JPWO2020111067A1 - 脂肪族アルコールとグリセリンとのエーテルを含む組成物 - Google Patents
脂肪族アルコールとグリセリンとのエーテルを含む組成物 Download PDFInfo
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- JPWO2020111067A1 JPWO2020111067A1 JP2020557740A JP2020557740A JPWO2020111067A1 JP WO2020111067 A1 JPWO2020111067 A1 JP WO2020111067A1 JP 2020557740 A JP2020557740 A JP 2020557740A JP 2020557740 A JP2020557740 A JP 2020557740A JP WO2020111067 A1 JPWO2020111067 A1 JP WO2020111067A1
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- ZCQJTYXMYDQDLF-UHFFFAOYSA-M potassium iodide hydroiodide Chemical compound I.I[K] ZCQJTYXMYDQDLF-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229920005653 propylene-ethylene copolymer Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008171 pumpkin seed oil Substances 0.000 description 1
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- 239000011674 pyridoxal Substances 0.000 description 1
- FCHXJFJNDJXENQ-UHFFFAOYSA-N pyridoxal hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(C=O)=C1O FCHXJFJNDJXENQ-UHFFFAOYSA-N 0.000 description 1
- PFIPZKASKUWLHH-UHFFFAOYSA-N pyridoxamine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CN)=C1O PFIPZKASKUWLHH-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 231100000475 skin irritation Toxicity 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
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- 229960005055 sodium ascorbate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
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- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
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- IWLROWZYZPNOFC-UHFFFAOYSA-N thiamine(1+) triphosphate(1-) Chemical compound CC1=C(CCOP(O)(=O)OP(O)(=O)OP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N IWLROWZYZPNOFC-UHFFFAOYSA-N 0.000 description 1
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- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 229920001862 ultra low molecular weight polyethylene Polymers 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
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- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
Description
