JP2010013462A5 - - Google Patents
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- Publication number
- JP2010013462A5 JP2010013462A5 JP2009199516A JP2009199516A JP2010013462A5 JP 2010013462 A5 JP2010013462 A5 JP 2010013462A5 JP 2009199516 A JP2009199516 A JP 2009199516A JP 2009199516 A JP2009199516 A JP 2009199516A JP 2010013462 A5 JP2010013462 A5 JP 2010013462A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- less
- chloride
- fenofibrate
- bromide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims description 111
- 229960002297 fenofibrate Drugs 0.000 claims description 109
- 229960000701 fenofibric acid Drugs 0.000 claims description 35
- MQOBSOSZFYZQOK-UHFFFAOYSA-N fenofibric acid Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 MQOBSOSZFYZQOK-UHFFFAOYSA-N 0.000 claims description 35
- 239000002775 capsule Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims 311
- -1 phosphatide Polymers 0.000 claims 99
- 238000004090 dissolution Methods 0.000 claims 63
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 60
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 59
- 239000002245 particle Substances 0.000 claims 54
- 239000003381 stabilizer Substances 0.000 claims 49
- 239000012736 aqueous medium Substances 0.000 claims 42
- 238000000034 method Methods 0.000 claims 42
- 244000060011 Cocos nucifera Species 0.000 claims 36
- 235000013162 Cocos nucifera Nutrition 0.000 claims 36
- 230000036765 blood level Effects 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 30
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 24
- 238000009472 formulation Methods 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 24
- AISMNBXOJRHCIA-UHFFFAOYSA-N trimethylazanium;bromide Chemical compound Br.CN(C)C AISMNBXOJRHCIA-UHFFFAOYSA-N 0.000 claims 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 18
- 150000001412 amines Chemical class 0.000 claims 18
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 15
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 12
- YJHSJERLYWNLQL-UHFFFAOYSA-N 2-hydroxyethyl(dimethyl)azanium;chloride Chemical compound Cl.CN(C)CCO YJHSJERLYWNLQL-UHFFFAOYSA-N 0.000 claims 12
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 12
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 12
- 229960000686 benzalkonium chloride Drugs 0.000 claims 12
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims 12
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 12
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 12
- 229940107161 cholesterol Drugs 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims 12
- 239000002552 dosage form Substances 0.000 claims 12
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 12
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 12
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 12
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 12
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 12
- 229960003943 hypromellose Drugs 0.000 claims 12
- HICYUNOFRYFIMG-UHFFFAOYSA-N n,n-dimethyl-1-naphthalen-1-ylmethanamine;hydrochloride Chemical compound [Cl-].C1=CC=C2C(C[NH+](C)C)=CC=CC2=C1 HICYUNOFRYFIMG-UHFFFAOYSA-N 0.000 claims 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 12
- 229920002678 cellulose Polymers 0.000 claims 11
- 239000001913 cellulose Substances 0.000 claims 11
- 235000010980 cellulose Nutrition 0.000 claims 11
- 239000002609 medium Substances 0.000 claims 9
- QAQSNXHKHKONNS-UHFFFAOYSA-N 1-ethyl-2-hydroxy-4-methyl-6-oxopyridine-3-carboxamide Chemical compound CCN1C(O)=C(C(N)=O)C(C)=CC1=O QAQSNXHKHKONNS-UHFFFAOYSA-N 0.000 claims 6
- RMAJTXKOOKJAAV-UHFFFAOYSA-N 2,2-dihydroxyethyl(methyl)azanium;bromide Chemical compound [Br-].C[NH2+]CC(O)O RMAJTXKOOKJAAV-UHFFFAOYSA-N 0.000 claims 6
