JP2010511621A5 - - Google Patents

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JP2010511621A5
JP2010511621A5 JP2009539355A JP2009539355A JP2010511621A5 JP 2010511621 A5 JP2010511621 A5 JP 2010511621A5 JP 2009539355 A JP2009539355 A JP 2009539355A JP 2009539355 A JP2009539355 A JP 2009539355A JP 2010511621 A5 JP2010511621 A5 JP 2010511621A5
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methyl
diazepan
benzoxazole
triazol
benzoyl
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JP2009539355A
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Japanese (ja)
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JP2010511621A (ja
JP4675427B2 (ja
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Priority claimed from PCT/US2007/024690 external-priority patent/WO2008069997A1/en
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JP2009539355A 2006-12-01 2007-11-30 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 Active JP4675427B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87239306P 2006-12-01 2006-12-01
US95974207P 2007-07-16 2007-07-16
PCT/US2007/024690 WO2008069997A1 (en) 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists

Related Child Applications (2)

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JP2010264809A Division JP5335758B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物
JP2010264812A Division JP5767803B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物

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JP2010511621A JP2010511621A (ja) 2010-04-15
JP2010511621A5 true JP2010511621A5 (cg-RX-API-DMAC7.html) 2011-01-20
JP4675427B2 JP4675427B2 (ja) 2011-04-20

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JP2009539355A Active JP4675427B2 (ja) 2006-12-01 2007-11-30 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物
JP2010264812A Active JP5767803B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物
JP2010264809A Active JP5335758B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物

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JP2010264812A Active JP5767803B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物
JP2010264809A Active JP5335758B2 (ja) 2006-12-01 2010-11-29 オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物

Country Status (34)

