JP2012513416A5 - - Google Patents
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- Publication number
- JP2012513416A5 JP2012513416A5 JP2011542631A JP2011542631A JP2012513416A5 JP 2012513416 A5 JP2012513416 A5 JP 2012513416A5 JP 2011542631 A JP2011542631 A JP 2011542631A JP 2011542631 A JP2011542631 A JP 2011542631A JP 2012513416 A5 JP2012513416 A5 JP 2012513416A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- optionally substituted
- alkyl
- membered heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *CN(C(CN(*)*)=Nc1c2c(Cl)cc(Cl)c1O)C2=O Chemical compound *CN(C(CN(*)*)=Nc1c2c(Cl)cc(Cl)c1O)C2=O 0.000 description 9
- ICFIMJZCNKEVKD-UHFFFAOYSA-N CC(C)CN(C(c1c(cc2Cl)Cl)O)C(CNC)=Nc1c2O Chemical compound CC(C)CN(C(c1c(cc2Cl)Cl)O)C(CNC)=Nc1c2O ICFIMJZCNKEVKD-UHFFFAOYSA-N 0.000 description 1
- RKJMWHCUOVDXLK-UHFFFAOYSA-N CC(C)N(C(CN(C)C)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CC(C)N(C(CN(C)C)=Nc(c1c(cc2Cl)Cl)c2O)C1=O RKJMWHCUOVDXLK-UHFFFAOYSA-N 0.000 description 1
- JZWJLOWGJQEANF-UHFFFAOYSA-N CC(C)N(C(CNC)=Nc(c1c(cc2C)Cl)c2O)C1=O Chemical compound CC(C)N(C(CNC)=Nc(c1c(cc2C)Cl)c2O)C1=O JZWJLOWGJQEANF-UHFFFAOYSA-N 0.000 description 1
- IUTZLOTXWCBLPC-UHFFFAOYSA-N CC(CN(C)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C=C Chemical compound CC(CN(C)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C=C IUTZLOTXWCBLPC-UHFFFAOYSA-N 0.000 description 1
- YRWABSJNCVPCGD-UHFFFAOYSA-N CCCCN(C)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCCN(C)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O YRWABSJNCVPCGD-UHFFFAOYSA-N 0.000 description 1
- NXPHUCHVUHBCIK-UHFFFAOYSA-N CCCN(C(CN(C)C)=Nc1c2c(Cl)cc(Cl)c1O)C2=O Chemical compound CCCN(C(CN(C)C)=Nc1c2c(Cl)cc(Cl)c1O)C2=O NXPHUCHVUHBCIK-UHFFFAOYSA-N 0.000 description 1
- LBMBQZLCYINPOC-UHFFFAOYSA-N CCCN(C(CN(CC)CC)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CCCN(C(CN(CC)CC)=Nc(c1c(cc2Cl)Cl)c2O)C1=O LBMBQZLCYINPOC-UHFFFAOYSA-N 0.000 description 1
- MNCAHOIUTZKAEN-UHFFFAOYSA-N CCCN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CCCN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O MNCAHOIUTZKAEN-UHFFFAOYSA-N 0.000 description 1
- LTSARCXAQNDBFC-UHFFFAOYSA-N CCCN(C(CNCC)=Nc1c2c(Cl)cc(Cl)c1O)C2=O Chemical compound CCCN(C(CNCC)=Nc1c2c(Cl)cc(Cl)c1O)C2=O LTSARCXAQNDBFC-UHFFFAOYSA-N 0.000 description 1
- PVESJEYNUMEIPT-UHFFFAOYSA-N CCCN(CCC)CC(N(C(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCN(CCC)CC(N(C(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O PVESJEYNUMEIPT-UHFFFAOYSA-N 0.000 description 1
- SKZHDRBPUDSGQY-UHFFFAOYSA-N CCCN(CCC)CC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCN(CCC)CC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O SKZHDRBPUDSGQY-UHFFFAOYSA-N 0.000 description 1
- VULPLJSFNAEMBV-UHFFFAOYSA-N CCCN(CCC)CC(N(CC)C(c1c(cc2Cl)Cl)O)=Nc1c2O Chemical compound CCCN(CCC)CC(N(CC)C(c1c(cc2Cl)Cl)O)=Nc1c2O VULPLJSFNAEMBV-UHFFFAOYSA-N 0.000 description 1
- QHSNWZCWMMNYNM-UHFFFAOYSA-N CCCN(CCC)CC(N1C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O Chemical compound CCCN(CCC)CC(N1C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O QHSNWZCWMMNYNM-UHFFFAOYSA-N 0.000 description 1
- RSLWWOSHGXNORD-UHFFFAOYSA-N CCCN(CCC)CC(N1CCC)=Nc(c(O)c(cc2Cl)Cl)c2C1=O Chemical compound CCCN(CCC)CC(N1CCC)=Nc(c(O)c(cc2Cl)Cl)c2C1=O RSLWWOSHGXNORD-UHFFFAOYSA-N 0.000 description 1
- QVJFSGBCEZHBNX-UHFFFAOYSA-N CCCNCC(N(C(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(C(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O QVJFSGBCEZHBNX-UHFFFAOYSA-N 0.000 description 1
