EA200500301A1 - Новые карбоксамидные соединения, обладающие антагонистическим в отношении мсн действием, содержащие эти соединения лекарственные средства и способ их получения - Google Patents

Новые карбоксамидные соединения, обладающие антагонистическим в отношении мсн действием, содержащие эти соединения лекарственные средства и способ их получения

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Publication number
EA200500301A1
EA200500301A1 EA200500301A EA200500301A EA200500301A1 EA 200500301 A1 EA200500301 A1 EA 200500301A1 EA 200500301 A EA200500301 A EA 200500301A EA 200500301 A EA200500301 A EA 200500301A EA 200500301 A1 EA200500301 A1 EA 200500301A1
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EA
Eurasian Patent Office
Prior art keywords
carboxamide compounds
antagonistic
sitting
medicines
concerning
Prior art date
Application number
EA200500301A
Other languages
English (en)
Other versions
EA012834B1 (ru
Inventor
Торстен Леманн-Линтц
Дирк Штенкамп
Мартин Лентер
Хайке-Андреа Виланд
Клаус Рудольф
Штефан Георг Мюллер
Ральф Р.Х. Лотц
Кирстен Арндт
Филипп Лустенбергер
Original Assignee
Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
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Application filed by Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг filed Critical Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Publication of EA200500301A1 publication Critical patent/EA200500301A1/ru
Publication of EA012834B1 publication Critical patent/EA012834B1/ru

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

В заявке описаны карбоксамидные соединения общей формулы (I)в которой группы и остатки A, B, W, X, Y, Z, R, R, Rи k имеют указанные в п.1 формулы изобретения значения. В заявке описаны далее способ получения таких карбоксамидных соединений, а также лекарственные средства, содержащие по меньшей мере одно предлагаемое в изобретении карбоксамидное соединение. Предлагаемые в изобретении лекарственные средства благодаря наличию у них антагонистической в отношении MCH-рецептора активности пригодны для лечения связанных с нарушением обмена веществ расстройств и/или расстройств приема пищи, прежде всего ожирения, булимии, анорексии, гиперфагии и диабета.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500301A 2002-08-24 2003-08-16 Новые карбоксамидные соединения, обладающие антагонистическим в отношении мсн действием, содержащие эти соединения лекарственные средства и способ их получения EA012834B1 (ru)

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DE10238865A DE10238865A1 (de) 2002-08-24 2002-08-24 Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP2003/009099 WO2004024702A1 (de) 2002-08-24 2003-08-16 Neue carbonsäureamid-verbindungen mit mch-antagonistischer wirkung, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

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CA2496563A1 (en) 2004-03-25
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BR0313790A (pt) 2005-07-12
AU2003258620A1 (en) 2004-04-30
DE10238865A1 (de) 2004-03-11
EP1534689A1 (de) 2005-06-01
ZA200500086B (en) 2006-07-26
JP2006507246A (ja) 2006-03-02
AR043046A1 (es) 2005-07-13
HRP20050179A2 (en) 2006-05-31
MXPA05002158A (es) 2005-05-23
EA012834B1 (ru) 2009-12-30
RS20050173A (en) 2007-09-21
CN1678591A (zh) 2005-10-05
UA82853C2 (en) 2008-05-26
PL375344A1 (en) 2005-11-28
NO20050068L (no) 2005-03-04
WO2004024702A1 (de) 2004-03-25
TW200413332A (en) 2004-08-01
PE20040974A1 (es) 2005-01-12

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