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US (2) US7951797B2 (cg-RX-API-DMAC7.html)
EP (2) EP2392572B1 (cg-RX-API-DMAC7.html)
JP (3) JP4675427B2 (cg-RX-API-DMAC7.html)
KR (2) KR101217057B1 (cg-RX-API-DMAC7.html)
CN (1) CN101880276B (cg-RX-API-DMAC7.html)
AR (2) AR063979A1 (cg-RX-API-DMAC7.html)
AU (2) AU2007328267B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719361B8 (cg-RX-API-DMAC7.html)
CA (1) CA2670892C (cg-RX-API-DMAC7.html)
CL (2) CL2007003441A1 (cg-RX-API-DMAC7.html)
CO (1) CO6190524A2 (cg-RX-API-DMAC7.html)
CR (1) CR10859A (cg-RX-API-DMAC7.html)
CY (1) CY1113798T1 (cg-RX-API-DMAC7.html)
DK (1) DK2089382T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2009000126A (cg-RX-API-DMAC7.html)
EC (1) ECSP099374A (cg-RX-API-DMAC7.html)
ES (1) ES2397188T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20130002T1 (cg-RX-API-DMAC7.html)
IL (1) IL198825A0 (cg-RX-API-DMAC7.html)
MA (1) MA31016B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009005712A (cg-RX-API-DMAC7.html)
MY (1) MY161834A (cg-RX-API-DMAC7.html)
NI (1) NI200900100A (cg-RX-API-DMAC7.html)
NO (1) NO342586B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ577334A (cg-RX-API-DMAC7.html)
PE (1) PE20081229A1 (cg-RX-API-DMAC7.html)
PL (1) PL2089382T3 (cg-RX-API-DMAC7.html)
PT (1) PT2089382E (cg-RX-API-DMAC7.html)
RS (1) RS52617B (cg-RX-API-DMAC7.html)
RU (2) RU2561727C2 (cg-RX-API-DMAC7.html)
SI (1) SI2089382T1 (cg-RX-API-DMAC7.html)
SV (1) SV2009003276A (cg-RX-API-DMAC7.html)
TW (2) TWI513696B (cg-RX-API-DMAC7.html)
WO (1) WO2008069997A1 (cg-RX-API-DMAC7.html)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007272854B2 (en) * 2006-07-14 2013-08-01 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
EP2049529B1 (en) * 2006-07-14 2010-08-11 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
WO2008143856A1 (en) 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
ATE540944T1 (de) 2007-05-23 2012-01-15 Merck Sharp & Dohme Pyridylpiperidinorexin-rezeptorantagonisten
CA2703904A1 (en) 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists
EP2242745A1 (de) * 2008-02-07 2010-10-27 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2010008746A1 (en) * 2008-06-19 2010-01-21 Takeda Pharmaceutical Company Limited Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues
US8466281B2 (en) 2008-10-21 2013-06-18 Merck Sharp & Dohme Corp. 2,5-disubstituted morpholine orexin receptor antagonists
JP2012506379A (ja) * 2008-10-21 2012-03-15 メルク・シャープ・エンド・ドーム・コーポレイション 二置換アゼパンオレキシン受容体アンタゴニスト
US8853202B2 (en) 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
KR101701367B1 (ko) * 2008-11-04 2017-02-02 케모센트릭스, 인크. Ｃｘｃｒ７의 모듈레이터
US20110046047A1 (en) * 2009-05-20 2011-02-24 Joslin Diabets Center, Inc. Bone Morphogenetic Proteins for Appetite Control
KR101350845B1 (ko) 2009-09-15 2014-01-14 주식회사 만도 전자 브레이크의 간극 조정 장치 및 그 방법
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
MX2012004753A (es) 2009-10-23 2012-09-07 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina.
WO2011050199A1 (en) 2009-10-24 2011-04-28 Anantha Shekhar Methods and compositions for panic disorders
CA2803118C (en) 2010-07-09 2015-11-03 Pfizer Limited Sulfonamide derivatives as nav 1.7 inhibitors
MX2013003218A (es) 2010-09-22 2013-06-28 Eisai R&D Man Co Ltd Compuestos de ciclopropano.
WO2012085857A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-3-yl amides
WO2012148553A1 (en) 2011-03-03 2012-11-01 Merck Sharp & Dohme Corp. Process for the preparation of an orexin receptor antagonist
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US9617517B2 (en) 2011-05-02 2017-04-11 National University Corporation Kumamoto University Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound
CN102827073A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
ES2572703T3 (es) 2011-11-08 2016-06-01 Actelion Pharmaceuticals Ltd. Derivados de 2-(1,2,3-triazol-2-il)benzamida y 3-(1,2,3-triazol-2-il)picolinamida como antagonistas del receptor de orexina
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
