JP2010116337A - 安定なエグアレンナトリウム固形製剤 - Google Patents
安定なエグアレンナトリウム固形製剤 Download PDFInfo
- Publication number
- JP2010116337A JP2010116337A JP2008289702A JP2008289702A JP2010116337A JP 2010116337 A JP2010116337 A JP 2010116337A JP 2008289702 A JP2008289702 A JP 2008289702A JP 2008289702 A JP2008289702 A JP 2008289702A JP 2010116337 A JP2010116337 A JP 2010116337A
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- Japan
- Prior art keywords
- sodium
- solid preparation
- eguarene
- weight
- basic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 239000007787 solid Substances 0.000 title claims abstract description 33
- 229950005370 egualen Drugs 0.000 title claims abstract description 16
- NARQSHREEUXZBT-UHFFFAOYSA-N egualen Chemical compound C1=C(C(C)C)C=CC=C2C(CC)=CC(S(O)(=O)=O)=C21 NARQSHREEUXZBT-UHFFFAOYSA-N 0.000 title claims abstract description 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000000654 additive Substances 0.000 claims abstract description 30
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 20
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 20
- 230000000996 additive effect Effects 0.000 claims abstract description 19
- 229940069328 povidone Drugs 0.000 claims abstract description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000011261 inert gas Substances 0.000 claims abstract description 15
- 229960000913 crospovidone Drugs 0.000 claims abstract description 14
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims abstract description 14
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 8
- 239000004475 Arginine Substances 0.000 claims abstract description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004472 Lysine Substances 0.000 claims abstract description 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000002484 inorganic compounds Chemical class 0.000 claims abstract description 7
- 229910010272 inorganic material Inorganic materials 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 5
- 239000006185 dispersion Substances 0.000 claims abstract description 5
- 150000002894 organic compounds Chemical class 0.000 claims abstract description 5
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims abstract description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims abstract description 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract description 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims abstract description 4
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 4
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims abstract description 4
- 239000001095 magnesium carbonate Substances 0.000 claims abstract description 4
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims abstract description 4
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims abstract description 4
- 239000000347 magnesium hydroxide Substances 0.000 claims abstract description 4
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims abstract description 4
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 4
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 4
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229960003104 ornithine Drugs 0.000 claims abstract description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 4
- 239000011734 sodium Substances 0.000 claims description 66
- 229910052708 sodium Inorganic materials 0.000 claims description 66
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 65
