JP2009541309A5 - - Google Patents
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- Publication number
- JP2009541309A5 JP2009541309A5 JP2009516443A JP2009516443A JP2009541309A5 JP 2009541309 A5 JP2009541309 A5 JP 2009541309A5 JP 2009516443 A JP2009516443 A JP 2009516443A JP 2009516443 A JP2009516443 A JP 2009516443A JP 2009541309 A5 JP2009541309 A5 JP 2009541309A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fluoroalkyl
- nhc
- methoxy
- benzoxazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 18
- 208000037259 Amyloid Plaque Diseases 0.000 claims description 3
- 230000003941 amyloidogenesis Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 57
- 125000000217 alkyl group Chemical group 0.000 claims 55
- -1 bromo, iodo Chemical group 0.000 claims 26
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 24
- 125000002947 alkylene group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 12
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- XCUAIINAJCDIPM-XVFCMESISA-N N(4)-hydroxycytidine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=NO)C=C1 XCUAIINAJCDIPM-XVFCMESISA-N 0.000 claims 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- RVJVDPDTDMWHQD-UHFFFAOYSA-N 2-(5-bromopyridin-2-yl)-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(Br)C=N1 RVJVDPDTDMWHQD-UHFFFAOYSA-N 0.000 claims 2
- YGOSXGXSOQDVMZ-UHFFFAOYSA-N 2-(6-bromopyridin-3-yl)-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(Br)N=C1 YGOSXGXSOQDVMZ-UHFFFAOYSA-N 0.000 claims 2
- NWQWRLMTZFTONP-UHFFFAOYSA-N 2-(6-fluoro-5-methylpyridin-3-yl)-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CN=C(F)C(C)=C1 NWQWRLMTZFTONP-UHFFFAOYSA-N 0.000 claims 2
- YJLXFCMFMJTMNI-UHFFFAOYSA-N 2-(6-fluoropyridin-3-yl)-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(F)N=C1 YJLXFCMFMJTMNI-UHFFFAOYSA-N 0.000 claims 2
- GCIWQBXSMSCWCO-UHFFFAOYSA-N 2-(6-methoxypyridin-3-yl)-1,3-benzoxazol-6-ol Chemical compound C1=NC(OC)=CC=C1C1=NC2=CC=C(O)C=C2O1 GCIWQBXSMSCWCO-UHFFFAOYSA-N 0.000 claims 2
- RTEOLQIZQATWRQ-UHFFFAOYSA-N 2-[6-(dimethylamino)pyridin-3-yl]-1,3-benzoxazol-5-ol Chemical compound C1=NC(N(C)C)=CC=C1C1=NC2=CC(O)=CC=C2O1 RTEOLQIZQATWRQ-UHFFFAOYSA-N 0.000 claims 2
- HMECLUHCEMVGIG-UHFFFAOYSA-N 2-[6-(dimethylamino)pyridin-3-yl]-1,3-benzoxazol-6-ol Chemical compound C1=NC(N(C)C)=CC=C1C1=NC2=CC=C(O)C=C2O1 HMECLUHCEMVGIG-UHFFFAOYSA-N 0.000 claims 2
- MUNSCAJTQCLVNR-UHFFFAOYSA-N 2-[6-(methylamino)pyridin-3-yl]-1,3-benzoxazol-6-ol Chemical compound C1=NC(NC)=CC=C1C1=NC2=CC=C(O)C=C2O1 MUNSCAJTQCLVNR-UHFFFAOYSA-N 0.000 claims 2
- TXFCYCHIDAWSKH-UHFFFAOYSA-N 5-(6-methoxy-1,3-benzoxazol-2-yl)-n-methylpyridin-2-amine Chemical compound C1=NC(NC)=CC=C1C1=NC2=CC=C(OC)C=C2O1 TXFCYCHIDAWSKH-UHFFFAOYSA-N 0.000 claims 2
- OKCTZPKXJWOEEN-UHFFFAOYSA-N 5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-amine Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(N)N=C1 OKCTZPKXJWOEEN-UHFFFAOYSA-N 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- MNCMBBIFTVWHIP-UHFFFAOYSA-N 1-anthracen-9-yl-2,2,2-trifluoroethanone Chemical group C1=CC=C2C(C(=O)C(F)(F)F)=C(C=CC=C3)C3=CC2=C1 MNCMBBIFTVWHIP-UHFFFAOYSA-N 0.000 claims 1
- FSFKUQZDHKZBLL-UHFFFAOYSA-N 2-(5-aminopyridin-2-yl)-1,3-benzoxazol-6-amine Chemical compound N1=CC(N)=CC=C1C1=NC2=CC=C(N)C=C2O1 FSFKUQZDHKZBLL-UHFFFAOYSA-N 0.000 claims 1
