JP2007523051A5 - - Google Patents
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- Publication number
- JP2007523051A5 JP2007523051A5 JP2006528258A JP2006528258A JP2007523051A5 JP 2007523051 A5 JP2007523051 A5 JP 2007523051A5 JP 2006528258 A JP2006528258 A JP 2006528258A JP 2006528258 A JP2006528258 A JP 2006528258A JP 2007523051 A5 JP2007523051 A5 JP 2007523051A5
- Authority
- JP
- Japan
- Prior art keywords
- following structural
- pharmaceutically acceptable
- structural formula
- compounds represented
- solvates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IIMBTLYMMRKHDQ-BQLGKWBJSA-N CC([C@H]([C@]1(C[C@H](C)[C@H]2C)O)C2(C)/C=C/c(nc2)ccc2-c(cccc2)c2F)OC1=O Chemical compound CC([C@H]([C@]1(C[C@H](C)[C@H]2C)O)C2(C)/C=C/c(nc2)ccc2-c(cccc2)c2F)OC1=O IIMBTLYMMRKHDQ-BQLGKWBJSA-N 0.000 description 1
- 0 CC[C@](C([C@]([C@@](C)O1)[C@@]2(C3)C1=O)C=C[C@@]1N=CC(c4ccccc4)=CC1)[C@]3(C)*C2=O Chemical compound CC[C@](C([C@]([C@@](C)O1)[C@@]2(C3)C1=O)C=C[C@@]1N=CC(c4ccccc4)=CC1)[C@]3(C)*C2=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/671,216 | 2003-09-25 | ||
| US10/671,216 US7488742B2 (en) | 2000-06-15 | 2003-09-25 | Thrombin receptor antagonists |
| PCT/US2004/031495 WO2005030712A2 (en) | 2003-09-25 | 2004-09-23 | Thrombin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523051A JP2007523051A (ja) | 2007-08-16 |
| JP2007523051A5 true JP2007523051A5 (https=) | 2007-11-01 |
| JP4694490B2 JP4694490B2 (ja) | 2011-06-08 |
Family
ID=34393462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528258A Expired - Fee Related JP4694490B2 (ja) | 2003-09-25 | 2004-09-23 | トロンビンレセプターアンタゴニスト |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7488742B2 (https=) |
| EP (1) | EP1663965B1 (https=) |
| JP (1) | JP4694490B2 (https=) |
| KR (1) | KR20060128848A (https=) |
| CN (1) | CN101128457A (https=) |
| AR (1) | AR045809A1 (https=) |
| AU (1) | AU2004276327B2 (https=) |
| BR (1) | BRPI0414592A (https=) |
| CA (1) | CA2540163C (https=) |
| CO (1) | CO5680428A2 (https=) |
| EC (1) | ECSP066455A (https=) |
| IL (1) | IL174538A0 (https=) |
| MX (1) | MXPA06003379A (https=) |
| MY (1) | MY143834A (https=) |
| NO (1) | NO20061797L (https=) |
| PE (1) | PE20050471A1 (https=) |
| RU (1) | RU2367660C9 (https=) |
| SG (1) | SG147466A1 (https=) |
| TW (1) | TWI331608B (https=) |
| WO (1) | WO2005030712A2 (https=) |
| ZA (1) | ZA200602448B (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US7304078B2 (en) * | 2002-04-16 | 2007-12-04 | Schering Corporation | Thrombin receptor antagonists |
| US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
| US7872133B2 (en) * | 2003-06-23 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tricyclic heterocycle compound |
| MXPA06013903A (es) * | 2004-05-28 | 2007-01-26 | Schering Corp | Analogos restringidos de himbacina como antagonistas del receptor de trombina. |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| AU2005294265A1 (en) * | 2004-10-06 | 2006-04-20 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| WO2006041872A2 (en) * | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
| EP1829874B1 (en) * | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
| ATE530516T1 (de) | 2005-01-14 | 2011-11-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
