AR061515A1 - Benzoxazoles sustituidos con heteroarilo. composiciones farmaceuticas. - Google Patents
Benzoxazoles sustituidos con heteroarilo. composiciones farmaceuticas.Info
- Publication number
- AR061515A1 AR061515A1 ARP070102680A ARP070102680A AR061515A1 AR 061515 A1 AR061515 A1 AR 061515A1 AR P070102680 A ARP070102680 A AR P070102680A AR P070102680 A ARP070102680 A AR P070102680A AR 061515 A1 AR061515 A1 AR 061515A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- fluororalkyl
- 3alkyl
- alkoxy
- Prior art date
Links
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 32
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000002947 alkylene group Chemical group 0.000 abstract 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 7
- 229910052794 bromium Inorganic materials 0.000 abstract 7
- 229910052731 fluorine Inorganic materials 0.000 abstract 6
- 239000011737 fluorine Chemical group 0.000 abstract 6
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- -1 C1-6 fluororalkoxy Chemical group 0.000 abstract 5
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- FSFKUQZDHKZBLL-UHFFFAOYSA-N 2-(5-aminopyridin-2-yl)-1,3-benzoxazol-6-amine Chemical compound N1=CC(N)=CC=C1C1=NC2=CC=C(N)C=C2O1 FSFKUQZDHKZBLL-UHFFFAOYSA-N 0.000 abstract 1
- WHXBBKCQUJHZDF-UHFFFAOYSA-N 2-(5-methylpyridin-2-yl)-1,3-benzoxazole Chemical compound N1=CC(C)=CC=C1C1=NC2=CC=CC=C2O1 WHXBBKCQUJHZDF-UHFFFAOYSA-N 0.000 abstract 1
- DECLYJIGPYNKTH-UHFFFAOYSA-N 5-(6-methoxy-1,3-benzoxazol-2-yl)-n-phenylpyrimidin-2-amine Chemical compound O1C2=CC(OC)=CC=C2N=C1C(C=N1)=CN=C1NC1=CC=CC=C1 DECLYJIGPYNKTH-UHFFFAOYSA-N 0.000 abstract 1
- UDAVSWULZNLITD-UHFFFAOYSA-N 5-(6-methyl-1,3-benzoxazol-2-yl)pyrimidin-2-amine Chemical compound O1C2=CC(C)=CC=C2N=C1C1=CN=C(N)N=C1 UDAVSWULZNLITD-UHFFFAOYSA-N 0.000 abstract 1
- BKRGFNKOVNFDQQ-UHFFFAOYSA-N 5-methyl-2-(6-methylpyridin-3-yl)-1,3-benzoxazole Chemical compound N=1C2=CC(C)=CC=C2OC=1C1=CC=C(C)N=C1 BKRGFNKOVNFDQQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81493606P | 2006-06-19 | 2006-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061515A1 true AR061515A1 (es) | 2008-09-03 |
Family
ID=38833677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102680A AR061515A1 (es) | 2006-06-19 | 2007-06-19 | Benzoxazoles sustituidos con heteroarilo. composiciones farmaceuticas. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7670591B2 (enExample) |
| EP (1) | EP2035418A1 (enExample) |
| JP (1) | JP5548842B2 (enExample) |
| KR (1) | KR20090021224A (enExample) |
| CN (1) | CN101506201B (enExample) |
| AR (1) | AR061515A1 (enExample) |
| AU (1) | AU2007261786A1 (enExample) |
| CA (1) | CA2655084A1 (enExample) |
| CL (1) | CL2007001784A1 (enExample) |
| IL (1) | IL195669A0 (enExample) |
| MX (1) | MX2008015718A (enExample) |
| NO (1) | NO20090201L (enExample) |
| TW (1) | TW200813035A (enExample) |
| UY (1) | UY30419A1 (enExample) |
| WO (1) | WO2007149030A1 (enExample) |
| ZA (1) | ZA200810163B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| JP2011524864A (ja) * | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