- KLXNFYDOVNTPMI-UHFFFAOYSA-N 2-(5-fluoro-6-methoxypyridin-3-yl)-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CN=C(OC)C(F)=C1 KLXNFYDOVNTPMI-UHFFFAOYSA-N 0.000 claims 1
- WHXBBKCQUJHZDF-UHFFFAOYSA-N 2-(5-methylpyridin-2-yl)-1,3-benzoxazole Chemical compound N1=CC(C)=CC=C1C1=NC2=CC=CC=C2O1 WHXBBKCQUJHZDF-UHFFFAOYSA-N 0.000 claims 1
- IEDOEYOGCKTFEL-UHFFFAOYSA-N 2-(6-aminopyridin-3-yl)-1,3-benzoxazol-6-ol Chemical compound C1=NC(N)=CC=C1C1=NC2=CC=C(O)C=C2O1 IEDOEYOGCKTFEL-UHFFFAOYSA-N 0.000 claims 1
- BAJBDICKCWWWHL-UHFFFAOYSA-N 2-(6-morpholin-4-ylpyridin-3-yl)-1,3-benzoxazole Chemical compound C1COCCN1C1=CC=C(C=2OC3=CC=CC=C3N=2)C=N1 BAJBDICKCWWWHL-UHFFFAOYSA-N 0.000 claims 1
- YOADTNNBRKOTAC-UHFFFAOYSA-N 2-[6-(2-fluoroethoxy)pyridin-3-yl]-6-methoxy-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(OCCF)N=C1 YOADTNNBRKOTAC-UHFFFAOYSA-N 0.000 claims 1
- WBQUBKGXZVXILO-UHFFFAOYSA-N 2-[6-(2-fluoroethylamino)pyridin-3-yl]-1,3-benzoxazol-6-ol Chemical compound O1C2=CC(O)=CC=C2N=C1C1=CC=C(NCCF)N=C1 WBQUBKGXZVXILO-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- UWHPNURHXXGJAZ-UHFFFAOYSA-N 5-(5-methoxy-1,3-benzoxazol-2-yl)-n,n-dimethylpyridin-2-amine Chemical compound N=1C2=CC(OC)=CC=C2OC=1C1=CC=C(N(C)C)N=C1 UWHPNURHXXGJAZ-UHFFFAOYSA-N 0.000 claims 1
- ZKTVEWCZBLTWOU-UHFFFAOYSA-N 5-(6-methoxy-1,3-benzoxazol-2-yl)-n,n-dimethylpyridin-2-amine Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(N(C)C)N=C1 ZKTVEWCZBLTWOU-UHFFFAOYSA-N 0.000 claims 1
- KSNMWTQKDUOCMX-UHFFFAOYSA-N 5-[6-[tert-butyl(dimethyl)silyl]oxy-1,3-benzoxazol-2-yl]pyridin-2-amine Chemical compound O1C2=CC(O[Si](C)(C)C(C)(C)C)=CC=C2N=C1C1=CC=C(N)N=C1 KSNMWTQKDUOCMX-UHFFFAOYSA-N 0.000 claims 1
- BKRGFNKOVNFDQQ-UHFFFAOYSA-N 5-methyl-2-(6-methylpyridin-3-yl)-1,3-benzoxazole Chemical compound N=1C2=CC(C)=CC=C2OC=1C1=CC=C(C)N=C1 BKRGFNKOVNFDQQ-UHFFFAOYSA-N 0.000 claims 1
- PVNIAKNZFUDCCQ-UHFFFAOYSA-N 6-methoxy-2-(6-methoxypyridin-3-yl)-1,3-benzoxazole Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(OC)N=C1 PVNIAKNZFUDCCQ-UHFFFAOYSA-N 0.000 claims 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- OWLGAGALTSVSSS-UHFFFAOYSA-N n-(2-fluoroethyl)-5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-amine Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(NCCF)N=C1 OWLGAGALTSVSSS-UHFFFAOYSA-N 0.000 claims 1
- PMYOVKULDGQRPS-UHFFFAOYSA-N n-[5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]-n-methylacetamide Chemical compound O1C2=CC(OC)=CC=C2N=C1C1=CC=C(N(C)C(C)=O)N=C1 PMYOVKULDGQRPS-UHFFFAOYSA-N 0.000 claims 1
- 125000001209 o-nitrophenyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])[N+]([O-])=O 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 108700028369 Alleles Proteins 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 description 1
- 0 CC(C)*C1CCCCC1 Chemical compound CC(C)*C1CCCCC1 0.000 description 1
- 201000010374 Down Syndrome Diseases 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 description 1
- 208000015756 familial Alzheimer disease Diseases 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81493606P | 2006-06-19 | 2006-06-19 | |
| US60/814,936 | 2006-06-19 | ||
