JP2010053135A5 - - Google Patents
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- JP2010053135A5 JP2010053135A5 JP2009272679A JP2009272679A JP2010053135A5 JP 2010053135 A5 JP2010053135 A5 JP 2010053135A5 JP 2009272679 A JP2009272679 A JP 2009272679A JP 2009272679 A JP2009272679 A JP 2009272679A JP 2010053135 A5 JP2010053135 A5 JP 2010053135A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- symptom
- neutropenia
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000004235 neutropenia Diseases 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 238000010322 bone marrow transplantation Methods 0.000 claims description 3
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 208000024891 symptom Diseases 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 206010065553 Bone marrow failure Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 238000001959 radiotherapy Methods 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 208000019838 Blood disease Diseases 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000003812 Interleukin-15 Human genes 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- -1 fatty acid triglycerides Chemical class 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 235000018343 nutrient deficiency Nutrition 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
- 238000004904 shortening Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28445801P | 2001-04-18 | 2001-04-18 | |
| US60/284,458 | 2001-04-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580924A Division JP5026655B2 (ja) | 2001-04-18 | 2002-04-18 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014165557A Division JP6420089B2 (ja) | 2001-04-18 | 2014-08-15 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010053135A JP2010053135A (ja) | 2010-03-11 |
| JP2010053135A5 true JP2010053135A5 (OSRAM) | 2014-01-16 |
| JP5657879B2 JP5657879B2 (ja) | 2015-01-21 |
Family
ID=23090294
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580924A Expired - Lifetime JP5026655B2 (ja) | 2001-04-18 | 2002-04-18 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
| JP2009272679A Expired - Lifetime JP5657879B2 (ja) | 2001-04-18 | 2009-11-30 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
| JP2014165557A Expired - Lifetime JP6420089B2 (ja) | 2001-04-18 | 2014-08-15 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580924A Expired - Lifetime JP5026655B2 (ja) | 2001-04-18 | 2002-04-18 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014165557A Expired - Lifetime JP6420089B2 (ja) | 2001-04-18 | 2014-08-15 | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7745488B2 (OSRAM) |
| EP (2) | EP1900364B1 (OSRAM) |
| JP (3) | JP5026655B2 (OSRAM) |
| KR (1) | KR20030096323A (OSRAM) |
| CN (1) | CN1633286A (OSRAM) |
| AP (1) | AP1740A (OSRAM) |
| AU (2) | AU2002308456B2 (OSRAM) |
| BG (1) | BG66418B1 (OSRAM) |
| BR (1) | BR0208984A (OSRAM) |
| CA (2) | CA2763637C (OSRAM) |
| CY (1) | CY1107081T1 (OSRAM) |
| CZ (1) | CZ305273B6 (OSRAM) |
| DE (1) | DE60223670T2 (OSRAM) |
| DK (2) | DK1900364T3 (OSRAM) |
| EA (1) | EA007322B1 (OSRAM) |
| EE (1) | EE200300510A (OSRAM) |
| ES (2) | ES2439738T3 (OSRAM) |
| HU (1) | HUP0303817A3 (OSRAM) |
| IL (3) | IL158322A0 (OSRAM) |
| MX (1) | MXPA03009436A (OSRAM) |
| NO (1) | NO335105B1 (OSRAM) |
| NZ (2) | NZ528690A (OSRAM) |
| OA (1) | OA12506A (OSRAM) |
| PL (2) | PL222876B1 (OSRAM) |
| PT (2) | PT1900364E (OSRAM) |
| SI (1) | SI1385498T1 (OSRAM) |
| SK (1) | SK12772003A3 (OSRAM) |
| TN (1) | TNSN03089A1 (OSRAM) |
| WO (1) | WO2002083120A2 (OSRAM) |
| ZA (1) | ZA200307778B (OSRAM) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1900364B1 (en) * | 2001-04-18 | 2013-09-25 | ProMetic BioSciences Inc. | Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors |
| CN100427081C (zh) * | 2003-02-07 | 2008-10-22 | 普罗米蒂克生物科学公司 | 作为红细胞生成刺激剂的中链长脂肪酸类、甘油酯类和类似物 |
| US7705169B2 (en) | 2003-07-25 | 2010-04-27 | Prometic Biosciences Inc. | Preparation of metal salts of medium-chain fatty acids |
| KR20070044805A (ko) * | 2004-04-15 | 2007-04-30 | 키아스마, 인코포레이티드 | 생물학적 장벽 투과를 촉진시킬 수 있는 조성물 |
| US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| JP2008511553A (ja) * | 2004-09-03 | 2008-04-17 | プロメティック バイオサイエンシズ インコーポレーテッド | 免疫調節活性および化学防護活性を有する置換型プリニル誘導体ならびにその単独使用または中鎖長の脂肪酸もしくはグリセリドとの併用 |
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| WO2009155439A2 (en) * | 2008-06-19 | 2009-12-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| ES2629131T3 (es) | 2008-09-17 | 2017-08-07 | Chiasma Inc. | Composiciones farmacéuticas y métodos de suministro relacionados. |
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| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| TWI572352B (zh) * | 2012-03-01 | 2017-03-01 | 波麥堤克藥學Ｓｍｔ有限公司 | 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法 |
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| EP3037090B1 (en) | 2013-08-19 | 2019-07-31 | Enzychem Lifesciences Corporation | Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating rheumatoid arthritis |
| KR20180015297A (ko) * | 2014-05-15 | 2018-02-12 | 주식회사 엔지켐생명과학 | 백혈구 감소증 및 혈소판 감소증에 대한 치료 방법 |
| RS66942B1 (sr) | 2015-02-03 | 2025-07-31 | Amryt Endo Inc | Lečenje akromegalije oralnim oktreotidom |
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| US10513524B2 (en) | 2015-07-07 | 2019-12-24 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| CN108430466A (zh) | 2015-10-02 | 2018-08-21 | 康普莱克夏公司 | 使用治疗有效量的活化脂肪酸预防、治疗和逆转疾病 |
| US9808438B2 (en) * | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
| CA3021660A1 (en) | 2016-04-22 | 2017-10-26 | Receptor Life Sciences, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
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| JP2021526134A (ja) | 2018-05-25 | 2021-09-30 | イマラ インク． | ６−［（３Ｓ，４Ｓ）−４−メチル−ｌ−（ピリミジン−２−イルメチル）ピロリジン−３−イル］−３−テトラヒドロピラン−４−イル−７Ｈ−イミダゾ［ｌ，５−Ａ］ピラジン−８−オンの一水和物および結晶形態 |
| KR20250108770A (ko) | 2018-08-31 | 2025-07-15 | 카듀리온 파마슈티칼스, 인크. | 겸상 세포 질환의 치료를 위한 pde9 억제제 |
| CN120923343A (zh) | 2018-10-11 | 2025-11-11 | 巴斯夫股份公司 | 芳族化合物及其医药用途 |
| CA3120001A1 (en) | 2018-11-19 | 2020-05-28 | Receptor Holdings, Inc. | N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions |
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