JP2010507367A - モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 - Google Patents

モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 Download PDF

Info

Publication number
JP2010507367A
JP2010507367A JP2009533566A JP2009533566A JP2010507367A JP 2010507367 A JP2010507367 A JP 2010507367A JP 2009533566 A JP2009533566 A JP 2009533566A JP 2009533566 A JP2009533566 A JP 2009533566A JP 2010507367 A JP2010507367 A JP 2010507367A
Authority
JP
Japan
Prior art keywords
amino acid
racemase
seq
monatin
aminotransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009533566A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010507367A5 (enExample
Inventor
ブライアン・ジェイ・ブラゾー
マービン・エル・デ・ソウザ
スティーブン・ジェイ・ゴート
ポーラ・エム・ヒックス
シェリー・アール・コールマン
ホセ・エム・ラプラザ
サラ・シー・マクファーラン
フェルナンド・エイ・サンチェズ−リーラ
クリストファー・ソルヘイド
Original Assignee
カーギル・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by カーギル・インコーポレイテッド filed Critical カーギル・インコーポレイテッド
Publication of JP2010507367A publication Critical patent/JP2010507367A/ja
Publication of JP2010507367A5 publication Critical patent/JP2010507367A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Indole Compounds (AREA)
  • Seasonings (AREA)
JP2009533566A 2006-10-20 2007-10-19 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 Pending JP2010507367A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58401606A 2006-10-20 2006-10-20
US11/714,279 US8076108B2 (en) 2005-04-26 2007-03-06 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
PCT/US2007/081932 WO2008085575A2 (en) 2006-10-20 2007-10-19 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015122370A Division JP2015211679A (ja) 2006-10-20 2015-06-17 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路

Publications (2)

Publication Number Publication Date
JP2010507367A true JP2010507367A (ja) 2010-03-11
JP2010507367A5 JP2010507367A5 (enExample) 2011-01-13

Family

ID=39615760

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009533566A Pending JP2010507367A (ja) 2006-10-20 2007-10-19 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路
JP2015122370A Pending JP2015211679A (ja) 2006-10-20 2015-06-17 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015122370A Pending JP2015211679A (ja) 2006-10-20 2015-06-17 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路

Country Status (7)