CA2863413A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
WO2013169610A1 (en) 2012-05-09 2013-11-14 Merck Sharp & Dohme Corp. Process for the preparation of an intermediate for an orexin receptor antagonist
BR112014025041B8 (pt) 2012-05-31 2023-04-18 Merck Sharp & Dohme Composição farmacêutica
CN104334544B (zh) 2012-06-04 2016-10-19 埃科特莱茵药品有限公司 苯并咪唑脯氨酸衍生物
MX2015004638A (es) 2012-10-10 2015-07-14 Actelion Pharmaceuticals Ltd Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-) aril]-[2-meta bi-(hetero-) aril)-pirrolidin-1-il]-metanona.
KR20150097486A (ko) * 2012-11-12 2015-08-26 닥터 레디스 레보러터리즈 리미티드 수보렉산트의 다형태
CN105189484B (zh) 2012-11-29 2018-05-04 凯莫森特里克斯股份有限公司 Cxcr7拮抗剂
US8999393B1 (en) * 2013-01-09 2015-04-07 Edgemont Pharmaceuticals Llc Sustained release formulations of lorazepam
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
AU2014287121B2 (en) 2013-07-11 2018-11-15 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
EP3021851A2 (en) * 2013-07-15 2016-05-25 Dr. Reddy's Laboratories Ltd. Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
SI3077389T1 (en) 2013-12-03 2018-01-31 Idorsia Pharmaceuticals Ltd (S) - (2- (6-CHLORO-7-METHYL-1 H-BENZO (D) IMIDAZOL-2-YL) -2-METHYLPYROLIDIN-1-YL (5-METHOXY-2- (2H- , 2,3-TRIAZOL-2-IL) PHENYL) METHANONE AND ITS USE AS ANTAGONISTS OF OREXIN RECEPTOR
CA2930053A1 (en) 2013-12-04 2015-06-11 Actelion Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
WO2015095111A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2015095442A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Piperidinyloxy lactone orexin receptor antagonists
NZ723859A (en) 2014-03-14 2023-01-27 Servier Lab Pharmaceutical compositions of therapeutically active compounds and their uses
US10206880B2 (en) 2014-04-17 2019-02-19 Sandoz Ag Solid dispersion comprising an orexin receptor antagonist
WO2015164160A1 (en) 2014-04-21 2015-10-29 Merck Sharp & Dohme Corp. Pharmaceutical salts of an orexin receptor antagonist
CN105377840B (zh) * 2014-05-28 2017-12-22 杭州普晒医药科技有限公司 一种二氮杂环庚烷化合物的盐及其晶型与无定型物
EP3177616B1 (en) 2014-08-04 2021-02-24 Sandoz AG Novel routes of synthesis for the preparation of suvorexant
WO2016020403A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
WO2016020404A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Process for the resolution of (r,s)-diazepane and diazepanone derivatives
CN107074780B (zh) 2014-08-06 2020-06-12 卫材R&D管理有限公司 用于生产嘧啶-1-醇化合物及其中间体的方法
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
CN107810006B (zh) 2014-10-23 2021-03-30 卫材R&D管理有限公司 用于治疗失眠的组合物
WO2016065584A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine oxadiazole and thiadiazole orexin receptor antagonists
WO2016065587A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Pyrazole orexin receptor antagonists
WO2016065586A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Pyrazole, triazole and tetrazole orexin receptor antagonists
WO2016065585A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine isoxazole and isothiazole orexin receptor antagonists
WO2016065583A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Oxazole orexin receptor antagonists
WO2016085783A1 (en) 2014-11-26 2016-06-02 Merck Sharp & Dohme Corp. Bridged diazepane orexin receptor antagonists
US10000499B2 (en) 2014-11-26 2018-06-19 Merck Sharp & Dohme Corp. Methyl diazepane orexin receptor antagonists
WO2016086358A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Hydroxymethyl piperidine orexin receptor antagonists
WO2016086357A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Methyl oxazole orexin receptor antagonists
WO2016095205A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Heteroaryl orexin receptor antagonists
WO2016095204A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Pyrrolidine orexin receptor antagonists
US10011595B2 (en) 2014-12-19 2018-07-03 Merck Sharp & Dohme Corp. Ethyldiamine orexin receptor antagonists
WO2016100157A2 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
WO2016100162A2 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. 5,5-bicyclic oxazole orexin receptor antagonists