- DBRHJJQHHSOXCQ-UHFFFAOYSA-N 2,2-dihydroxyethyl(methyl)azanium;chloride Chemical compound [Cl-].C[NH2+]CC(O)O DBRHJJQHHSOXCQ-UHFFFAOYSA-N 0.000 claims 6
- CTTJWXVQRJUJQW-UHFFFAOYSA-N 2,2-dioctyl-3-sulfobutanedioic acid Chemical compound CCCCCCCCC(C(O)=O)(C(C(O)=O)S(O)(=O)=O)CCCCCCCC CTTJWXVQRJUJQW-UHFFFAOYSA-N 0.000 claims 6
- BSTPEQSVYGELTA-UHFFFAOYSA-N 2-(dimethylamino)ethanol;hydrobromide Chemical compound [Br-].C[NH+](C)CCO BSTPEQSVYGELTA-UHFFFAOYSA-N 0.000 claims 6
- MPNXSZJPSVBLHP-UHFFFAOYSA-N 2-chloro-n-phenylpyridine-3-carboxamide Chemical compound ClC1=NC=CC=C1C(=O)NC1=CC=CC=C1 MPNXSZJPSVBLHP-UHFFFAOYSA-N 0.000 claims 6
- BZSJQMAZLOWECR-UHFFFAOYSA-N 2-methylprop-2-enoate trimethylazanium bromide Chemical compound [Br-].C[NH+](C)C.C(C(=C)C)(=O)[O-].C[NH+](C)C BZSJQMAZLOWECR-UHFFFAOYSA-N 0.000 claims 6
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical group BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 6
- 244000215068 Acacia senegal Species 0.000 claims 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 6
- 241000416162 Astragalus gummifer Species 0.000 claims 6
- JXBLYRUGWAGROE-UHFFFAOYSA-L CCCCCCCCCC[N+](C)(C)CCO.CCCCCCCCCC[N+](C)(C)CCO.[Cl-].[Cl-].Br Chemical compound CCCCCCCCCC[N+](C)(C)CCO.CCCCCCCCCC[N+](C)(C)CCO.[Cl-].[Cl-].Br JXBLYRUGWAGROE-UHFFFAOYSA-L 0.000 claims 6
- CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 claims 6
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 6
- 244000303965 Cyamopsis psoralioides Species 0.000 claims 6
- 229920002307 Dextran Polymers 0.000 claims 6
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 6
- 108010010803 Gelatin Proteins 0.000 claims 6
- 229920000084 Gum arabic Polymers 0.000 claims 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 6
- 102000016943 Muramidase Human genes 0.000 claims 6
- 108010014251 Muramidase Proteins 0.000 claims 6
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 6
- 229910019142 PO4 Inorganic materials 0.000 claims 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims 6
- 229920000289 Polyquaternium Polymers 0.000 claims 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 235000021355 Stearic acid Nutrition 0.000 claims 6
- 229920001615 Tragacanth Polymers 0.000 claims 6
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 6
- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 claims 6
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 6
- GBSORQPIBBOORR-UHFFFAOYSA-N [Cl-].[Br-].C[NH+](C)CCO.C[NH+](C)CCO Chemical compound [Cl-].[Br-].C[NH+](C)CCO.C[NH+](C)CCO GBSORQPIBBOORR-UHFFFAOYSA-N 0.000 claims 6
- 235000010489 acacia gum Nutrition 0.000 claims 6
- 239000000205 acacia gum Substances 0.000 claims 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 6
- 229940072056 alginate Drugs 0.000 claims 6
- 235000010443 alginic acid Nutrition 0.000 claims 6
- 229920000615 alginic acid Polymers 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 6
- 125000006177 alkyl benzyl group Chemical group 0.000 claims 6
- 150000005215 alkyl ethers Chemical class 0.000 claims 6
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims 6
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 claims 6
- 235000019270 ammonium chloride Nutrition 0.000 claims 6
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims 6
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims 6
- UUZYBYIOAZTMGC-UHFFFAOYSA-M benzyl(trimethyl)azanium;bromide Chemical compound [Br-].C[N+](C)(C)CC1=CC=CC=C1 UUZYBYIOAZTMGC-UHFFFAOYSA-M 0.000 claims 6
- BCOZLGOHQFNXBI-UHFFFAOYSA-M benzyl-bis(2-chloroethyl)-ethylazanium;bromide Chemical compound [Br-].ClCC[N+](CC)(CCCl)CC1=CC=CC=C1 BCOZLGOHQFNXBI-UHFFFAOYSA-M 0.000 claims 6
- WMLFGKCFDKMAKB-UHFFFAOYSA-M benzyl-diethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CC)(CC)CC1=CC=CC=C1 WMLFGKCFDKMAKB-UHFFFAOYSA-M 0.000 claims 6
