|
CA2657552A1
(en)
*
|
2006-07-14 |
2008-01-17 |
Merck & Co., Inc. |
Substituted diazepan orexin receptor antagonists
|
|
EP2049110B1
(en)
*
|
2006-07-14 |
2014-08-20 |
Merck Sharp & Dohme Corp. |
Bridged diazepan orexin receptor antagonists
|
|
PE20081229A1
(es)
*
|
2006-12-01 |
2008-08-28 |
Merck & Co Inc |
Antagonistas de receptor de orexina de diazepam sustituido
|
|
JP2010527924A
(ja)
|
2007-05-18 |
2010-08-19 |
メルク・シャープ・エンド・ドーム・コーポレイション |
オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
|
|
WO2008147518A1
(en)
*
|
2007-05-23 |
2008-12-04 |
Merck & Co., Inc. |
Pyridyl piperidine orexin receptor antagonists
|
|
JP2011502146A
(ja)
|
2007-10-29 |
2011-01-20 |
メルク・シャープ・エンド・ドーム・コーポレイション |
置換ジアゼパンオレキシン受容体アンタゴニスト
|
|
WO2009097995A1
(de)
*
|
2008-02-07 |
2009-08-13 |
Sanofi-Aventis |
Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2369926B1
(en)
*
|
2008-06-19 |
2015-04-22 |
Takeda Pharmaceutical Company Limited |
Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues
|
|
CA2739927A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
Disubstituted azepan orexin receptor antagonists
|
|
AU2009307916A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted morpholine orexin receptor antagonists
|
|
US8853202B2
(en)
|
2008-11-04 |
2014-10-07 |
Chemocentryx, Inc. |
Modulators of CXCR7
|
|
CN102271681B
(zh)
*
|
2008-11-04 |
2014-11-12 |
凯莫森特里克斯股份有限公司 |
Cxcr7调节剂
|
|
US20110046047A1
(en)
*
|
2009-05-20 |
2011-02-24 |
Joslin Diabets Center, Inc. |
Bone Morphogenetic Proteins for Appetite Control
|
|
KR101350845B1
(ko)
|
2009-09-15 |
2014-01-14 |
주식회사 만도 |
전자 브레이크의 간극 조정 장치 및 그 방법
|
|
EP2491034B1
(en)
|
2009-10-23 |
2013-12-18 |
Janssen Pharmaceutica, N.V. |
Fused heterocyclic compounds as orexin receptor modulators
|
|
WO2011050202A1
(en)
*
|
2009-10-23 |
2011-04-28 |
Janssen Pharmaceutica Nv |
Fused heterocyclic compounds as orexin receptor modulators
|
|
ES2585806T3
(es)
|
2009-10-23 |
2016-10-10 |
Janssen Pharmaceutica N.V. |
Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
|
|
EP2491019B1
(en)
|
2009-10-24 |
2016-06-29 |
Indiana University Research and Technology Corporation |
Methods and compositions for panic disorders
|
|
JP5860045B2
(ja)
|
2010-07-09 |
2016-02-16 |
ファイザー・リミテッドPfizer Limited |
化合物
|
|
SI2626350T1
(sl)
|
2010-09-22 |
2015-09-30 |
Eisai R&D Management Co., Ltd. |
Spojina ciklopropana
|
|
WO2012085852A1
(en)
|
2010-12-22 |
2012-06-28 |
Actelion Pharmaceuticals Ltd |
3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
|
|
EP2680697B1
(en)
*
|
2011-03-03 |
2018-01-10 |
Merck Sharp & Dohme Corp. |
Process for the preparation of an orexin receptor antagonist
|
|
WO2012145581A1
(en)
|
2011-04-20 |
2012-10-26 |
Janssen Pharmaceutica Nv |
Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
|
|
JP6051378B2
(ja)
*
|
2011-05-02 |
2016-12-27 |
国立大学法人 熊本大学 |
幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
WO2013050938A1
(en)
|
2011-10-04 |
2013-04-11 |
Actelion Pharmaceuticals Ltd |
3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
DK2776430T3
(en)
|
2011-11-08 |
2016-05-09 |
Actelion Pharmaceuticals Ltd |
2- (1,2,3-triazol-2-yl) benzamide and 3- (1,2,3-triazol-2-yl) PICOLINAMIDDERIVATER AS orexin receptor antagonists
|
|
US9474779B2
(en)
|
2012-01-19 |
2016-10-25 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their methods of use
|
|
WO2013119639A1
(en)
|
2012-02-07 |
2013-08-15 |
Eolas Therapeutics, Inc. |
Substituted prolines / piperidines as orexin receptor antagonists
|
|
US9440982B2
(en)
|
2012-02-07 |
2016-09-13 |
Eolas Therapeutics, Inc. |
Substituted prolines/piperidines as orexin receptor antagonists
|
|
EP2847343A4
(en)
|
2012-05-09 |
2016-04-06 |
Merck Sharp & Dohme |
METHOD FOR PRODUCING A INTERMEDIATE PRODUCT FOR AN OREXINE RECEPTOR ANTAGONIST
|
|
MX368859B
(es)
*
|
2012-05-31 |
2019-10-18 |
Merck Sharp & Dohme |
Formulaciones de dosis solida de un antagonista del receptor de orexina.
