JP2009541386A5 - - Google Patents
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- JP2009541386A5 JP2009541386A5 JP2009516964A JP2009516964A JP2009541386A5 JP 2009541386 A5 JP2009541386 A5 JP 2009541386A5 JP 2009516964 A JP2009516964 A JP 2009516964A JP 2009516964 A JP2009516964 A JP 2009516964A JP 2009541386 A5 JP2009541386 A5 JP 2009541386A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acid
- alkoxy
- substituted
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0612721.1A GB0612721D0 (en) | 2006-06-27 | 2006-06-27 | Organic compounds |
| PCT/EP2007/005597 WO2008000419A1 (en) | 2006-06-27 | 2007-06-25 | S1p receptor modulators for treating multiple sclerosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013076909A Division JP2013166761A (ja) | 2006-06-27 | 2013-04-02 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009541386A JP2009541386A (ja) | 2009-11-26 |
| JP2009541386A5 true JP2009541386A5 (https=) | 2010-08-26 |
Family
ID=36888144
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516964A Pending JP2009541386A (ja) | 2006-06-27 | 2007-06-25 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2013076909A Pending JP2013166761A (ja) | 2006-06-27 | 2013-04-02 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2016087703A Withdrawn JP2016185957A (ja) | 2006-06-27 | 2016-04-26 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2018021389A Withdrawn JP2018109018A (ja) | 2006-06-27 | 2018-02-08 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2019089217A Active JP6931019B2 (ja) | 2006-06-27 | 2019-05-09 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2020176666A Active JP7258832B2 (ja) | 2006-06-27 | 2020-10-21 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2023061697A Pending JP2023098949A (ja) | 2006-06-27 | 2023-04-05 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2024172795A Pending JP2025016462A (ja) | 2006-06-27 | 2024-10-01 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013076909A Pending JP2013166761A (ja) | 2006-06-27 | 2013-04-02 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2016087703A Withdrawn JP2016185957A (ja) | 2006-06-27 | 2016-04-26 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2018021389A Withdrawn JP2018109018A (ja) | 2006-06-27 | 2018-02-08 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2019089217A Active JP6931019B2 (ja) | 2006-06-27 | 2019-05-09 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2020176666A Active JP7258832B2 (ja) | 2006-06-27 | 2020-10-21 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2023061697A Pending JP2023098949A (ja) | 2006-06-27 | 2023-04-05 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
| JP2024172795A Pending JP2025016462A (ja) | 2006-06-27 | 2024-10-01 | 多発性硬化症を処置するためのs1p受容体モジュレーター |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20100168078A1 (https=) |
| EP (4) | EP2959894B1 (https=) |
| JP (8) | JP2009541386A (https=) |
| KR (6) | KR20090024281A (https=) |
| CN (2) | CN101478961B (https=) |
| AU (7) | AU2007264031C1 (https=) |
| BR (1) | BRPI0713985A2 (https=) |
| CA (1) | CA2653569C (https=) |
| DE (1) | DE15177166T1 (https=) |
| DK (1) | DK2959894T3 (https=) |
| ES (1) | ES2887042T3 (https=) |
| GB (1) | GB0612721D0 (https=) |
| HU (1) | HUE059922T4 (https=) |
| LT (1) | LT2959894T (https=) |
| MX (3) | MX2008016133A (https=) |
| PL (1) | PL2959894T3 (https=) |
| PT (1) | PT2959894T (https=) |
| RU (1) | RU2617502C2 (https=) |
| SI (1) | SI2959894T1 (https=) |
