AR043046A1 - Compuestos de amida de acido carboxilico con efecto antagonico de la hcm, medicamentos que contienen estos compuestos y procedimientos para su preparacion - Google Patents
Compuestos de amida de acido carboxilico con efecto antagonico de la hcm, medicamentos que contienen estos compuestos y procedimientos para su preparacionInfo
- Publication number
- AR043046A1 AR043046A1 ARP030103034A ARP030103034A AR043046A1 AR 043046 A1 AR043046 A1 AR 043046A1 AR P030103034 A ARP030103034 A AR P030103034A AR P030103034 A ARP030103034 A AR P030103034A AR 043046 A1 AR043046 A1 AR 043046A1
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- Argentina
- Prior art keywords
- alkyl
- group
- phenyl
- atoms
- independently
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract
Compuestos de amida de ácido carboxílico de fórmula general (1) en la cual R1, R2 son, de modo independiente entre sí, H, un grupo alquilo C1-8 o cicloalquilo C3-7, opcionalmente sustituido con el radical R11 o un radical fenilo opcionalmente mono o polisustituido con el radical R12 y/o monosustituido con nitro, o R1 y R2 forman un puente alquileno C2-8, en el cual --uno o dos grupos -CH2 pueden estar reemplazados, de modo independiente entre sí, por -CH=N- ó -CH=CH- y/o uno o dos grupos -CH2 pueden estar reemplazados, de modo independiente entre sí por -O-, -S-, -CO-, -C(=CH2)- ó -NR13 de modo tal que los heteroátomos no estén unidos entre sí de manera directa, donde en el puente alquileno definido con anterioridad pueden estar reemplazados uno o varios átomos de H con R14, y/o donde el puente alquileno definido con anterioridad puede estar sustituido con uno o dos grupos C y carbo- o heterocíclicos iguales o diferentes de modo tal que la unión entre el puente de alquileno y el grupo Cy se realiza a través de un enlace simple o doble, a través de un átomo de C común, conformando un sistema de anillo espirocíclico, a través de dos átomos de C y/o N comunes adyacentes, conformando un sistema de anillo bicíclico condensado o a través de tres o más átomos de C y/o N, conformando un sistema de anillo puenteado; R3 es H, alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, cicloalquenilo C3-7, cicloalquenil C3-7-alquilo C1-4, fenilo, fenilalquilo C1-4, alcoxi C1-3-alquilo C2-6, aminoalquilo C2-6, alquil C1-3- aminoalquilo C2-6 ó di-(alquil C1-3)-aminoalquilo C2-6; X es un enlace simple o un puente alquileno C1-8, en el cual --uno o dos grupos -CH2 pueden estar reemplazados, de modo independiente entre sí, por -CH=CH- ó -C:::C- y/o --uno o dos grupos -CH2 pueden estar reemplazados, de modo independiente entre sí, por -O-, -S-, -(SO)-, -(SO2)-, -CO- ó -NR4- de manera tal que dos átomos de O, S ó N ó un átomo de O no estén unidos entre sí de forma directa con un átomo de S, donde uno o dos átomos de C pueden estar sustituidos, de modo independiente entre sí, por un radical hidroxi, omega-hidroxialquilo C1-3, omega-(alcoxi C1-3)-alquilo C1-3 y/o alcoxi C1-3, y/o por uno o dos radicales alquilo C1-6 iguales o diferentes, y/o donde el puente alquileno puede estar unido con R1, incluyendo el átomo de N unido con R1 y X, conformando un grupo heterocíclico; Z es un puente alquileno C1-4, donde dos átomos de C adyacentes pueden estar unidos entre sí con un puente alquileno C1-4 adicional, donde en el grupo Z un grupo -CH2 puede estar reemplazado por -O- ó -NR5-, donde uno o dos átomos de C del puente alquileno pueden estar sustituidos, de modo independiente entre sí, con un radical hidroxi, omega-hidroxialquilo C1-3, omega-(alcoxi C1-3)-alquilo C1-3, alcoxi C1-3, aminoalquilo C1-3, alquil C1-3-aminoalquilo C1-3, ó di-(alquil C1-3)-aminoalquilo C1-3 y/o por uno o dos radicales alquilo C1-6 iguales o diferentes, y/o donde R3 puede estar unido con Z, incluyendo el átomo de N unido con R3, conformando un grupo heterocíclico; A, Y tienen, de modo independiente entre sí, uno de los significados indicados para C y, donde R1 puede estar unido con