例えば、特開2000−191488号公報(特許文献1)には、特定の防臭化粧料組成物を構成する界面活性剤として、アルキルグリセリルエーテルを挙げている。
[1]
(A)脂肪族アルコールとグリセリンとのエーテル及び/又は(B)アシルグルタミン酸リシン塩[通常、少なくとも(A)脂肪族アルコールとグリセリンとのエーテル、特に(A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩]を含有する組成物。
[2]
(A)成分が、グリセリンモノ−2−エチルへキシルエーテルであり、(B)成分がジラウロイルグルタミン酸リシン塩である、[1]記載の組成物。
[3]
(A)成分の割合が、0.5質量%未満である[1]又は[2]記載の組成物。
[4]
(B)成分の割合が、1質量%以下である[1]〜[3]のいずれかに記載の組成物。
[5]
(B)成分の割合が、(A)成分1質量部に対して、0.05質量部超である[1]〜[4]のいずれかに記載の組成物。
[6]
(A)成分の割合が0.5質量%未満であり、(B)成分の割合が、(A)成分1質量部に対して0.05質量部を超えて100質量部以下である[1]〜[5]のいずれかに記載の組成物。
[7]
さらに、(C)水溶性成分を含む[1]〜[6]のいずれかに記載の組成物。
[8]
(C)成分が、logP値が0以下及び分子量1000以下を充足する[7]記載の組成物。
[9]
(C)成分が水溶性美白成分を含む[7]又は[8]記載の組成物。
[10]
(C)成分が、アスコルビン酸類、トラネキサム酸類、イプシロンアミノカプロン酸類、ハイドロキノン類、ニコチン酸アミド類、グリチルリチン酸類、アラントイン類、及びリボフラビン類から選択された少なくとも1種を含む、[7]〜[9]のいずれかに記載の組成物。
[11]
(C)成分が、アスコルビン酸、アスコルビン酸リン酸エステル、アスコルビン酸アルキル、アスコルビン酸−2−グルコシド、トラネキサム酸、イプシロンアミノカプロン酸、ハイドロキノン、アルブチン、ニコチン酸アミド、グリチルリチン酸、アラントイン、リボフラビン、及びこれらの塩から選択された少なくとも1種を含む、[7]〜[10]のいずれかに記載の組成物。
[12]
(C)成分の割合が、0.05質量%以上である[7]〜[11]のいずれかに記載の組成物。
[13]
リーブオン化粧料用である[1]〜[12]のいずれかに記載の組成物。
[14]
(A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性を向上するための剤であって、(B)アシルグルタミン酸リシン塩を含有する剤。
[15]
(C)水溶性成分の経皮吸収性を向上するための剤であって、(A)脂肪族アルコールとグリセリンとのエーテル又は(B)アシルグルタミン酸リシン塩を含有する剤。
[16]
(C)水溶性成分の経皮吸収性を向上するための剤であって、(A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩を含有する剤。
[17]
(A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性を向上する方法であって、(A)脂肪族アルコールとグリセリンとのエーテルと、(B)アシルグルタミン酸リシン塩を共存させる方法。
[18]
(C)水溶性成分の経皮吸収性を向上する方法であって、(C)水溶性成分と、(A)脂肪族アルコールとグリセリンとのエーテル又は(B)アシルグルタミン酸リシン塩とを共存させる方法。
[19]
(C)水溶性成分の経皮吸収性を向上する方法であって、(C)水溶性成分と、(A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩とを共存させる方法。
本発明の組成物は、(A)脂肪族アルコールとグリセリンのエーテル及び(B)アシルグルタミン酸リシン塩から選択された少なくとも1種を含有する。特に、本発明の組成物は、(A)脂肪族アルコールとグリセリンのエーテル及び(B)アシルグルタミン酸リシン塩を含有してもよい。
脂肪族アルコールは、鎖状又は分岐状アルコールであってもよく、飽和又は不飽和アルコールであってもよい。
本発明の組成物は、水溶性成分を含んでいてもよい。上記のように、本発明の組成物は、通常、(A)脂肪族アルコールとグリセリンのエーテル及び/又は(B)アシルグルタミン酸リシン塩を含有するが、このような成分[(A)成分及び/又は(B)成分(例えば、少なくとも(A)成分、特に(A)成分及び(B)成分)]と水溶性成分を組み合わせることで、水溶性成分の機能を効率よく発揮しうる。
とりわけ、水溶性成分(例えば、後述のアスコルビン酸類、トラネキサム酸類などの水溶性美白成分)は、皮膚への透過性が低く、なかなか目的部位まで到達することができない場合も多い。
そのため、水溶性成分の機能(美白効果等)を水性の外皮用組成物において効率よく発揮させるべく、(C)成分を含有する組成物は、特に、(A)成分及び(B)成分の双方を含んでいてもよい。