WO2016101118A1 (en) 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Amidoethyl azole orexin receptor antagonists
WO2016101119A1 (en) 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Fused heteroaryl derivatives as orexin receptor antagonists
CZ201587A3 (cs) 2015-02-10 2016-08-17 Zentiva, K.S. Amorfní pevná forma suvorexantu s kyselinou sírovou
WO2016149628A1 (en) * 2015-03-19 2016-09-22 Chembridge Corporation Tgr5 agonists
EP3287454B1 (en) 2015-04-24 2020-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound
AR105025A1 (es) * 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
WO2017001499A1 (en) 2015-06-30 2017-01-05 Hexal Ag Liquid composition comprising suvorexant
AU2016295693B2 (en) 2015-07-17 2020-05-21 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
PT3362066T (pt) 2015-10-15 2021-11-16 Celgene Corp Terapia de combinação para tratar malignidades
BR112018007671B1 (pt) 2015-10-15 2023-10-17 Les Laboratoires Servier Usos de um inibidor da idh1 e combinações
WO2017072264A1 (en) 2015-10-29 2017-05-04 Hexal Ag Solid composition comprising suvorexant
EA201891054A1 (ru) 2015-10-29 2018-10-31 Юниверсити Оф Цукуба Морфинановое производное и его медицинское применение
JP6936224B2 (ja) 2015-11-23 2021-09-15 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． オクタヒドロピロロ［３，４−ｃ］ピロール誘導体およびその使用
CN107021955B (zh) * 2016-02-01 2021-03-30 上海奥博生物医药股份有限公司 苏沃雷生中间体化合物及其制备方法
EA036542B9 (ru) 2016-02-12 2020-12-22 Астразенека Аб Галоген-замещенные пиперидины в качестве модуляторов орексинового рецептора
UA125873C2 (uk) 2016-03-10 2022-06-29 Янссен Фармацевтика Нв Спосіб лікування депресії з використанням антагоністів рецептора орексин-2
CN107179356B (zh) * 2016-03-11 2021-07-16 广东东阳光药业有限公司 一种用hplc法测定苏沃雷生有关物质的方法
CN107304204B (zh) * 2016-04-18 2020-12-22 广东东阳光药业有限公司 一种制备n-杂环化合物的方法
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
JP2019517585A (ja) 2016-06-06 2019-06-24 エナンティア，エセ．エレ． スボレキサントの中間体及びその共結晶のキラル分割
AU2017382160A1 (en) * 2016-12-19 2019-06-06 Druggability Technologies Ip Holdco Limited Pharmaceutical formulations of suvorexant
GB201702174D0 (en) 2017-02-09 2017-03-29 Benevolentai Bio Ltd Orexin receptor antagonists
EP3619199B1 (en) * 2017-05-03 2021-07-07 Idorsia Pharmaceuticals Ltd Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives
GB201707504D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
GB201707499D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
JP7179049B2 (ja) * 2017-08-01 2022-11-28 ベルゲン ファーマシューティカル、 エルエルシー オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途
ES2919572T3 (es) 2018-04-24 2022-07-27 Merck Patent Gmbh Compuestos antiproliferación y usos de los mismos
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
WO2020007977A1 (en) * 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
JP7590084B2 (ja) 2018-12-12 2024-11-26 ケモセントリックス，インコーポレイティド 癌治療のためのｃｘｃｒ７阻害剤
CA3140170A1 (en) 2019-06-04 2020-12-10 Belew Mekonnen Imidazolo derivatives, compositions and methods as orexin antagonists
CZ310035B6 (cs) * 2019-12-09 2024-05-29 Univerzita PalackĂ©ho v Olomouci N-(furan-2-ylmethyl)-7H-purin-6-amin pro modulaci cirkadiánních rytmů
EP4175572A4 (en) 2020-08-12 2024-03-27 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
US20230331720A1 (en) * 2020-09-03 2023-10-19 Orexia Therapeutics Limited Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists
CN111943945B (zh) * 2020-09-03 2022-07-12 上海应用技术大学 一种苏沃雷生中间体及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536156B2 (cg-RX-API-DMAC7.html) * 1972-10-30 1978-03-04
GB2068961B (en) * 1980-02-13 1983-11-30 Sankyo Co Quinazoline derivatives
JPH0747574B2 (ja) * 1989-03-03 1995-05-24 大日本製薬株式会社 ピリジン誘導体及びそれを有効成分とする向精神剤
EP0794178A4 (en) * 1994-11-25 1998-02-25 Nippon Chemiphar Co CHINAZOLIN DERIVATIVES
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
AR016817A1 (es) 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
AU4037799A (en) 1998-05-08 1999-11-29 Smithkline Beecham Plc Phenylurea and phenylthio urea derivatives