| WO2006105217A2 (en) * | 2005-03-31 | 2006-10-05 | Schering Corporation | Spirocyclic thrombin receptor antagonists |
| US20070219154A1 (en) * | 2005-12-20 | 2007-09-20 | Suxing Liu | Methods for preventing and/or treating a cell proliferative disorder |
| WO2007075809A2 (en) * | 2005-12-22 | 2007-07-05 | Schering Corporation | Oxazoloisoquinoline derivatives as thrombin receptor antagonists |
| EP1971336A2 (en) * | 2005-12-22 | 2008-09-24 | Shering Corporation | Thrombin receptor antagonists as phophylaxis to complications from cardiopulmonary surgery |
| MX2008012574A (es) | 2006-03-29 | 2008-10-10 | Schering Corp | Derivados de himbacina monociclitos y biciclicos utiles como antagonistas del receptor de trombina. |
| TW200812619A (en) * | 2006-04-06 | 2008-03-16 | Schering Corp | TRA combination therapies |
| EP2007755B1 (en) * | 2006-04-13 | 2012-06-27 | Schering Corporation | Fused ring thrombin receptor antagonists |
| CA2655720A1 (en) | 2006-06-29 | 2008-01-10 | Schering Corporation | Substituted bicyclic and tricyclic thrombin receptor antagonists |
| TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| DE102006036023A1 (de) * | 2006-08-02 | 2008-02-07 | Sanofi-Aventis | Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität |
| TWI343262B (en) * | 2006-09-26 | 2011-06-11 | Schering Corp | Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist |
| CN101541782A (zh) * | 2006-10-04 | 2009-09-23 | 先灵公司 | 作为凝血酶受体拮抗剂的二环和三环衍生物 |
| WO2008079260A2 (en) * | 2006-12-22 | 2008-07-03 | Schering Corporation | Disintegration promoters in solid dose wet granulation formulations |
| WO2008118320A1 (en) * | 2007-03-23 | 2008-10-02 | Schering Corporation | Reduction of adverse events.after percutaneous intervention by use of a thrombin receptor antagonist |
| WO2009097970A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
| KR20100120139A (ko) * | 2008-02-05 | 2010-11-12 | 사노피-아벤티스 | Ｐａｒ１ 억제제로서의 트리아졸륨 염, 이들의 제조방법, 및 약제로서의 용도 |
| ES2400322T3 (es) | 2008-02-05 | 2013-04-09 | Sanofi | Derivados de SF5 como inhibidores de PAR-1, su preparación y utilización como medicamento |
| ES2437100T3 (es) | 2009-06-04 | 2014-01-08 | Merck Sharp & Dohme Corp. | Metabolito activo de un antagonista de los receptores de la trombina |
| MX2011013091A (es) | 2009-06-08 | 2012-01-12 | Schering Corp | Un antagonista del receptor de trombina y tableta con dosificacion fija de clopidogrel. |
| PL2558462T3 (pl) | 2010-04-16 | 2015-03-31 | Sanofi Sa | Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1 |
| ES2532902T3 (es) | 2010-04-16 | 2015-04-01 | Sanofi | Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1 |
| US9340530B2 (en) | 2012-03-06 | 2016-05-17 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists |
| EP3024550A4 (en) | 2013-07-22 | 2016-12-07 | Merck Sharp & Dohme | CO-CRYSTAL FROM THE PAR-1 RECEPTOR ANTAGONIST VORAPAXAR AND ASPIRIN |
| WO2015026685A1 (en) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives |
| WO2015026693A1 (en) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | 7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives |
| WO2015026686A1 (en) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | 3'-pyridyl substituted- 6,6-difluoro bicyclic himbacine derivatives |
| WO2016114386A1 (ja) * | 2015-01-15 | 2016-07-21 | 国立研究開発法人国立精神・神経医療研究センター | 進行型免疫性脱髄疾患治療剤 |
