|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
RS51752B
(sr)
|
2002-07-29 |
2011-12-31 |
Rigel Pharmaceuticals |
Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina
|
|
NZ540612A
(en)
|
2003-01-14 |
2008-02-29 |
Arena Pharm Inc |
1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
JP2004313181A
(ja)
*
|
2003-04-02 |
2004-11-11 |
Canon Inc |
感染症起炎菌検出用プローブ及びプローブセット、ならびに担体及び遺伝子検査方法
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
RS53109B
(sr)
|
2003-07-30 |
2014-06-30 |
Rigel Pharmaceuticals Inc. |
Jedinjenja 2,4 pirimidindiamina za upotrebu u tretmanu ili prevenciji autoimunih bolesti
|
|
BRPI0413616B8
(pt)
*
|
2003-08-15 |
2021-05-25 |
Irm Llc |
2,4-pirimidinadiaminas, seus usos, e composição farmacêutica
|
|
US8131475B2
(en)
*
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
NZ551027A
(en)
|
2004-04-08 |
2011-01-28 |
Targegen Inc |
Benzotriazine inhibitors of kinases
|
|
EP1598343A1
(de)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
US7521457B2
(en)
*
|
2004-08-20 |
2009-04-21 |
Boehringer Ingelheim International Gmbh |
Pyrimidines as PLK inhibitors
|
|
JP5275628B2
(ja)
|
2004-08-25 |
2013-08-28 |
ターゲジェン インコーポレーティッド |
複素環式化合物および使用方法
|
|
GB0419161D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
KR101278397B1
(ko)
|
2005-01-19 |
2013-06-25 |
리겔 파마슈티칼스, 인크. |
2,4-피리미딘디아민 화합물의 전구약물 및 이의 용도
|
|
CN105348203B
(zh)
*
|
2005-06-08 |
2018-09-18 |
里格尔药品股份有限公司 |
抑制jak途径的组合物和方法
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
PE20070362A1
(es)
*
|
2005-07-15 |
2007-04-23 |
Glaxo Group Ltd |
COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk)
|
|
WO2007028445A1
(en)
*
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
|
GB0517329D0
(en)
*
|
2005-08-25 |
2005-10-05 |
Merck Sharp & Dohme |
Stimulation of neurogenesis
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
BR122021011787B1
(pt)
|
2005-11-01 |
2022-01-25 |
Impact Biomedicines, Inc |
Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2007085540A1
(en)
*
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
|
ES2439948T3
(es)
|
2006-02-17 |
2014-01-27 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para el tratamiento o la prevención de enfermedades autoinmunitarias
|
|
US8962643B2
(en)
|
2006-02-24 |
2015-02-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
ES2561406T3
(es)
|
2006-04-14 |
2016-02-26 |
Cell Signaling Technology, Inc. |
Defectos de genes y quinasa ALK mutante en tumores sólidos humanos
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
EP1914240B1
(en)
|
2006-10-11 |
2009-12-02 |
Astellas Pharma Inc. |
EML4-ALK fusion gene
|
|
CA2598893C
(en)
|
2006-10-11 |
2012-04-10 |
Astellas Pharma Inc. |
Eml4-alk fusion gene
|
|
MX2009004426A
(es)
|
2006-10-23 |
2009-08-12 |
Cephalon Inc |
Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
|
|
GEP20125691B
(en)
|
2006-12-08 |
2012-11-26 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
KR101149295B1
(ko)
*
|
2006-12-08 |
2012-07-05 |
아이알엠 엘엘씨 |
단백질 키나제 억제제로서의 화합물
|
|
CN101563327A
(zh)
*
|
2006-12-19 |
2009-10-21 |
健泰科生物技术公司 |
嘧啶类激酶抑制剂
|
|
TW200902010A
(en)
|
2007-01-26 |
2009-01-16 |
Smithkline Beecham Corp |
Anthranilamide inhibitors of aurora kinase
|
|
NZ580372A
(en)
|
2007-04-18 |
2012-01-12 |
Pfizer Prod Inc |
Pyrimidine and triazine derivatives including a sulfonamide group for the treatment of abnormal cell growth such as cancer
|
|
TWI389893B
(zh)
*
|
2007-07-06 |
2013-03-21 |
Astellas Pharma Inc |
二(芳胺基)芳基化合物
|
|
BRPI0814821A2
(pt)
