JP2010505902A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010505902A5 JP2010505902A5 JP2009531813A JP2009531813A JP2010505902A5 JP 2010505902 A5 JP2010505902 A5 JP 2010505902A5 JP 2009531813 A JP2009531813 A JP 2009531813A JP 2009531813 A JP2009531813 A JP 2009531813A JP 2010505902 A5 JP2010505902 A5 JP 2010505902A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acceptable salt
- pharmaceutically acceptable
- hcv
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 21
- 241000711549 Hepacivirus C Species 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- -1 monophosphate ester Chemical class 0.000 claims 9
- 102000014150 Interferons Human genes 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 210000000987 immune system Anatomy 0.000 claims 6
- 229940079322 interferon Drugs 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 4
- 239000003443 antiviral agent Substances 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 2
- 229940121759 Helicase inhibitor Drugs 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 229940122488 Primase inhibitor Drugs 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000007891 compressed tablet Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940125777 fusion inhibitor Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 239000001226 triphosphate Substances 0.000 claims 2
- 235000011178 triphosphate Nutrition 0.000 claims 2
- 102000003390 tumor necrosis factor Human genes 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 0 CC(C)C(O[C@@]([C@]1C)[C@@](*)(CO)O[C@]1N(C=CC(N)=N1)C1=O)=O Chemical compound CC(C)C(O[C@@]([C@]1C)[C@@](*)(CO)O[C@]1N(C=CC(N)=N1)C1=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85092606P | 2006-10-10 | 2006-10-10 | |
| PCT/EP2007/060557 WO2008043704A1 (en) | 2006-10-10 | 2007-10-04 | Hcv nucleoside inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011167159A Division JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505902A JP2010505902A (ja) | 2010-02-25 |
| JP2010505902A5 true JP2010505902A5 (cg-RX-API-DMAC7.html) | 2011-09-15 |
Family
ID=38925483
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531813A Ceased JP2010505902A (ja) | 2006-10-10 | 2007-10-04 | Ｈｃｖヌクレオシド阻害剤 |
| JP2011167159A Ceased JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011167159A Ceased JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Country Status (31)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007306405A1 (en) * | 2006-10-10 | 2008-04-17 | Medivir Ab | HCV nucleoside inhibitor |
| CN100532388C (zh) | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| AR072428A1 (es) * | 2008-07-01 | 2010-08-25 | Medivir Ab | Derivados de pirimidin nucleotidos inhibidores de polimerasas del virus de la hepatitis c (vhc), composiciones farmaceuticas que los contienen y metodo para prepararlos. |
| TWI454476B (zh) | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物 |
| EP2166016A1 (en) | 2008-09-18 | 2010-03-24 | Centocor Ortho Biotech Products L.P. | Phosphoramidate Derivatives of Nucleosides |
| TW201023858A (en) * | 2008-09-18 | 2010-07-01 | Ortho Mcneil Janssen Pharm | Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside |
| PA8852101A1 (es) | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
| DE102009028015A1 (de) * | 2009-07-24 | 2011-01-27 | Virologik Gmbh | Mittel zur Behandlung von Hepatitis C-Infektionen |
| EP2483288B1 (en) | 2009-09-29 | 2016-11-16 | Janssen Products, L.P. | Phosphoramidate derivatives of nucleosides |
| AU2011239974B2 (en) | 2010-04-13 | 2015-12-03 | Janssen Pharmaceuticals, Inc. | Combination of a macrocyclic inhibitor of HCV, a non-nucleoside and a nucleoside |
| CA2810928A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| EP2619215B1 (en) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2755983B1 (en) | 2011-09-12 | 2017-03-15 | Idenix Pharmaceuticals LLC. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| NZ631601A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのｄ−アミノ酸化合物 |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
