MX366754B - Método para producir compuesto de pirimidin-1-ol e intermedio de este. - Google Patents

Método para producir compuesto de pirimidin-1-ol e intermedio de este.

Info

Publication number
MX366754B
MX366754B MX2017001222A MX2017001222A MX366754B MX 366754 B MX366754 B MX 366754B MX 2017001222 A MX2017001222 A MX 2017001222A MX 2017001222 A MX2017001222 A MX 2017001222A MX 366754 B MX366754 B MX 366754B
Authority
MX
Mexico
Prior art keywords
producing
pyrimidin
substituted
compound
ols
Prior art date
Application number
MX2017001222A
Other languages
English (en)
Other versions
MX2017001222A (es
Inventor
Watanabe Yuzo
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2017001222A publication Critical patent/MX2017001222A/es
Publication of MX366754B publication Critical patent/MX366754B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un método para producir pirimidin-5-ol disustituido en las posiciones 2 y 4 y, especialmente, 2,4-dimetilpirimidin-5-ol y un intermedio de este utilizado en la producción industrial. El método de producción de acuerdo con la presente invención incluye una etapa de producción de pirimidin-5-ol disustituido en las posiciones 2 y 4 de acuerdo con una reacción de hidrólisis de un compuesto de tipo 5-(4-(nitrofenil)oxi)pirimidina disustituida en las posiciones 2 y 4 y es adecuado para la producción industrial ya que se puede utilizar un material de partida barato y fácil de conseguir, la regioselectividad de un grupo sustituyente se controla fácilmente, las impurezas se controlan fácilmente y se puede producir pirimidin-5-ol disustituido en las posiciones 2,4 sin utilizar reactivos e intermedios que provoquen riesgos, problemas de salud y similares.
MX2017001222A 2014-08-06 2015-08-03 Método para producir compuesto de pirimidin-1-ol e intermedio de este. MX366754B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462033665P 2014-08-06 2014-08-06
PCT/JP2015/071930 WO2016021539A1 (ja) 2014-08-06 2015-08-03 ピリミジン－１－オール化合物の製造方法及びその中間体

Publications (2)

Publication Number Publication Date
MX2017001222A MX2017001222A (es) 2017-05-01
MX366754B true MX366754B (es) 2019-07-23

Family

ID=55263805

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001222A MX366754B (es) 2014-08-06 2015-08-03 Método para producir compuesto de pirimidin-1-ol e intermedio de este.

Country Status (12)

Country Link
US (1) US10065930B2 (es)
EP (1) EP3178814B1 (es)
JP (1) JP6283748B2 (es)
KR (1) KR102325655B1 (es)
CN (1) CN107074780B (es)
ES (1) ES2731648T3 (es)
HU (1) HUE043849T2 (es)
IL (1) IL250223B (es)
MX (1) MX366754B (es)
RU (1) RU2681937C2 (es)
SG (1) SG11201700603TA (es)
WO (1) WO2016021539A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102930546B1 (ko) * 2019-05-15 2026-02-25 에자이 알앤드디 매니지먼트 가부시키가이샤 오렉신-2 수용체 길항제의 제조에 유용한 방법 및 화합물, 및 약간의 불순물을 갖는 렘보렉산트
CN113214164B (zh) * 2021-05-20 2022-10-18 广西天铭药业有限公司 一种莱博雷生中间体2,4-二甲基嘧啶-5-醇的合成方法
ES2933074B2 (es) 2021-07-26 2023-09-29 Moehs Iberica Sl Procedimiento de sintesis de 2,4-dimetilpirimidin-5-ol, nuevos intermedios de dicho procedimiento y uso del producto en la sintesis de lemborexant

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311703A1 (de) * 1983-03-30 1984-10-04 Bayer Ag, 5090 Leverkusen Harnstoffderivate
DE3431272A1 (de) * 1984-08-25 1986-03-06 Bayer Ag, 5090 Leverkusen Substituierte phenylharnstoffe
JPS6229266A (ja) * 1985-07-29 1987-02-07 Matsushita Graphic Commun Syst Inc 自動利得制御回路
JPH0684358B2 (ja) * 1986-06-11 1994-10-26 帝国化学産業株式会社 アルキルチオフエニルピリミジン誘導体
JPH0684359B2 (ja) * 1986-06-11 1994-10-26 帝国化学産業株式会社 ２−（ｐ−アルコキシカルボニル）フエニルピリミジン誘導体
JP2655359B2 (ja) * 1990-01-25 1997-09-17 富士写真フイルム株式会社 芳香族求核置換反応による芳香族アミン類、芳香族アルコール類、芳香族チオール類の合成法
SG34208A1 (en) 1995-03-01 1996-12-06 Guy Andrew Vaz Blast and fragment resistant polyurethane boot sole for safety footwear
CA2220036A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
US6159605A (en) 1997-02-18 2000-12-12 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Ink-jet recording sheet
US6166193A (en) 1997-07-25 2000-12-26 Board Of Regents, University Of Texas System Polynucleotides encoding MY1 receptor
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템
DK3042894T1 (da) * 2001-08-10 2016-11-07 Shionogi & Co Antiviralt middel
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
SI2626350T1 (sl) 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
WO2013123240A1 (en) 2012-02-17 2013-08-22 Eisai R&D Management Co., Ltd Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

Also Published As

Publication number Publication date
KR20170035917A (ko) 2017-03-31
JPWO2016021539A1 (ja) 2017-04-27
US20170204068A1 (en) 2017-07-20
ES2731648T3 (es) 2019-11-18
US10065930B2 (en) 2018-09-04
MX2017001222A (es) 2017-05-01
EP3178814B1 (en) 2019-04-10
RU2017102349A3 (es) 2018-10-18
CN107074780A (zh) 2017-08-18
IL250223A0 (en) 2017-03-30
RU2681937C2 (ru) 2019-03-14
HUE043849T2 (hu) 2019-09-30
WO2016021539A1 (ja) 2016-02-11
CN107074780B (zh) 2020-06-12
KR102325655B1 (ko) 2021-11-15
RU2017102349A (ru) 2018-09-06
EP3178814A4 (en) 2018-04-04
EP3178814A1 (en) 2017-06-14
IL250223B (en) 2019-05-30
SG11201700603TA (en) 2017-03-30
JP6283748B2 (ja) 2018-02-21

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