GB0612721D0 - Organic compounds - Google Patents

Organic compounds

Info

Publication number
GB0612721D0
GB0612721D0 GBGB0612721.1A GB0612721A GB0612721D0 GB 0612721 D0 GB0612721 D0 GB 0612721D0 GB 0612721 A GB0612721 A GB 0612721A GB 0612721 D0 GB0612721 D0 GB 0612721D0
Authority
GB
United Kingdom
Prior art keywords
organic compounds
amino
neo
diol
propane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0612721.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36888144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0612721(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Priority to GBGB0612721.1A priority Critical patent/GB0612721D0/en
Publication of GB0612721D0 publication Critical patent/GB0612721D0/en
Priority to EP13186359.9A priority patent/EP2698154A1/en
Priority to EP07764828A priority patent/EP2037906A1/en
Priority to PCT/EP2007/005597 priority patent/WO2008000419A1/en
Priority to KR1020197007465A priority patent/KR20190030776A/ko
Priority to SI200732191T priority patent/SI2959894T1/sl
Priority to KR1020097001390A priority patent/KR20090024281A/ko
Priority to RU2009102278A priority patent/RU2617502C2/ru
Priority to KR1020217001928A priority patent/KR20210010956A/ko
Priority to AU2007264031A priority patent/AU2007264031C1/en
Priority to BRPI0713985-3A priority patent/BRPI0713985A2/pt
Priority to KR1020147010290A priority patent/KR20140069178A/ko
Priority to US12/303,765 priority patent/US20100168078A1/en
Priority to DK15177166.4T priority patent/DK2959894T3/da
Priority to KR1020157030213A priority patent/KR20150122812A/ko
Priority to CN2007800236012A priority patent/CN101478961B/zh
Priority to PT151771664T priority patent/PT2959894T/pt
Priority to DE15177166.4T priority patent/DE15177166T1/de
Priority to LTEP2959894T priority patent/LT2959894T/lt
Priority to ES15177166T priority patent/ES2887042T3/es
Priority to CA2653569A priority patent/CA2653569C/en
Priority to KR1020177034918A priority patent/KR20170138583A/ko
Priority to PL15177166.4T priority patent/PL2959894T3/pl
Priority to HUE15177166A priority patent/HUE059922T4/hu
Priority to EP20208442.2A priority patent/EP3797765A1/en
Priority to MX2008016133A priority patent/MX2008016133A/es
Priority to EP15177166.4A priority patent/EP2959894B1/en
Priority to CN201310446846.3A priority patent/CN103550195A/zh
Priority to JP2009516964A priority patent/JP2009541386A/ja
Priority to RU2013131176/15A priority patent/RU2569732C9/ru
Priority to MX2019012750A priority patent/MX2019012750A/es
Priority to MX2022008950A priority patent/MX2022008950A/es
Priority to AU2011201844A priority patent/AU2011201844B2/en
Priority to US13/149,468 priority patent/US8741963B2/en
Priority to AU2013200356A priority patent/AU2013200356B2/en
Priority to JP2013076909A priority patent/JP2013166761A/ja
Priority to US14/257,342 priority patent/US9187405B2/en
Priority to HK16102706.3A priority patent/HK1214758B/en
Priority to JP2016087703A priority patent/JP2016185957A/ja
Priority to AU2016266058A priority patent/AU2016266058A1/en
Priority to JP2018021389A priority patent/JP2018109018A/ja
Priority to AU2018202210A priority patent/AU2018202210A1/en
Priority to JP2019089217A priority patent/JP6931019B2/ja
Priority to AU2019219818A priority patent/AU2019219818A1/en
Priority to JP2020176666A priority patent/JP7258832B2/ja
Priority to AU2021202395A priority patent/AU2021202395A1/en
Priority to JP2023061697A priority patent/JP2023098949A/ja
Priority to JP2024172795A priority patent/JP2025016462A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0612721.1A 2006-06-27 2006-06-27 Organic compounds Ceased GB0612721D0 (en)

Priority Applications (48)