*
|
2007-07-16 |
2015-02-03 |
Astrazeneca Ab |
Composto, composição farmacêutica, e, processo para preparar um composto
|
|
US7981903B2
(en)
|
2007-08-08 |
2011-07-19 |
Glaxosmithkline Llc |
2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer
|
|
WO2009032703A1
(en)
*
|
2007-08-28 |
2009-03-12 |
Irm Llc |
2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
|
|
JP2010538004A
(ja)
*
|
2007-08-28 |
2010-12-09 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
キナーゼ阻害剤としての2−ビフェニルアミノ−4−アミノピリミジン誘導体
|
|
CA2710118A1
(en)
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
JP2011512413A
(ja)
*
|
2008-02-19 |
2011-04-21 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
Fakの阻害剤としてのアニリノピリジン
|
|
AU2009233964B2
(en)
*
|
2008-04-07 |
2012-06-07 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
JP5802127B2
(ja)
|
2008-04-16 |
2015-10-28 |
ポートラ ファーマシューティカルズ, インコーポレイテッド |
Syk又はjakキナーゼ阻害剤としての2,6−ジアミノ−ピリミジン−5−イル−カルボキサミド類
|
|
AU2009244897B2
(en)
|
2008-04-16 |
2014-11-13 |
Alexion Pharmaceuticals, Inc. |
2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
|
|
WO2009131687A2
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
PT2300013T
(pt)
*
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Derivados de fósforo como inibidores de cinases
|
|
EA020807B1
(ru)
*
|
2008-06-17 |
2015-01-30 |
Астразенека Аб |
Соединения пиридина
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8445505B2
(en)
|
2008-06-25 |
2013-05-21 |
Irm Llc |
Pyrimidine derivatives as kinase inhibitors
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
BRPI0914682B8
(pt)
*
|
2008-06-27 |
2021-05-25 |
Avila Therapeutics Inc |
compostos de heteroarila e composições compreendendo os referidos compostos
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
JO3067B1
(ar)
*
|
2008-10-27 |
2017-03-15 |
Glaxosmithkline Llc |
بيرميدينات بيرازولو امينو كمثبطات ل fak
|
|
AR074210A1
(es)
|
2008-11-24 |
2010-12-29 |
Boehringer Ingelheim Int |
Derivados de pirimidina como inhibidores de ptk2-quinasa
|
|
TW201024281A
(en)
|
2008-11-24 |
2010-07-01 |
Boehringer Ingelheim Int |
New compounds
|
|
AR074830A1
(es)
|
2008-12-19 |
2011-02-16 |
Cephalon Inc |
Pirrolotriazinas como inhibidores de alk y jak2
|
|
SI2565193T1
(sl)
|
2009-01-23 |
2014-07-31 |
Rigel Pharmaceuticals, Inc. |
Sestavki in metode inhibicije JAK poti
|
|
ES2423804T3
(es)
|
2009-04-03 |
2013-09-24 |
Cellzome Gmbh |
Métodos para la identificación de moléculas que interaccionan con cinasas y para la purificación de proteínas de cinasa
|
|
WO2010118986A1
(en)
|
2009-04-14 |
2010-10-21 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
US9908884B2
(en)
|
2009-05-05 |
2018-03-06 |
Dana-Farber Cancer Institute, Inc. |
EGFR inhibitors and methods of treating disorders
|
|
TW201100441A
(en)
*
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
EP2440548A1
(en)
*
|
2009-06-10 |
2012-04-18 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
US20120142667A1
(en)
*
|
2009-06-10 |
2012-06-07 |
Nigel Ramsden |
Pyrimidine derivatives as zap-70 inhibitors
|
|
EP2440058A4
(en)
|
2009-06-12 |
2012-11-21 |
Dana Farber Cancer Inst Inc |
MELTED HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
|
|
EP2443106A1
(en)
*
|
2009-06-18 |
2012-04-25 |
Cellzome Limited |
Heterocyclylaminopyrimidines as kinase inhibitors
|
|
US20120165332A1
(en)
*
|
2009-06-18 |
2012-06-28 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
CA2771675A1
(en)
*
|
2009-09-11 |
2011-03-17 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