Country Link
US (2) US8076108B2 (enExample)
EP (1) EP2089529B1 (enExample)
JP (2) JP2010507367A (enExample)
AR (1) AR063348A1 (enExample)
AU (1) AU2007342275B2 (enExample)
CA (1) CA2666348A1 (enExample)
WO (1) WO2008085575A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012147674A1 (ja) * 2011-04-25 2012-11-01 味の素株式会社 モナティンの製造方法
CN106636227A (zh) * 2016-09-22 2017-05-10 精晶药业股份有限公司 一种酶法转化l‑丙氨酸制备丙酮酸的方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US8372989B2 (en) * 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) * 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
RU2307871C2 (ru) 2002-08-26 2007-10-10 Адзиномото Ко., Инк. НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ
EP2050821A3 (en) * 2002-12-09 2009-05-13 Ajinomoto Co., Inc. Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
KR20060061811A (ko) * 2003-08-01 2006-06-08 카아길, 인코포레이팃드 모나틴 식탁용 감미제 조성물 및 이의 제조 방법
EP1653810B1 (en) * 2003-08-14 2007-04-25 Cargill, Incorporated Chewing gum compositions comprising monatin and methods of making same
EP1657985A1 (en) * 2003-08-25 2006-05-24 Cargill Inc. Beverage compositions comprising monatin and methods of making same
ATE498691T1 (de) * 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
JP5059746B2 (ja) * 2005-04-20 2012-10-31 カーギル，インコーポレイティド モナチンの生体内分泌のための生成物及び方法
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076108B2 (en) * 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
CN102690833B (zh) * 2006-03-07 2015-09-09 巴斯夫酶有限责任公司 醛缩酶、编码它们的核酸及制备和使用它们的方法
ES2416104T3 (es) * 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
AU2007267618B2 (en) * 2006-05-24 2013-07-18 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
CN101239941B (zh) * 2007-02-08 2012-02-29 味之素株式会社 光学活性化合物的制造方法
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
WO2009088442A2 (en) * 2008-01-03 2009-07-16 Cargill, Incorporated Isomerases and epimerases and methods of using
JP5683962B2 (ja) * 2008-01-03 2015-03-11 カーギル・インコーポレイテッド アミノトランスフェラーゼおよびオキシドレダクターゼの核酸およびポリペプチドおよび使用方法
WO2012050125A1 (ja) 2010-10-14 2012-04-19 味の素株式会社 モナティンの製造方法
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
ES2538720B1 (es) * 2013-12-20 2016-05-12 Universidad Autónoma de Madrid Racemasa BsrAh para la racemización de aminoácidos
US11685942B2 (en) 2016-03-04 2023-06-27 President And Fellows Of Harvard College Methods for making polypeptides including d-amino acids
CN113025602A (zh) * 2021-03-18 2021-06-25 绵阳晟氏健康科技有限公司 固定化精氨酸消旋酶及其制备方法、应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500981A (ja) * 1995-11-30 2000-02-02 マキシジェン，インコーポレイテッド 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP2001508660A (ja) * 1997-01-24 2001-07-03 バイオインヴェント インターナショナル アーベー タンパク質機能のインビトロ分子進化の方法
JP2004222657A (ja) * 2003-01-24 2004-08-12 Ajinomoto Co Inc ２ｒ−モナティンの製造方法
WO2005016022A1 (en) * 2003-08-14 2005-02-24 Cargill, Incorporated Chewing gum compositions comprising monatin and methods of making same
WO2005020721A1 (en) * 2003-08-25 2005-03-10 Cargill, Incorporated Beverage compositions comprising monatin and methods of making same
JP2005523696A (ja) * 2002-04-23 2005-08-11 カーギル，インコーポレイティド ポリペプチド及び生合成経路
US20050282260A1 (en) * 2002-04-23 2005-12-22 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002889A (en) 1960-06-20 1961-10-03 Kyowa Hakko Kogyo Kk Method of producing l-glutamic acid
US3128237A (en) 1961-02-24 1964-04-07 Ajinomoto Kk Process for producing l-glutamic acid by bacterial fermentation
US3399114A (en) 1964-08-22 1968-08-27 Asahi Chemical Ind Process for producing l-glutamic acid by using bacteria
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
EP0232262A4 (en) 1985-08-15 1989-09-19 Stauffer Chemical Co TRYPTOPHANE GENERATING MICROORGANISM.
GB2205834B (en) 1987-06-15 1990-10-31 South African Inventions 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds
US5300437A (en) 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
WO1989011212A2 (en) 1989-08-30 1989-11-30 Wm. Wrigley Jr. Company Method of controlling release of cyclamate in chewing gum and gum produced thereby
ES2063443T3 (es) 1990-01-19 1995-01-01 Technology Finance Corp Procedimiento para la produccion de 3-(1-amino-1,3-dicarboxi-3-hidroxi-but-4-il) indol.
US5360724A (en) 1992-12-18 1994-11-01 Celgene Corporation Process for the preparation of chiral 1-aryl-2-aminopropanes
US6264999B1 (en) 1993-09-30 2001-07-24 Wm. Wrigley Jr. Company Chewing gum containing erythritol and method of making
JP3698742B2 (ja) 1994-03-01 2005-09-21 協和醗酵工業株式会社 光学活性４−ヒドロキシ−２−ケトグルタル酸の製造法
US5985617A (en) 1997-02-18 1999-11-16 Liao; James C. Microorganisms and methods for overproduction of DAHP by cloned PPS gene
CA2234412C (en) 1997-06-09 2008-09-02 Kyowa Hakko Kogyo Co., Ltd. Method for producing optically active compound
US6099848A (en) * 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
DE19818541C2 (de) 1998-04-24 2003-04-10 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III