- SECUVVJCBAWAQT-UHFFFAOYSA-N CCCNCC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O SECUVVJCBAWAQT-UHFFFAOYSA-N 0.000 description 1
- AHSAGTANRYXCQG-UHFFFAOYSA-N CCCNCC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O AHSAGTANRYXCQG-UHFFFAOYSA-N 0.000 description 1
- HULFOBODHYIIPO-UHFFFAOYSA-N CCCNCC(N(CC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(CC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O HULFOBODHYIIPO-UHFFFAOYSA-N 0.000 description 1
- BMZJOJZWLAKNAS-UHFFFAOYSA-N CCCNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O BMZJOJZWLAKNAS-UHFFFAOYSA-N 0.000 description 1
- KOEKSVWBOUIWFH-UHFFFAOYSA-N CCCNCC(N(CCC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCCNCC(N(CCC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O KOEKSVWBOUIWFH-UHFFFAOYSA-N 0.000 description 1
- KXMIWJQYTSKTBQ-UHFFFAOYSA-N CCN(C(CN(C)CC(C)=C)=Nc1c2c(Cl)cc(Cl)c1O)C2=O Chemical compound CCN(C(CN(C)CC(C)=C)=Nc1c2c(Cl)cc(Cl)c1O)C2=O KXMIWJQYTSKTBQ-UHFFFAOYSA-N 0.000 description 1
- KFWKJDHIJGATSZ-UHFFFAOYSA-N CCN(C(CN(C)Cc(cc1)ccc1F)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CCN(C(CN(C)Cc(cc1)ccc1F)=Nc(c1c(cc2Cl)Cl)c2O)C1=O KFWKJDHIJGATSZ-UHFFFAOYSA-N 0.000 description 1
- NOQQNQFFDIFTQO-UHFFFAOYSA-N CCN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CCN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O NOQQNQFFDIFTQO-UHFFFAOYSA-N 0.000 description 1
- CNKGPAFKNZZBAV-UHFFFAOYSA-N CCN(C)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCN(C)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O CNKGPAFKNZZBAV-UHFFFAOYSA-N 0.000 description 1
- XMHARDLALAWSQZ-UHFFFAOYSA-N CCN(C)CC(N1CC2CC2)=Nc(c(O)c(cc2Cl)Cl)c2C1=O Chemical compound CCN(C)CC(N1CC2CC2)=Nc(c(O)c(cc2Cl)Cl)c2C1=O XMHARDLALAWSQZ-UHFFFAOYSA-N 0.000 description 1
- KFATUHDYSGZCED-UHFFFAOYSA-N CCN(CC)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCN(CC)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O KFATUHDYSGZCED-UHFFFAOYSA-N 0.000 description 1
- RVBUEZHQIRDXRZ-UHFFFAOYSA-N CCN(CC)CC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCN(CC)CC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O RVBUEZHQIRDXRZ-UHFFFAOYSA-N 0.000 description 1
- ZLPZMBJORYQBNY-UHFFFAOYSA-N CCN(CC)CC(N(CC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCN(CC)CC(N(CC)C(c1c(cc2Cl)Cl)=O)=Nc1c2O ZLPZMBJORYQBNY-UHFFFAOYSA-N 0.000 description 1
- VVHDWAYQKOKIKQ-UHFFFAOYSA-N CCN(CC)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCN(CC)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O VVHDWAYQKOKIKQ-UHFFFAOYSA-N 0.000 description 1
- XKMMFLLVUXPPFZ-UHFFFAOYSA-N CCN(CC)CC(N1C(C)C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O Chemical compound CCN(CC)CC(N1C(C)C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O XKMMFLLVUXPPFZ-UHFFFAOYSA-N 0.000 description 1
- YNQFEVJFALAYON-UHFFFAOYSA-N CCN1CCN(CC(N2CC3CC3)=Nc(c(O)c(cc3Cl)Cl)c3C2=O)CC1 Chemical compound CCN1CCN(CC(N2CC3CC3)=Nc(c(O)c(cc3Cl)Cl)c3C2=O)CC1 YNQFEVJFALAYON-UHFFFAOYSA-N 0.000 description 1
- JEIWCCMNYPULSB-UHFFFAOYSA-N CCNCC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCNCC(N(CC(C)C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O JEIWCCMNYPULSB-UHFFFAOYSA-N 0.000 description 1
- BCRYXRLIJACYSZ-UHFFFAOYSA-N CCNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CCNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O BCRYXRLIJACYSZ-UHFFFAOYSA-N 0.000 description 1