| US20110212031A1 (en) * | 2008-10-31 | 2011-09-01 | Cyrille Sur | Novel substituted azabenzoxazoles |
| US8779149B2 (en) | 2010-08-23 | 2014-07-15 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| JP5937102B2 (ja) * | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| WO2014132919A1 (ja) * | 2013-02-28 | 2014-09-04 | 国立大学法人京都大学 | 診断用組成物 |
| KR101499329B1 (ko) * | 2013-06-17 | 2015-03-06 | 주식회사 대웅제약 | (2-(3,4-다이메톡시페닐)-5-(3-메톡시프로필)벤조퓨란)의결정형 및 이의 제조방법 |
| JP6149684B2 (ja) * | 2013-10-21 | 2017-06-21 | ブラザー工業株式会社 | 携帯端末、画像処理装置、及びプログラム |
| WO2015112048A1 (en) * | 2014-01-24 | 2015-07-30 | Huawei Technologies Co., Ltd. | Method and device for cross-polarization interference suppression |
| CN104059028B (zh) * | 2014-06-06 | 2020-10-16 | 北京智博高科生物技术有限公司 | 与Aβ斑块具有亲和力的含手性侧链取代的氟代2-芳基苯并杂环化合物、其制备方法及应用 |
| KR101709731B1 (ko) * | 2015-05-22 | 2017-02-23 | 한국과학기술연구원 | 벤조옥사졸 또는 벤조티아졸 화합물, 그의 제조, 및 용도 |
| US10324943B2 (en) * | 2015-08-10 | 2019-06-18 | Business Objects Software, Ltd. | Auto-monitoring and adjustment of dynamic data visualizations |
| WO2017031239A1 (en) * | 2015-08-18 | 2017-02-23 | The Regents Of The University Of California | Nitroxide containing amyloid binding agents for imaging and therapeutic uses |
| KR101812424B1 (ko) * | 2016-12-28 | 2017-12-27 | 충북대학교 산학협력단 | 2-(2-아미노-5-(1-(피퍼리딘-4-일)-1H-피라졸-3-일)피리딘-3-일)벤조[d]옥사졸-6-올 및 이를 유효성분으로 포함하는 치매의 예방 및 치료용 조성물 |
| EP4097092A1 (en) * | 2020-01-28 | 2022-12-07 | Protego Biopharma, Inc. | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523040B2 (en) * | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| GB8305245D0 (en) | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| JPS6394248A (ja) * | 1986-10-08 | 1988-04-25 | Canon Inc | 電子写真感光体 |
| CA2034309C (en) * | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| EP0735821A4 (en) | 1993-12-21 | 1998-04-01 | Lilly Co Eli | METHODS FOR TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH AMYLO DOGEN PEPTIDES |
| US5518713A (en) * | 1995-02-13 | 1996-05-21 | 3V Inc. | Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them |
| JPH11116476A (ja) | 1997-10-16 | 1999-04-27 | Sankyo Co Ltd | 縮合複素環化合物 |
| EP2264018B1 (en) | 2000-08-24 | 2015-02-11 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thioflavin derivatives for use in the diagnosis of Alzheimer's disease |
| US7045539B2 (en) | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| ES2274973T3 (es) | 2001-04-23 | 2007-06-01 | The Trustees Of The University Of Pennsylvania | Inhibidores de la agregacion de placas amiloides y agentes de obtencion de imagenes diagnosticas. |
| US7622479B2 (en) * | 2001-11-26 | 2009-11-24 | Takeda Pharmaceutical Company Limited | Bicyclic derivative, its production and use |
| GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
| TW200401194A (en) | 2002-07-11 | 2004-01-16 | Advanced Micro Devices Inc | Method and apparatus for determining a processor state without interrupting processor operation |
| AU2003258022A1 (en) | 2002-08-02 | 2004-02-23 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| JPWO2004087641A1 (ja) | 2003-03-31 | 2006-06-29 | 第一製薬株式会社 | ヒドラゾン誘導体 |
