JP2009544681A5 - - Google Patents

Download PDF

Info

Publication number
JP2009544681A5
JP2009544681A5 JP2009521343A JP2009521343A JP2009544681A5 JP 2009544681 A5 JP2009544681 A5 JP 2009544681A5 JP 2009521343 A JP2009521343 A JP 2009521343A JP 2009521343 A JP2009521343 A JP 2009521343A JP 2009544681 A5 JP2009544681 A5 JP 2009544681A5
Authority
JP
Japan
Prior art keywords
epo
polysaccharide
protein
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009521343A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009544681A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2007/002841 external-priority patent/WO2008012542A2/en
Publication of JP2009544681A publication Critical patent/JP2009544681A/ja
Publication of JP2009544681A5 publication Critical patent/JP2009544681A5/ja
Pending legal-status Critical Current

Links

JP2009521343A 2006-07-25 2007-07-25 エリスロポエチンの多糖誘導体 Pending JP2009544681A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117830 2006-07-25
PCT/GB2007/002841 WO2008012542A2 (en) 2006-07-25 2007-07-25 Polysaccharide derivatives of erythropoietin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012287324A Division JP5542195B2 (ja) 2006-07-25 2012-12-28 エリスロポエチンの多糖誘導体

Publications (2)

Publication Number Publication Date
JP2009544681A JP2009544681A (ja) 2009-12-17
JP2009544681A5 true JP2009544681A5 (https=) 2011-03-03

Family

ID=37397314

Family Applications (14)

Application Number Title Priority Date Filing Date
JP2009521337A Expired - Fee Related JP5096466B2 (ja) 2006-07-25 2007-07-25 Ｎ末端ポリシアリル化
JP2009521336A Expired - Fee Related JP5419689B2 (ja) 2006-07-25 2007-07-25 顆粒球コロニー刺激因子の誘導体化
JP2009521342A Pending JP2009544680A (ja) 2006-07-25 2007-07-25 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2009521343A Pending JP2009544681A (ja) 2006-07-25 2007-07-25 エリスロポエチンの多糖誘導体
JP2012205475A Expired - Fee Related JP5586669B2 (ja) 2006-07-25 2012-09-19 Ｎ末端ポリシアリル化
JP2012287324A Expired - Fee Related JP5542195B2 (ja) 2006-07-25 2012-12-28 エリスロポエチンの多糖誘導体
JP2013022825A Expired - Fee Related JP5420091B2 (ja) 2006-07-25 2013-02-08 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2013160269A Expired - Fee Related JP5941440B2 (ja) 2006-07-25 2013-08-01 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2014025061A Expired - Fee Related JP6165079B2 (ja) 2006-07-25 2014-02-13 エリスロポエチンの多糖誘導体
JP2014154037A Expired - Fee Related JP5912152B2 (ja) 2006-07-25 2014-07-29 Ｎ末端ポリシアリル化
JP2015075148A Expired - Fee Related JP6055506B2 (ja) 2006-07-25 2015-04-01 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2016020557A Expired - Fee Related JP6243456B2 (ja) 2006-07-25 2016-02-05 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2016149090A Expired - Fee Related JP6203342B2 (ja) 2006-07-25 2016-07-29 エリスロポエチンの多糖誘導体
JP2017157728A Expired - Fee Related JP6581157B2 (ja) 2006-07-25 2017-08-18 エリスロポエチンの多糖誘導体

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2009521337A Expired - Fee Related JP5096466B2 (ja) 2006-07-25 2007-07-25 Ｎ末端ポリシアリル化
JP2009521336A Expired - Fee Related JP5419689B2 (ja) 2006-07-25 2007-07-25 顆粒球コロニー刺激因子の誘導体化
JP2009521342A Pending JP2009544680A (ja) 2006-07-25 2007-07-25 ポリサッカライドによるタンパク質のｎ末端誘導体化

Family Applications After (10)

Application Number Title Priority Date Filing Date
JP2012205475A Expired - Fee Related JP5586669B2 (ja) 2006-07-25 2012-09-19 Ｎ末端ポリシアリル化
JP2012287324A Expired - Fee Related JP5542195B2 (ja) 2006-07-25 2012-12-28 エリスロポエチンの多糖誘導体
JP2013022825A Expired - Fee Related JP5420091B2 (ja) 2006-07-25 2013-02-08 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2013160269A Expired - Fee Related JP5941440B2 (ja) 2006-07-25 2013-08-01 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2014025061A Expired - Fee Related JP6165079B2 (ja) 2006-07-25 2014-02-13 エリスロポエチンの多糖誘導体
JP2014154037A Expired - Fee Related JP5912152B2 (ja) 2006-07-25 2014-07-29 Ｎ末端ポリシアリル化
JP2015075148A Expired - Fee Related JP6055506B2 (ja) 2006-07-25 2015-04-01 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2016020557A Expired - Fee Related JP6243456B2 (ja) 2006-07-25 2016-02-05 ポリサッカライドによるタンパク質のｎ末端誘導体化
JP2016149090A Expired - Fee Related JP6203342B2 (ja) 2006-07-25 2016-07-29 エリスロポエチンの多糖誘導体
JP2017157728A Expired - Fee Related JP6581157B2 (ja) 2006-07-25 2017-08-18 エリスロポエチンの多糖誘導体

