JP2010229084A - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP2010229084A JP2010229084A JP2009078733A JP2009078733A JP2010229084A JP 2010229084 A JP2010229084 A JP 2010229084A JP 2009078733 A JP2009078733 A JP 2009078733A JP 2009078733 A JP2009078733 A JP 2009078733A JP 2010229084 A JP2010229084 A JP 2010229084A
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- Prior art keywords
- extract
- acid
- viscosity
- oil
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
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- -1 acyl phosphatidylcholine Chemical compound 0.000 claims abstract description 29
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Abstract
【解決手段】アクリル系高分子化合物とジステアロイルホスファチジルコリンの含量が90質量%以上であるジ脂肪酸アシルホスファチジルコリンを含有することを特徴とする皮膚外用剤。
【選択図】図1
Description
皮膚外用剤の粘度を高める技術として、水溶性エチレン性不飽和モノマーをラジカル重合して得られる水膨潤性のミクロゲルと疎水変性ポリエーテルウレタンを配合することにより相乗的な増粘効果が得られることが知られている(特許文献1:特開2007−291026号公報)。しかしながら、更なる増粘技術が求められており、特に増粘剤として汎用されているアクリル系高分子化合物を用いて効果的に皮膚外用剤の粘度を高める技術が求められている。
本発明の主な構成は、次のとおりである。
1.アクリル系高分子化合物とジステアロイルホスファチジルコリンの含量が90質量%以上であるジ脂肪酸アシルホスファチジルコリンを含有することを特徴とする皮膚外用剤。
2.アクリル酸系高分子がカルボキシビニルポリマー又は(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体であることを特徴とする1に記載の皮膚外用剤。
3.ジ脂肪酸アシルホスファチジルコリンが全体の0.5〜1.0質量%であることを特徴とする1又は2記載の皮膚外用剤。
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体としては、例えばSEPPIC社のセピノブEMT10もしくは複合原料であるSEPPIC社のSIMULGEL NS((アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体、スクワラン、ポリソルベート、水)を用いることができる。
(アクリル酸Na/アクリロイルジメチルタウリン)共重合体としては、例えば、SEPPIC社の複合原料であるSIMULGEL EG((アクリル酸Na/アクリロイルジメチルタウリン)共重合体、イソヘキサデカン、ポリソルベート80、水)、SIMULGEL EPG((アクリル酸Na/アクリロイルジメチルタウリン)共重合体、ポリイソブテン、(カプリリル/カプリル)グルコシド、水)等を用いることができる。
ポリアクリルアミドとしては例えばSEPPIC社の複合原料であるセピゲル305(ポリアクリルアミド、水添ポリイソブテン、ラウレス−7、水)を用いることができる。 ポリアクリル酸Naとしては例えば東レ・ダウコーニング株式会社の複合原料であるRM2051 Thickening Agent(ポリアクリル酸Na、ジメチコン、シクロペンタシロキサン、トリデセス−6、PEG/PPG−18/18ジメチコン)等を用いることができる。
(アクリルアミド/アクリル酸アンモニウム)共重合体としてはSEPPIC社の複合原料であるSEPIPLUS 265((アクリルアミド/アクリル酸アンモニウム)共重合体、ポリイソブテン、ポリソルベート20、水)等を用いることができる。
非イオン界面活性剤としては、例えば、ソルビタン脂肪酸エステル類、ポリオキシエチレンソルビタン脂肪酸エステル類、ポリオキシエチレン硬化ヒマシ油類、ポリグリセリン脂肪酸エステル類、ショ糖脂肪酸エステル類、ポリオキシエチレンポリオキシプロピレンアルキルエーテル類等が挙げられる。
アニオン界面活性剤としては、例えば、ラウリン酸ナトリウム等の脂肪酸塩、ラウリル硫酸ナトリウム等の高級アルキル硫酸エステル塩、POEラウリル硫酸トリエタノールアミン等のアルキルエーテル硫酸エステル塩、N−アシルサルコシン酸、スルホコハク酸塩、N−アシルアミノ酸塩等が挙げられる。