- NJXQKXBGAAHVGG-UHFFFAOYSA-N CCNCC(N1C(C)C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O Chemical compound CCNCC(N1C(C)C)=Nc(c(O)c(cc2Cl)Cl)c2C1=O NJXQKXBGAAHVGG-UHFFFAOYSA-N 0.000 description 1
- SFTVTKGFLJBYFG-UHFFFAOYSA-N CN(C(CCNCc(cc1)ccc1F)=Nc1c2c(Cl)cc(Cl)c1O)C2=O Chemical compound CN(C(CCNCc(cc1)ccc1F)=Nc1c2c(Cl)cc(Cl)c1O)C2=O SFTVTKGFLJBYFG-UHFFFAOYSA-N 0.000 description 1
- LEJSUWTWJXMDMB-UHFFFAOYSA-N CN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O Chemical compound CN(C(CN1CCCCC1)=Nc(c1c(cc2Cl)Cl)c2O)C1=O LEJSUWTWJXMDMB-UHFFFAOYSA-N 0.000 description 1
- GDGXLSJSTSGFEV-UHFFFAOYSA-N CN(CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C1CCCCC1 Chemical compound CN(CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C1CCCCC1 GDGXLSJSTSGFEV-UHFFFAOYSA-N 0.000 description 1
- XEIAMHREVTUBFA-UHFFFAOYSA-N CN(CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C1CCCCC1 Chemical compound CN(CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O)C1CCCCC1 XEIAMHREVTUBFA-UHFFFAOYSA-N 0.000 description 1
- VAYQVFDKVQAJPB-UHFFFAOYSA-N CN(Cc(cc1)ccc1F)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CN(Cc(cc1)ccc1F)CC(N(C)C(c1c(cc2Cl)Cl)=O)=Nc1c2O VAYQVFDKVQAJPB-UHFFFAOYSA-N 0.000 description 1
- YKIQAHVAJHBVST-UHFFFAOYSA-N CN(Cc(cc1)ccc1F)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CN(Cc(cc1)ccc1F)CC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O YKIQAHVAJHBVST-UHFFFAOYSA-N 0.000 description 1
- RFPVSWUKQINNQD-UHFFFAOYSA-N CNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O Chemical compound CNCC(N(CC1CC1)C(c1c(cc2Cl)Cl)=O)=Nc1c2O RFPVSWUKQINNQD-UHFFFAOYSA-N 0.000 description 1
- YZHMQTYOJJBLBC-UHFFFAOYSA-N Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCCC1)N(CC1=CC1)C2=O Chemical compound Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCCC1)N(CC1=CC1)C2=O YZHMQTYOJJBLBC-UHFFFAOYSA-N 0.000 description 1
- IHDZEPFAZVBGOS-UHFFFAOYSA-N Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCCCC1)N(CC1CC1)C2=O Chemical compound Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCCCC1)N(CC1CC1)C2=O IHDZEPFAZVBGOS-UHFFFAOYSA-N 0.000 description 1
- RCHGERUDZYTSJR-UHFFFAOYSA-N Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCOCC1)N(CC1CC1)C2=O Chemical compound Oc(c(Cl)cc(Cl)c12)c1N=C(CN1CCOCC1)N(CC1CC1)C2=O RCHGERUDZYTSJR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008906650 | 2008-12-24 | ||
| AU2008906650A AU2008906650A0 (en) | 2008-12-24 | Quinazolinone compounds | |
| PCT/AU2009/001701 WO2010071944A1 (en) | 2008-12-24 | 2009-12-23 | Quinazolinone compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015058888A Division JP2015143249A (ja) | 2008-12-24 | 2015-03-23 | キナゾリノン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513416A JP2012513416A (ja) | 2012-06-14 |
| JP2012513416A5 true JP2012513416A5 (cg-RX-API-DMAC10.html) | 2013-02-14 |
| JP5719779B2 JP5719779B2 (ja) | 2015-05-20 |
Family
ID=42286805
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542631A Expired - Fee Related JP5719779B2 (ja) | 2008-12-24 | 2009-12-23 | キナゾリノン化合物 |
| JP2015058888A Pending JP2015143249A (ja) | 2008-12-24 | 2015-03-23 | キナゾリノン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015058888A Pending JP2015143249A (ja) | 2008-12-24 | 2015-03-23 | キナゾリノン化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8889695B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2379510B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5719779B2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK2379510T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2634492T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010071944A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| PT2612862T (pt) | 2004-05-13 | 2016-12-15 | Icos Corp | Quinazolinonas como inibidores de fosfatidilinositol 3-quinase delta humana |