- WNBGYVXHFTYOBY-UHFFFAOYSA-N benzyl-dimethyl-tetradecylazanium Chemical compound CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 WNBGYVXHFTYOBY-UHFFFAOYSA-N 0.000 claims 6
- 229920001222 biopolymer Polymers 0.000 claims 6
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 6
- 239000008116 calcium stearate Substances 0.000 claims 6
- 235000013539 calcium stearate Nutrition 0.000 claims 6
- 229940078456 calcium stearate Drugs 0.000 claims 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 6
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 6
- 239000005018 casein Substances 0.000 claims 6
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 6
- 235000021240 caseins Nutrition 0.000 claims 6
- 239000004359 castor oil Substances 0.000 claims 6
- 235000019438 castor oil Nutrition 0.000 claims 6
- 125000002091 cationic group Chemical group 0.000 claims 6
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 6
- 235000012000 cholesterol Nutrition 0.000 claims 6
- 229960001231 choline Drugs 0.000 claims 6
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 6
- 238000013270 controlled release Methods 0.000 claims 6
- WOQQAWHSKSSAGF-WXFJLFHKSA-N decyl beta-D-maltopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 WOQQAWHSKSSAGF-WXFJLFHKSA-N 0.000 claims 6
- JDRSMPFHFNXQRB-IBEHDNSVSA-N decyl glucoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JDRSMPFHFNXQRB-IBEHDNSVSA-N 0.000 claims 6
- CDJGWBCMWHSUHR-UHFFFAOYSA-M decyl(triethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](CC)(CC)CC CDJGWBCMWHSUHR-UHFFFAOYSA-M 0.000 claims 6
- PLMFYJJFUUUCRZ-UHFFFAOYSA-M decyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)C PLMFYJJFUUUCRZ-UHFFFAOYSA-M 0.000 claims 6
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- GQOKIYDTHHZSCJ-UHFFFAOYSA-M dimethyl-bis(prop-2-enyl)azanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC=C GQOKIYDTHHZSCJ-UHFFFAOYSA-M 0.000 claims 6
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims 6
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims 6
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 claims 6
- 229960000878 docusate sodium Drugs 0.000 claims 6
- VVNBOKHXEBSBQJ-UHFFFAOYSA-M dodecyl(triethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](CC)(CC)CC VVNBOKHXEBSBQJ-UHFFFAOYSA-M 0.000 claims 6
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 claims 6
- 239000008387 emulsifying waxe Substances 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 239000008273 gelatin Substances 0.000 claims 6
- 229920000159 gelatin Polymers 0.000 claims 6
- 235000019322 gelatine Nutrition 0.000 claims 6
- 235000011852 gelatine desserts Nutrition 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims 6
- 235000011187 glycerol Nutrition 0.000 claims 6
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 6
- 150000004820 halides Chemical class 0.000 claims 6
- NIDYWHLDTIVRJT-UJPOAAIJSA-N heptyl-β-d-glucopyranoside Chemical compound CCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NIDYWHLDTIVRJT-UJPOAAIJSA-N 0.000 claims 6
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 6
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 6
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims 6
- 239000004325 lysozyme Substances 0.000 claims 6
- 229960000274 lysozyme Drugs 0.000 claims 6
- 235000010335 lysozyme Nutrition 0.000 claims 6
- 239000000463 material Substances 0.000 claims 6
- VXBSKVAMQMBCCA-UHFFFAOYSA-M methyl sulfate;trimethyl(tetradecyl)azanium Chemical compound COS([O-])(=O)=O.CCCCCCCCCCCCCC[N+](C)(C)C VXBSKVAMQMBCCA-UHFFFAOYSA-M 0.000 claims 6
- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 claims 6
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 6
- UMWKZHPREXJQGR-XOSAIJSUSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]decanamide Chemical compound CCCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO UMWKZHPREXJQGR-XOSAIJSUSA-N 0.000 claims 6