|
|
TWI570120B
(zh)
|
2012-06-04 |
2017-02-11 |
艾克泰聯製藥有限公司 |
苯并咪唑脯胺酸衍生物
|
|
AU2013328301A1
(en)
|
2012-10-10 |
2015-05-28 |
Actelion Pharmaceuticals Ltd |
Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
|
|
MX2015005891A
(es)
*
|
2012-11-12 |
2015-12-09 |
Reddys Lab Ltd Dr |
Formas polimórficas de suvorexant.
|
|
ES2681593T3
(es)
|
2012-11-29 |
2018-09-14 |
Chemocentryx, Inc. |
Antagonistas de CXCR7
|
|
US8999393B1
(en)
*
|
2013-01-09 |
2015-04-07 |
Edgemont Pharmaceuticals Llc |
Sustained release formulations of lorazepam
|
|
CN105051040A
(zh)
|
2013-03-12 |
2015-11-11 |
埃科特莱茵药品有限公司 |
作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
|
|
WO2015003355A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
US10376510B2
(en)
|
2013-07-11 |
2019-08-13 |
Agios Pharmaceuticals, Inc. |
2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
|
|
WO2015003360A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
WO2015008218A2
(en)
*
|
2013-07-15 |
2015-01-22 |
Dr. Reddy’S Laboratories Limited |
Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
|
|
WO2015010297A1
(en)
|
2013-07-25 |
2015-01-29 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
UA119151C2
(uk)
|
2013-12-03 |
2019-05-10 |
Ідорсія Фармасьютікалз Лтд |
КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
|
|
JP6496733B2
(ja)
|
2013-12-03 |
2019-04-03 |
イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd |
(s)−(2−(6−クロロ−7−メチル−1h−ベンゾ[d]イミダゾール−2−イル)−2−メチルピロリジン−1−イル)(5−メトキシ−2−(2h−1,2,3−トリアゾール−2−イル)フェニル)メタノンの結晶形及びオレキシン受容体アンタゴニストとしてのその使用
|
|
KR102330133B1
(ko)
|
2013-12-04 |
2021-11-23 |
이도르시아 파마슈티컬스 리미티드 |
벤즈이미다졸-프롤린 유도체의 용도
|
|
WO2015095111A1
(en)
*
|
2013-12-18 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Diazepane orexin receptor antagonists
|
|
US9556190B2
(en)
|
2013-12-20 |
2017-01-31 |
Merck Sharp & Dohme Corp. |
Piperidinyloxy lactone orexin receptor antagonists
|
|
US9968595B2
(en)
|
2014-03-14 |
2018-05-15 |
Agios Pharmaceuticals, Inc. |
Pharmaceutical compositions of therapeutically active compounds
|
|
CA2945641A1
(en)
|
2014-04-17 |
2015-10-22 |
Sandoz Ag |
Solid dispersion comprising an orexin receptor antagonist
|
|
WO2015164160A1
(en)
|
2014-04-21 |
2015-10-29 |
Merck Sharp & Dohme Corp. |
Pharmaceutical salts of an orexin receptor antagonist
|
|
WO2015180060A1
(zh)
*
|
2014-05-28 |
2015-12-03 |
杭州普晒医药科技有限公司 |
一种二氮杂环庚烷化合物的盐及其晶型与无定型物
|
|
CN106573882B
(zh)
|
2014-08-04 |
2020-09-01 |
桑多斯股份公司 |
制备苏沃雷生的合成途径
|
|
WO2016020403A1
(en)
*
|
2014-08-04 |
2016-02-11 |
Sandoz Ag |
Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
|
|
WO2016020404A1
(en)
*
|
2014-08-04 |
2016-02-11 |
Sandoz Ag |
Process for the resolution of (r,s)-diazepane and diazepanone derivatives
|
|
ES2731648T3
(es)
|
2014-08-06 |
2019-11-18 |
Eisai R&D Man Co Ltd |
Método para producir un compuesto de pirimidina-1-ol y compuesto intermedio del mismo
|
|
TW201613902A
(en)
|
2014-08-13 |
2016-04-16 |
Eolas Therapeutics Inc |
Difluoropyrrolidines as orexin receptor modulators
|
|
SG10202007759RA
