TWI413520B - 用作抗細菌劑之喹啉衍生物 - Google Patents

用作抗細菌劑之喹啉衍生物 Download PDF

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Publication number
TWI413520B
TWI413520B TW095123049A TW95123049A TWI413520B TW I413520 B TWI413520 B TW I413520B TW 095123049 A TW095123049 A TW 095123049A TW 95123049 A TW95123049 A TW 95123049A TW I413520 B TWI413520 B TW I413520B
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TW
Taiwan
Prior art keywords
group
alkyl
compound
formula
patent application
Prior art date
Application number
TW095123049A
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English (en)
Chinese (zh)
Other versions
TW200800183A (en
Inventor
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
David Francis Alain Lancois
Magali Madeleine Simone Motte
Jerome Emile Georges Guillemont
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35447198&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI413520(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TW200800183A publication Critical patent/TW200800183A/zh
Application granted granted Critical
Publication of TWI413520B publication Critical patent/TWI413520B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
TW095123049A 2005-06-28 2006-06-27 用作抗細菌劑之喹啉衍生物 TWI413520B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05105755 2005-06-28

Publications (2)

Publication Number Publication Date
TW200800183A TW200800183A (en) 2008-01-01
TWI413520B true TWI413520B (zh) 2013-11-01

Family

ID=35447198

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095123049A TWI413520B (zh) 2005-06-28 2006-06-27 用作抗細菌劑之喹啉衍生物

Country Status (31)

Country Link
US (1) US20130030016A1 (enExample)
EP (1) EP1898909B1 (enExample)
JP (1) JP5193857B2 (enExample)
KR (1) KR101329587B1 (enExample)
CN (1) CN101252927B (enExample)
AP (1) AP2547A (enExample)
AR (1) AR054804A1 (enExample)
AU (1) AU2006263882B2 (enExample)
BR (1) BRPI0613999B8 (enExample)
CA (1) CA2612614C (enExample)
CY (1) CY1119402T1 (enExample)
DK (1) DK1898909T3 (enExample)
EA (1) EA014431B1 (enExample)
ES (1) ES2610472T3 (enExample)
HR (1) HRP20170044T1 (enExample)
HU (1) HUE030264T2 (enExample)
IL (1) IL188395A (enExample)
JO (1) JO3322B1 (enExample)
LT (1) LT1898909T (enExample)
MX (1) MX2008000079A (enExample)
MY (1) MY173664A (enExample)
NO (1) NO341285B1 (enExample)
NZ (1) NZ564340A (enExample)
PL (1) PL1898909T3 (enExample)
PT (1) PT1898909T (enExample)
RS (1) RS55601B1 (enExample)
SG (1) SG166798A1 (enExample)
TW (1) TWI413520B (enExample)
UA (1) UA88701C2 (enExample)
WO (1) WO2007000434A1 (enExample)
ZA (1) ZA200711148B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JP5397881B2 (ja) * 2008-09-04 2014-01-22 昇一 城武 グラム陽性細菌用抗菌剤及び抗菌活性増強剤
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
AU2018348796B2 (en) * 2017-10-13 2024-09-26 Adelaide university Zinc ionophores and uses thereof
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法
CN117843568A (zh) * 2024-01-03 2024-04-09 中国药科大学 一种芳烷基取代-1-甲基喹啉季铵盐类衍生物及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410939A (en) * 2002-07-25 2004-07-01 Janssen Pharmaceutica Nv Novel mycobacterial inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410939A (en) * 2002-07-25 2004-07-01 Janssen Pharmaceutica Nv Novel mycobacterial inhibitors

Also Published As

Publication number Publication date
AU2006263882B2 (en) 2012-12-13
EA014431B1 (ru) 2010-12-30
US20130030016A1 (en) 2013-01-31
IL188395A (en) 2012-05-31
JO3322B1 (ar) 2019-03-13
NO341285B1 (no) 2017-10-02
ZA200711148B (en) 2013-03-27
PL1898909T3 (pl) 2017-03-31
CA2612614A1 (en) 2007-01-04
WO2007000434A1 (en) 2007-01-04
IL188395A0 (en) 2008-08-07
EP1898909A1 (en) 2008-03-19
TW200800183A (en) 2008-01-01
CY1119402T1 (el) 2018-03-07
NO20080499L (no) 2008-02-29
CN101252927B (zh) 2014-01-01
EA200800151A1 (ru) 2008-06-30
BRPI0613999A2 (pt) 2011-03-01
BRPI0613999B8 (pt) 2021-05-25
UA88701C2 (ru) 2009-11-10
BRPI0613999B1 (pt) 2020-04-22
RS55601B1 (sr) 2017-06-30
MX2008000079A (es) 2008-03-19
MY173664A (en) 2020-02-14
EP1898909B1 (en) 2016-10-19
KR20080028459A (ko) 2008-03-31
KR101329587B1 (ko) 2013-11-15
DK1898909T3 (en) 2017-02-06
NZ564340A (en) 2011-02-25
PT1898909T (pt) 2016-12-07
AU2006263882A1 (en) 2007-01-04
AR054804A1 (es) 2007-07-18
AP2547A (en) 2012-12-26
CA2612614C (en) 2017-07-25
ES2610472T3 (es) 2017-04-27
CN101252927A (zh) 2008-08-27
JP2008546824A (ja) 2008-12-25
HK1120732A1 (en) 2009-04-09
LT1898909T (lt) 2017-02-10
JP5193857B2 (ja) 2013-05-08
HUE030264T2 (en) 2017-04-28
HRP20170044T1 (hr) 2017-03-10
SG166798A1 (en) 2010-12-29

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