MXPA05013596A - Antagonistas de hormona concentradora de melanina para el tratamiento de obesidad. - Google Patents

Antagonistas de hormona concentradora de melanina para el tratamiento de obesidad.

Info

Publication number
MXPA05013596A
MXPA05013596A MXPA05013596A MXPA05013596A MXPA05013596A MX PA05013596 A MXPA05013596 A MX PA05013596A MX PA05013596 A MXPA05013596 A MX PA05013596A MX PA05013596 A MXPA05013596 A MX PA05013596A MX PA05013596 A MXPA05013596 A MX PA05013596A
Authority
MX
Mexico
Prior art keywords
mch
antagonists
obesity
treatment
compounds
Prior art date
Application number
MXPA05013596A
Other languages
English (en)
Inventor
Mark Mcbriar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MXPA05013596A publication Critical patent/MXPA05013596A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion describe metodos para usar antagonistas para hormona concentradora de melanina (MCH), para tratar obesidad, trastornos metabolicos, trastornos de la alimentacion tales como hiperfagia, y diabetes, asi como compuestos novedosos que son antagonistas para hormona concentradora de melanina (MCH); en otros aspectos, la invencion esta dirigida a composiciones farmaceuticas que comprenden dichos antagonistas de MCH asi como metodos para preparar dichos compuestos; los compuestos de la invencion generalmente tienen la estructura de la formula (I) (ver formula (I)) en donde los sustituyentes son como se define aqui.
MXPA05013596A 2003-06-30 2004-06-28 Antagonistas de hormona concentradora de melanina para el tratamiento de obesidad. MXPA05013596A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48361903P 2003-06-30 2003-06-30
PCT/US2004/020763 WO2005005419A1 (en) 2003-06-30 2004-06-28 Mch antagonists for the treatment of obesity

Publications (1)

Publication Number Publication Date
MXPA05013596A true MXPA05013596A (es) 2006-03-09

Family

ID=34061963

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013596A MXPA05013596A (es) 2003-06-30 2004-06-28 Antagonistas de hormona concentradora de melanina para el tratamiento de obesidad.

Country Status (7)

Country Link
US (1) US7345042B2 (es)
EP (1) EP1644366A1 (es)
JP (1) JP4605801B2 (es)
CN (1) CN1812985A (es)
CA (1) CA2526725A1 (es)
MX (1) MXPA05013596A (es)
WO (1) WO2005005419A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678798B2 (en) 2004-04-13 2010-03-16 Incyte Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
WO2007124045A2 (en) * 2006-04-20 2007-11-01 Ampla Pharmaceuticals, Inc. Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
AU2018289303B2 (en) 2017-06-20 2023-12-21 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
CZ20013940A3 (cs) 1999-05-04 2002-04-17 Schering Corporation Piperazinové deriváty uľitečné jako CCR5 antagonisté
US6391865B1 (en) * 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6569861B2 (en) * 2000-07-06 2003-05-27 Neurogen Corporation Melanin concentrating hormone receptor ligands
US6900329B2 (en) * 2001-03-21 2005-05-31 Schering Corporation MCH antagonists and their use in the treatment of obesity
CA2448080A1 (en) * 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
MXPA04004956A (es) * 2001-11-26 2004-08-11 Schering Corp Antagonistas de la hormona concentradora de melanina basados en la piperidina para tratamiento de la obesidad y de trastornos del sistema nervioso central.
US6906075B2 (en) * 2002-01-10 2005-06-14 Neurogen Corp. Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
US7160886B2 (en) * 2003-03-03 2007-01-09 Merck & Co., Inc. Acylated piperazine derivatives as melanocortin-4 receptor agonists
MXPA05013474A (es) * 2003-06-13 2006-03-09 Schering Ag Derivados de quinolilamida como antagonistas de ccr-5.

Also Published As

Publication number Publication date
US7345042B2 (en) 2008-03-18
JP4605801B2 (ja) 2011-01-05
US20050004121A1 (en) 2005-01-06
JP2007521286A (ja) 2007-08-02
EP1644366A1 (en) 2006-04-12
CA2526725A1 (en) 2005-01-20
WO2005005419A1 (en) 2005-01-20
CN1812985A (zh) 2006-08-02

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal