JP2010180207A5 - - Google Patents
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- JP2010180207A5 JP2010180207A5 JP2010026299A JP2010026299A JP2010180207A5 JP 2010180207 A5 JP2010180207 A5 JP 2010180207A5 JP 2010026299 A JP2010026299 A JP 2010026299A JP 2010026299 A JP2010026299 A JP 2010026299A JP 2010180207 A5 JP2010180207 A5 JP 2010180207A5
- Authority
- JP
- Japan
- Prior art keywords
- process according
- amino acid
- acid changes
- immunoglobulin
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 10
- 108060003951 Immunoglobulin Proteins 0.000 claims 7
- 102000018358 immunoglobulin Human genes 0.000 claims 7
- 241000725643 Respiratory syncytial virus Species 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17842600P | 2000-01-27 | 2000-01-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561064A Division JP4992068B2 (ja) | 2000-01-27 | 2001-01-26 | 超高親和性中和抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010180207A JP2010180207A (ja) | 2010-08-19 |
| JP2010180207A5 true JP2010180207A5 (https=) | 2010-11-11 |
Family
ID=22652515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561064A Expired - Fee Related JP4992068B2 (ja) | 2000-01-27 | 2001-01-26 | 超高親和性中和抗体 |
| JP2010026299A Pending JP2010180207A (ja) | 2000-01-27 | 2010-02-09 | 超高親和性中和抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561064A Expired - Fee Related JP4992068B2 (ja) | 2000-01-27 | 2001-01-26 | 超高親和性中和抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6656467B2 (https=) |
| EP (2) | EP2289550A3 (https=) |
| JP (2) | JP4992068B2 (https=) |
| AT (1) | ATE474854T1 (https=) |
| AU (2) | AU785038B2 (https=) |
| CA (1) | CA2398466A1 (https=) |
| CY (1) | CY1111542T1 (https=) |
| DE (1) | DE60142614D1 (https=) |
| DK (1) | DK1265928T3 (https=) |
| ES (1) | ES2349348T3 (https=) |
| PT (1) | PT1265928E (https=) |
| WO (1) | WO2001055217A1 (https=) |
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| US6855493B2 (en) * | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
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| US8852608B2 (en) | 2009-02-02 | 2014-10-07 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
| JP5762408B2 (ja) | 2009-08-13 | 2015-08-12 | クルセル ホランド ベー ヴェー | ヒト呼吸器合胞体ウイルス（ｒｓｖ）に対する抗体および使用方法 |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| BR112012031638B1 (pt) | 2010-07-09 | 2021-01-12 | Janssen Vaccines & Prevention B.V. | anticorpo anti-rsv ou fragmento de ligação de antígeno do mesmo, anticorpo multivalente, composição farmacêutica, uso de anticorpo ou fragmento de ligação de antígeno, método de detectar infecção por rsv, e, ácido nucleico isolado |
| CN109776676A (zh) | 2012-11-28 | 2019-05-21 | Cnj控股公司 | 针对艰难梭菌的抗体 |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| WO2017027858A1 (en) | 2015-08-12 | 2017-02-16 | The Trustees Of Columbia University In The City Of New York | Methods of treating volume depletion and kidney injury |
| PT3387019T (pt) * | 2015-12-09 | 2022-01-14 | Scripps Research Inst | Proteínas de fusão de imunoglobulina de relaxina e métodos de uso |
| CN110035771B (zh) | 2016-10-21 | 2024-03-08 | 阿迪马布有限责任公司 | 抗呼吸道合胞病毒抗体及其产生和使用方法 |
| AU2017345786B2 (en) | 2016-10-21 | 2024-08-01 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11479600B2 (en) | 2016-10-21 | 2022-10-25 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| CN115811987A (zh) | 2020-03-18 | 2023-03-17 | 纪念斯隆凯特琳癌症中心 | 抗神经酰胺抗体 |
| WO2021202463A1 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Anti-rsv antibodies |
| WO2025104604A1 (en) | 2023-11-14 | 2025-05-22 | Janssen Pharmaceuticals, Inc. | Anti-respiratory syncytial virus antibodies and uses thereof |
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-
2001
- 2001-01-26 EP EP10007381A patent/EP2289550A3/en not_active Withdrawn
- 2001-01-26 CA CA002398466A patent/CA2398466A1/en not_active Abandoned
- 2001-01-26 JP JP2001561064A patent/JP4992068B2/ja not_active Expired - Fee Related
- 2001-01-26 PT PT01903352T patent/PT1265928E/pt unknown
- 2001-01-26 WO PCT/US2001/002618 patent/WO2001055217A1/en not_active Ceased
- 2001-01-26 US US09/771,415 patent/US6656467B2/en not_active Expired - Fee Related
- 2001-01-26 EP EP01903352A patent/EP1265928B1/en not_active Expired - Lifetime
- 2001-01-26 DK DK01903352.1T patent/DK1265928T3/da active
- 2001-01-26 AT AT01903352T patent/ATE474854T1/de active
- 2001-01-26 AU AU31180/01A patent/AU785038B2/en not_active Ceased
- 2001-01-26 DE DE60142614T patent/DE60142614D1/de not_active Expired - Lifetime
- 2001-01-26 ES ES01903352T patent/ES2349348T3/es not_active Expired - Lifetime
-
2003
- 2003-09-08 US US10/657,363 patent/US7740851B2/en not_active Expired - Fee Related
-
2010
- 2010-02-09 JP JP2010026299A patent/JP2010180207A/ja active Pending
- 2010-03-19 AU AU2010201090A patent/AU2010201090B2/en not_active Ceased
- 2010-05-11 US US12/777,814 patent/US20100266614A1/en not_active Abandoned
- 2010-10-21 CY CY20101100947T patent/CY1111542T1/el unknown
-
2011
- 2011-10-24 US US13/279,592 patent/US20120135006A1/en not_active Abandoned
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