| CN110407819B (zh) * | 2019-08-02 | 2020-06-26 | 牡丹江医学院 | 一种作为预防外科手术并发症的凝血酶受体拮抗剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000229961A (ja) * | 1998-12-11 | 2000-08-22 | Sagami Chem Res Center | ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法 |
| KR100393492B1 (ko) * | 1997-11-25 | 2003-08-02 | 쉐링 코포레이션 | 트롬빈 수용체 길항제 |
| US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| ES2291323T3 (es) | 2000-06-15 | 2008-03-01 | Schering Corporation | Antagonistas de receptores de trombina. |
| US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
| US7304078B2 (en) * | 2002-04-16 | 2007-12-04 | Schering Corporation | Thrombin receptor antagonists |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| BR0213967A (pt) * | 2001-10-18 | 2005-08-30 | Schering Corp | Análogos de himbacina como antagonistas do receptor de trombina |
| MXPA06013903A (es) * | 2004-05-28 | 2007-01-26 | Schering Corp | Analogos restringidos de himbacina como antagonistas del receptor de trombina. |
| US7541471B2 (en) * | 2005-01-14 | 2009-06-02 | Schering Corporation | Synthesis of himbacine analogs |
| ATE530516T1 (de) * | 2005-01-14 | 2011-11-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
| JP4775971B2 (ja) * | 2005-01-14 | 2011-09-21 | シェーリング コーポレイション | ヒンバシンアナログのエキソ−選択的合成 |
| US20060172397A1 (en) * | 2005-01-14 | 2006-08-03 | Schering Corporation | Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs |
-
2003
- 2003-09-25 US US10/671,216 patent/US7488742B2/en not_active Expired - Lifetime
-
2004
- 2004-09-23 CA CA2540163A patent/CA2540163C/en not_active Expired - Fee Related
- 2004-09-23 RU RU2006113638/04A patent/RU2367660C9/ru not_active IP Right Cessation
- 2004-09-23 WO PCT/US2004/031495 patent/WO2005030712A2/en not_active Ceased
- 2004-09-23 EP EP04789042.1A patent/EP1663965B1/en not_active Expired - Lifetime
- 2004-09-23 AU AU2004276327A patent/AU2004276327B2/en not_active Ceased
- 2004-09-23 AR ARP040103439A patent/AR045809A1/es unknown
- 2004-09-23 CN CNA2004800278261A patent/CN101128457A/zh active Pending
- 2004-09-23 MX MXPA06003379A patent/MXPA06003379A/es active IP Right Grant
- 2004-09-23 SG SG200807889-1A patent/SG147466A1/en unknown
- 2004-09-23 JP JP2006528258A patent/JP4694490B2/ja not_active Expired - Fee Related
- 2004-09-23 BR BRPI0414592-5A patent/BRPI0414592A/pt not_active IP Right Cessation
- 2004-09-23 TW TW093128874A patent/TWI331608B/zh not_active IP Right Cessation
- 2004-09-23 KR KR1020067005753A patent/KR20060128848A/ko not_active Ceased
- 2004-09-23 PE PE2004000927A patent/PE20050471A1/es not_active Application Discontinuation
- 2004-09-24 MY MYPI20043931A patent/MY143834A/en unknown
-
2006
- 2006-03-23 CO CO06029040A patent/CO5680428A2/es not_active Application Discontinuation
- 2006-03-23 IL IL174538A patent/IL174538A0/en unknown
- 2006-03-24 EC EC2006006455A patent/ECSP066455A/es unknown
- 2006-03-24 ZA ZA200602448A patent/ZA200602448B/en unknown
- 2006-04-24 NO NO20061797A patent/NO20061797L/no not_active Application Discontinuation
-
2008
- 2008-10-30 US US12/261,514 patent/US20090076088A1/en not_active Abandoned
- 2008-10-30 US US12/261,545 patent/US20090069383A1/en not_active Abandoned
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