| US9192621B2 (en) | 2012-09-27 | 2015-11-24 | Idenix Pharmaceuticals Llc | Esters and malonates of SATE prodrugs |
| HK1207647A1 (en) | 2012-10-08 | 2016-02-05 | Idenix Pharmaceuticals Llc | 2'-chloro nucleoside analogs for hcv infection |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| EA201590943A1 (ru) * | 2012-12-21 | 2016-01-29 | Алиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3027636B1 (en) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6339752A (ja) | 1986-08-02 | 1988-02-20 | Kawada Tekko Kk | インデツクス装置 |
| SE8701605D0 (sv) | 1987-04-16 | 1987-04-16 | Astra Ab | Novel medicinal compounds |
| DE3715666A1 (de) | 1987-05-11 | 1988-11-24 | Kodak Ag | Kassettenentlade- und beladegeraet |
| GB8712115D0 (en) | 1987-05-22 | 1987-06-24 | Hoffmann La Roche | Pyrimidine derivatives |
| US5246924A (en) | 1987-09-03 | 1993-09-21 | Sloan-Kettering Institute For Cancer Research | Method for treating hepatitis B virus infections using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil |
| SE8802173D0 (sv) | 1988-06-10 | 1988-06-10 | Astra Ab | Pyrimidine derivatives |
| SE8802687D0 (sv) | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
| NO171507C (no) * | 1988-11-21 | 1993-03-24 | Syntex Inc | Analogifremgangsmaate ved fremstilling av terapeutisk aktive nukleotidderivater |
| US5034518A (en) | 1989-05-23 | 1991-07-23 | Southern Research Institute | 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides |
| CA2055460C (en) | 1990-03-30 | 1997-04-01 | Neil Warren Boaz | Alcohol-ester separation by reaction with acetate |
| AU7623991A (en) * | 1990-05-17 | 1991-11-21 | Syntex (U.S.A.) Inc. | Antiviral agents |
| IT1249732B (it) | 1991-11-26 | 1995-03-09 | Angeletti P Ist Richerche Bio | Oligonucleotidi antisenso. |
| US5418151A (en) | 1992-08-07 | 1995-05-23 | Genencor International, Inc. | Regio-selective process for resolution of carbohydrate monoesters |
| US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| DE69933860T2 (de) | 1998-02-25 | 2007-05-31 | Emory University | 2'-fluoronukleoside |
| ES2244204T3 (es) | 1998-07-27 | 2005-12-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Derivados de dicetoacidos como inhibidores de polimerasas. |
| IL141456A0 (en) | 1998-08-21 | 2002-03-10 | Viropharma Inc | Rhodanine derivatives and pharmaceutical compositions containing the same |
| CA2343522A1 (en) | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
| WO2000018231A1 (en) | 1998-09-25 | 2000-04-06 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
| ES2207504T3 (es) | 1999-05-12 | 2004-06-01 | Yamasa Corporation | Nucleosidos 4'-c-etinilpurina. |
| US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| WO2001047833A1 (en) | 1999-12-24 | 2001-07-05 | Asahi Glass Company, Limited | Silicon nitride filter and method of manufacture thereof |
| AU2001253206A1 (en) | 2000-04-05 | 2001-10-23 | Tularik, Inc. | Ns5b hcv polymerase inhibitors |
| WO2001085172A1 (en) | 2000-05-10 | 2001-11-15 | Smithkline Beecham Corporation | Novel anti-infectives |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| AU2001269524A1 (en) | 2000-07-17 | 2002-01-30 | Takeda Chemical Industries Ltd. | Production method for freeze-dried products |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| BR0206614A (pt) | 2001-01-22 | 2004-02-17 | Merck & Co Inc | Composto, composição farmacêutica, método para inibir a polimerase viral de rna dependente de rna e/ou inibir a replicação viral de rna dependente de rna, método para tratar uma infecção viral de rna dependente de rna, e, uso de um composto |
| US6677120B2 (en) | 2001-03-30 | 2004-01-13 | Isis Pharmaceuticals, Inc. | Building blocks for the solution phase synthesis of oligonucleotides |