|
US20130137709A1
(en)
*
|
2010-05-05 |
2013-05-30 |
Nathanael S. Gray |
Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith
|
|
US8927547B2
(en)
|
2010-05-21 |
2015-01-06 |
Noviga Research Ab |
Pyrimidine derivatives
|
|
WO2012019132A2
(en)
|
2010-08-06 |
2012-02-09 |
Cell Signaling Technology, Inc. |
Anaplastic lymphoma kinase in kidney cancer
|
|
NZ607845A
(en)
|
2010-08-10 |
2015-03-27 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
CN103221410B
(zh)
|
2010-09-22 |
2017-09-15 |
艾尼纳制药公司 |
Gpr119受体调节剂和对与其相关的障碍的治疗
|
|
EP2635556B1
(en)
|
2010-11-01 |
2017-06-21 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as syk modulators
|
|
WO2012061415A1
(en)
|
2010-11-01 |
2012-05-10 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
US9238629B2
(en)
|
2010-11-01 |
2016-01-19 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
CN103269704B
(zh)
|
2010-11-01 |
2018-07-06 |
西建卡尔有限责任公司 |
杂环化合物和其用途
|
|
EP2635557A2
(en)
|
2010-11-01 |
2013-09-11 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
CA2816957A1
(en)
|
2010-11-07 |
2012-05-10 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
|
PT2646448T
(pt)
|
2010-11-29 |
2017-10-04 |
Osi Pharmaceuticals Llc |
Inibidores macrocíclicos de cinases
|
|
KR102325775B1
(ko)
*
|
2010-12-17 |
2021-11-12 |
노파르티스 아게 |
5-클로로-n2-(2-이소프로폭시-5-메틸-4-피페리딘-4-일-페닐)-n4[2-(프로판-2-술포닐)-페닐]-피리미딘-2,4-디아민의 결정질 형태
|
|
US8546443B2
(en)
|
2010-12-21 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Benzylic oxindole pyrimidines
|
|
JP2012153674A
(ja)
|
2011-01-28 |
2012-08-16 |
Astellas Pharma Inc |
ジ(アリールアミノ)アリール化合物の製造方法及びその合成中間体
|
|
PL2670401T3
(pl)
*
|
2011-02-02 |
2015-11-30 |
Novartis Ag |
Sposoby stosowania inhibitorów ALK
|
|
WO2012110773A1
(en)
|
2011-02-17 |
2012-08-23 |
Cancer Therapeutics Crc Pty Limited |
Fak inhibitors
|
|
AU2012216894B2
(en)
|
2011-02-17 |
2016-07-14 |
Cancer Therapeutics Crc Pty Limited |
Selective FAK inhibitors
|
|
US9006241B2
(en)
|
2011-03-24 |
2015-04-14 |
Noviga Research Ab |
Pyrimidine derivatives
|
|
WO2012135641A2
(en)
|
2011-03-30 |
2012-10-04 |
H. Lee Moffitt Cancer Center And Research Institute |
Aurora kinase inhibitors and methods of making and using thereof
|
|
RU2625309C2
(ru)
|
2011-04-22 |
2017-07-13 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Замещенные диаминокарбоксамидные и диаминокарбонитрильные производные пиримидинов, их композиции и способы лечения с их помощью
|
|
AU2012250517B2
(en)
|
2011-05-04 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
TW201325593A
(zh)
|
2011-10-28 |
2013-07-01 |
Celgene Avilomics Res Inc |
治療布魯頓(bruton’s)酪胺酸激酶疾病或病症之方法
|
|
EP3569598A1
(en)
|
2011-11-17 |
2019-11-20 |
Dana Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
US8877760B2
(en)
|
2011-11-23 |
2014-11-04 |
Portola Pharmaceuticals, Inc. |
Substituted pyrazine-2-carboxamide kinase inhibitors
|
|
AU2013229995B2
(en)
|
2012-03-06 |
2017-04-13 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivative as a dual ALK and FAK inhibitor
|
|
CN108658873B
(zh)
|
2012-03-15 |
2021-09-14 |
西建卡尔有限责任公司 |
表皮生长因子受体激酶抑制剂的固体形式
|
|
JP6317320B2
(ja)
|
2012-03-15 |
2018-04-25 |
セルジーン シーエーアール エルエルシー |
上皮成長因子受容体キナーゼ阻害剤の塩
|
|
JP6469567B2
(ja)
|
2012-05-05 |
2019-02-13 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
Egfr発動性がんの細胞増殖阻害用化合物
|
|
KR101582852B1
(ko)
|
2012-05-24 |
2016-01-07 |
서울대학교 산학협력단 |
타우 단백질 매개 신경 퇴행성 질환 치료제
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
EP2903970A4
(en)
|
2012-10-08 |
2016-11-30 |