Country Status (10)

Country Link
US (22) US8394921B2 (https=)
EP (6) EP2041167B1 (https=)
JP (14) JP5096466B2 (https=)
KR (1) KR101400105B1 (https=)
CN (2) CN103169984B (https=)
AT (1) ATE467642T1 (https=)
DE (1) DE602007006492D1 (https=)
ES (5) ES2581902T3 (https=)
RU (1) RU2432175C2 (https=)
WO (4) WO2008012528A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016974A1 (en) 2003-08-12 2005-02-24 Lipoxen Technologies Limited Sialic acid derivatives for protein derivatisation and conjugation
JP2007501888A (ja) 2003-08-12 2007-02-01 リポクセン テクノロジーズ リミテッド ポリシアル酸誘導体
WO2008012528A1 (en) 2006-07-25 2008-01-31 Lipoxen Technologies Limited N-terminal polysialylation
CA2670618C (en) 2006-12-15 2016-10-04 Baxter International Inc. Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life
JP2010520320A (ja) 2007-02-28 2010-06-10 リポクセン テクノロジーズ リミテッド ポリシアル酸におけるエンドトキシンの低減
EP2192924B1 (en) 2007-08-20 2017-10-11 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
RU2391354C1 (ru) * 2008-10-15 2010-06-10 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН, Российская Федерация, от имени которой выступает Федеральное агентство по науке и инновациям Комплекс биологически активного рекомбинантного белка с полисиаловой кислотой
RU2472806C1 (ru) * 2008-10-20 2013-01-20 Юсв Лимитед Усовершенствованный способ пегилирования белков
CA2742064A1 (en) * 2008-10-31 2010-05-06 Amgen Inc. Materials and methods relating to stem cell mobilization by multi-pegylated granulocyte colony stimulating factor
KR101635689B1 (ko) 2009-01-28 2016-07-01 스마트쎌스, 인크. 제어 약물 전달을 위한 접합체 기재 시스템
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
CA2750223A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
US8906850B2 (en) 2009-01-28 2014-12-09 Smartcells, Inc. Crystalline insulin-conjugates
EP2408808A4 (en) 2009-03-20 2015-05-06 Smartcells Inc TERMINAL-FUNCTIONALIZED CONJUGATES AND THEIR USE
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
KR101912335B1 (ko) * 2009-07-27 2018-10-26 리폭센 테크놀로지즈 리미티드 비혈액 응고 단백질의 글리코폴리시알화
CN106110311A (zh) 2009-07-27 2016-11-16 百深公司 凝血蛋白缀合物
CN102497884A (zh) 2009-07-27 2012-06-13 巴克斯特国际公司 凝血蛋白缀合物
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
CN101787117B (zh) * 2010-02-08 2012-05-23 江南大学 聚乙二醇-聚唾液酸嵌段共聚物的制备方法及应用
CA2798518A1 (en) 2010-05-17 2011-11-24 Cebix, Inc. Pegylated c-peptide
WO2011156242A2 (en) * 2010-06-11 2011-12-15 Lpath, Inc. Improved anti-lysophospholipid antibody design using antibody structures
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
EP2598522A4 (en) 2010-07-28 2014-11-12 Smartcells Inc RECOMBINANT LKTINE, BINDING POINT MODIFIED LECTIN AND APPLICATIONS THEREOF
CN103443270B (zh) 2011-01-20 2017-06-06 普罗塔里克斯有限公司 用于在植物和植物细胞中表达α‑半乳糖苷酶的核酸构建体
US8962553B2 (en) 2011-11-17 2015-02-24 Cebix Ab Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide
TW201605470A (zh) 2013-10-04 2016-02-16 默沙東藥廠 葡萄糖反應性胰島素結合物
WO2015130963A2 (en) 2014-02-27 2015-09-03 Xenetic Biosciences, Inc. Compositions and methods for administering insulin or insulin-like protein to the brain
JP2019218265A (ja) * 2016-09-14 2019-12-26 生化学工業株式会社 ペプチドの血中滞留性を増強させる方法
WO2018197545A1 (en) * 2017-04-25 2018-11-01 Lipoxen Technologies Limited Methods of treating multiple myeloma cancers expressing high levels of epo-receptor using psa-epo
US20190083636A1 (en) * 2017-04-25 2019-03-21 Lipoxen Technologies Limited Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i
WO2020099513A1 (en) * 2018-11-13 2020-05-22 Lipoxen Technologies Limited Glycopolysialylation of blinatumomab
WO2020163269A1 (en) * 2019-02-04 2020-08-13 Xenetic Biosciences, Inc. Methods of using glycopolysialylated therapeutic proteins
BR112022000246A2 (pt) 2019-07-08 2022-02-22 Gi Innovation Inc Dímero polipeptídico com elevado teor de ácido siálico, compreendendo o domínio extracelular da subunidade alfa do receptor fc de ige e composição farmacêutica compreendendo o mesmo
WO2022033480A1 (zh) * 2020-08-11 2022-02-17 隆延生物科技（上海）有限公司 一种液体制剂及其应用
CN114966021B (zh) * 2022-05-19 2025-03-04 山东博科生物产业有限公司 一种稳定的脂蛋白相关磷脂酶a2测定试剂盒