| WO (1) | WO2008000419A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| CA2684953C (en) * | 2007-05-04 | 2016-08-09 | Novartis Ag | Use of s1p receptor modulator |
| JP2011525189A (ja) * | 2008-06-20 | 2011-09-15 | ノバルティス アーゲー | 多発性硬化症を治療するための小児科の組成物 |
| KR101618906B1 (ko) * | 2008-08-18 | 2016-05-09 | 노파르티스 아게 | 말초 신경병증의 치료를 위한 화합물 |
| EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| KR20110101159A (ko) * | 2008-12-18 | 2011-09-15 | 노파르티스 아게 | 신규 염 |
| JP2012512884A (ja) | 2008-12-18 | 2012-06-07 | ノバルティス アーゲー | 1−(4−{1−[(e)−4−シクロヘキシル−3−トリフルオロメチル−ベンジルオキシイミノ]−エチル}−2−エチル−ベンジル)−アゼチジン−3−カルボン酸の新規の多形相 |
| US20120115840A1 (en) * | 2008-12-18 | 2012-05-10 | Lech Ciszewski | Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid |
| EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
| EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
| EP2305660A1 (en) | 2009-09-25 | 2011-04-06 | Almirall, S.A. | New thiadiazole derivatives |
| US20110124605A1 (en) * | 2009-11-20 | 2011-05-26 | Shreeram Aradhye | Use of an S1P Receptor Agonist |
| MX2012006028A (es) * | 2009-11-24 | 2012-06-19 | Allergan Inc | Compuestos novedosos como moduladores de receptor con utilidad terapeutica. |
| EP2343287A1 (en) | 2009-12-10 | 2011-07-13 | Almirall, S.A. | New 2-aminothiadiazole derivatives |
| EP2366702A1 (en) | 2010-03-18 | 2011-09-21 | Almirall, S.A. | New oxadiazole derivatives |
| EP2390252A1 (en) | 2010-05-19 | 2011-11-30 | Almirall, S.A. | New pyrazole derivatives |
| JP6111202B2 (ja) | 2011-01-07 | 2017-04-05 | ノバルティス アーゲー | 免疫抑制製剤 |
| CN102120720B (zh) * | 2011-01-25 | 2013-05-22 | 上海华升生物科技有限公司 | 盐酸芬戈莫德的合成新方法 |
| BR112014009141A8 (pt) * | 2011-10-21 | 2017-06-20 | Novartis Ag | regime de dosagem para um modulador ou agonista do receptor s1p |
| CN104170419B (zh) * | 2012-03-23 | 2018-11-02 | 日本电气株式会社 | 订户服务器、监视服务器、移动终端、与之相关的方法和计算机可读介质 |
| RU2506949C1 (ru) * | 2012-06-13 | 2014-02-20 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
| CN102887829B (zh) * | 2012-09-05 | 2014-07-02 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
| CN105611917A (zh) | 2013-10-11 | 2016-05-25 | 帝国制药美国公司 | 局部鞘氨醇-1-磷酸酯受体激动剂制剂及其使用方法 |
| US10675254B2 (en) | 2013-10-11 | 2020-06-09 | Teikoku Seiyaku Co., Ltd. | Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same |
| WO2016135644A1 (en) | 2015-02-26 | 2016-09-01 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
| US20190047951A1 (en) | 2016-01-04 | 2019-02-14 | Auspex Pharmaceuticals, Inc. | Azetidine modulators of the sphingosine 1-phosphate receptor |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| JP7749552B2 (ja) | 2019-10-31 | 2025-10-06 | イドルシア・ファーマシューティカルズ・リミテッド | Cxcr7アンタゴニストのs1p1受容体調節剤との合剤 |
| AU2022328858A1 (en) * | 2021-08-20 | 2024-02-22 | The Brain Protection Company PTY LTD | Combinatorial therapies including implantable damping devices and therapeutic agents for treating a condition and associated systems and methods of use |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB612721A (en) | 1946-02-11 | 1948-11-17 | Richard William Bailey | Improvements in combustion product power plant |
| DE69321823T2 (de) | 1992-10-21 | 1999-06-02 | Taito Co., Ltd., Tokio/Tokyo | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| AU687727B2 (en) | 1992-10-28 | 1998-03-05 | Genentech Inc. | Vascular endothelial cell growth factor antagonists |
| EP0778263B1 (en) | 1994-08-22 | 2002-01-09 | Welfide Corporation | Benzene compound and medicinal use thereof |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| ES2240868T3 (es) | 1997-04-04 | 2005-10-16 | Mitsubishi Pharma Corporation | Compuesto de 2-aminopropano -1,3-diol, su uso farmaceutico e intermedios en su sintesis. |