| PL1636217T3 (pl) | 2003-05-13 | 2009-02-27 | Hoffmann La Roche | 1-Imidazobenzotiazole jako ligandy receptora adenozynowego |
| DK1771208T3 (da) | 2004-07-02 | 2013-09-02 | Univ Pittsburgh | Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| WO2006125324A1 (en) | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
| WO2007033080A2 (en) | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| EP1937260A2 (en) | 2005-09-16 | 2008-07-02 | University of Pittsburgh | In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein |
| ES2379987T3 (es) | 2005-10-11 | 2012-05-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compuestos de benzofurano marcados isotópicamente como radiotrazadores para proteínas amiloidógenas |
| WO2007063946A1 (ja) | 2005-11-30 | 2007-06-07 | Fujifilm Ri Pharma Co., Ltd. | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| AU2007213451B2 (en) * | 2006-02-10 | 2013-02-07 | Summit (Oxford) Limited | Treatment of Duchenne muscular dystrophy |
| WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| CN101641354A (zh) | 2007-01-22 | 2010-02-03 | 阿斯利康(瑞典)有限公司 | 杂芳基取代的新咪唑并[1，2-a]吡啶衍生物 |
-
2007
- 2007-06-08 TW TW096120843A patent/TW200813035A/zh unknown
- 2007-06-14 US US11/763,151 patent/US7670591B2/en not_active Expired - Fee Related
- 2007-06-18 AU AU2007261786A patent/AU2007261786A1/en not_active Abandoned
- 2007-06-18 CL CL2007001784A patent/CL2007001784A1/es unknown
- 2007-06-18 MX MX2008015718A patent/MX2008015718A/es not_active Application Discontinuation
- 2007-06-18 EP EP07748254A patent/EP2035418A1/en not_active Withdrawn
- 2007-06-18 WO PCT/SE2007/000591 patent/WO2007149030A1/en not_active Ceased
- 2007-06-18 JP JP2009516443A patent/JP5548842B2/ja not_active Expired - Fee Related
- 2007-06-18 CN CN2007800308078A patent/CN101506201B/zh not_active Expired - Fee Related
- 2007-06-18 CA CA002655084A patent/CA2655084A1/en not_active Abandoned
- 2007-06-18 UY UY30419A patent/UY30419A1/es not_active Application Discontinuation
- 2007-06-18 KR KR1020097000992A patent/KR20090021224A/ko not_active Withdrawn
- 2007-06-19 AR ARP070102680A patent/AR061515A1/es unknown
-
2008
- 2008-11-28 ZA ZA200810163A patent/ZA200810163B/xx unknown
- 2008-12-02 IL IL195669A patent/IL195669A0/en unknown
-
2009
- 2009-01-13 NO NO20090201A patent/NO20090201L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101506201B (zh) | 2012-03-14 |
| UY30419A1 (es) | 2008-01-31 |
| TW200813035A (en) | 2008-03-16 |
| JP2009541309A (ja) | 2009-11-26 |
| AU2007261786A1 (en) | 2007-12-27 |
| NO20090201L (no) | 2009-01-13 |
| IL195669A0 (en) | 2009-09-01 |
| MX2008015718A (es) | 2008-12-19 |
| CA2655084A1 (en) | 2007-12-27 |
| EP2035418A1 (en) | 2009-03-18 |
| US7670591B2 (en) | 2010-03-02 |
| CN101506201A (zh) | 2009-08-12 |
| KR20090021224A (ko) | 2009-02-27 |
| JP5548842B2 (ja) | 2014-07-16 |
| CL2007001784A1 (es) | 2008-01-18 |
| WO2007149030A8 (en) | 2008-02-28 |
| ZA200810163B (en) | 2010-05-26 |
| WO2007149030A1 (en) | 2007-12-27 |
| US20080027051A1 (en) | 2008-01-31 |
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