US5994559A (en) 1998-08-06 1999-11-30 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Synthesis of monatin-A high intensity natural sweetener
JP2002060382A (ja) 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
DE10129711B4 (de) 2001-06-22 2007-08-23 Forschungszentrum Jülich GmbH Verfahren zur fermentativen Herstellung von Pyruvat
JP2003171365A (ja) 2001-11-30 2003-06-20 Ajinomoto Co Inc モナティン類及びその製造中間体の製造方法並びに新規中間体
EP2409968A1 (en) 2001-11-30 2012-01-25 Ajinomoto Co., Inc. Crystals of non-natural-type stereoisomer salt of monatin and use thereof
DE60239072D1 (de) 2001-12-27 2011-03-10 Ajinomoto Kk Verfahren zur herstellung von glutaminsäurederivaten
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
CN100465156C (zh) 2001-12-27 2009-03-04 味之素株式会社 谷氨酸化合物及其制备中间体的制造方法与为此所用的新型中间体
US7247466B2 (en) 2002-03-01 2007-07-24 Kyowa Hakko Kogyo Co., Ltd. Amino acid racemase having low substrate specificity and process for producing racemic amino acid
JP2003292484A (ja) 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
RU2307871C2 (ru) 2002-08-26 2007-10-10 Адзиномото Ко., Инк. НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ
EP2050821A3 (en) 2002-12-09 2009-05-13 Ajinomoto Co., Inc. Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
CA2512752C (en) 2003-01-09 2012-05-29 Ajinomoto Co., Inc. Process for manufacturing a glutamic acid derivative and a pyroglutamic acid derivative and a novel intermediate in the manufacture thereof
WO2004085624A2 (en) 2003-03-24 2004-10-07 Diversa Corporation Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification
JP2004331650A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
JP2004331644A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
WO2005001105A1 (ja) 2003-06-26 2005-01-06 Ajinomoto Co., Inc. モナティンの製造方法
KR20060061811A (ko) 2003-08-01 2006-06-08 카아길, 인코포레이팃드 모나틴 식탁용 감미제 조성물 및 이의 제조 방법
ATE498691T1 (de) 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
JP4500977B2 (ja) 2003-11-05 2010-07-14 味の素株式会社 新規アミノ酸誘導体及び甘味剤
JP5113978B2 (ja) 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
EP1719758B1 (en) 2004-02-27 2012-02-22 Ajinomoto Co., Inc. Process for producing monatin
JP4604524B2 (ja) 2004-03-16 2011-01-05 味の素株式会社 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法
JP4604537B2 (ja) 2004-03-31 2011-01-05 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
US7935377B2 (en) 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
CA2506247C (en) 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
KR101216575B1 (ko) 2004-07-14 2012-12-31 아지노모토 가부시키가이샤 (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물
JP2007284349A (ja) 2004-07-27 2007-11-01 Ajinomoto Co Inc モナティンまたはその塩の製造方法
ATE554178T1 (de) 2004-10-05 2012-05-15 Ajinomoto Kk Verfahren zur herstellung von aminosäurederivaten aus hydroxyiminosäuren
BRPI0517419A (pt) 2004-10-15 2008-10-07 Ajinomoto Kk composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico, estabilizador de conservação para monatina ou um sal da mesma, métodos de conservação de monatina ou de um sal da mesma e de composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico compreendendo monatina ou um sal da mesma, e, monatina ou um sal da mesma
JP2008530978A (ja) 2005-03-03 2008-08-14 味の素株式会社 ４−ハイドロキシ−ｌ−イソロイシン又はその塩の製造法
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
JP5059746B2 (ja) 2005-04-20 2012-10-31 カーギル，インコーポレイティド モナチンの生体内分泌のための生成物及び方法
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
CN102690833B (zh) 2006-03-07 2015-09-09 巴斯夫酶有限责任公司 醛缩酶、编码它们的核酸及制备和使用它们的方法
ES2416104T3 (es) 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
RU2338784C2 (ru) 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
AU2007267618B2 (en) 2006-05-24 2013-07-18 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US20090198072A1 (en) 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US7354746B1 (en) 2006-12-11 2008-04-08 Ajinomoto Co., Inc. Method for producing optically active IHOG and monatin
CN101239941B (zh) 2007-02-08 2012-02-29 味之素株式会社 光学活性化合物的制造方法
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8076107B2 (en) 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
WO2011002469A1 (en) 2009-07-02 2011-01-06 Cargill, Incorporated Isomerases and epimerases and methods of using
JP5683962B2 (ja) 2008-01-03 2015-03-11 カーギル・インコーポレイテッド アミノトランスフェラーゼおよびオキシドレダクターゼの核酸およびポリペプチドおよび使用方法
JP2012520079A (ja) 2009-03-12 2012-09-06 カーギル・インコーポレイテッド モナチンおよびカルシウムを含む組成物
CN102481007A (zh) 2009-05-28 2012-05-30 嘉吉公司 储存稳定的莫纳汀增甜饮料
WO2011082365A2 (en) 2009-12-30 2011-07-07 Cargill, Incorporated Improved bioreactor performance in the production of monatin
WO2011082353A1 (en) 2009-12-30 2011-07-07 Cargill, Incorporated Separation and purification of monatin
EP2519406A4 (en) 2009-12-30 2014-03-26 Cargill Inc POLYMER AND METHODS FOR PREPARING AND USING POLYMER
US20120264948A1 (en) 2009-12-30 2012-10-18 Cargill, Incorporated Membrane separation and purification of monatin