| PT1107964E (pt) | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| DK1140173T4 (da) | 1998-12-22 | 2013-06-10 | Genentech Inc | Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf |
| CN1660840A (zh) | 1999-03-30 | 2005-08-31 | 诺瓦提斯公司 | 治疗炎性疾病的酞嗪衍生物 |
| AR025068A1 (es) | 1999-08-10 | 2002-11-06 | Bayer Corp | Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis |
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| PT1254138E (pt) | 2000-02-09 | 2005-09-30 | Novartis Ag | Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf |
| DE10033541C2 (de) | 2000-07-11 | 2003-05-15 | Litef Gmbh | Lichtleitfaserspule für ein faseroptisches Sagnac-Interferometer und Verfahren zu ihrer Herstellung |
| CN1328387C (zh) | 2000-07-13 | 2007-07-25 | 三共株式会社 | 氨基醇衍生物 |
| EP1315735A4 (en) | 2000-08-31 | 2005-04-06 | Merck & Co Inc | Phosphate derivatives as immunoregulatory compounds |
| RU2199339C2 (ru) | 2001-02-23 | 2003-02-27 | Общество с ограниченной ответственностью "Биотех" | Способ лечения рассеянного склероза |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| ATE448193T1 (de) | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| JP4430941B2 (ja) | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Edg受容体作動薬 |
| PT1505959E (pt) * | 2002-05-16 | 2009-02-05 | Novartis Ag | Utilização de agentes de ligação do receptor edg em cancro |
| BR0311347A (pt) * | 2002-05-27 | 2005-02-22 | Novartis Ag | Alcanóis bis-aromáticos |
| EP1575576A2 (en) | 2002-09-24 | 2005-09-21 | Novartis AG | Organic compounds |
| KR20040048231A (ko) * | 2002-12-02 | 2004-06-07 | 주식회사 두산 | 신생혈관생성 억제제 및 그를 포함한 암 치료용 키트 |
| FR2848495B1 (fr) * | 2002-12-12 | 2006-11-17 | Sidel Sa | Four pour chauffer au defile des ebauches de recipients en materiau thermoplastique |
| PE20130200A1 (es) | 2003-04-08 | 2013-03-09 | Novartis Ag | Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar |
| CL2004001120A1 (es) | 2003-05-19 | 2005-04-15 | Irm Llc | Compuestos derivados de amina sustituidas con heterociclos, inmunosupresores; composicion farmaceutica; y uso para tratar enfermedades mediadas por interacciones de linfocito, tales como enfermedades autoinmunes, inflamatorias, infecciosas, cancer. |
| EP1644367B1 (en) * | 2003-05-19 | 2015-10-14 | Novartis AG | Immunosuppressant compounds and compositions |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| UA74941C2 (en) | 2004-04-26 | 2006-02-15 | Fos Internat S A | A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same |
| WO2005113330A1 (en) | 2004-05-05 | 2005-12-01 | Adler, Richard, S. | Systems and methods for protecting ship from attack on the surface or under water |
| CA2567686A1 (en) * | 2004-06-10 | 2005-12-29 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for the treatment of human cancer |
| CN101102791B (zh) * | 2004-11-18 | 2011-12-14 | 英克隆有限责任公司 | 抗血管内皮生长因子受体-1的抗体 |
| KR20070085465A (ko) * | 2004-11-29 | 2007-08-27 | 노파르티스 아게 | S1p 수용체 효능제의 투여 용법 |
| US20060134111A1 (en) * | 2004-12-17 | 2006-06-22 | Genentech, Inc. | Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy |
| RU2278687C1 (ru) | 2005-06-16 | 2006-06-27 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" (ГОУ ВПО БГМУ РОСЗДРАВА РОССИИ) | Способ лечения ремиттирующего рассеянного склероза |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| EP2323679A4 (en) | 2008-07-25 | 2012-08-22 | Univ Colorado | CLIP INHIBITORS AND METHODS FOR MODULATING IMMUNE FUNCTION |
