1) PT1912648E (ru)
RS (1) RS52808B (ru)
SI (1) SI1912648T1 (ru)
TW (1) TWI422374B (ru)
UA (1) UA95915C2 (ru)
WO (1) WO2007014941A2 (ru)
ZA (1) ZA200801110B (ru)

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JP2004186452A (ja) 2002-12-04 2004-07-02 Renesas Technology Corp 不揮発性半導体記憶装置およびその製造方法
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
EA038350B1 (ru) 2012-04-27 2021-08-12 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
PL2841425T3 (pl) 2012-04-27 2016-10-31 Antybakteryjne pochodne chinoliny
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
AR093017A1 (es) 2012-10-16 2015-05-13 Janssen Pharmaceutica Nv MODULARES DE RORgT DE QUINOLINILO UNIDOS POR METILENO
BR112015008515A2 (pt) 2012-10-16 2017-07-04 Janssen Pharmaceutica Nv moduladores de ror t de quinolinila ligada à heteroarila
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
CN109111396B (zh) * 2018-08-28 2021-09-03 广东工业大学 一种喹啉芳香乙烯衍生物及其制备方法和应用
CN109111397B (zh) * 2018-08-28 2021-12-10 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN112110907B (zh) * 2020-10-09 2021-12-21 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用
CN112079825B (zh) * 2020-10-09 2021-12-21 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用

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GB9317491D0 (en) * 1993-08-23 1993-10-06 Fujisawa Pharmaceutical Co New compound and a process for preparation thereof
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Also Published As

Publication number Publication date
NO341242B1 (no) 2017-09-25
KR101413997B1 (ko) 2014-07-01
CA2615903C (en) 2016-08-30
US20080207687A1 (en) 2008-08-28
CN101277696B (zh) 2015-09-02
KR20080035666A (ko) 2008-04-23
PT1912648E (pt) 2013-06-27
NO20081026L (no) 2008-02-27
BRPI0614493A2 (pt) 2011-03-29
BRPI0614493B8 (pt) 2021-05-25
HRP20130540T1 (en) 2013-07-31
JP2009503025A (ja) 2009-01-29
ZA200801110B (en) 2011-10-26
MX2008001603A (es) 2008-02-19
RS52808B (en) 2013-10-31
ME01616B (me) 2014-09-20
AU2006274880B2 (en) 2012-12-13
WO2007014941A8 (en) 2007-05-31
MY159560A (en) 2017-01-13
DK1912648T3 (da) 2013-06-24
PL1912648T3 (pl) 2013-08-30
WO2007014941A2 (en) 2007-02-08
TW200744595A (en) 2007-12-16
AR054890A1 (es) 2007-07-25
ES2414956T3 (es) 2013-07-23
JP5302680B2 (ja) 2013-10-02
TWI422374B (zh) 2014-01-11
BRPI0614493B1 (pt) 2019-11-12
US8802671B2 (en) 2014-08-12
IL189142A0 (en) 2008-08-07
EP1912648A2 (en) 2008-04-23
HK1124234A1 (zh) 2009-07-10
AP2654A (en) 2013-04-25
NZ565947A (en) 2011-05-27
JO2855B1 (en) 2015-03-15
WO2007014941A3 (en) 2007-03-29
CA2615903A1 (en) 2007-02-08
UA95915C2 (ru) 2011-09-26
EP1912648B1 (en) 2013-04-10
EA014833B1 (ru) 2011-02-28
CY1114318T1 (el) 2016-08-31
CN101277696B8 (zh) 2016-07-06
CN101277696A (zh) 2008-10-01
AU2006274880A1 (en) 2007-02-08
SI1912648T1 (sl) 2013-07-31

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