Application Number Priority Date Filing Date Title
GBGB0612721.1A GB0612721D0 (en) 2006-06-27 2006-06-27 Organic compounds
EP13186359.9A EP2698154A1 (en) 2006-06-27 2007-06-25 S1P receptor modulators for treating multiple sclerosis
EP07764828A EP2037906A1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
PCT/EP2007/005597 WO2008000419A1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
KR1020197007465A KR20190030776A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
SI200732191T SI2959894T1 (sl) 2006-06-27 2007-06-25 S1P receptorski modulatorji za zdravljenje multiple skleroze
KR1020097001390A KR20090024281A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
RU2009102278A RU2617502C2 (ru) 2006-06-27 2007-06-25 Модуляторы рецептора s1p для лечения рассеянного склероза
KR1020217001928A KR20210010956A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
AU2007264031A AU2007264031C1 (en) 2006-06-27 2007-06-25 S1P receptor modulators for treating multiple sclerosis
BRPI0713985-3A BRPI0713985A2 (pt) 2006-06-27 2007-06-25 compostos orgÂnicos
KR1020147010290A KR20140069178A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
US12/303,765 US20100168078A1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
DK15177166.4T DK2959894T3 (da) 2006-06-27 2007-06-25 S1p-receptormodulatorer til behandling af multipel sklerose
KR1020157030213A KR20150122812A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
CN2007800236012A CN101478961B (zh) 2006-06-27 2007-06-25 用于治疗多发硬化症的s1p受体调节剂
PT151771664T PT2959894T (pt) 2006-06-27 2007-06-25 Modulador de um receptor de s1p para o tratamento de esclerose múltipla
DE15177166.4T DE15177166T1 (de) 2006-06-27 2007-06-25 S1p-rezeptormodulatoren für die behandlung von multipler sklerose
LTEP2959894T LT2959894T (lt) 2006-06-27 2007-06-25 S1p receptoriaus moduliatoriai, skirti išsėtinės sklerozės gydymui
ES15177166T ES2887042T3 (es) 2006-06-27 2007-06-25 Moduladores del receptor S1P para el tratamiento de la esclerosis múltiple
CA2653569A CA2653569C (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
KR1020177034918A KR20170138583A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 ｓ１ｐ 수용체 조절제
PL15177166.4T PL2959894T3 (pl) 2006-06-27 2007-06-25 Modulatory receptora s1p do leczenia stwardnienia rozsianego
HUE15177166A HUE059922T4 (hu) 2006-06-27 2007-06-25 S1 receptor modulátorok sclerosis multiplex kezelésére
EP20208442.2A EP3797765A1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
MX2008016133A MX2008016133A (es) 2006-06-27 2007-06-25 Moduladores del receptor s1p para el tratamiento de esclerosis multiple.
EP15177166.4A EP2959894B1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis
CN201310446846.3A CN103550195A (zh) 2006-06-27 2007-06-25 用于治疗多发硬化症的s1p受体调节剂
JP2009516964A JP2009541386A (ja) 2006-06-27 2007-06-25 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
RU2013131176/15A RU2569732C9 (ru) 2006-06-27 2007-06-25 Модуляторы рецептора s1p для лечения рассеянного склероза
MX2019012750A MX2019012750A (es) 2006-06-27 2008-12-16 Moduladores del receptor s1p para el tratamiento de esclerosis multiple.
MX2022008950A MX2022008950A (es) 2006-06-27 2008-12-16 Moduladores del receptor s1p para el tratamiento de esclerosis multiple.
AU2011201844A AU2011201844B2 (en) 2006-06-27 2011-04-21 S1P receptor modulators for treating multiple sclerosis
US13/149,468 US8741963B2 (en) 2006-06-27 2011-05-31 S1P receptor modulators for treating multiple sclerosis
AU2013200356A AU2013200356B2 (en) 2006-06-27 2013-01-24 S1P receptor modulators for treating multiple sclerosis
JP2013076909A JP2013166761A (ja) 2006-06-27 2013-04-02 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
US14/257,342 US9187405B2 (en) 2006-06-27 2014-04-21 S1P receptor modulators for treating relasping-remitting multiple sclerosis
HK16102706.3A HK1214758B (en) 2006-06-27 2014-05-02 S1p receptor modulators for treating multiple sclerosis
JP2016087703A JP2016185957A (ja) 2006-06-27 2016-04-26 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
AU2016266058A AU2016266058A1 (en) 2006-06-27 2016-12-01 S1P receptor modulators for treating multiple sclerosis
JP2018021389A JP2018109018A (ja) 2006-06-27 2018-02-08 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
AU2018202210A AU2018202210A1 (en) 2006-06-27 2018-03-28 S1P receptor modulators for treating multiple sclerosis
JP2019089217A JP6931019B2 (ja) 2006-06-27 2019-05-09 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
AU2019219818A AU2019219818A1 (en) 2006-06-27 2019-08-22 S1P receptor modulators for treating multiple sclerosis
JP2020176666A JP7258832B2 (ja) 2006-06-27 2020-10-21 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
AU2021202395A AU2021202395A1 (en) 2006-06-27 2021-04-20 S1P receptor modulators for treating multiple sclerosis
JP2023061697A JP2023098949A (ja) 2006-06-27 2023-04-05 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター
JP2024172795A JP2025016462A (ja) 2006-06-27 2024-10-01 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0612721.1A GB0612721D0 (en) 2006-06-27 2006-06-27 Organic compounds

