JP2010260849A5 - - Google Patents

Info

Publication number

JP2010260849A5

JP2010260849A5 JP2010066884A JP2010066884A JP2010260849A5 JP 2010260849 A5 JP2010260849 A5 JP 2010260849A5 JP 2010066884 A JP2010066884 A JP 2010066884A JP 2010066884 A JP2010066884 A JP 2010066884A JP 2010260849 A5 JP2010260849 A5 JP 2010260849A5

Authority

JP

Japan

Prior art keywords

pneumococcal vaccine

vaccine according

pneumococcal

conjugated

serotypes

Prior art date

2010-03-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229940124733 pneumococcal vaccine Drugs 0.000 claims 40
• 150000001720 carbohydrates Chemical class 0.000 claims 26
• 108091034117 Oligonucleotide Proteins 0.000 claims 13
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 8
• 239000000427 antigen Substances 0.000 claims 8
• 102000036639 antigens Human genes 0.000 claims 8
• 108091007433 antigens Proteins 0.000 claims 8
• 206010061598 Immunodeficiency Diseases 0.000 claims 7
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 5
• 238000011282 treatment Methods 0.000 claims 5
• 241000282414 Homo sapiens Species 0.000 claims 4
• 239000000556 agonist Substances 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 4
• 229960000814 tetanus toxoid Drugs 0.000 claims 4
• 229960005486 vaccine Drugs 0.000 claims 4
• 102000014914 Carrier Proteins Human genes 0.000 claims 3
• 108010078791 Carrier Proteins Proteins 0.000 claims 3
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 3
• 229960003983 diphtheria toxoid Drugs 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 239000011780 sodium chloride Substances 0.000 claims 3
• 229940074404 sodium succinate Drugs 0.000 claims 3
• ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims 3
• 239000008362 succinate buffer Substances 0.000 claims 3
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• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 241001494479 Pecora Species 0.000 claims 1
• 241000009328 Perro Species 0.000 claims 1
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• 101710183389 Pneumolysin Proteins 0.000 claims 1
• 206010036790 Productive cough Diseases 0.000 claims 1
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• 230000032683 aging Effects 0.000 claims 1
• 229940037003 alum Drugs 0.000 claims 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
• DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
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• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000000973 chemotherapeutic effect Effects 0.000 claims 1
• BOKOVLFWCAFYHP-UHFFFAOYSA-N dihydroxy-methoxy-sulfanylidene-$l^{5}-phosphane Chemical compound COP(O)(O)=S BOKOVLFWCAFYHP-UHFFFAOYSA-N 0.000 claims 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
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• 150000007523 nucleic acids Chemical group 0.000 claims 1
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• QMDCLAZNUPXSOJ-UHFFFAOYSA-N odn 10103 Chemical compound O=C1NC(=O)C(C)=CN1C1OC(COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(O)=O)C(O)C1 QMDCLAZNUPXSOJ-UHFFFAOYSA-N 0.000 claims 1
• VRHMPUJYJVJKNI-UHFFFAOYSA-N odn 10104 Chemical compound O=C1NC(=O)C(C)=CN1C1OC(COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(O)=O)C(O)C1 VRHMPUJYJVJKNI-UHFFFAOYSA-N 0.000 claims 1
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Cited By (1)