CA2398466A1 - Ultra high affinity neutralizing antibodies - Google Patents

Ultra high affinity neutralizing antibodies Download PDF

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Publication number
CA2398466A1
CA2398466A1 CA002398466A CA2398466A CA2398466A1 CA 2398466 A1 CA2398466 A1 CA 2398466A1 CA 002398466 A CA002398466 A CA 002398466A CA 2398466 A CA2398466 A CA 2398466A CA 2398466 A1 CA2398466 A1 CA 2398466A1
Authority
CA
Canada
Prior art keywords
immunoglobulin
high affinity
cdr
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002398466A
Other languages
English (en)
French (fr)
Inventor
James F. Young
Scott Koenig
Leslie S. Johnson
William D. Huse
Herren Wu
Jeffry D. Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Applied Molecular Evolution Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2398466A1 publication Critical patent/CA2398466A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicinal Preparation (AREA)
CA002398466A 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies Abandoned CA2398466A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17842600P 2000-01-27 2000-01-27
US60/178,426 2000-01-27
PCT/US2001/002618 WO2001055217A1 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies

Publications (1)

Publication Number Publication Date
CA2398466A1 true CA2398466A1 (en) 2001-08-02

Family

ID=22652515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002398466A Abandoned CA2398466A1 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies

Country Status (12)

Country Link
US (4) US6656467B2 (https=)
EP (2) EP2289550A3 (https=)
JP (2) JP4992068B2 (https=)
AT (1) ATE474854T1 (https=)
AU (2) AU785038B2 (https=)
CA (1) CA2398466A1 (https=)
CY (1) CY1111542T1 (https=)
DE (1) DE60142614D1 (https=)
DK (1) DK1265928T3 (https=)
ES (1) ES2349348T3 (https=)
PT (1) PT1265928E (https=)
WO (1) WO2001055217A1 (https=)

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US20120135006A1 (en) 2012-05-31
EP1265928A1 (en) 2002-12-18
WO2001055217A1 (en) 2001-08-02
DE60142614D1 (de) 2010-09-02
CY1111542T1 (el) 2015-08-05
JP2003528052A (ja) 2003-09-24
US7740851B2 (en) 2010-06-22
EP2289550A3 (en) 2012-02-15
AU785038C (en) 2001-08-07
ES2349348T3 (es) 2010-12-30
AU785038B2 (en) 2006-08-31
ATE474854T1 (de) 2010-08-15
DK1265928T3 (da) 2010-11-15
EP2289550A2 (en) 2011-03-02
EP1265928B1 (en) 2010-07-21
US6656467B2 (en) 2003-12-02
US20040131609A1 (en) 2004-07-08
AU3118001A (en) 2001-08-07
PT1265928E (pt) 2010-09-30
US20100266614A1 (en) 2010-10-21
US20020164326A1 (en) 2002-11-07
JP2010180207A (ja) 2010-08-19

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