EP1150977B1 (en) 1999-02-12 2004-08-25 SmithKline Beecham plc Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
ATE282614T1 (de) 1999-02-12 2004-12-15 Smithkline Beecham Plc Phenylharnstoff und phenylthioharnstoffderivate
WO2000047576A1 (en) 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
HU227811B1 (en) 2000-03-14 2012-03-28 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
WO2001085693A1 (en) 2000-05-11 2001-11-15 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
PT1289955E (pt) 2000-06-16 2005-08-31 Smithkline Beecham Plc Piperidinas para utilizacao como antagonistas dos receptores da orexina
DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
JP4246490B2 (ja) 2000-11-28 2009-04-02 スミスクライン ビーチャム ピー エル シー オレキシン受容体のアンタゴニストとしてのモルホリン誘導体
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
IL158463A0 (en) 2001-05-05 2004-05-12 Smithkline Beecham Plc N-aroyl cyclic amines
EP1435955A2 (en) 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
CN1549816A (zh) 2001-06-28 2004-11-24 ʷ 作为阿立新受体拮抗药的n-芳酰基环胺衍生物
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
GB0124463D0 (en) 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0127145D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Compounds
GB0130393D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130335D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130341D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
MXPA04002269A (es) 2002-07-09 2004-06-29 Actelion Pharmaceuticals Ltd Derivados de 7,8,9,10-tetrahidro-6h-azepino,6,7,8,9-tetrahidro-pirido y 2,3-dihidro-2h-pirrolo[2,1-b]-quinazolinona.
US20060040937A1 (en) 2002-09-18 2006-02-23 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
DE60335891D1 (de) 2002-10-11 2011-03-10 Actelion Pharmaceuticals Ltd Sulphonylaminoessigsaeure derivate und deren verwendung als orexin rezeptor antagoniste
GB0225884D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
GB0225938D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US6951882B2 (en) 2002-12-12 2005-10-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-[1,3]-dioxanes
WO2004080976A1 (en) 2003-03-12 2004-09-23 Kudos Pharmaceuticals Limited Phthalazinone derivatives
CL2004000553A1 (es) 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
AU2004224156B2 (en) 2003-03-26 2010-08-12 Actelion Pharmaceuticals Ltd. Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists
DE602004011204T2 (de) 2003-04-28 2008-12-24 Actelion Pharmaceuticals Ltd. Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten.
PT1703909E (pt) * 2003-09-09 2009-05-27 Hoffmann La Roche Derivados de 1-benzoil-piperazina como inibidores da absorção de glicina para o tratamento de psicoses
HUP0304101A3 (en) 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
HUP0400405A3 (en) 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
CN1926109B (zh) 2004-03-01 2011-04-13 埃科特莱茵药品有限公司 经取代的1,2,3,4-四氢异喹啉衍生物
WO2006067224A2 (en) 2004-12-23 2006-06-29 Biovitrum Ab (Publ) Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists
US20080262046A1 (en) 2005-04-12 2008-10-23 Coleman Paul J Amidopropoxyphenyl Orexin Receptor Antagonists
ZA200709626B (en) * 2005-05-13 2009-02-25 Lexicon Pharmaceuticals Inc Multicyclic compounds and methods of their use
US20060258762A1 (en) * 2005-05-13 2006-11-16 Dobransky Michael A Hydrocarbon or hydrofluorocarbon blown ASTM E-84 class I rigid polyurethane foams
US20090118200A1 (en) 2005-05-23 2009-05-07 Bergman Jeffrey M Proline bis-amide orexin receptor antagonists
EP1912655A2 (en) 2005-08-04 2008-04-23 Merck & Co., Inc. Aminoethane sulfonamide orexin receptor antagonists
JP2009506061A (ja) 2005-08-26 2009-02-12 メルク エンド カムパニー インコーポレーテッド ジアザスピロデカンオレキシン受容体拮抗薬
WO2007126935A2 (en) 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
EP2049529B1 (en) * 2006-07-14 2010-08-11 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists
AU2007272854B2 (en) 2006-07-14 2013-08-01 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CA2703904A1 (en) 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists

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