カチオン界面活性剤としては、例えば、塩化ステアリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ベンザルコニウム、塩化ベンゼトニウム等が挙げられる。
両性界面活性剤としては、例えば、アルキルベタイン、アミドベタイン等のベタイン系界面活性剤等が挙げられる。
紫外線遮断剤として、例えば、酸化チタン、タルク、カルミン、ベントナイト、カオリン、酸化亜鉛等を挙げることができる。
1.試験溶液の調製
5種類のジ脂肪酸アシルホスファチジルコリン(PCと略記する。)
1.DSPC(ジステアロイルホスファチジルコリン)、
2.DSPC:DPPC=90:10(ジステアロイルホスファチジルコリン:ジパ ルミトイルホスファチジルコリン=90:10)、
3.DSPC:DPPC=80:20(ジステアロイルホスファチジルコリン:ジパ ルミトイルホスファチジルコリン=80:20)、
4.DPPC(ジパルミトイルホスファチジルコリン)、
5.S−10EX(水素添加大豆リン脂質 日光ケミカルズ株式会社製レシノールS −10EX)(ジ脂肪酸アシルホスファチジルコリンを含有する。)
を、最終濃度が0、0.0625、0.125、0.25、0.5、1質量%の濃度となるように、最終濃度10質量%のジプロピレングリコールに85℃以上で溶解し、室温まで冷却した。
カルボキシビニルポリマー(ハイビスワコー103)を、最終濃度0.24質量%、水酸化カリウムを最終濃度0.0216質量%となるように水に溶解し、先のジ脂肪酸アシルホスファチジルコリンのジプロピレングリコール溶液と混合し、水を添加して100質量%とした。
B型粘度計にて粘度を測定した。測定条件は、ローターNo.4、12rpm、30s、25±2℃とした。
試験溶液の粘度を表1に示す。ジ脂肪酸アシルホスファチジルコリンを配合しない試験溶液の粘度を100%としたときの粘度の百分率比を表2に示す。
ジステアロイルホスファチジルコリン:ジパルミトイルホスファチジルコリン=90:10を1質量%配合した場合でも、配合しないものと比べて百分率比で584%(6倍)に粘度が上昇した。
しかしながら、ジステアロイルホスファチジルコリン:ジパルミトイルホスファチジルコリン=80:20を1質量%配合した場合は、配合しないものと比べて百分率比で275%(3倍)に粘度が上昇した。
1.試験溶液の調製
5種類のジ脂肪酸アシルホスファチジルコリン(PCと略記する。)
1.DSPC(ジステアロイルホスファチジルコリン)、
2.DSPC:DPPC=90:10(ジステアロイルホスファチジルコリン:ジパ ルミトイルホスファチジルコリン=90:10)、
3.DSPC:DPPC=80:20(ジステアロイルホスファチジルコリン:ジパ ルミトイルホスファチジルコリン=80:20)、
4.DPPC(ジパルミトイルホスファチジルコリン)、
5.S−10EX(水素添加大豆リン脂質 日光ケミカルズ株式会社製レシノールS −10EX)(ジ脂肪酸アシルホスファチジルコリンを含有する。)
を、最終濃度が0、0.0625、0.125、0.25、0.5、1質量%の濃度となるように、最終濃度10質量%のジプロピレングリコールに85℃以上で溶解し、室温まで冷却した。
(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体(セピノブEMT10)を、最終濃度0.6質量%となるように水に溶解し、先のジ脂肪酸アシルホスファチジルコリンのジプロピレングリコール溶液と混合し、水を添加して100質量%とした。
B型粘度計にて粘度を測定した。測定条件は、ローターNo.4、12rpm、30s、25±2℃とした。
試験溶液の粘度を表3に示す。ジ脂肪酸アシルホスファチジルコリンを配合しない試験溶液の粘度を100%としたときの粘度の百分率比を表4に示す。
ジステアロイルホスファチジルコリン:ジパルミトイルホスファチジルコリン=90:10を1質量%配合した場合でも、配合しないものと比べて百分率比で392%(4倍)に粘度が上昇した。
しかしながら、ジステアロイルホスファチジルコリン:ジパルミトイルホスファチジルコリン=80:20を1質量%配合した場合は、配合しないものと比べて百分率比で132%(1.3倍)の粘度であり、粘度は殆ど上昇しなかった。
成分 配合量(質量%)
1.ジステアロイルホスファチジルコリン 0.5
2.水素添加大豆リン脂質 0.05
3.カルボキシビニルポリマー 0.05
4.(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体 0.35
5.水酸化カリウム 0.01
6.グリセリン 5
7.1,3−ブチレングリコール 5.5
8.ジプロピレングリコール 5
9.ラフィノース 2
10.トリメチルグリシン 2
11.PEG−75 0.5
12.ジステアリン酸ポリグリセリル−9 0.3
13.ステアリン酸ポリグリセリル−10 0.5
14.スクワラン 3
15.ホホバ油 2
16.ジメチコン 0.5
17.精製水 残余
Claims (3)
- アクリル系高分子化合物とジステアロイルホスファチジルコリンの含量が90質量%以上であるジ脂肪酸アシルホスファチジルコリンを含有することを特徴とする皮膚外用剤。