| KR100798579B1 (ko) | 2001-03-31 | 2008-01-28 | 동화약품공업주식회사 | 신규의 메톡시-1,3,5-트리아진 유도체 및 그를 포함하는약학적 조성물 |
| AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
| WO2002100851A2 (en) | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| CA2448737C (en) | 2001-07-20 | 2010-06-01 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US6899700B2 (en) | 2001-08-29 | 2005-05-31 | Kimberly-Clark Worldwide, Inc. | Therapeutic agent delivery tampon |
| US20040006002A1 (en) | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| WO2003026589A2 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| AU2002359320A1 (en) | 2001-10-29 | 2003-05-12 | Smithkline Beecham Corporation | Novel anit-infectives |
| AU2002365198A1 (en) | 2001-10-30 | 2003-07-30 | Smithkline Beecham Corporation | Novel anti-infectives |
| AU2002351077A1 (en) | 2001-11-05 | 2003-05-19 | Exiqon A/S | Oligonucleotides modified with novel alpha-l-rna analogues |
| WO2003052248A1 (es) | 2001-12-18 | 2003-06-26 | Fernandez Del Castillo Y Simon | Multipiston en columna |
| US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| AU2003248566A1 (en) | 2002-05-24 | 2003-12-12 | Smithkline Beecham Corporation | Novel anti-infectives |
| RS114104A (sr) | 2002-06-28 | 2007-02-05 | Idenix (Cayman) Limited, | 2'i 3'-nukleozidni prolekovi za lečenje flaviviridae infekcija |
| JP2005533817A (ja) | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウィルス科ウィルス感染治療用の修飾２′および３′−ヌクレオシドプロドラッグ |
| JP2005533824A (ja) * | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
| US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| EP2361913A1 (en) | 2002-11-01 | 2011-08-31 | Abbott Laboratories | Anti-infective agents |
| NO319194B1 (no) | 2002-11-14 | 2005-06-27 | Pronova Biocare As | Lipase-katalysert forestringsfremgangsmate av marine oljer |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| TWI294882B (en) | 2002-12-09 | 2008-03-21 | Hoffmann La Roche | Anhydrous crystalline azido cytosine hemisulfate derivative |
| WO2004052312A2 (en) | 2002-12-11 | 2004-06-24 | Smithkline Beecham Corporation | Anti-infectives |
| AU2003300957A1 (en) | 2002-12-11 | 2004-06-30 | Smithkline Beecham Corporation | Anti-infectives |
| WO2004058150A2 (en) | 2002-12-17 | 2004-07-15 | Smithkline Beecham Corporation | Anti-infectives |
| US20040259934A1 (en) | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| ATE346078T1 (de) | 2003-06-19 | 2006-12-15 | Hoffmann La Roche | Verfahren zur herstellung von 4'- azidonukleosidderivaten |
| US7125845B2 (en) | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
| WO2005019191A2 (en) | 2003-08-25 | 2005-03-03 | Abbott Laboratories | 1, 1-dioxido-4h-1,2,4-benzothiadiazine derivate und verwandte verbindungen als inhibitoren der hcv polymerase zur behandlung von hepatitis c |
| DE602004031645D1 (de) | 2003-09-22 | 2011-04-14 | Boehringer Ingelheim Pharma | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus |
| HRP20100048T1 (hr) | 2004-01-30 | 2010-04-30 | Medivir Ab | Inhibitori hcv ns-3 serin proteaze |
| EP1786807B1 (en) | 2004-08-23 | 2009-07-29 | F.Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| CA2577526A1 (en) * | 2004-08-23 | 2006-03-02 | Joseph Armstrong Martin | Antiviral 4'-azido-nucleosides |
| AU2007306405A1 (en) * | 2006-10-10 | 2008-04-17 | Medivir Ab | HCV nucleoside inhibitor |
-
2007
- 2007-10-04 AU AU2007306405A patent/AU2007306405A1/en not_active Abandoned
- 2007-10-04 SI SI200730544T patent/SI2084175T1/sl unknown
- 2007-10-04 PT PT07820934T patent/PT2084175E/pt unknown
- 2007-10-04 CN CN201010274006XA patent/CN101979397B/zh not_active Expired - Fee Related
- 2007-10-04 ES ES07820934T patent/ES2358853T3/es active Active
- 2007-10-04 ES ES10196341T patent/ES2392948T3/es active Active
- 2007-10-04 PL PL07820934T patent/PL2084175T3/pl unknown
- 2007-10-04 RS RS20110127A patent/RS51643B/sr unknown
- 2007-10-04 CA CA2665049A patent/CA2665049C/en not_active Expired - Fee Related