logP値は、例えば、日本工業規格Z7260−107(2000)「分配係数(1−オクタノール/水)の測定−フラスコ振とう法」に従って、測定(決定、算出)してもよい。
水溶性成分の分子量(化学式量)の下限値は、特に限定されず、例えば、50、70、80、90、100、110、120、130、140,150などであってもよい。
本発明では、前記のように、水溶性成分を効率よく経皮吸収しうるため、このような機能を効率よく発揮しうる。
本発明の組成物は、必要に応じて、有効成分を含んでいてもよい。有効成分の具体例としては、例えば、保湿成分、抗炎症成分、抗菌成分、ビタミン類、ペプチド又はその誘導体、アミノ酸又はその誘導体、細胞賦活化成分、老化防止成分、血行促進成分、角質軟化成分、美白成分、収斂成分、紫外線防御成分などが挙げられる。
本発明では、このような有効成分を含んでいても、前記(A)〜(C)成分の機能を有効に発揮しうる。
なお、有効成分は、(C)成分に該当する成分であってもよく、該当しない成分であってもよい。
本発明の組成物は、必要に応じて、添加剤、例えば、界面活性剤、酸化防止剤、防腐剤、増粘剤、pH調整剤、緩衝剤、等張化剤、増粘剤又は粘稠化剤、油分、安定化剤、刺激軽減剤、着色剤、香料、キレート剤等を含んでいてもよい。
本発明では、このような添加剤を含んでいても、前記(A)〜(C)成分の機能を有効に発揮しうる。
なお、添加剤は、(C)成分に該当する成分であってもよく、該当しない成分であってもよい。
なお、常温(25℃)における油分の性状は、固体状、液体状、半固形状、ペースト状(例えば、30℃の粘度が5000〜100000mPa・s程度のもの)等であってもよい。また、本発明の組成物は、このような油分[例えば、ペースト状の油分(ペースト油)]を含んでいてもよく、含んでいなくてもよい。このような油分を含む場合、組成物における割合は、特に限定されず、15質量%未満、10質量%以下(例えば、10質量%未満)などであってもよい。
本発明の組成物は、通常、基剤又は担体を含んでいてもよい。
基剤又は担体は、1種を単独で、又は2種以上を組み合わせて使用できる。
このように、本発明によれば、高品質な水性組成物を効率よく得ることができる。
本発明の組成物のpHは、例えば、2〜10、好ましくは2.5〜9、さらに好ましくは3〜8程度であってもよい。
本発明の組成物は、上記各成分(例えば、(A)〜(B)成分及び基剤又は担体を少なくとも含む組成物、(A)成分及び基剤又は担体を少なくとも含む組成物、(A)〜(C)成分及び基剤又は担体を少なくとも含む組成物等)を混合することにより調製できる。
粘度は、例えば、回転粘度計(RB80L型粘度計、東機産業社製)を用いて25℃において測定できる。
本発明の組成物は、容器に収容(充填、注入、封入)されていてもよい。
容器は、組成物(製剤)と接触する部分(面)を有する包装体であればよく、例えば、組成物(例えば、液状の組成物)を収容する容器本体部分、容器の抽出口を含む部分(ノズル、中栓)、吸い上げチューブ、キャップなどで構成されていてもよい。
本発明の組成物は、使用対象の皮膚の状態、年齢、性別などによって異なるが、例えば以下のような方法で使用しうる。
例えば、組成物((C)水溶性成分を含む組成物等)は、1日1回又は複数回(例えば、約1〜5回、好ましくは1〜3回)、適量(例えば、約0.05〜10g)を皮膚に塗布してもよい。また、(C)水溶性成分(VCエチル、トラネキサム酸等)の1日使用量が、好ましくは約0.01〜500mg、より好ましくは約0.2〜200mgとなるように組成物を塗布してもよい。塗布期間は、例えば、約1〜14日間、好ましくは約3〜14日間であってもよい。
本発明の一態様では、組成物において(A)成分の溶解性又は分散性を向上(又は改善)しうる。
(A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性を向上(又は改善又は補助)する方法であって、(A)脂肪族アルコールとグリセリンとのエーテルと、(B)アシルグルタミン酸リシン塩を共存させる方法[又は(A)脂肪族アルコールとグリセリンとのエーテルを含む組成物(例えば、水を含む組成物)に、(B)アシルグルタミン酸リシン塩を含有(共存)させる方法]。
(A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性(特に、水を含む溶媒に対する溶解性又は分散性)を向上(又は改善又は補助)するための剤であって、(B)アシルグルタミン酸リシン塩を含有する剤(溶解性向上剤、分散性向上剤、溶解補助剤、分散補助剤)。
本発明の一態様では、(C)水溶性成分の経皮吸収性(皮膚浸透性)を向上(又は改善)しうる。
(C)水溶性成分の経皮吸収性を向上(又は改善又は補助)する方法であって、(C)水溶性成分と、(A)脂肪族アルコールとグリセリンとのエーテル及び/又は(B)アシルグルタミン酸リシン塩とを共存させる方法[又は(C)水溶性成分を含む組成物に、(A)脂肪族アルコールとグリセリンとのエーテル及び/又は(B)アシルグルタミン酸リシン塩を含有(共存)させる方法]。