(en)
|
2014-10-23 |
2020-09-29 |
Eisai R&D Man Co Ltd |
Compositions and methods for treating insomnia
|
|
WO2016065583A1
(en)
|
2014-10-30 |
2016-05-06 |
Merck Sharp & Dohme Corp. |
Oxazole orexin receptor antagonists
|
|
WO2016065587A1
(en)
|
2014-10-30 |
2016-05-06 |
Merck Sharp & Dohme Corp. |
Pyrazole orexin receptor antagonists
|
|
WO2016065585A1
(en)
|
2014-10-30 |
2016-05-06 |
Merck Sharp & Dohme Corp. |
Piperidine isoxazole and isothiazole orexin receptor antagonists
|
|
WO2016065586A1
(en)
|
2014-10-30 |
2016-05-06 |
Merck Sharp & Dohme Corp. |
Pyrazole, triazole and tetrazole orexin receptor antagonists
|
|
WO2016065584A1
(en)
|
2014-10-30 |
2016-05-06 |
Merck Sharp & Dohme Corp. |
Piperidine oxadiazole and thiadiazole orexin receptor antagonists
|
|
WO2016085784A1
(en)
*
|
2014-11-26 |
2016-06-02 |
Merck Sharp & Dohme Corp. |
Methyl diazepane orexin receptor antagonists
|
|
WO2016085783A1
(en)
|
2014-11-26 |
2016-06-02 |
Merck Sharp & Dohme Corp. |
Bridged diazepane orexin receptor antagonists
|
|
WO2016086358A1
(en)
|
2014-12-02 |
2016-06-09 |
Merck Sharp & Dohme Corp. |
Hydroxymethyl piperidine orexin receptor antagonists
|
|
WO2016086357A1
(en)
|
2014-12-02 |
2016-06-09 |
Merck Sharp & Dohme Corp. |
Methyl oxazole orexin receptor antagonists
|
|
US10011595B2
(en)
|
2014-12-19 |
2018-07-03 |
Merck Sharp & Dohme Corp. |
Ethyldiamine orexin receptor antagonists
|
|
WO2016095204A1
(en)
|
2014-12-19 |
2016-06-23 |
Merck Sharp & Dohme Corp. |
Pyrrolidine orexin receptor antagonists
|
|
WO2016095205A1
(en)
|
2014-12-19 |
2016-06-23 |
Merck Sharp & Dohme Corp. |
Heteroaryl orexin receptor antagonists
|
|
US9938276B2
(en)
|
2014-12-19 |
2018-04-10 |
Merck Sharp & Dohme Corp. |
6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
|
|
WO2016100162A2
(en)
|
2014-12-19 |
2016-06-23 |
Merck Sharp & Dohme Corp. |
5,5-bicyclic oxazole orexin receptor antagonists
|
|
WO2016101118A1
(en)
|
2014-12-23 |
2016-06-30 |
Merck Sharp & Dohme Corp. |
Amidoethyl azole orexin receptor antagonists
|
|
WO2016101119A1
(en)
|
2014-12-23 |
2016-06-30 |
Merck Sharp & Dohme Corp. |
Fused heteroaryl derivatives as orexin receptor antagonists
|
|
CZ201587A3
(cs)
|
2015-02-10 |
2016-08-17 |
Zentiva, K.S. |
Amorfní pevná forma suvorexantu s kyselinou sírovou
|
|
WO2016149628A1
(en)
*
|
2015-03-19 |
2016-09-22 |
Chembridge Corporation |
Tgr5 agonists
|
|
US10131653B2
(en)
|
2015-04-24 |
2018-11-20 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
AR105025A1
(es)
*
|
2015-06-19 |
2017-08-30 |
Astellas Pharma Inc |
Compuesto de imidazodiazepina
|
|
WO2017001499A1
(en)
|
2015-06-30 |
2017-01-05 |
Hexal Ag |
Liquid composition comprising suvorexant
|
|
WO2017012502A1
(en)
|
2015-07-17 |
2017-01-26 |
Sunshine Lake Pharma Co., Ltd. |
Substituted quinazoline compounds and preparation and uses thereof
|
|
UA123401C2
(uk)
|
2015-10-15 |
2021-03-31 |
Аджиос Фармасьютікалз, Інк. |
Комбінована терапія для лікування злоякісних пухлин
|
|
DK3362066T3
(da)
|
2015-10-15 |