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500981A (ja) * 1995-11-30 2000-02-02 マキシジェン，インコーポレイテッド 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP2001508660A (ja) * 1997-01-24 2001-07-03 バイオインヴェント インターナショナル アーベー タンパク質機能のインビトロ分子進化の方法
JP2005523696A (ja) * 2002-04-23 2005-08-11 カーギル，インコーポレイティド ポリペプチド及び生合成経路
US20050282260A1 (en) * 2002-04-23 2005-12-22 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
JP2004222657A (ja) * 2003-01-24 2004-08-12 Ajinomoto Co Inc ２ｒ−モナティンの製造方法
WO2005016022A1 (en) * 2003-08-14 2005-02-24 Cargill, Incorporated Chewing gum compositions comprising monatin and methods of making same
WO2005020721A1 (en) * 2003-08-25 2005-03-10 Cargill, Incorporated Beverage compositions comprising monatin and methods of making same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CSNG199901368002; 伏見 譲 Ｙｕｚｕｒｕ ＨＵＳＩＭＩ: '生物学の立場から：進化分子工学 Ａ-Ｌｉｆｅ ｆｒｏｍ ａ Ｂｉｏｌｏｇｉｃａｌ Ｐｒｅｓｐｅｃｔｉｖｅ： Ｅｖｏｌｕｔｉｏｎａｒｙ Ｍｏｌｏｃｕｌａｒ Ｅｎｇｉｎｅｅ' 電子情報通信学会誌 第７７巻 第２号 ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＩＮＳＴＩＴＵＴＥ ＯＦ ＥＬＥＣＴＲＯＮＩＣＳ，ＩＮＦＯＲＭＡＴＩＯＮ ＡＮＤ ＣＯ 第７７巻, 社団法人電子情報通信学会 ＴＨＥ ＩＮＳＴＩＴＵＴＥ ＯＦ ＥＬＥＣＴＲＯ *
CSNG200501163006; 伏見 譲 Ｙｕｚｕｒｕ Ｈｕｓｉｍｉ: '進化の周辺 Ａｒｏｕｎｄ Ｅｖｏｌｕｔｉｎａｒｙ Ｓｙｓｔｅｍｓ' 人工知能学会誌 第１９巻 第６号 Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｊａｐａｎｅｓｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ａｒｔｉｆｉｃｉａｌ Ｉｎｔｅｌｌｉｇｅｎｃｅ 第１９巻, （社）人工知能学会 Ｔｈｅ Ｊａｐａｎｅｓｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ａｒｔｉｆ *
JPN6014009629; 伏見 譲 Ｙｕｚｕｒｕ Ｈｕｓｉｍｉ: '進化の周辺 Ａｒｏｕｎｄ Ｅｖｏｌｕｔｉｎａｒｙ Ｓｙｓｔｅｍｓ' 人工知能学会誌 第１９巻 第６号 Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｊａｐａｎｅｓｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ａｒｔｉｆｉｃｉａｌ Ｉｎｔｅｌｌｉｇｅｎｃｅ 第１９巻, （社）人工知能学会 Ｔｈｅ Ｊａｐａｎｅｓｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ａｒｔｉｆ *
JPN6014009631; 伏見 譲 Ｙｕｚｕｒｕ ＨＵＳＩＭＩ: '生物学の立場から：進化分子工学 Ａ-Ｌｉｆｅ ｆｒｏｍ ａ Ｂｉｏｌｏｇｉｃａｌ Ｐｒｅｓｐｅｃｔｉｖｅ： Ｅｖｏｌｕｔｉｏｎａｒｙ Ｍｏｌｏｃｕｌａｒ Ｅｎｇｉｎｅｅ' 電子情報通信学会誌 第７７巻 第２号 ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＩＮＳＴＩＴＵＴＥ ＯＦ ＥＬＥＣＴＲＯＮＩＣＳ，ＩＮＦＯＲＭＡＴＩＯＮ ＡＮＤ ＣＯ 第７７巻, 社団法人電子情報通信学会 ＴＨＥ ＩＮＳＴＩＴＵＴＥ ＯＦ ＥＬＥＣＴＲＯ *
JPN6015005666; Ａｐｐｌ．　Ｍｉｃｒｏｂｉｏｌ．　Ｂｉｏｔｅｃｈｎｏｌ． ｖｏｌ．７３, 20061007, ｐｐ．１２９９-１３０５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012147674A1 (ja) * 2011-04-25 2012-11-01 味の素株式会社 モナティンの製造方法
CN106636227A (zh) * 2016-09-22 2017-05-10 精晶药业股份有限公司 一种酶法转化l‑丙氨酸制备丙酮酸的方法
CN106636227B (zh) * 2016-09-22 2020-11-06 精晶药业股份有限公司 一种酶法转化l-丙氨酸制备丙酮酸的方法