- 239000000126 substance Substances 0.000 claims description 17
- 238000003860 storage Methods 0.000 abstract description 9
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 230000001747 exhibiting effect Effects 0.000 abstract 3
- 239000003826 tablet Substances 0.000 description 27
- 239000008187 granular material Substances 0.000 description 15
- 239000007857 degradation product Substances 0.000 description 13
- -1 magnesium aluminate Chemical class 0.000 description 13
- 238000000034 method Methods 0.000 description 13
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- 239000000243 solution Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
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- 230000000052 comparative effect Effects 0.000 description 10
- KXGWXVVNYQOMQZ-UHFFFAOYSA-M egualen sodium Chemical compound [Na+].C1=C(C(C)C)C=CC=C2C(CC)=CC(S([O-])(=O)=O)=C21 KXGWXVVNYQOMQZ-UHFFFAOYSA-M 0.000 description 10
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
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- 239000000843 powder Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- 229920000881 Modified starch Polymers 0.000 description 5
- 239000000314 lubricant Substances 0.000 description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 208000007107 Stomach Ulcer Diseases 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 4
- 229950008138 carmellose Drugs 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 201000005917 gastric ulcer Diseases 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 229960003511 macrogol Drugs 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
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- 238000006731 degradation reaction Methods 0.000 description 3
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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Abstract
【解決手段】ポビドン及びその誘導体並びに塩基性を有する添加物から選択される一種以上の添加物を配合してなるエグアレンナトリウム固形製剤である。ポビドン誘導体は、クロスポビドンが好ましい。塩基性を有する添加物は、炭酸マグネシウム、炭酸カルシウム、水酸化マグネシウム、酸化マグネシウム、炭酸ナトリウム、炭酸水素ナトリウム及び水酸化ナトリウムから選ばれた塩基性無機化合物、或いはアルギニン、リジン、ヒスチジン及びオルニチンから選ばれた塩基性有機化合物が好ましい。また、本発明は、固形製剤を水に1W/V%濃度に分散させたときの水分散液のpHが7以上になるに十分な量の塩基性を有する添加物を配合してなるエグアレンナトリウム固形製剤である。また、本発明は、不活性ガス置換包装されてなるエグアレンナトリウム固形製剤である。
【選択図】なし
Description
以下、本発明について実施例及び比較例により更に詳細に説明するが、本発明の範囲はこれら実施例及び比較例に何ら限定されるものではない。
トウモロコシデンプン(133重量部)、ヒドロキシプロピルセルロース(2重量部)、結晶セルロース(10重量部)を混合し、実施例1で調製したエグアレンナトリウム溶液(エグアレンナトリウムとして15重量部を含有する)を加え、造粒した。得られた顆粒を乾燥、整粒した後、打錠機で圧縮成型して錠剤とした。
実施例及び比較例で得られた錠剤につき、その安定性を試験した。この試験は、実施例及び比較例で得られた錠剤を、以下の条件1〜3の保存条件にて5日間保存した。エグアレンナトリウムの分解によって種々の類縁物質が生成するが、5日間保存後に、エグアレンナトリウムの分解によって生成する類縁物質類の合計含量(総類縁物質の含量:質量%)を、高速液体クロマトグラフィーにて測定した。その測定結果を表1に示す。また、打錠用粉末1錠分を秤取し、水を加えて1W/V%の水分散液を調製し、そのpHを測定した。その結果も表1に示す。
条件1
保存条件:室温、暗所
包装形態:ガラス瓶密栓
条件2
保存条件:50℃、暗所
包装形態:ガラス瓶密栓
条件3
保存条件:50℃、75%RH、暗所
包装形態:ガラス瓶開放
密栓状態での保管において、実験例1の条件1及び条件2の保存条件下で、実験1と同様にして、エグアレンナトリウムの分解によって生成する類縁物質類の合計含量(総類縁物質の含量:質量%)を測定して、その安定性を試験した。その結果、条件1(室温、暗所)では、総類縁物質の含量は0.15質量%であり、条件2(50℃、暗所)では、総類縁物質の含量は0.16質量%であった。なお、不活性ガス置換しない場合(比較例1)については、条件1(室温、暗所)では総類縁物質の含量は0.30質量%であり、条件2(50℃、暗所)では、総類縁物質の含量は0.43質量%であった。窒素置換した場合は、窒素置換しない場合に比べ、総類縁物質量の生成量が少なく、製剤中のエグアレンナトリウム由来の分解物の生成量が減少したことが分かる。
Claims (7)
- ポビドン及びその誘導体並びに塩基性を有する添加物から選択される一種以上の添加物を配合してなるエグアレンナトリウム固形製剤。
- ポビドン誘導体が、クロスポビドンである請求項1記載のエグアレンナトリウム固形製剤。
- 塩基性を有する添加物が、塩基性無機化合物及び塩基性有機化合物から選ばれた一種以上である請求項1又は2記載のエグアレンナトリウム固形製剤。
- 塩基性無機化合物が、炭酸マグネシウム、炭酸カルシウム、水酸化マグネシウム、酸化マグネシウム、炭酸ナトリウム、炭酸水素ナトリウム及び水酸化ナトリウムから選ばれた一種又は二種以上である請求項3記載のエグアレンナトリウム固形製剤。