- アクリル酸系高分子がカルボキシビニルポリマー又は(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)共重合体であることを特徴とする請求項1に記載の皮膚外用剤。
- ジ脂肪酸アシルホスファチジルコリンが全体の0.5〜1.0質量%であることを特徴とする請求項1又は2記載の皮膚外用剤。
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Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63277691A (ja) * | 1987-02-26 | 1988-11-15 | インデナ エス.ピー.エー. | サポニンとりん脂質との複合体及びそれらを含有する薬学的及び化粧用の組成物 |
JPH01100132A (ja) * | 1987-07-10 | 1989-04-18 | Indena Spa | フラバノリグナンとリン脂質との錯体を含有する薬用及び化粧用組成物 |
JPH01299292A (ja) * | 1988-05-26 | 1989-12-04 | Q P Corp | リン脂質誘導体 |
JPH0248528A (ja) * | 1988-07-26 | 1990-02-19 | Indena Spa | 血管運動作用を有する化粧用組成物 |
JPH02502907A (ja) * | 1987-04-06 | 1990-09-13 | ベスター・インコーポレイテッド | 治療剤を腹膜内投与するためのリポソーム小胞 |
JP2002322026A (ja) * | 2001-04-23 | 2002-11-08 | Fancl Corp | 水中油型化粧料 |
EP1304160A1 (de) * | 2001-10-19 | 2003-04-23 | Novosom AG | Stabilisierte Mischungen von Liposomen und Emulsionen |
JP2007314442A (ja) * | 2006-05-24 | 2007-12-06 | Shiseido Co Ltd | 水中油型乳化化粧料 |
JP2008007430A (ja) * | 2006-06-27 | 2008-01-17 | Kracie Home Products Kk | ゲル状化粧料及びその製造方法 |
JP2008231056A (ja) * | 2007-03-22 | 2008-10-02 | Fancl Corp | 乳化化粧料 |
JP2008291014A (ja) * | 2007-04-27 | 2008-12-04 | Fancl Corp | 乳液状化粧料 |
-
2009
- 2009-03-27 JP JP2009078733A patent/JP5476013B2/ja active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63277691A (ja) * | 1987-02-26 | 1988-11-15 | インデナ エス.ピー.エー. | サポニンとりん脂質との複合体及びそれらを含有する薬学的及び化粧用の組成物 |
JPH02502907A (ja) * | 1987-04-06 | 1990-09-13 | ベスター・インコーポレイテッド | 治療剤を腹膜内投与するためのリポソーム小胞 |
JPH01100132A (ja) * | 1987-07-10 | 1989-04-18 | Indena Spa | フラバノリグナンとリン脂質との錯体を含有する薬用及び化粧用組成物 |
JPH01299292A (ja) * | 1988-05-26 | 1989-12-04 | Q P Corp | リン脂質誘導体 |
JPH0248528A (ja) * | 1988-07-26 | 1990-02-19 | Indena Spa | 血管運動作用を有する化粧用組成物 |
JP2002322026A (ja) * | 2001-04-23 | 2002-11-08 | Fancl Corp | 水中油型化粧料 |
EP1304160A1 (de) * | 2001-10-19 | 2003-04-23 | Novosom AG | Stabilisierte Mischungen von Liposomen und Emulsionen |
JP2007314442A (ja) * | 2006-05-24 | 2007-12-06 | Shiseido Co Ltd | 水中油型乳化化粧料 |
JP2008007430A (ja) * | 2006-06-27 | 2008-01-17 | Kracie Home Products Kk | ゲル状化粧料及びその製造方法 |
JP2008231056A (ja) * | 2007-03-22 | 2008-10-02 | Fancl Corp | 乳化化粧料 |
JP2008291014A (ja) * | 2007-04-27 | 2008-12-04 | Fancl Corp | 乳液状化粧料 |
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