- VHYYJWLKCODCNM-OIMNJJJWSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]heptanamide Chemical compound CCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO VHYYJWLKCODCNM-OIMNJJJWSA-N 0.000 claims 6
- SBWGZAXBCCNRTM-CTHBEMJXSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]octanamide Chemical compound CCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SBWGZAXBCCNRTM-CTHBEMJXSA-N 0.000 claims 6
- HEGSGKPQLMEBJL-UHFFFAOYSA-N n-octyl beta-D-glucopyranoside Natural products CCCCCCCCOC1OC(CO)C(O)C(O)C1O HEGSGKPQLMEBJL-UHFFFAOYSA-N 0.000 claims 6
- CGVLVOOFCGWBCS-RGDJUOJXSA-N n-octyl β-d-thioglucopyranoside Chemical compound CCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CGVLVOOFCGWBCS-RGDJUOJXSA-N 0.000 claims 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 6
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| KR20240108664A (ko) | 2023-01-02 | 2024-07-09 | 주식회사 다산제약 | 생체 이용률이 개선된 페노피브레이트를 포함하는 약학 조성물 |
| KR20250016040A (ko) | 2023-07-25 | 2025-02-03 | 주식회사 제뉴원사이언스 | 페노피브레이트 및 피타바스타틴칼슘 포함하는 약학 조성물 및 그 제조방법 |
| KR20250101196A (ko) | 2023-12-27 | 2025-07-04 | 주식회사 다산제약 | 생체 이용률이 개선된 페노피브레이트를 포함하는 약제학적 조성물 |
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2003
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- 2003-05-23 JP JP2004549886A patent/JP4395074B2/ja not_active Expired - Lifetime
- 2003-05-23 WO PCT/US2003/014542 patent/WO2004041250A2/en not_active Ceased
- 2003-05-23 BR BRPI0311275A patent/BRPI0311275A2/pt not_active Application Discontinuation
- 2003-05-23 SG SG200705850-6A patent/SG159391A1/en unknown
- 2003-05-23 CN CN201010144539A patent/CN101797233A/zh active Pending
- 2003-05-23 PT PT38083630T patent/PT1519715T/pt unknown
- 2003-05-23 EA EA200900485A patent/EA023686B1/ru unknown
- 2003-05-23 MX MXPA04011653A patent/MXPA04011653A/es active IP Right Grant
- 2003-05-23 KR KR1020047019041A patent/KR101300654B1/ko not_active Expired - Lifetime
- 2003-05-23 KR KR1020127012698A patent/KR20120057664A/ko not_active Abandoned
- 2003-05-23 IL IL16533203A patent/IL165332A0/xx unknown
- 2003-05-23 CN CNA038172704A patent/CN1668281A/zh active Pending
- 2003-05-23 EA EA200401556A patent/EA012842B1/ru unknown
- 2003-05-23 EP EP03808363.0A patent/EP1519715B1/en not_active Expired - Lifetime
- 2003-05-23 NZ NZ537324A patent/NZ537324A/en not_active IP Right Cessation
- 2003-05-23 CN CN201010144105.6A patent/CN101797245B/zh not_active Expired - Lifetime
- 2003-05-23 TW TW092114057A patent/TWI347198B/zh not_active IP Right Cessation
- 2003-05-23 CA CA002487054A patent/CA2487054C/en not_active Expired - Lifetime
- 2003-05-23 AU AU2003301807A patent/AU2003301807B9/en not_active Expired
- 2003-05-23 KR KR1020117022782A patent/KR101216853B1/ko not_active Expired - Lifetime
- 2003-05-23 ES ES03808363T patent/ES2946493T3/es not_active Expired - Lifetime
- 2003-05-24 MY MYPI20031929A patent/MY143202A/en unknown
- 2003-05-26 UY UY27822A patent/UY27822A1/es not_active Application Discontinuation
- 2003-05-26 AR ARP030101837A patent/AR040110A1/es not_active Application Discontinuation
-
2004
- 2004-11-22 IL IL165332A patent/IL165332A/en active IP Right Grant
- 2004-11-23 TN TNP2004000230A patent/TNSN04230A1/en unknown
- 2004-11-24 MA MA27964A patent/MA27250A1/fr unknown
-
2005
- 2005-01-14 NO NO20050224A patent/NO20050224L/no not_active Application Discontinuation
-
2008
- 2008-12-24 AU AU2008264174A patent/AU2008264174B2/en not_active Expired
-
2009
- 2009-08-31 JP JP2009199516A patent/JP2010013462A/ja active Pending
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2018
- 2018-12-31 UY UY0001038044A patent/UY38044A/es not_active Application Discontinuation
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