2021-11-22 |
Les Laboratoires Servier Sas |
Kombinationsterapi til behandling af maligniteter
|
|
SG11201803191VA
(en)
|
2015-10-29 |
2018-05-30 |
Univ Tsukuba |
Morphinan derivative and medical usage thereof
|
|
WO2017072264A1
(en)
|
2015-10-29 |
2017-05-04 |
Hexal Ag |
Solid composition comprising suvorexant
|
|
SG11201804223TA
(en)
|
2015-11-23 |
2018-06-28 |
Sunshine Lake Pharma Co Ltd |
OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF
|
|
CN107021955B
(zh)
*
|
2016-02-01 |
2021-03-30 |
上海奥博生物医药股份有限公司 |
苏沃雷生中间体化合物及其制备方法
|
|
LT3414241T
(lt)
|
2016-02-12 |
2022-08-25 |
Astrazeneca Ab |
Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai
|
|
HRP20220642T1
(hr)
|
2016-03-10 |
2022-06-24 |
Janssen Pharmaceutica Nv |
Postupci za liječenje depresije uporabom antagonista receptora oreksina 2
|
|
CN107179356B
(zh)
*
|
2016-03-11 |
2021-07-16 |
广东东阳光药业有限公司 |
一种用hplc法测定苏沃雷生有关物质的方法
|
|
CN107304204B
(zh)
*
|
2016-04-18 |
2020-12-22 |
广东东阳光药业有限公司 |
一种制备n-杂环化合物的方法
|
|
WO2017194548A1
(en)
|
2016-05-10 |
2017-11-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
|
|
WO2017211733A1
(en)
|
2016-06-06 |
2017-12-14 |
Enantia, S.L. |
Chiral resolution of an intermediate of suvorexant and cocrystals thereof
|
|
CA3045313A1
(en)
*
|
2016-12-19 |
2018-06-28 |
Druggability Technologies Ip Holdco Limited |
Pharmaceutical formulations of suvorexant
|
|
GB201702174D0
(en)
|
2017-02-09 |
2017-03-29 |
Benevolentai Bio Ltd |
Orexin receptor antagonists
|
|
KR102582197B1
(ko)
*
|
2017-05-03 |
2023-09-22 |
이도르시아 파마슈티컬스 리미티드 |
2-([1,2,3]트리아졸-2-일)-벤조산 유도체의 제조
|
|
GB201707504D0
(en)
|
2017-05-10 |
2017-06-21 |
Benevolentai Bio Ltd |
Orexin receptor antagonists
|
|
GB201707499D0
(en)
|
2017-05-10 |
2017-06-21 |
Benevolentai Bio Ltd |
Orexin receptor antagonists
|
|
CN115710250A
(zh)
*
|
2017-08-01 |
2023-02-24 |
博健制药有限责任公司 |
一种食欲素受体拮抗剂的晶型及其制备方法和用途
|
|
HUE067936T2
(hu)
|
2018-04-24 |
2024-11-28 |
Merck Patent Gmbh |
Proliferáció-gátló vegyületek és alkalmazásuk
|
|
US10980788B2
(en)
|
2018-06-08 |
2021-04-20 |
Agios Pharmaceuticals, Inc. |
Therapy for treating malignancies
|
|
WO2020007977A1
(en)
*
|
2018-07-06 |
2020-01-09 |
Idorsia Pharmaceuticals Ltd |
7-trifluoromethyl-[1,4]diazepan derivatives
|
|
MA54465A
(fr)
|
2018-12-12 |
2021-10-20 |
Chemocentryx Inc |
Inhibiteurs de cxcr7 destinés au traitement du cancer
|
|
AU2020286381C1
(en)
|
2019-06-04 |
2025-07-10 |
Hager Biosciences, Llc |
Imidazolo derivatives, compositions and methods as orexin antagonists
|
|
CZ310035B6
(cs)
|
2019-12-09 |
2024-05-29 |
Univerzita Palackého v Olomouci |
N-(furan-2-ylmethyl)-7H-purin-6-amin pro modulaci cirkadiánních rytmů
|
|
MX2023001688A
(es)
|
2020-08-12 |
2023-02-22 |
Spruce Biosciences Inc |
Metodos y composiciones para tratar el sindrome de ovario poliquistico.
|
|
CN111943945B
(zh)
*
|
2020-09-03 |
2022-07-12 |
上海应用技术大学 |
一种苏沃雷生中间体及其制备方法
|
|
US20230331720A1
(en)
*
|
2020-09-03 |
2023-10-19 |
Orexia Therapeutics Limited |
Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists
|