- 塩基性有機物が、アルギニン、リジン、ヒスチジン及びオルニチンから選ばれた一種叉は二種以上であるである請求項3記載のエグアレンナトリウム固形製剤。
- 固形製剤を水に1W/V%濃度に分散させたときの水分散液のpHが6.5以上になるに十分な量の塩基性を有する添加物を配合してなるエグアレンナトリウム固形製剤。
- 不活性ガス置換包装されてなるエグアレンナトリウム固形製剤。
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JP2008289702A JP5465867B2 (ja) | 2008-11-12 | 2008-11-12 | 安定なエグアレンナトリウム固形製剤 |
KR1020090107814A KR101627860B1 (ko) | 2008-11-12 | 2009-11-10 | 안정한 에구알렌나트륨 고형 제제 |
CN2009102260483A CN101732290B (zh) | 2008-11-12 | 2009-11-12 | 稳定的乙呱仑钠固体制剂 |
HK10109226.5A HK1142806A1 (en) | 2008-11-12 | 2010-09-27 | Stable solid preparation of egualen sodium |
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JP2015000968A (ja) * | 2013-06-18 | 2015-01-05 | 紀州技研工業株式会社 | インクジェットインキ、その製造方法及びその使用方法 |
JP2015174869A (ja) * | 2014-03-13 | 2015-10-05 | 紀州技研工業株式会社 | インクジェットインク及びその作製方法並びにインクジェットインクを用いた印字方法 |
JP2016121197A (ja) * | 2016-04-06 | 2016-07-07 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
JP2016145242A (ja) * | 2016-04-06 | 2016-08-12 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
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CN102861337B (zh) * | 2012-03-26 | 2017-08-11 | 北京阜康仁生物制药科技有限公司 | 一种含乙呱仑钠固体制剂 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59176247A (ja) * | 1983-03-28 | 1984-10-05 | Taiyo Yakuhin Kogyo Kk | 水溶性アズノ−ルの分解防止方法 |
JPS6048960A (ja) * | 1983-08-24 | 1985-03-16 | Kotobuki Seiyaku Kk | アズレン誘導体及びその製法並びにこの化合物を有効成分とする抗潰瘍剤 |
JPH05148138A (ja) * | 1991-11-27 | 1993-06-15 | Yoshitomi Pharmaceut Ind Ltd | アズレンスルホン酸ナトリウムの安定化法および製剤 |
JP2003160484A (ja) * | 2001-11-27 | 2003-06-03 | Kotobuki Seiyaku Kk | 苦味軽減した経口投与製剤組成物 |
JP2003206238A (ja) * | 2001-11-06 | 2003-07-22 | Rohto Pharmaceut Co Ltd | 医薬組成物 |
JP2003212769A (ja) * | 2001-11-13 | 2003-07-30 | Kotobuki Seiyaku Kk | L−グルタミンおよびアズレンスルホン酸ナトリウムを含有する速崩錠または口腔内崩壊錠並びにその製造方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0648960A (ja) * | 1990-02-22 | 1994-02-22 | Glaxo Group Ltd | 医 薬 |
CN101065121A (zh) * | 2004-10-20 | 2007-10-31 | 寿制药株式会社 | 用于治疗或预防胃粘膜疾病的组合物 |
-
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59176247A (ja) * | 1983-03-28 | 1984-10-05 | Taiyo Yakuhin Kogyo Kk | 水溶性アズノ−ルの分解防止方法 |
JPS6048960A (ja) * | 1983-08-24 | 1985-03-16 | Kotobuki Seiyaku Kk | アズレン誘導体及びその製法並びにこの化合物を有効成分とする抗潰瘍剤 |
JPH05148138A (ja) * | 1991-11-27 | 1993-06-15 | Yoshitomi Pharmaceut Ind Ltd | アズレンスルホン酸ナトリウムの安定化法および製剤 |
JP2003206238A (ja) * | 2001-11-06 | 2003-07-22 | Rohto Pharmaceut Co Ltd | 医薬組成物 |
JP2003212769A (ja) * | 2001-11-13 | 2003-07-30 | Kotobuki Seiyaku Kk | L−グルタミンおよびアズレンスルホン酸ナトリウムを含有する速崩錠または口腔内崩壊錠並びにその製造方法 |
JP2003160484A (ja) * | 2001-11-27 | 2003-06-03 | Kotobuki Seiyaku Kk | 苦味軽減した経口投与製剤組成物 |
Non-Patent Citations (2)
Title |
---|
"第13章 医薬品の安定化と保存", 新・薬剤学総論(改訂第3版) INTRODUCTION TO MODERN PHARMACEUTICS, vol. 第1版, JPN6013012509, pages 345 - 372, ISSN: 0002483890 * |
"臨床医のための新薬の知識2000", 臨床と薬物治療, vol. 19, no. 4, JPN6013012511, 2000, pages 294 - 295, ISSN: 0002713083 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015000968A (ja) * | 2013-06-18 | 2015-01-05 | 紀州技研工業株式会社 | インクジェットインキ、その製造方法及びその使用方法 |
JP2015174869A (ja) * | 2014-03-13 | 2015-10-05 | 紀州技研工業株式会社 | インクジェットインク及びその作製方法並びにインクジェットインクを用いた印字方法 |
JP2016121197A (ja) * | 2016-04-06 | 2016-07-07 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
JP2016145242A (ja) * | 2016-04-06 | 2016-08-12 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
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