Also Published As

Publication number Publication date
AU2007342275A1 (en) 2008-07-17
US8076108B2 (en) 2011-12-13
EP2089529A2 (en) 2009-08-19
EP2089529A4 (en) 2012-04-11
WO2008085575A2 (en) 2008-07-17
WO2008085575A3 (en) 2009-03-19
EP2089529B1 (en) 2019-03-20
JP2015211679A (ja) 2015-11-26
AR063348A1 (es) 2009-01-21
AU2007342275A2 (en) 2009-07-09
US20120164697A1 (en) 2012-06-28
CA2666348A1 (en) 2008-07-17
AU2007342275B2 (en) 2013-06-20
US8975046B2 (en) 2015-03-10
US20080020434A1 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
US8076108B2 (en) Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
JP4988803B2 (ja) ポリペプチド及び生合成経路
JP4829117B2 (ja) モナチンおよびモナチン前駆体の製造
CN101374954B (zh) 用于生产莫纳甜和其前体的多肽和生物合成途径
JP5336182B2 (ja) モナティンの立体異性体及びそれらの前駆体の製造のためのポリペプチド及び生合成経路
AU2012201740B2 (en) Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101018

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101018

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110927

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130618

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140304

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140603

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140610

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140704

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140711

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140724

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150617

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150629

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20150828