Portola Pharm Inc |
SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
WO2014063054A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
|
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
CA2890346A1
(en)
|
2012-11-05 |
2014-05-08 |
Foundation Medicine, Inc. |
Novel fusion molecules and uses thereof
|
|
KR102156398B1
(ko)
*
|
2012-11-06 |
2020-09-15 |
상하이 포천 파마슈티컬 씨오 엘티디 |
Alk 키나아제 억제제
|
|
CN103804299A
(zh)
*
|
2012-11-14 |
2014-05-21 |
韩冰 |
一类具有神经保护作用的化合物及其用途
|
|
EP2935226A4
(en)
|
2012-12-21 |
2016-11-02 |
Celgene Avilomics Res Inc |
HETEROARYL COMPOUNDS AND USES THEREOF
|
|
EP3939614A1
(en)
|
2013-01-18 |
2022-01-19 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
CA2900012A1
(en)
|
2013-02-08 |
2014-08-14 |
Celgene Avilomics Research, Inc. |
Erk inhibitors and uses thereof
|
|
WO2014128235A1
(en)
|
2013-02-22 |
2014-08-28 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer and preventing drug resistance
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
MX2015016332A
(es)
|
2013-05-29 |
2016-07-20 |
Cephalon Inc |
Inhibidores de alk biciclicos fusionados.
|
|
CN105338980A
(zh)
|
2013-06-18 |
2016-02-17 |
诺华股份有限公司 |
药物组合
|
|
WO2015003658A1
(en)
*
|
2013-07-11 |
2015-01-15 |
Betta Pharmaceuticals Co., Ltd |
Protein tyrosine kinase modulators and methods of use
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
WO2015038868A1
(en)
*
|
2013-09-13 |
2015-03-19 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivatives
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
WO2015058140A1
(en)
|
2013-10-18 |
2015-04-23 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
ES2676734T3
(es)
|
2013-10-18 |
2018-07-24 |
Syros Pharmaceuticals, Inc. |
Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
|
|
KR102357699B1
(ko)
|
2013-11-06 |
2022-02-04 |
더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 |
발현 프로파일링에 의한 림프종 유형의 하위유형 분류 방법
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
WO2015164604A1
(en)
*
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
WO2015164614A1
(en)
*
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
DK3179858T3
(da)
|
2014-08-13 |
2019-07-22 |
Celgene Car Llc |
Forme og sammensætninger af en ERK-inhibitor
|
|
WO2016029002A2
(en)
*
|
2014-08-22 |
2016-02-25 |
Clovis Oncology, Inc. |
Growth factor receptor inhibitors
|
|
PT3209647T
(pt)
|
2014-10-21 |
2020-09-10 |
Ariad Pharma Inc |
Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidino-2,4-diamina
|
|
US9513297B2
(en)
|
2014-12-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
|
|
ES2877642T3
(es)
|
2014-12-16 |
2021-11-17 |
Signal Pharm Llc |
Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida
|
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
EP4445956A3
(en)
|
2015-01-06 |
2024-12-04 |
Arena Pharmaceuticals, Inc. |
Compound for use in treating conditions related to the s1p1 receptor
|
|
CA2975260C
(en)
|
2015-01-29 |
2024-05-21 |
Signal Pharmaceuticals Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CN107427521B
(zh)
|
2015-03-27 |
2021-08-03 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
WO2016167511A2
(ko)
*
|
2015-04-14 |
2016-10-20 |
한국화학연구원 |
N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
PL3310760T3
(pl)
|
2015-06-22 |
2023-03-06 |
Arena Pharmaceuticals, Inc. |
Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
|
|
EP3325432B1
(en)
|
2015-07-24 |
2020-09-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|
|
CA2996978A1
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