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2930542A1 (de) 1979-07-27 1981-02-12 Hoechst Ag Neue insulinderivate und verfahren zu ihrer herstellung
US5308617A (en) * 1988-08-10 1994-05-03 Halzyme Ltd. Protein heparin conjugates
AU646822B2 (en) * 1989-10-13 1994-03-10 Kirin-Amgen Inc. Erythropoietin isoforms
US7217689B1 (en) * 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5846951A (en) 1991-06-06 1998-12-08 The School Of Pharmacy, University Of London Pharmaceutical compositions
GB9112212D0 (en) 1991-06-06 1991-07-24 Gregoriadis Gregory Pharmaceutical compositions
DE69224809T2 (de) 1991-12-30 1998-07-09 Akzo Nobel Nv Thyroaktive Zusammensetzung mit kontrollierter Freigabe
JP2747967B2 (ja) 1993-07-23 1998-05-06 雪印乳業株式会社 シアル酸粉末
US20030053982A1 (en) * 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JP4335435B2 (ja) * 1997-08-05 2009-09-30 バイオニケ ライフ サイエンシーズ インコーポレイテッド 細胞増殖および細胞死を調節する組成物および方法
AU2794199A (en) 1998-02-26 1999-09-15 Robertas Bunevicius Thyroid hormone replacement using sustained release triiodothyronine
RU2141531C1 (ru) 1999-05-26 1999-11-20 Российское акционерное общество открытого типа "Биопрепарат" Способ получения рекомбинантного инсулина человека
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
AU2001258536A1 (en) * 2000-05-16 2001-11-26 Lipoxen Technologies Limited Derivatisation of proteins in aqueous solution
CA2408956C (en) 2000-05-18 2011-07-12 Therics, Inc. Method and form of a drug delivery device,such as encapsulating a toxic core within a non-toxic region in an oral dosage form
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US20040082765A1 (en) * 2000-10-16 2004-04-29 Teruo Nakamura Peg-modified erythropoietin
CA2431964C (en) * 2000-12-20 2013-09-10 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
KR100401296B1 (ko) 2000-12-27 2003-10-11 드림바이오젠 주식회사 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법
EP2042196B1 (en) * 2001-10-10 2016-07-13 ratiopharm GmbH Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
US7125843B2 (en) * 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
WO2003055526A2 (en) 2001-12-21 2003-07-10 Maxygen Aps Erythropoietin conjugates
ITPD20010302A1 (it) 2001-12-28 2003-06-28 Bbs Riva Spa Dispositivo idraulico per pompare e / p intercettare metallo allo stato fuso
US6763226B1 (en) 2002-07-31 2004-07-13 Computer Science Central, Inc. Multifunctional world wide walkie talkie, a tri-frequency cellular-satellite wireless instant messenger computer and network for establishing global wireless volp quality of service (qos) communications, unified messaging, and video conferencing via the internet
BR0314106A (pt) * 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Polipeptìdeos hasilados, especialmente eritropoietina hasilada
EP1400533A1 (en) * 2002-09-11 2004-03-24 Fresenius Kabi Deutschland GmbH HASylated polypeptides, especially HASylated erythropoietin
EP1681303B1 (en) * 2002-09-11 2013-09-04 Fresenius Kabi Deutschland GmbH HASylated polypeptides, especially HASylated erythropoietin
CA2521381C (en) 2003-04-11 2020-05-26 Rezolute, Inc. Method for preparation of site-specific protein conjugates
JPWO2004101619A1 (ja) 2003-05-15 2006-10-26 塩野義製薬株式会社 機能的糖ペプチドの合理的設計および合成
US7074755B2 (en) * 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
US7550593B2 (en) 2003-07-03 2009-06-23 Cipla Limited Process for the preparation of finasteride Form I
CA2534652C (en) 2003-08-05 2013-12-10 Dematic Corp. Motorized roller transverse drive
CN100423774C (zh) 2003-08-06 2008-10-08 美国政府健康及人类服务部 制备多糖-蛋白轭合物疫苗的方法
KR101154343B1 (ko) * 2003-08-08 2012-07-05 프레제니우스 카비 도이치란트 게엠베하 히드록시알킬 스타치 및 ｇ-ｃｓｆ의 컨쥬게이트
JP2007501888A (ja) * 2003-08-12 2007-02-01 リポクセン テクノロジーズ リミテッド ポリシアル酸誘導体
WO2005016974A1 (en) * 2003-08-12 2005-02-24 Lipoxen Technologies Limited Sialic acid derivatives for protein derivatisation and conjugation
ES2445948T3 (es) * 2003-11-24 2014-03-06 Ratiopharm Gmbh Eritropoyetina glicopegilada
KR101237884B1 (ko) * 2003-12-03 2013-02-27 바이오제너릭스 에이지 글리코 peg화 과립구 콜로니 자극인자
US7956032B2 (en) * 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
TWI417303B (zh) * 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
DE102004030392A1 (de) 2004-06-23 2006-01-19 Endress + Hauser Flowtec Ag, Reinach Meßwandler vom Vibrationstyp
WO2006014148A2 (fr) 2004-08-04 2006-02-09 Sergey Alexandrovich Orlov Procede permettant d'organiser un processus de jeu a action intermittente
GB2416993A (en) 2004-08-11 2006-02-15 Dinesh Verma Opthalmic prosthesis
WO2006016168A2 (en) 2004-08-12 2006-02-16 Lipoxen Technologies Limited Sialic acid derivatives
US8652334B2 (en) 2004-08-12 2014-02-18 Lipoxen Technologies Limited Fractionation of charged polysaccharide
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
CN101160326B (zh) 2005-02-23 2013-04-10 利普生技术有限公司 用于蛋白质衍生和缀合的活化的唾液酸衍生物
JP3989936B2 (ja) * 2005-04-07 2007-10-10 進 須永 抗腫瘍剤及び新規ｄｎアーゼ
US7687608B2 (en) * 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
WO2008012528A1 (en) * 2006-07-25 2008-01-31 Lipoxen Technologies Limited N-terminal polysialylation
JP2011037843A (ja) 2009-07-16 2011-02-24 Kao Corp 食後血中インスリン濃度上昇抑制剤
UY34346A (es) 2011-09-26 2013-04-30 Novartis Ag Proteínas de fusión para tratar trastornos metabólicos

