AR063348A1 - Polipeptidos y vias de biosintesis para la produccion de estereoisomeros de monatina y sus precursores - Google Patents
Polipeptidos y vias de biosintesis para la produccion de estereoisomeros de monatina y sus precursoresInfo
- Publication number
- AR063348A1 AR063348A1 ARP070104644A ARP070104644A AR063348A1 AR 063348 A1 AR063348 A1 AR 063348A1 AR P070104644 A ARP070104644 A AR P070104644A AR P070104644 A ARP070104644 A AR P070104644A AR 063348 A1 AR063348 A1 AR 063348A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- monatina
- stereoisomers
- precursors
- ways
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 3
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 1
- SLWQCDYJBNGHQV-CQSZACIVSA-N (2r)-2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(C[C@@](O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-CQSZACIVSA-N 0.000 abstract 1
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Indole Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58401606A | 2006-10-20 | 2006-10-20 | |
| US11/714,279 US8076108B2 (en) | 2005-04-26 | 2007-03-06 | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063348A1 true AR063348A1 (es) | 2009-01-21 |
Family
ID=39615760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104644A AR063348A1 (es) | 2006-10-20 | 2007-10-19 | Polipeptidos y vias de biosintesis para la produccion de estereoisomeros de monatina y sus precursores |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8076108B2 (enExample) |
| EP (1) | EP2089529B1 (enExample) |
| JP (2) | JP2010507367A (enExample) |
| AR (1) | AR063348A1 (enExample) |
| AU (1) | AU2007342275B2 (enExample) |
| CA (1) | CA2666348A1 (enExample) |
| WO (1) | WO2008085575A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US8372989B2 (en) * | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| RU2307871C2 (ru) | 2002-08-26 | 2007-10-10 | Адзиномото Ко., Инк. | НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ |
| EP2050821A3 (en) * | 2002-12-09 | 2009-05-13 | Ajinomoto Co., Inc. | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| KR20060061811A (ko) * | 2003-08-01 | 2006-06-08 | 카아길, 인코포레이팃드 | 모나틴 식탁용 감미제 조성물 및 이의 제조 방법 |
| EP1653810B1 (en) * | 2003-08-14 | 2007-04-25 | Cargill, Incorporated | Chewing gum compositions comprising monatin and methods of making same |
| EP1657985A1 (en) * | 2003-08-25 | 2006-05-24 | Cargill Inc. | Beverage compositions comprising monatin and methods of making same |
| ATE498691T1 (de) * | 2003-10-21 | 2011-03-15 | Cargill Inc | Herstellung von monatin und monatinvorstufen |
| JP5059746B2 (ja) * | 2005-04-20 | 2012-10-31 | カーギル,インコーポレイティド | モナチンの生体内分泌のための生成物及び方法 |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| CN102690833B (zh) * | 2006-03-07 | 2015-09-09 | 巴斯夫酶有限责任公司 | 醛缩酶、编码它们的核酸及制备和使用它们的方法 |
| ES2416104T3 (es) * | 2006-03-07 | 2013-07-30 | Cargill, Incorporated | Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| AU2007267618B2 (en) * | 2006-05-24 | 2013-07-18 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| CN101239941B (zh) * | 2007-02-08 | 2012-02-29 | 味之素株式会社 | 光学活性化合物的制造方法 |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| WO2009088442A2 (en) * | 2008-01-03 | 2009-07-16 | Cargill, Incorporated | Isomerases and epimerases and methods of using |
| JP5683962B2 (ja) * | 2008-01-03 | 2015-03-11 | カーギル・インコーポレイテッド | アミノトランスフェラーゼおよびオキシドレダクターゼの核酸およびポリペプチドおよび使用方法 |
| WO2012050125A1 (ja) | 2010-10-14 | 2012-04-19 | 味の素株式会社 | モナティンの製造方法 |
| US8771997B2 (en) | 2011-04-20 | 2014-07-08 | Ajinomoto Co., Inc. | Method for producing monatin using an L-amino acid aminotransferase |