Publications (1)

Publication Number Publication Date
GB0612721D0 true GB0612721D0 (en) 2006-08-09

Family

ID=36888144

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0612721.1A Ceased GB0612721D0 (en) 2006-06-27 2006-06-27 Organic compounds

Country Status (20)

Country Link
US (3) US20100168078A1 (https=)
EP (4) EP2959894B1 (https=)
JP (8) JP2009541386A (https=)
KR (6) KR20090024281A (https=)
CN (2) CN101478961B (https=)
AU (7) AU2007264031C1 (https=)
BR (1) BRPI0713985A2 (https=)
CA (1) CA2653569C (https=)
DE (1) DE15177166T1 (https=)
DK (1) DK2959894T3 (https=)
ES (1) ES2887042T3 (https=)
GB (1) GB0612721D0 (https=)
HU (1) HUE059922T4 (https=)
LT (1) LT2959894T (https=)
MX (3) MX2008016133A (https=)
PL (1) PL2959894T3 (https=)
PT (1) PT2959894T (https=)
RU (1) RU2617502C2 (https=)
SI (1) SI2959894T1 (https=)
WO (1) WO2008000419A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
CA2684953C (en) * 2007-05-04 2016-08-09 Novartis Ag Use of s1p receptor modulator
JP2011525189A (ja) * 2008-06-20 2011-09-15 ノバルティス アーゲー 多発性硬化症を治療するための小児科の組成物
KR101618906B1 (ko) * 2008-08-18 2016-05-09 노파르티스 아게 말초 신경병증의 치료를 위한 화합물
EP2177521A1 (en) 2008-10-14 2010-04-21 Almirall, S.A. New 2-Amidothiadiazole Derivatives
KR20110101159A (ko) * 2008-12-18 2011-09-15 노파르티스 아게 신규 염
JP2012512884A (ja) 2008-12-18 2012-06-07 ノバルティス アーゲー １−（４−｛１−［（ｅ）−４−シクロヘキシル−３−トリフルオロメチル−ベンジルオキシイミノ］−エチル｝−２−エチル−ベンジル）−アゼチジン−３−カルボン酸の新規の多形相
US20120115840A1 (en) * 2008-12-18 2012-05-10 Lech Ciszewski Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
EP2305660A1 (en) 2009-09-25 2011-04-06 Almirall, S.A. New thiadiazole derivatives
US20110124605A1 (en) * 2009-11-20 2011-05-26 Shreeram Aradhye Use of an S1P Receptor Agonist
MX2012006028A (es) * 2009-11-24 2012-06-19 Allergan Inc Compuestos novedosos como moduladores de receptor con utilidad terapeutica.
EP2343287A1 (en) 2009-12-10 2011-07-13 Almirall, S.A. New 2-aminothiadiazole derivatives
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
EP2390252A1 (en) 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
JP6111202B2 (ja) 2011-01-07 2017-04-05 ノバルティス アーゲー 免疫抑制製剤
CN102120720B (zh) * 2011-01-25 2013-05-22 上海华升生物科技有限公司 盐酸芬戈莫德的合成新方法
BR112014009141A8 (pt) * 2011-10-21 2017-06-20 Novartis Ag regime de dosagem para um modulador ou agonista do receptor s1p
CN104170419B (zh) * 2012-03-23 2018-11-02 日本电气株式会社 订户服务器、监视服务器、移动终端、与之相关的方法和计算机可读介质
RU2506949C1 (ru) * 2012-06-13 2014-02-20 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
CN102887829B (zh) * 2012-09-05 2014-07-02 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
CN105611917A (zh) 2013-10-11 2016-05-25 帝国制药美国公司 局部鞘氨醇-1-磷酸酯受体激动剂制剂及其使用方法
US10675254B2 (en) 2013-10-11 2020-06-09 Teikoku Seiyaku Co., Ltd. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
WO2016135644A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
US20190047951A1 (en) 2016-01-04 2019-02-14 Auspex Pharmaceuticals, Inc. Azetidine modulators of the sphingosine 1-phosphate receptor
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
AU2022328858A1 (en) * 2021-08-20 2024-02-22 The Brain Protection Company PTY LTD Combinatorial therapies including implantable damping devices and therapeutic agents for treating a condition and associated systems and methods of use
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB612721A (en) 1946-02-11 1948-11-17 Richard William Bailey Improvements in combustion product power plant
DE69321823T2 (de) 1992-10-21 1999-06-02 Taito Co., Ltd., Tokio/Tokyo 2-amino-1, 3- propandiolverbindung und immunosuppressium
AU687727B2 (en) 1992-10-28 1998-03-05 Genentech Inc. Vascular endothelial cell growth factor antagonists
EP0778263B1 (en) 1994-08-22 2002-01-09 Welfide Corporation Benzene compound and medicinal use thereof