Similar Documents

Publication Publication Date Title
JP2009544681A5 (https=)
JP2015145400A5 (https=)
RU2009105696A (ru) N-концевое полисиалилирование
EP2709645B1 (en) Improved peptide pharmaceuticals
US20230057847A1 (en) Glp2 receptor agonists and methods of use
JP4119428B2 (ja) 糖鎖アスパラギンを有する糖ペプチドの製造法及び該糖ペプチド
JP2008538743A5 (https=)
JP4607017B2 (ja) アミノ化複合型糖鎖誘導体及びその製造方法
MA25654A1 (fr) Cristallisation selective du sel de sodium de l'acide 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonique, sous la forme hemipentahydrate au monohydrate.
KR20070108535A (ko) 폴리펩티드와 5당류의 접합체
JP2005179362A5 (https=)
BRPI0717505B1 (pt) Conjugado de peptídeo e formulação farmacêutica
US20130281368A1 (en) Glucagon-Like Peptide-1 Glycopeptides
US7622576B1 (en) Halide-free glucosamine base and method of preparation
RU2010107283A (ru) Способ получения пептида
RU2016140844A (ru) Модифицированная сульфамидаза и способ её получения
JPS5811427B2 (ja) インシユリン ナラビニ ソノルイエンタイ オヨビ ユウドウタイノセイホウ
CA2741209C (en) An improved process for pegylation of proteins
JPH11255807A (ja) 糖鎖アスパラギン活性エステル誘導体とその合成中間体
CA2569715A1 (en) Method of improving the crushing strength and reducing the dust formation and the caking tendency of urea, and urea composition
EP1666496A4 (en) COMPOSITE COMPRISING INTERFERON BETA
JPS6112920B2 (https=)
CA2376986A1 (en) Method for purification of proteins
JP2008150464A (ja) コア物質への糖鎖付加方法
PL210455B1 (pl) Sposób otrzymywania acylowanych peptydów