| WO2012147674A1 (ja) * | 2011-04-25 | 2012-11-01 | 味の素株式会社 | モナティンの製造方法 |
| ES2538720B1 (es) * | 2013-12-20 | 2016-05-12 | Universidad Autónoma de Madrid | Racemasa BsrAh para la racemización de aminoácidos |
| US11685942B2 (en) | 2016-03-04 | 2023-06-27 | President And Fellows Of Harvard College | Methods for making polypeptides including d-amino acids |
| CN106636227B (zh) * | 2016-09-22 | 2020-11-06 | 精晶药业股份有限公司 | 一种酶法转化l-丙氨酸制备丙酮酸的方法 |
| CN113025602A (zh) * | 2021-03-18 | 2021-06-25 | 绵阳晟氏健康科技有限公司 | 固定化精氨酸消旋酶及其制备方法、应用 |
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| EP1653810B1 (en) | 2003-08-14 | 2007-04-25 | Cargill, Incorporated | Chewing gum compositions comprising monatin and methods of making same |
| EP1657985A1 (en) | 2003-08-25 | 2006-05-24 | Cargill Inc. | Beverage compositions comprising monatin and methods of making same |
| ATE498691T1 (de) | 2003-10-21 | 2011-03-15 | Cargill Inc | Herstellung von monatin und monatinvorstufen |
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| JP5059746B2 (ja) | 2005-04-20 | 2012-10-31 | カーギル,インコーポレイティド | モナチンの生体内分泌のための生成物及び方法 |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
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| CN102690833B (zh) | 2006-03-07 | 2015-09-09 | 巴斯夫酶有限责任公司 | 醛缩酶、编码它们的核酸及制备和使用它们的方法 |
| ES2416104T3 (es) | 2006-03-07 | 2013-07-30 | Cargill, Incorporated | Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas |
| RU2338784C2 (ru) | 2006-03-24 | 2008-11-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты) |
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| US8003361B2 (en) | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| WO2011002469A1 (en) | 2009-07-02 | 2011-01-06 | Cargill, Incorporated | Isomerases and epimerases and methods of using |
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| WO2011082365A2 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Improved bioreactor performance in the production of monatin |
| WO2011082353A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Separation and purification of monatin |
| EP2519406A4 (en) | 2009-12-30 | 2014-03-26 | Cargill Inc | POLYMER AND METHODS FOR PREPARING AND USING POLYMER |
| US20120264948A1 (en) | 2009-12-30 | 2012-10-18 | Cargill, Incorporated | Membrane separation and purification of monatin |
-
2007
- 2007-03-06 US US11/714,279 patent/US8076108B2/en not_active Expired - Fee Related
- 2007-10-19 CA CA002666348A patent/CA2666348A1/en not_active Abandoned
- 2007-10-19 AU AU2007342275A patent/AU2007342275B2/en not_active Ceased
- 2007-10-19 EP EP07872326.9A patent/EP2089529B1/en not_active Not-in-force
- 2007-10-19 JP JP2009533566A patent/JP2010507367A/ja active Pending
- 2007-10-19 WO PCT/US2007/081932 patent/WO2008085575A2/en not_active Ceased
- 2007-10-19 AR ARP070104644A patent/AR063348A1/es not_active Application Discontinuation
-
2011
- 2011-11-02 US US13/287,900 patent/US8975046B2/en not_active Expired - Fee Related
-
2015
- 2015-06-17 JP JP2015122370A patent/JP2015211679A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007342275A1 (en) | 2008-07-17 |
| US8076108B2 (en) | 2011-12-13 |
| EP2089529A2 (en) | 2009-08-19 |
| EP2089529A4 (en) | 2012-04-11 |
| WO2008085575A2 (en) | 2008-07-17 |
| WO2008085575A3 (en) | 2009-03-19 |
| EP2089529B1 (en) | 2019-03-20 |
| JP2010507367A (ja) | 2010-03-11 |
| JP2015211679A (ja) | 2015-11-26 |
| AU2007342275A2 (en) | 2009-07-09 |
| US20120164697A1 (en) | 2012-06-28 |
| CA2666348A1 (en) | 2008-07-17 |
| AU2007342275B2 (en) | 2013-06-20 |
| US8975046B2 (en) | 2015-03-10 |
| US20080020434A1 (en) | 2008-01-24 |
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