| WO2010057048A1 (en) | 2008-11-13 | 2010-05-20 | Calistoga Pharmaceuticals Inc. | Therapies for hematologic malignancies |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| WO2010071944A1 (en) * | 2008-12-24 | 2010-07-01 | Prana Biotechnology Limited | Quinazolinone compounds |
| AP2011005956A0 (en) * | 2009-04-20 | 2011-10-31 | Gilead Calistoga Llc | Methods of treatment for solid tumors. |
| AU2010276160A1 (en) | 2009-07-21 | 2012-02-09 | Gilead Calistoga Llc | Treatment of liver disorders with PI3K inhibitors |
| MD20140100A2 (ro) | 2012-03-05 | 2015-01-31 | Gilead Calistoga Llc | Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei |
| RU2642779C2 (ru) | 2012-12-27 | 2018-01-26 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы сомт |
| JP2017500319A (ja) | 2013-12-20 | 2017-01-05 | ギリアード カリストガ エルエルシー | （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態 |
| US9567337B2 (en) | 2013-12-20 | 2017-02-14 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| WO2015191726A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| CN104016929B (zh) * | 2014-06-25 | 2016-03-30 | 北京理工大学 | 一种合成喹唑啉-4(3h)-酮的方法 |
| WO2017027064A1 (en) | 2015-08-12 | 2017-02-16 | The General Hospital Corporation | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents |
| WO2025059726A1 (en) * | 2023-09-22 | 2025-03-27 | Alterity Therapeutics Limited | Novel therapy |
| WO2026020054A1 (en) * | 2024-07-18 | 2026-01-22 | Neumora Therapeutics, Inc. | Compounds and methods for treating neurological disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE507210T1 (de) * | 2002-03-07 | 2011-05-15 | X Ceptor Therapeutics Inc | Chinazolinon modulatoren von nukleinrezeptoren |
| MXPA05003607A (es) * | 2002-10-04 | 2005-11-17 | Prana Biotechnology Ltd | Compuestos neurologicamente activos. |
| ATE440825T1 (de) * | 2003-06-06 | 2009-09-15 | Vertex Pharma | Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern |
| EP1737831B1 (en) * | 2004-04-02 | 2013-05-22 | Prana Biotechnology Limited | Neurologically-active compounds |
| EP2012789B1 (en) | 2006-04-14 | 2013-09-25 | Prana Biotechnology Limited | Method of treatment of age-related macular degeneration (AMD) |
| ES2474865T3 (es) * | 2006-06-22 | 2014-07-09 | Prana Biotechnology Limited | Método de tratamiento de un tumor cerebral glioma |
| WO2008074068A1 (en) | 2006-12-20 | 2008-06-26 | Prana Biotechnology Limited | Substituted quinoline derivatives as antiamyloidogeneic agents |
| WO2010071944A1 (en) * | 2008-12-24 | 2010-07-01 | Prana Biotechnology Limited | Quinazolinone compounds |
-
2009
- 2009-12-23 WO PCT/AU2009/001701 patent/WO2010071944A1/en not_active Ceased
- 2009-12-23 EP EP09833944.3A patent/EP2379510B1/en active Active
- 2009-12-23 DK DK09833944.3T patent/DK2379510T3/en active
- 2009-12-23 US US13/142,162 patent/US8889695B2/en active Active
- 2009-12-23 ES ES09833944.3T patent/ES2634492T3/es active Active
- 2009-12-23 JP JP2011542631A patent/JP5719779B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-07 US US14/508,646 patent/US9145375B2/en active Active
-
2015
- 2015-03-23 JP JP2015058888A patent/JP2015143249A/ja active Pending
- 2015-08-21 US US14/832,130 patent/US20150359796A1/en not_active Abandoned