PE20040974A1 - Compuestos de amida de acido carboxilico con efecto antagonico de la hcm, medicamentos que los contienen y procedimientos para su preparacion - Google Patents
Compuestos de amida de acido carboxilico con efecto antagonico de la hcm, medicamentos que los contienen y procedimientos para su preparacionInfo
- Publication number
- PE20040974A1 PE20040974A1 PE2003000849A PE2003000849A PE20040974A1 PE 20040974 A1 PE20040974 A1 PE 20040974A1 PE 2003000849 A PE2003000849 A PE 2003000849A PE 2003000849 A PE2003000849 A PE 2003000849A PE 20040974 A1 PE20040974 A1 PE 20040974A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- hcm
- carboxyl acid
- drugs
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON CADA UNO H, ALQUILO C1-C8, CICLOALQUILO C3-C7 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, CICLOALQUILO, C3-C7-CICLOALQUIL-ALQUILOC1-C4-FENILO, ENTRE OTROS; X ES UN ENLACE SIMPLE O UN PUENTE DE ALQUILENO C1-C8 OPCIONALMENTE SUSTITUIDO; Z ES UN PUENTE ALQUILENO C1-C4; A E Y FORMAN UN GRUPO HETEROCICLICO CONDENSADO EN Y, INCLUYENDO X Y EL ATOMO DE N UNIDO CON R1 Y X; W ES UN ENLACE SIMPLE, ALQUILENO C1-C4, -O-, ALQUILENOXI DE C1-C4, ENTRE OTROS; k ES 0-1; B ES ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 7-(4-CLORO-FENIL)-3-[2-(4-PIRROLIDIN-1-ILMETIL-FENIL)-ETIL]-3H-QUINAZOLIN-4-ONA; 3-[2-(4-PIRROLIDIN-1-ILMETIL-FENIL)-ETIL]-7-p-TOLIL-3H-QUINAZOLIN-4-ONA Y [2-(4-PIRROLIDIN-1-ILMETIL-FENIL)-ETIL]-AMIDA DEL ACIDO 4'- CLORO-BIFENIL-4-CARBOXILICO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA EN LA QUE DICHOS COMPUESTOS SON ANTAGONISTAS DE LA HCM UTILES EN EL TRATAMIENTO DE TRASTORNOS METABOLICO
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DE10238865A DE10238865A1 (de) | 2002-08-24 | 2002-08-24 | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
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CA2386474A1 (en) * | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
AU2001256733A1 (en) * | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
JP2004504303A (ja) * | 2000-07-05 | 2004-02-12 | シナプティック・ファーマスーティカル・コーポレーション | 選択的メラニン凝集ホルモン−1(mch1)受容体アンタゴニストおよびその使用 |
US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
CN1273451C (zh) * | 2000-12-22 | 2006-09-06 | 先灵公司 | 哌啶mch拮抗剂及其治疗肥胖症的用途 |
GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-08-24 DE DE10238865A patent/DE10238865A1/de not_active Withdrawn
-
2003
- 2003-08-16 MX MXPA05002158A patent/MXPA05002158A/es unknown
- 2003-08-16 BR BR0313790-2A patent/BR0313790A/pt not_active Expired - Fee Related
- 2003-08-16 WO PCT/EP2003/009099 patent/WO2004024702A1/de active Application Filing
- 2003-08-16 KR KR1020057003110A patent/KR20050040928A/ko not_active Application Discontinuation
- 2003-08-16 EP EP03794886A patent/EP1534689A1/de not_active Withdrawn
- 2003-08-16 PL PL03375344A patent/PL375344A1/xx not_active Application Discontinuation
- 2003-08-16 UA UAA200502601A patent/UA82853C2/uk unknown
- 2003-08-16 RS YUP-2005/0173A patent/RS20050173A/sr unknown
- 2003-08-16 AU AU2003258620A patent/AU2003258620A1/en not_active Abandoned
- 2003-08-16 CN CNA038200767A patent/CN1678591A/zh active Pending
- 2003-08-16 CA CA002496563A patent/CA2496563A1/en not_active Abandoned
- 2003-08-16 EA EA200500301A patent/EA012834B1/ru not_active IP Right Cessation
- 2003-08-16 JP JP2004535098A patent/JP2006507246A/ja active Pending
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/es not_active Application Discontinuation
- 2003-08-22 TW TW092123197A patent/TW200413332A/zh unknown
- 2003-08-22 AR ARP030103034A patent/AR043046A1/es unknown
-
2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/xx unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/no not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/es unknown
- 2005-02-23 HR HR20050179A patent/HRP20050179A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20050068L (no) | 2005-03-04 |
CN1678591A (zh) | 2005-10-05 |
ECSP055615A (es) | 2005-05-30 |
MXPA05002158A (es) | 2005-05-23 |
RS20050173A (en) | 2007-09-21 |
PL375344A1 (en) | 2005-11-28 |
WO2004024702A1 (de) | 2004-03-25 |
KR20050040928A (ko) | 2005-05-03 |
EA012834B1 (ru) | 2009-12-30 |
BR0313790A (pt) | 2005-07-12 |
TW200413332A (en) | 2004-08-01 |
EA200500301A1 (ru) | 2006-02-24 |
AU2003258620A1 (en) | 2004-04-30 |
AR043046A1 (es) | 2005-07-13 |
ZA200500086B (en) | 2006-07-26 |
HRP20050179A2 (en) | 2006-05-31 |
UA82853C2 (en) | 2008-05-26 |
CA2496563A1 (en) | 2004-03-25 |
JP2006507246A (ja) | 2006-03-02 |
DE10238865A1 (de) | 2004-03-11 |
EP1534689A1 (de) | 2005-06-01 |
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