KR101329587B1 - 항균제로서의 퀴놀린 유도체 - Google Patents

항균제로서의 퀴놀린 유도체 Download PDF

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Publication number
KR101329587B1
KR101329587B1 KR1020087002246A KR20087002246A KR101329587B1 KR 101329587 B1 KR101329587 B1 KR 101329587B1 KR 1020087002246 A KR1020087002246 A KR 1020087002246A KR 20087002246 A KR20087002246 A KR 20087002246A KR 101329587 B1 KR101329587 B1 KR 101329587B1
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KR
South Korea
Prior art keywords
alkyl
compound
formula
halo
alkyloxy
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Expired - Fee Related
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KR1020087002246A
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English (en)
Korean (ko)
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KR20080028459A (ko
Inventor
코엔라드 요제프 로데비이크 마르셀 안드리스
아닐 코울
데이비드 프란시스 알랜 란코이스
마갈리 마델렌 시몬 모테
제롬 에밀 조리 귈레몽
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얀센 파마슈티카 엔.브이.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
KR1020087002246A 2005-06-28 2006-06-26 항균제로서의 퀴놀린 유도체 Expired - Fee Related KR101329587B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05105755.2 2005-06-28
EP05105755 2005-06-28
PCT/EP2006/063552 WO2007000434A1 (en) 2005-06-28 2006-06-26 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
KR20080028459A KR20080028459A (ko) 2008-03-31
KR101329587B1 true KR101329587B1 (ko) 2013-11-15

Family

ID=35447198

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087002246A Expired - Fee Related KR101329587B1 (ko) 2005-06-28 2006-06-26 항균제로서의 퀴놀린 유도체

Country Status (31)

Country Link
US (1) US20130030016A1 (enExample)
EP (1) EP1898909B1 (enExample)
JP (1) JP5193857B2 (enExample)
KR (1) KR101329587B1 (enExample)
CN (1) CN101252927B (enExample)
AP (1) AP2547A (enExample)
AR (1) AR054804A1 (enExample)
AU (1) AU2006263882B2 (enExample)
BR (1) BRPI0613999B8 (enExample)
CA (1) CA2612614C (enExample)
CY (1) CY1119402T1 (enExample)
DK (1) DK1898909T3 (enExample)
EA (1) EA014431B1 (enExample)
ES (1) ES2610472T3 (enExample)
HR (1) HRP20170044T1 (enExample)
HU (1) HUE030264T2 (enExample)
IL (1) IL188395A (enExample)
JO (1) JO3322B1 (enExample)
LT (1) LT1898909T (enExample)
MX (1) MX2008000079A (enExample)
MY (1) MY173664A (enExample)
NO (1) NO341285B1 (enExample)
NZ (1) NZ564340A (enExample)
PL (1) PL1898909T3 (enExample)
PT (1) PT1898909T (enExample)
RS (1) RS55601B1 (enExample)
SG (1) SG166798A1 (enExample)
TW (1) TWI413520B (enExample)
UA (1) UA88701C2 (enExample)
WO (1) WO2007000434A1 (enExample)
ZA (1) ZA200711148B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JP5397881B2 (ja) * 2008-09-04 2014-01-22 昇一 城武 グラム陽性細菌用抗菌剤及び抗菌活性増強剤
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
JP7514763B2 (ja) * 2017-10-13 2024-07-11 ザ ユニバーシティー オブ クイーンズランド 亜鉛イオノフォアおよびその使用
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034265A2 (en) * 1998-12-11 2000-06-15 Sepracor, Inc. Quinoline-indole antimicrobial agents
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1753427B1 (en) * 2004-05-28 2008-04-02 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034265A2 (en) * 1998-12-11 2000-06-15 Sepracor, Inc. Quinoline-indole antimicrobial agents
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Also Published As

Publication number Publication date
EA200800151A1 (ru) 2008-06-30
CA2612614C (en) 2017-07-25
US20130030016A1 (en) 2013-01-31
CN101252927A (zh) 2008-08-27
LT1898909T (lt) 2017-02-10
DK1898909T3 (en) 2017-02-06
HRP20170044T1 (hr) 2017-03-10
AU2006263882B2 (en) 2012-12-13
IL188395A (en) 2012-05-31
AR054804A1 (es) 2007-07-18
JP2008546824A (ja) 2008-12-25
MY173664A (en) 2020-02-14
AP2547A (en) 2012-12-26
CN101252927B (zh) 2014-01-01
CY1119402T1 (el) 2018-03-07
IL188395A0 (en) 2008-08-07
BRPI0613999A2 (pt) 2011-03-01
HK1120732A1 (en) 2009-04-09
MX2008000079A (es) 2008-03-19
HUE030264T2 (en) 2017-04-28
ES2610472T3 (es) 2017-04-27
UA88701C2 (ru) 2009-11-10
TW200800183A (en) 2008-01-01
WO2007000434A1 (en) 2007-01-04
EA014431B1 (ru) 2010-12-30
EP1898909B1 (en) 2016-10-19
EP1898909A1 (en) 2008-03-19
NZ564340A (en) 2011-02-25
BRPI0613999B1 (pt) 2020-04-22
JP5193857B2 (ja) 2013-05-08
AU2006263882A1 (en) 2007-01-04
NO20080499L (no) 2008-02-29
CA2612614A1 (en) 2007-01-04
TWI413520B (zh) 2013-11-01
NO341285B1 (no) 2017-10-02
PT1898909T (pt) 2016-12-07
SG166798A1 (en) 2010-12-29
KR20080028459A (ko) 2008-03-31
PL1898909T3 (pl) 2017-03-31
ZA200711148B (en) 2013-03-27
JO3322B1 (ar) 2019-03-13
RS55601B1 (sr) 2017-06-30
BRPI0613999B8 (pt) 2021-05-25

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