CN106699743B
(zh)
*
|
2015-11-05 |
2020-06-12 |
湖北生物医药产业技术研究院有限公司 |
嘧啶类衍生物及其用途
|
|
CN106883213B
(zh)
*
|
2015-12-15 |
2021-04-20 |
合肥中科普瑞昇生物医药科技有限公司 |
一种egfr和alk激酶的双重抑制剂
|
|
WO2018001251A1
(zh)
*
|
2016-06-27 |
2018-01-04 |
杭州雷索药业有限公司 |
苯并呋喃吡唑胺类蛋白激酶抑制剂
|
|
SG11201901251SA
(en)
|
2016-08-29 |
2019-03-28 |
Univ Michigan Regents |
Aminopyrimidines as alk inhibitors
|
|
KR101876514B1
(ko)
*
|
2016-11-08 |
2018-07-10 |
한국화학연구원 |
신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물
|
|
MA47504A
(fr)
|
2017-02-16 |
2019-12-25 |
Arena Pharm Inc |
Composés et méthodes de traitement de l'angiocholite biliaire primitive
|
|
CN110678182B
(zh)
|
2017-02-24 |
2022-08-23 |
大邱庆北尖端医疗产业振兴财团 |
含有能够穿透血脑屏障的化合物作为预防或治疗脑癌的有效成分的药物组合物
|
|
JOP20190281A1
(ar)
*
|
2017-06-13 |
2019-12-02 |
Korea Res Inst Chemical Tech |
مشتق n2، n4 ثنائي فينيل بيريميدين -2، 4- ثنائي أمين، وطريقة لتحضيره، وتركيبة صيدلانية تحتوي على المشتق بوصفه مكون فعال للوقاية من السرطان أو علاجه
|
|
MX2020002608A
(es)
|
2017-09-07 |
2020-09-18 |
Revolution Medicines Inc |
Composiciones que comprenden inhibidores de shp2 y metodos para tratar el cáncer.
|
|
KR101992621B1
(ko)
|
2017-12-07 |
2019-09-27 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
WO2019117813A1
(en)
*
|
2017-12-15 |
2019-06-20 |
National University Of Singapore |
Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
|
|
EP3715350B1
(en)
*
|
2017-12-21 |
2024-05-08 |
Shenzhen TargetRx, Inc. |
Arylphosphine oxides for inhibiting kinase activity
|
|
JP2021524835A
(ja)
|
2018-04-05 |
2021-09-16 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
Axlキナーゼ阻害剤およびその使用
|
|
ES2987794T3
(es)
|
2018-06-06 |
2024-11-18 |
Arena Pharm Inc |
Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
|
|
JP7590185B2
(ja)
|
2018-06-25 |
2024-11-26 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
Taireファミリーキナーゼインヒビターおよびそれらの使用
|
|
JP2022508651A
(ja)
|
2018-10-08 |
2022-01-19 |
レヴォリューション・メディスンズ,インコーポレイテッド |
癌を処置するためのshp2阻害剤組成物および方法
|
|
WO2020088390A1
(zh)
*
|
2018-10-29 |
2020-05-07 |
江苏先声药业有限公司 |
作为第四代egfr抑制剂的嘧啶吡唑类化合物
|
|
US12522583B2
(en)
|
2018-11-07 |
2026-01-13 |
Dana-Farber Cancer Institute, Inc. |
Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof
|
|
WO2020097400A1
(en)
|
2018-11-07 |
2020-05-14 |
Dana-Farber Cancer Institute, Inc. |
Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
|
|
US12415816B2
(en)
|
2018-11-07 |
2025-09-16 |
Dana-Farber Cancer Institute, Inc. |
Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
AU2019413694B2
(en)
|
2018-12-28 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
US20220064196A1
(en)
*
|
2019-01-17 |
2022-03-03 |
Betta Pharmaceuticals Co., Ltd. |
EGFR Inhibitors, Compositions and Methods Thereof
|
|
AU2020232616A1
(en)
|
2019-03-01 |
2021-09-09 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
|
AU2020241258B2
(en)
*
|
2019-03-15 |
2025-09-11 |
The General Hospital Corporation |
Novel small molecule inhibitors of TEAD transcription factors
|
|
CN114364798A
(zh)
|
2019-03-21 |
2022-04-15 |
欧恩科斯欧公司 |
用于治疗癌症的Dbait分子与激酶抑制剂的组合
|
|
JP2022539208A
(ja)
|
2019-07-03 |
2022-09-07 |
スミトモ ファーマ オンコロジー, インコーポレイテッド |
チロシンキナーゼ非受容体1(tnk1)阻害剤およびその使用
|
|
KR102168179B1
(ko)
*
|
2019-10-31 |
2020-10-20 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 헤테로 고리 치환 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
US11608346B2
(en)
|
2019-11-04 |
2023-03-21 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
IL320513A
(en)
|
2019-11-04 |