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE19638745C2 (de) 1996-09-11 2001-05-10 Schering Ag Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR)
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ES2240868T3 (es) 1997-04-04 2005-10-16 Mitsubishi Pharma Corporation Compuesto de 2-aminopropano -1,3-diol, su uso farmaceutico e intermedios en su sintesis.
PT1107964E (pt) 1998-08-11 2010-06-11 Novartis Ag Derivados de isoquinolina com actividade inibidora da angiogénese
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
DK1140173T4 (da) 1998-12-22 2013-06-10 Genentech Inc Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf
CN1660840A (zh) 1999-03-30 2005-08-31 诺瓦提斯公司 治疗炎性疾病的酞嗪衍生物
AR025068A1 (es) 1999-08-10 2002-11-06 Bayer Corp Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
PT1254138E (pt) 2000-02-09 2005-09-30 Novartis Ag Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf
DE10033541C2 (de) 2000-07-11 2003-05-15 Litef Gmbh Lichtleitfaserspule für ein faseroptisches Sagnac-Interferometer und Verfahren zu ihrer Herstellung
CN1328387C (zh) 2000-07-13 2007-07-25 三共株式会社 氨基醇衍生物
EP1315735A4 (en) 2000-08-31 2005-04-06 Merck & Co Inc Phosphate derivatives as immunoregulatory compounds
RU2199339C2 (ru) 2001-02-23 2003-02-27 Общество с ограниченной ответственностью "Биотех" Способ лечения рассеянного склероза
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
ATE448193T1 (de) 2002-01-18 2009-11-15 Merck & Co Inc ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß
JP4430941B2 (ja) 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Ｅｄｇ受容体作動薬
PT1505959E (pt) * 2002-05-16 2009-02-05 Novartis Ag Utilização de agentes de ligação do receptor edg em cancro
BR0311347A (pt) * 2002-05-27 2005-02-22 Novartis Ag Alcanóis bis-aromáticos
EP1575576A2 (en) 2002-09-24 2005-09-21 Novartis AG Organic compounds
KR20040048231A (ko) * 2002-12-02 2004-06-07 주식회사 두산 신생혈관생성 억제제 및 그를 포함한 암 치료용 키트
FR2848495B1 (fr) * 2002-12-12 2006-11-17 Sidel Sa Four pour chauffer au defile des ebauches de recipients en materiau thermoplastique
PE20130200A1 (es) 2003-04-08 2013-03-09 Novartis Ag Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar
CL2004001120A1 (es) 2003-05-19 2005-04-15 Irm Llc Compuestos derivados de amina sustituidas con heterociclos, inmunosupresores; composicion farmaceutica; y uso para tratar enfermedades mediadas por interacciones de linfocito, tales como enfermedades autoinmunes, inflamatorias, infecciosas, cancer.
EP1644367B1 (en) * 2003-05-19 2015-10-14 Novartis AG Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
UA74941C2 (en) 2004-04-26 2006-02-15 Fos Internat S A A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same
WO2005113330A1 (en) 2004-05-05 2005-12-01 Adler, Richard, S. Systems and methods for protecting ship from attack on the surface or under water
CA2567686A1 (en) * 2004-06-10 2005-12-29 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for the treatment of human cancer
CN101102791B (zh) * 2004-11-18 2011-12-14 英克隆有限责任公司 抗血管内皮生长因子受体-1的抗体
KR20070085465A (ko) * 2004-11-29 2007-08-27 노파르티스 아게 Ｓ１ｐ 수용체 효능제의 투여 용법
US20060134111A1 (en) * 2004-12-17 2006-06-22 Genentech, Inc. Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy
RU2278687C1 (ru) 2005-06-16 2006-06-27 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" (ГОУ ВПО БГМУ РОСЗДРАВА РОССИИ) Способ лечения ремиттирующего рассеянного склероза
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
EP2323679A4 (en) 2008-07-25 2012-08-22 Univ Colorado CLIP INHIBITORS AND METHODS FOR MODULATING IMMUNE FUNCTION
GB2527550B (en) 2014-06-25 2016-09-21 Cook Medical Technologies Llc Implantable medical device with lumen constriction

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