JP2008546824A5 - - Google Patents
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- Publication number
- JP2008546824A5 JP2008546824A5 JP2008518809A JP2008518809A JP2008546824A5 JP 2008546824 A5 JP2008546824 A5 JP 2008546824A5 JP 2008518809 A JP2008518809 A JP 2008518809A JP 2008518809 A JP2008518809 A JP 2008518809A JP 2008546824 A5 JP2008546824 A5 JP 2008546824A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- use according
- compound
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000005843 halogen group Chemical group 0.000 claims 12
- -1 cyano, hydroxy Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 208000035143 Bacterial infection Diseases 0.000 claims 9
- 208000022362 bacterial infectious disease Diseases 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000001204 N-oxides Chemical class 0.000 claims 8
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 239000004599 antimicrobial Substances 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 3
- 239000003926 antimycobacterial agent Substances 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000002346 iodo group Chemical group I* 0.000 claims 3
- 229960003085 meticillin Drugs 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000004364 3-pyrrolinyl group Chemical group [H]C1=C([H])C([H])([H])N(*)C1([H])[H] 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 206010062207 Mycobacterial infection Diseases 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 229940034014 antimycobacterial agent Drugs 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 CC(*)(CCC(*)=[P+])C(c1ccccc1)c1c(*)c2ccccc2nc1* Chemical compound CC(*)(CCC(*)=[P+])C(c1ccccc1)c1c(*)c2ccccc2nc1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105755.2 | 2005-06-28 | ||
| EP05105755 | 2005-06-28 | ||
| PCT/EP2006/063552 WO2007000434A1 (en) | 2005-06-28 | 2006-06-26 | Quinoline derivatives as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546824A JP2008546824A (ja) | 2008-12-25 |
| JP2008546824A5 true JP2008546824A5 (enExample) | 2009-08-20 |
| JP5193857B2 JP5193857B2 (ja) | 2013-05-08 |
Family
ID=35447198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518809A Expired - Fee Related JP5193857B2 (ja) | 2005-06-28 | 2006-06-26 | 抗菌剤としてのキノリン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20130030016A1 (enExample) |
| EP (1) | EP1898909B1 (enExample) |
| JP (1) | JP5193857B2 (enExample) |
| KR (1) | KR101329587B1 (enExample) |
| CN (1) | CN101252927B (enExample) |
| AP (1) | AP2547A (enExample) |
| AR (1) | AR054804A1 (enExample) |
| AU (1) | AU2006263882B2 (enExample) |
| BR (1) | BRPI0613999B8 (enExample) |
| CA (1) | CA2612614C (enExample) |
| CY (1) | CY1119402T1 (enExample) |
| DK (1) | DK1898909T3 (enExample) |
| EA (1) | EA014431B1 (enExample) |
| ES (1) | ES2610472T3 (enExample) |
| HR (1) | HRP20170044T1 (enExample) |
| HU (1) | HUE030264T2 (enExample) |
| IL (1) | IL188395A (enExample) |
| JO (1) | JO3322B1 (enExample) |
| LT (1) | LT1898909T (enExample) |
| MX (1) | MX2008000079A (enExample) |
| MY (1) | MY173664A (enExample) |
| NO (1) | NO341285B1 (enExample) |
| NZ (1) | NZ564340A (enExample) |
| PL (1) | PL1898909T3 (enExample) |
| PT (1) | PT1898909T (enExample) |
| RS (1) | RS55601B1 (enExample) |
| SG (1) | SG166798A1 (enExample) |
| TW (1) | TWI413520B (enExample) |
| UA (1) | UA88701C2 (enExample) |
| WO (1) | WO2007000434A1 (enExample) |
| ZA (1) | ZA200711148B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JP5397881B2 (ja) * | 2008-09-04 | 2014-01-22 | 昇一 城武 | グラム陽性細菌用抗菌剤及び抗菌活性増強剤 |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2013254670B2 (en) | 2012-04-27 | 2017-03-30 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| JP7514763B2 (ja) * | 2017-10-13 | 2024-07-11 | ザ ユニバーシティー オブ クイーンズランド | 亜鉛イオノフォアおよびその使用 |
| CN110606825A (zh) * | 2019-10-30 | 2019-12-24 | 成都海杰亚医药科技有限公司 | 一种制备吡啶-2-硫醇的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| EP1753427B1 (en) * | 2004-05-28 | 2008-04-02 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
-
2006
- 2006-06-26 DK DK06763888.2T patent/DK1898909T3/en active
- 2006-06-26 AP AP2008004298A patent/AP2547A/xx active
- 2006-06-26 EP EP06763888.2A patent/EP1898909B1/en active Active
- 2006-06-26 ES ES06763888.2T patent/ES2610472T3/es active Active
- 2006-06-26 HR HRP20170044TT patent/HRP20170044T1/hr unknown
- 2006-06-26 PL PL06763888T patent/PL1898909T3/pl unknown
- 2006-06-26 EA EA200800151A patent/EA014431B1/ru unknown
- 2006-06-26 UA UAA200714928A patent/UA88701C2/ru unknown
- 2006-06-26 RS RS20170045A patent/RS55601B1/sr unknown
- 2006-06-26 SG SG201007976-2A patent/SG166798A1/en unknown
- 2006-06-26 MX MX2008000079A patent/MX2008000079A/es active IP Right Grant
- 2006-06-26 HU HUE06763888A patent/HUE030264T2/en unknown
- 2006-06-26 JP JP2008518809A patent/JP5193857B2/ja not_active Expired - Fee Related
- 2006-06-26 CA CA2612614A patent/CA2612614C/en active Active
- 2006-06-26 PT PT67638882T patent/PT1898909T/pt unknown
- 2006-06-26 WO PCT/EP2006/063552 patent/WO2007000434A1/en not_active Ceased
- 2006-06-26 KR KR1020087002246A patent/KR101329587B1/ko not_active Expired - Fee Related
- 2006-06-26 NZ NZ564340A patent/NZ564340A/en not_active IP Right Cessation
- 2006-06-26 AU AU2006263882A patent/AU2006263882B2/en not_active Ceased
- 2006-06-26 LT LTEP06763888.2T patent/LT1898909T/lt unknown
- 2006-06-26 MY MYPI20063021A patent/MY173664A/en unknown
- 2006-06-26 BR BRPI0613999A patent/BRPI0613999B8/pt not_active IP Right Cessation
- 2006-06-26 CN CN200680031302.9A patent/CN101252927B/zh not_active Expired - Fee Related
- 2006-06-27 AR ARP060102758A patent/AR054804A1/es unknown
- 2006-06-27 TW TW095123049A patent/TWI413520B/zh not_active IP Right Cessation
- 2006-06-29 JO JOP/2006/0183A patent/JO3322B1/ar active
-
2007
- 2007-12-20 ZA ZA2007/11148A patent/ZA200711148B/en unknown
- 2007-12-25 IL IL188395A patent/IL188395A/en active IP Right Grant
-
2008
- 2008-01-28 NO NO20080499A patent/NO341285B1/no not_active IP Right Cessation
-
2012
- 2012-08-07 US US13/568,569 patent/US20130030016A1/en not_active Abandoned
-
2017
- 2017-01-18 CY CY20171100071T patent/CY1119402T1/el unknown
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