- 2007-10-04 NZ NZ575889A patent/NZ575889A/en not_active IP Right Cessation
- 2007-10-04 AT AT07820934T patent/ATE493428T1/de active
- 2007-10-04 EP EP10196341A patent/EP2361922B1/en active Active
- 2007-10-04 WO PCT/EP2007/060557 patent/WO2008043704A1/en not_active Ceased
- 2007-10-04 MX MX2009003452A patent/MX2009003452A/es active IP Right Grant
- 2007-10-04 JP JP2009531813A patent/JP2010505902A/ja not_active Ceased
- 2007-10-04 EA EA200970358A patent/EA018935B1/ru not_active IP Right Cessation
- 2007-10-04 MY MYPI20091428A patent/MY145314A/en unknown
- 2007-10-04 KR KR1020097009591A patent/KR20090078347A/ko not_active Ceased
- 2007-10-04 DK DK07820934.3T patent/DK2084175T3/da active
- 2007-10-04 BR BRPI0719258-4A2A patent/BRPI0719258A2/pt active Search and Examination
- 2007-10-04 HR HR20110193T patent/HRP20110193T1/hr unknown
- 2007-10-04 AP AP2009004812A patent/AP2009004812A0/xx unknown
- 2007-10-04 PL PL10196341T patent/PL2361922T3/pl unknown
- 2007-10-04 CN CN2007800379054A patent/CN101573370B/zh not_active Expired - Fee Related
- 2007-10-04 DE DE602007011658T patent/DE602007011658D1/de active Active
- 2007-10-04 EP EP07820934A patent/EP2084175B1/en active Active
- 2007-10-10 US US11/973,681 patent/US7666856B2/en not_active Expired - Fee Related
-
2009
- 2009-03-31 GT GT200900069A patent/GT200900069A/es unknown
- 2009-03-31 CO CO09033094A patent/CO6180441A2/es not_active Application Discontinuation
- 2009-04-05 IL IL197907A patent/IL197907A0/en unknown
- 2009-04-09 ZA ZA200902496A patent/ZA200902496B/xx unknown
- 2009-04-13 HN HN2009000614A patent/HN2009000614A/es unknown
- 2009-05-11 NO NO20091834A patent/NO20091834L/no not_active Application Discontinuation
- 2009-05-11 CR CR10789A patent/CR10789A/es not_active Application Discontinuation
-
2010
- 2010-01-20 US US12/690,842 patent/US7825239B2/en not_active Expired - Fee Related
- 2010-09-24 US US12/890,538 patent/US7935681B2/en not_active Expired - Fee Related
-
2011
- 2011-03-17 CY CY20111100298T patent/CY1111342T1/el unknown
- 2011-03-28 US US13/073,821 patent/US8158779B2/en not_active Expired - Fee Related
- 2011-07-29 JP JP2011167159A patent/JP2011246485A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010505902A5 (cg-RX-API-DMAC7.html) | ||
| CA2665049A1 (en) | Hcv nucleoside inhibitor | |
| JP5951690B2 (ja) | 抗ウイルス処置のためのカルバ−ヌクレオシドアナログ | |
| JP5425187B2 (ja) | 抗ウイルス処置のための１’−置換カルバ−ヌクレオシドアナログ | |
| JP6043338B2 (ja) | 抗ウイルス治療用の１’−置換ピリミジンｎ−ヌクレオシド類似体 | |
| JP4959900B2 (ja) | 抗ウイルスピリミジンヌクレオシド類 | |
| AU2021214911A1 (en) | Methods for treating SARS CoV-2 infections | |
| CA2632626C (en) | Ester prodrugs of 2'-fluoro-2'-alkyl-2'-deoxycytidines and their use in the treatment of hcv infection | |
| JP2011525171A5 (cg-RX-API-DMAC7.html) | ||
| RU2012136379A (ru) | 4'-азидонуклеозиды, активные в отношении hcv | |
| JP2010515760A5 (cg-RX-API-DMAC7.html) | ||
| JP2019056017A (ja) | Ｔｏｌｌ様受容体モジュレーターの固体形態 | |
| JP2013056886A5 (cg-RX-API-DMAC7.html) | ||
| CN1324212A (zh) | 治疗或预防病毒感染及有关疾病的方法 | |
| IL217228A (en) | Compounds of Type 2'-Deoxy-2'-Fluoro-2'-c-Methyluridine Nucleoside Phosphoramide Compounds | |
| JP2012519691A5 (cg-RX-API-DMAC7.html) | ||
| CA2490200A1 (en) | 2' and 3'-nucleoside prodrugs for treating flaviviridae infections | |
| HRP20151075T1 (hr) | Kristalni (s)-izopropil 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-diokso-3,4-dihidropirimidin-1-(2h)-il)-4-fluoro-3-hidroksi-4-metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino) propanoat | |
| EP3174889B1 (en) | Sofosbuvir in crystalline form and process for its preparation | |
| JP2016516773A5 (cg-RX-API-DMAC7.html) | ||
| TW201306839A (zh) | 治療ｈｃｖ感染之組合療法 | |
| CN1897937A (zh) | 2－(3,4－二甲基苯基)－4－{[2－羟基－3′－(1h－四唑－5－基)联苯基－3－基]－亚肼基}－5－甲基－2,4－二氢吡唑－3－酮胆碱 | |
| AU732120B2 (en) | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis | |
| JP2011524359A5 (cg-RX-API-DMAC7.html) | ||
| JPWO2019200005A5 (cg-RX-API-DMAC7.html) |