| PCT/SE2007/000591 WO2007149030A1 (en) | 2006-06-19 | 2007-06-18 | Novel heteroaryl substituted benzoxazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541309A JP2009541309A (ja) | 2009-11-26 |
| JP2009541309A5 true JP2009541309A5 (enExample) | 2010-08-05 |
| JP5548842B2 JP5548842B2 (ja) | 2014-07-16 |
Family
ID=38833677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516443A Expired - Fee Related JP5548842B2 (ja) | 2006-06-19 | 2007-06-18 | 新規なヘテロアリール置換ベンゾオキサゾール |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7670591B2 (enExample) |
| EP (1) | EP2035418A1 (enExample) |
| JP (1) | JP5548842B2 (enExample) |
| KR (1) | KR20090021224A (enExample) |
| CN (1) | CN101506201B (enExample) |
| AR (1) | AR061515A1 (enExample) |
| AU (1) | AU2007261786A1 (enExample) |
| CA (1) | CA2655084A1 (enExample) |
| CL (1) | CL2007001784A1 (enExample) |
| IL (1) | IL195669A0 (enExample) |
| MX (1) | MX2008015718A (enExample) |
| NO (1) | NO20090201L (enExample) |
| TW (1) | TW200813035A (enExample) |
| UY (1) | UY30419A1 (enExample) |
| WO (1) | WO2007149030A1 (enExample) |
| ZA (1) | ZA200810163B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| JP2011524864A (ja) * | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
| US20110212031A1 (en) * | 2008-10-31 | 2011-09-01 | Cyrille Sur | Novel substituted azabenzoxazoles |
| US8779149B2 (en) | 2010-08-23 | 2014-07-15 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| JP5937102B2 (ja) * | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| WO2014132919A1 (ja) * | 2013-02-28 | 2014-09-04 | 国立大学法人京都大学 | 診断用組成物 |
| KR101499329B1 (ko) * | 2013-06-17 | 2015-03-06 | 주식회사 대웅제약 | (2-(3,4-다이메톡시페닐)-5-(3-메톡시프로필)벤조퓨란)의결정형 및 이의 제조방법 |
| JP6149684B2 (ja) * | 2013-10-21 | 2017-06-21 | ブラザー工業株式会社 | 携帯端末、画像処理装置、及びプログラム |
| WO2015112048A1 (en) * | 2014-01-24 | 2015-07-30 | Huawei Technologies Co., Ltd. | Method and device for cross-polarization interference suppression |
| CN104059028B (zh) * | 2014-06-06 | 2020-10-16 | 北京智博高科生物技术有限公司 | 与Aβ斑块具有亲和力的含手性侧链取代的氟代2-芳基苯并杂环化合物、其制备方法及应用 |
| KR101709731B1 (ko) * | 2015-05-22 | 2017-02-23 | 한국과학기술연구원 | 벤조옥사졸 또는 벤조티아졸 화합물, 그의 제조, 및 용도 |
| US10324943B2 (en) * | 2015-08-10 | 2019-06-18 | Business Objects Software, Ltd. | Auto-monitoring and adjustment of dynamic data visualizations |
| WO2017031239A1 (en) * | 2015-08-18 | 2017-02-23 | The Regents Of The University Of California | Nitroxide containing amyloid binding agents for imaging and therapeutic uses |
| KR101812424B1 (ko) * | 2016-12-28 | 2017-12-27 | 충북대학교 산학협력단 | 2-(2-아미노-5-(1-(피퍼리딘-4-일)-1H-피라졸-3-일)피리딘-3-일)벤조[d]옥사졸-6-올 및 이를 유효성분으로 포함하는 치매의 예방 및 치료용 조성물 |
| EP4097092A1 (en) * | 2020-01-28 | 2022-12-07 | Protego Biopharma, Inc. | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
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| AU523040B2 (en) * | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| GB8305245D0 (en) | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| JPS6394248A (ja) * | 1986-10-08 | 1988-04-25 | Canon Inc | 電子写真感光体 |
| CA2034309C (en) * | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| EP0735821A4 (en) | 1993-12-21 | 1998-04-01 | Lilly Co Eli | METHODS FOR TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH AMYLO DOGEN PEPTIDES |
| US5518713A (en) * | 1995-02-13 | 1996-05-21 | 3V Inc. | Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them |