2025-06-01 |
Revolution Medicines Inc |
RAS inhibitors
|
|
CR20220240A
(es)
|
2019-11-04 |
2022-08-03 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CN114901662A
(zh)
|
2019-11-08 |
2022-08-12 |
锐新医药公司 |
双环杂芳基化合物及其用途
|
|
JP2023500906A
(ja)
|
2019-11-08 |
2023-01-11 |
インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) |
キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
|
|
EP4074697B1
(en)
*
|
2019-12-03 |
2025-05-21 |
Samjin Pharmaceutical Co., Ltd. |
Novel adamantane derivatives as inhibitors of focal adhesion kinase
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
AU2021227907A1
(en)
*
|
2020-02-25 |
2022-09-29 |
Dana-Farber Cancer Institute, Inc. |
Potent and selective degraders of ALK
|
|
EP4168002A1
(en)
|
2020-06-18 |
2023-04-26 |
Revolution Medicines, Inc. |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
|
CA3187757A1
(en)
|
2020-09-03 |
2022-03-24 |
Ethan AHLER |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
US11690915B2
(en)
|
2020-09-15 |
2023-07-04 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20240051956A1
(en)
|
2020-12-22 |
2024-02-15 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
|
CA3204401A1
(en)
*
|
2021-01-07 |
2022-07-14 |
Rima AL-AWAR |
Isoindolinone aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof
|
|
CA3207015A1
(en)
*
|
2021-04-01 |
2022-10-06 |
Tae Bo Sim |
Pyrimidine derivative with inhibitory activity against protein kinases and therapeutic pharmaceutical composition including the same
|
|
US12297194B2
(en)
|
2021-04-02 |
2025-05-13 |
Bridge Biotherapeutics, Inc. |
N2-phenylpyrimidine-2,4-diamine compounds, and preparation methods and methods of use thereof
|
|
EP4320153A1
(en)
|
2021-04-09 |
2024-02-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
|
CR20230558A
(es)
|
2021-05-05 |
2024-01-24 |
Revolution Medicines Inc |
Inhibidores de ras para el tratamiento del cáncer
|
|
CN118561952A
(zh)
|
2021-05-05 |
2024-08-30 |
锐新医药公司 |
Ras抑制剂
|
|
CN117500811A
(zh)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
共价ras抑制剂及其用途
|
|
EP4359570A4
(en)
|
2021-06-25 |
2025-04-30 |
Foundation Medicine, Inc. |
METHODS OF USING SOMATIC HLA-I LOH TO PREDICT RESPONSE IN IMMUNE CHECKPOINT INHIBITOR-TREATED PATIENTS WITH LUNG CANCER
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023107705A1
(en)
|
2021-12-10 |
2023-06-15 |
Incyte Corporation |
Bicyclic amines as cdk12 inhibitors
|
|
US20250282782A1
(en)
|
2021-12-17 |
2025-09-11 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
CN119136806A
(zh)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
用于治疗免疫难治性肺癌的方法
|
|
EP4536364A1
(en)
|
2022-06-10 |
2025-04-16 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
KR20240143136A
(ko)
|
2023-03-23 |
2024-10-02 |
청주대학교 산학협력단 |
콘크리트 양생용 광발열 단열시트 및 콘크리트 구조물의 조기 시공 방법
|
|
CR20250458A
(es)
|
2023-03-30 |
2025-11-21 |
Revolution Medicines Inc |
Composiciones para inducir la hidrólisis de ras gtp y sus usos
|
|
KR20260005904A
(ko)
|
2023-04-07 |
2026-01-12 |
레볼루션 메디슨즈, 인크. |
매크로사이클릭 ras 억제제
|
|
AU2024251341A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
AU2024252105A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
|
AU2024265078A1
(en)
|
2023-05-04 |
2025-12-11 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
CN121335887A
(zh)
*
|
2023-06-08 |
2026-01-13 |
希格生科(深圳)有限公司 |
含氮芳环化合物及其医药用途
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
US20250154171A1
(en)
|
2023-10-12 |
2025-05-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|