JP2010509374A5 - - Google Patents

Info

Publication number

JP2010509374A5

JP2010509374A5 JP2009536560A JP2009536560A JP2010509374A5 JP 2010509374 A5 JP2010509374 A5 JP 2010509374A5 JP 2009536560 A JP2009536560 A JP 2009536560A JP 2009536560 A JP2009536560 A JP 2009536560A JP 2010509374 A5 JP2010509374 A5 JP 2010509374A5

Authority

JP

Japan

Prior art keywords

derivative

analog

topical

comfrey

compound

Prior art date

2007-11-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 13
• 239000012049 topical pharmaceutical composition Substances 0.000 claims 13
• 241001442052 Symphytum Species 0.000 claims 12
• 235000005865 Symphytum officinale Nutrition 0.000 claims 12
• 230000000699 topical effect Effects 0.000 claims 12
• 239000000126 substance Substances 0.000 claims 11
• 125000002252 acyl group Chemical group 0.000 claims 10
• 125000003342 alkenyl group Chemical group 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 10
• 125000000304 alkynyl group Chemical group 0.000 claims 10
• 125000003118 aryl group Chemical group 0.000 claims 10
• LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims 10
• TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims 5
• 239000001263 FEMA 3042 Substances 0.000 claims 5
• LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims 5
• 229940033123 tannic acid Drugs 0.000 claims 5
• 235000015523 tannic acid Nutrition 0.000 claims 5
• 229920002258 tannic acid Polymers 0.000 claims 5
• 206010061218 Inflammation Diseases 0.000 claims 3
• 230000004054 inflammatory process Effects 0.000 claims 3
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
• 201000002661 Spondylitis Diseases 0.000 claims 2
• 230000007850 degeneration Effects 0.000 claims 2
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• 239000003961 penetration enhancing agent Substances 0.000 claims 2
• NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims 1
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
• 206010053555 Arthritis bacterial Diseases 0.000 claims 1
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000282472 Canis lupus familiaris Species 0.000 claims 1
• 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 1
• 241000283086 Equidae Species 0.000 claims 1
• 241000282326 Felis catus Species 0.000 claims 1
• 201000005569 Gout Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 208000004575 Infectious Arthritis Diseases 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 206010034464 Periarthritis Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• APZYKUZPJCQGPP-UHFFFAOYSA-N Tetrahydropiperine Chemical compound C=1C=C2OCOC2=CC=1CCCCC(=O)N1CCCCC1 APZYKUZPJCQGPP-UHFFFAOYSA-N 0.000 claims 1
• 235000021324 borage oil Nutrition 0.000 claims 1
• 208000002849 chondrocalcinosis Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940044949 eucalyptus oil Drugs 0.000 claims 1
• 239000010642 eucalyptus oil Substances 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000007764 o/w emulsion Substances 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 201000001223 septic arthritis Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 229940042129 topical gel Drugs 0.000 claims 1
• 0 C*C(Cc1ccc(*)c(*)c1)OC(C=Cc(cc1)cc(*)c1O*)=O Chemical compound C*C(Cc1ccc(*)c(*)c1)OC(C=Cc(cc1)cc(*)c1O*)=O 0.000 description 1