(C)水溶性成分の経皮吸収性を向上(又は改善又は補助)するための剤であって、(A)脂肪族アルコールとグリセリンとのエーテル及び/又は(B)アシルグルタミン酸リシン塩を含有する剤(経皮吸収向上又は改善剤、経皮吸収剤、経皮吸収促進剤、経皮吸収補助剤、経皮吸収調節剤)。
下記表に示す成分を、70℃で5分間、加熱混合して組成物を調製した。そして、調製した組成物を室温にて透明ガラス瓶に充填し、組成物の状態を目視にて観察した。
下記表に示す組成の組成物を調製した。
その後専用のアッセイ培地を0.5mLPBSに置き換え、37度の恒温槽上で30分間プレインキュベーションした。さらにPBSを同量のフレッシュなPBSに置き換え、細胞の上部に直接薬液を0.3mL加え、薬液を加えた時間をゼロとした。
その後、360分までの所定時間経過後に経時的に下部から0.1mLの薬液をサンプリングし、その後速やかに同量のPBSを加えた。サンプリングした薬液はHPLCを用いて定量し、下式に基づいて透過係数(P)を算出した。
下記表に示す組成の組成物を調製し、試験例2と同様にして、VCエチル(3−O−エチルアスコルビン酸)の透過性を評価した。
下記表に示す組成の組成物を調製し、試験例2と同様にして、種々の(C)水溶性成分の透過性を評価した。
下記表に示す組成の組成物を調製し、試験例2と同様にして、ニコチン酸アミドの透過性を評価した。
なお、透過係数(Pc)は、試験例5C〜5Dについては試験例5Aの透過係数(Pc)を、試験例5E〜5Gについては試験例5Bの透過係数(Pc)を、それぞれ用いてERとした。
以下の表に記載の処方に従い、組成物を調製した。なお、下記の表において、各成分の単位は(質量%)である。
Claims (19)
- (A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩を含有する組成物。
- (A)成分がグリセリンモノ−2−エチルへキシルエーテルであり、(B)成分がジラウロイルグルタミン酸リシン塩である、請求項1記載の組成物。
- (A)成分の割合が、0.5質量%未満である請求項1又は2記載の組成物。
- (B)成分の割合が、1質量%以下である請求項1〜3のいずれかに記載の組成物。
- (B)成分の割合が、(A)成分1質量部に対して、0.05質量部超である請求項1〜4のいずれかに記載の組成物。
- (A)成分の割合が0.5質量%未満であり、(B)成分の割合が(A)成分1質量部に対して0.05質量部を超えて100質量部以下である請求項1〜5のいずれかに記載の組成物。
- さらに、(C)水溶性成分を含む請求項1〜6のいずれかに記載の組成物。
- (C)成分が、logP値が0以下及び分子量1000以下を充足する請求項7記載の組成物。
- (C)成分が水溶性美白成分を含む請求項7又は8記載の組成物。
- (C)成分が、アスコルビン酸類、トラネキサム酸類、イプシロンアミノカプロン酸類、ハイドロキノン類、ニコチン酸アミド類、グリチルリチン酸類、アラントイン類、及びリボフラビン類から選択された少なくとも1種を含む、請求項7〜9のいずれかに記載の組成物。
- (C)成分が、アスコルビン酸、アスコルビン酸リン酸エステル、アスコルビン酸アルキル、アスコルビン酸−2−グルコシド、トラネキサム酸、イプシロンアミノカプロン酸、ハイドロキノン、アルブチン、ニコチン酸アミド、グリチルリチン酸、アラントイン、リボフラビン、及びこれらの塩から選択された少なくとも1種を含む、請求項7〜10のいずれかに記載の組成物。
- (C)成分の割合が、0.05質量%以上である請求項7〜11のいずれかに記載の組成物。
- リーブオン化粧料用である請求項1〜12のいずれかに記載の組成物。
- (A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性を向上するための剤であって、(B)アシルグルタミン酸リシン塩を含有する剤。
- (C)水溶性成分の経皮吸収性を向上するための剤であって、(A)脂肪族アルコールとグリセリンとのエーテル又は(B)アシルグルタミン酸リシン塩を含有する剤。
- (C)水溶性成分の経皮吸収性を向上するための剤であって、(A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩を含有する剤。
- (A)脂肪族アルコールとグリセリンとのエーテルの溶解性又は分散性を向上する方法であって、(A)脂肪族アルコールとグリセリンとのエーテルと、(B)アシルグルタミン酸リシン塩を共存させる方法。
- (C)水溶性成分の経皮吸収性を向上する方法であって、(C)水溶性成分と、(A)脂肪族アルコールとグリセリンとのエーテル又は(B)アシルグルタミン酸リシン塩とを共存させる方法。
- (C)水溶性成分の経皮吸収性を向上する方法であって、(C)水溶性成分と、(A)脂肪族アルコールとグリセリンとのエーテル及び(B)アシルグルタミン酸リシン塩とを共存させる方法。
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