| GB2527550B (en) | 2014-06-25 | 2016-09-21 | Cook Medical Technologies Llc | Implantable medical device with lumen constriction |
-
2006
- 2006-06-27 GB GBGB0612721.1A patent/GB0612721D0/en not_active Ceased
-
2007
- 2007-06-25 KR KR1020097001390A patent/KR20090024281A/ko not_active Withdrawn
- 2007-06-25 CN CN2007800236012A patent/CN101478961B/zh not_active Expired - Fee Related
- 2007-06-25 JP JP2009516964A patent/JP2009541386A/ja active Pending
- 2007-06-25 US US12/303,765 patent/US20100168078A1/en not_active Abandoned
- 2007-06-25 PT PT151771664T patent/PT2959894T/pt unknown
- 2007-06-25 LT LTEP2959894T patent/LT2959894T/lt unknown
- 2007-06-25 DE DE15177166.4T patent/DE15177166T1/de active Pending
- 2007-06-25 WO PCT/EP2007/005597 patent/WO2008000419A1/en not_active Ceased
- 2007-06-25 PL PL15177166.4T patent/PL2959894T3/pl unknown
- 2007-06-25 DK DK15177166.4T patent/DK2959894T3/da active
- 2007-06-25 BR BRPI0713985-3A patent/BRPI0713985A2/pt not_active Application Discontinuation
- 2007-06-25 AU AU2007264031A patent/AU2007264031C1/en active Active
- 2007-06-25 KR KR1020197007465A patent/KR20190030776A/ko not_active Ceased
- 2007-06-25 RU RU2009102278A patent/RU2617502C2/ru active
- 2007-06-25 CA CA2653569A patent/CA2653569C/en active Active
- 2007-06-25 CN CN201310446846.3A patent/CN103550195A/zh active Pending
- 2007-06-25 EP EP15177166.4A patent/EP2959894B1/en active Active
- 2007-06-25 EP EP20208442.2A patent/EP3797765A1/en not_active Withdrawn
- 2007-06-25 KR KR1020157030213A patent/KR20150122812A/ko not_active Ceased
- 2007-06-25 KR KR1020177034918A patent/KR20170138583A/ko not_active Ceased
- 2007-06-25 EP EP13186359.9A patent/EP2698154A1/en not_active Withdrawn
- 2007-06-25 ES ES15177166T patent/ES2887042T3/es active Active
- 2007-06-25 KR KR1020217001928A patent/KR20210010956A/ko not_active Ceased
- 2007-06-25 KR KR1020147010290A patent/KR20140069178A/ko not_active Withdrawn
- 2007-06-25 HU HUE15177166A patent/HUE059922T4/hu unknown
- 2007-06-25 EP EP07764828A patent/EP2037906A1/en not_active Withdrawn
- 2007-06-25 SI SI200732191T patent/SI2959894T1/sl unknown
- 2007-06-25 MX MX2008016133A patent/MX2008016133A/es not_active Application Discontinuation
-
2008
- 2008-12-16 MX MX2019012750A patent/MX2019012750A/es unknown
- 2008-12-16 MX MX2022008950A patent/MX2022008950A/es unknown
-
2011
- 2011-04-21 AU AU2011201844A patent/AU2011201844B2/en active Active
- 2011-05-31 US US13/149,468 patent/US8741963B2/en active Active
-
2013
- 2013-01-24 AU AU2013200356A patent/AU2013200356B2/en active Active
- 2013-04-02 JP JP2013076909A patent/JP2013166761A/ja active Pending
-
2014
- 2014-04-21 US US14/257,342 patent/US9187405B2/en active Active
-
2016
- 2016-04-26 JP JP2016087703A patent/JP2016185957A/ja not_active Withdrawn
- 2016-12-01 AU AU2016266058A patent/AU2016266058A1/en not_active Abandoned
-
2018
- 2018-02-08 JP JP2018021389A patent/JP2018109018A/ja not_active Withdrawn
- 2018-03-28 AU AU2018202210A patent/AU2018202210A1/en not_active Abandoned
-
2019
- 2019-05-09 JP JP2019089217A patent/JP6931019B2/ja active Active
- 2019-08-22 AU AU2019219818A patent/AU2019219818A1/en not_active Abandoned
-
2020
- 2020-10-21 JP JP2020176666A patent/JP7258832B2/ja active Active
-
2021
- 2021-04-20 AU AU2021202395A patent/AU2021202395A1/en not_active Abandoned
-
2023
- 2023-04-05 JP JP2023061697A patent/JP2023098949A/ja active Pending
-
2024
- 2024-10-01 JP JP2024172795A patent/JP2025016462A/ja active Pending
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