| JPH11116476A (ja) | 1997-10-16 | 1999-04-27 | Sankyo Co Ltd | 縮合複素環化合物 |
| EP2264018B1 (en) | 2000-08-24 | 2015-02-11 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thioflavin derivatives for use in the diagnosis of Alzheimer's disease |
| US7045539B2 (en) | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| ES2274973T3 (es) | 2001-04-23 | 2007-06-01 | The Trustees Of The University Of Pennsylvania | Inhibidores de la agregacion de placas amiloides y agentes de obtencion de imagenes diagnosticas. |
| US7622479B2 (en) * | 2001-11-26 | 2009-11-24 | Takeda Pharmaceutical Company Limited | Bicyclic derivative, its production and use |
| GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
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| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
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| JPWO2004087641A1 (ja) | 2003-03-31 | 2006-06-29 | 第一製薬株式会社 | ヒドラゾン誘導体 |
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| DK1771208T3 (da) | 2004-07-02 | 2013-09-02 | Univ Pittsburgh | Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| WO2006125324A1 (en) | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
| WO2007033080A2 (en) | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| EP1937260A2 (en) | 2005-09-16 | 2008-07-02 | University of Pittsburgh | In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein |
| ES2379987T3 (es) | 2005-10-11 | 2012-05-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compuestos de benzofurano marcados isotópicamente como radiotrazadores para proteínas amiloidógenas |
| WO2007063946A1 (ja) | 2005-11-30 | 2007-06-07 | Fujifilm Ri Pharma Co., Ltd. | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| AU2007213451B2 (en) * | 2006-02-10 | 2013-02-07 | Summit (Oxford) Limited | Treatment of Duchenne muscular dystrophy |
| WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| CN101641354A (zh) | 2007-01-22 | 2010-02-03 | 阿斯利康(瑞典)有限公司 | 杂芳基取代的新咪唑并[1，2-a]吡啶衍生物 |
-
2007
- 2007-06-08 TW TW096120843A patent/TW200813035A/zh unknown
- 2007-06-14 US US11/763,151 patent/US7670591B2/en not_active Expired - Fee Related
- 2007-06-18 AU AU2007261786A patent/AU2007261786A1/en not_active Abandoned
- 2007-06-18 CL CL2007001784A patent/CL2007001784A1/es unknown
- 2007-06-18 MX MX2008015718A patent/MX2008015718A/es not_active Application Discontinuation
- 2007-06-18 EP EP07748254A patent/EP2035418A1/en not_active Withdrawn
- 2007-06-18 WO PCT/SE2007/000591 patent/WO2007149030A1/en not_active Ceased
- 2007-06-18 JP JP2009516443A patent/JP5548842B2/ja not_active Expired - Fee Related
- 2007-06-18 CN CN2007800308078A patent/CN101506201B/zh not_active Expired - Fee Related
- 2007-06-18 CA CA002655084A patent/CA2655084A1/en not_active Abandoned
- 2007-06-18 UY UY30419A patent/UY30419A1/es not_active Application Discontinuation
- 2007-06-18 KR KR1020097000992A patent/KR20090021224A/ko not_active Withdrawn
- 2007-06-19 AR ARP070102680A patent/AR061515A1/es unknown
-
2008
- 2008-11-28 ZA ZA200810163A patent/ZA200810163B/xx unknown
- 2008-12-02 IL IL195669A patent/IL195669A0/en unknown
-
2009
- 2009-01-13 NO NO20090201A patent/NO20090201L/no not_active Application Discontinuation
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