Y, incluyendo el grupo X y el átomo de N unido con R1 y X, conformando un grupo heterocíclico condensado en Y, y/o donde R3 puede estar unido con Y, incluyendo el grupo Z y el átomo de N unido con R3 y Z , conformando un grupo heterocíclico condensado en Y, saturado o parcialmente no saturado, o donde A y R3 pueden estar unidos entre sí de modo tal que el grupo -NR3-CO-A- de la fórmula (1) signifique un grupo de la fórmula (2) y Q significa un grupo seleccionado de las subfórmulas: -CR6R7-, -CR6=R7-, -N=CR8-, -N=N-, -CO-NR9-, -CR8=N-, -CO-; L1, L2, L3 tienen, de modo independiente entre sí, uno de los significados indicados para R20; B es alquilo C1-6, alquenilo C1-6, alquinilo C1-6, cicloalquil C3-7-alquilo C1-3, cicloalquenil C3-7-alquilo C1-3, cicloalquil C3-7-alquenilo C1-3 ó cicloalquil C3-7-alquinilo C1-3, donde uno o varios átomos de C pueden estar mono o polisustituidos con halógeno y/o monosustituidos con hidroxi o ciano y/o grupos cíclicos pueden estar mono o polisustituidos con R20, o uno de los significados para Cy, donde la unión con el grupo W u opcionalmente en forma directa con el grupo A se realiza a través de un átomo de C de la parte carbocíclica o del anillo fenilo o piridina opcionalmente condensado o a través de un átomo de N ó C de la parte heterocíclica, donde para el caso de que k = 0, el grupo B puede estar unido entre sí con el grupo A a través de un átomo de C común conformando un sistema de anillo espirocíclico o a través de dos átomos comunes adyacentes, conformando un sistema de anillos bicíclicos condensados; W es un enlace simple, -O-, un grupo alquileno C1-4, alquenileno C2-4, alquinileno C2-4, alquilenoxi C1-4, oxi-alquileno C1-4, oxi-alquilen C1-3-alquileno C1-3, imino, N-(alquil C1-3)-imino, imino-alquileno C1-4, N-(alquil C1-3)-imino-alquileno C1-4, alquilen-imino C1-4 ó alquilen C1-4-N-(alquil C1-3)-imino, donde uno o dos átomos de C pueden estar sustituidos, de modo independiente entre sí, con un radical hidroxi, omega-hidroxi alquilo C1-3, omega-(alcoxi C1-3)-alquilo C1-3 y/o alcoxi C1-3 y/o con uno o dos radicales alquilo C1-6 iguales o diferentes, y/o donde W en los significados alquileno, oxialquileno y alquilenoxialquileno también pueden estar unidos con B en el significado Cy a través de un enlace doble; k es 0 ó 1; Cy es un grupo carbo- o heterocíclico seleccionado de uno de los siguientes significados: un grupo carbocíclico saturado de 3 a 7 miembros, un grupo carbocíclico no saturado de 5 a 7 miembros, un grupo fenilo, un grupo heterocíclico saturado de 4 a 7 miembros o no saturado de 5 a 7 miembros con un átomo de N, O ó S como heteroátomo, un grupo heterocíclico saturado o no saturado de 5 a 7 miembros con dos o más átomos de N o con uno o dos átomos de N y un átomo de O ó S como heteroátomos, un grupo aromático heterocíclico de 5 ó 6 miembros con uno o varios heteroátomos iguales o diferentes seleccionados de N, O y/o S, donde los grupos de 5, 6 ó 7 miembros detallados con anterioridad pueden estar unidos en forma condensada a través de dos átomos de C comunes adyacentes con un anillo fenilo o piridina, y donde en los grupos de 5, 6 ó 7 miembros mencionados con anterioridad uno o dos grupos -CH2 no adyacentes pueden estar sustituidos con un grupo -CO-, -C(=CH2)-, -(SO)- ó -(SO2), y donde los grupo saturados de 6 ó 7 miembros detallados con anterioridad también pueden estar presentes como sistemas de anillos puenteados con un puente imino, N-(alquil C1-4)-imino, metileno, (alquil C1-4)-metileno ó di-(alquil C1-4)-metileno, y donde los grupos cíclicos mencionados con anterioridad pueden estar mono o polisustituidos en uno o varios átomos de C con R20, en el caso de un grupo fenilo adicionalmente también monosustituido con nitro, y/o en uno o varios átomos de N con R21; R4, R5 tienen, de modo independiente entre sí, uno de los significados indicados para R16; R6, R7, R8, R9 son, de modo independiente entre sí, H, un grupo alquilo C1-6, omega-alcoxi C1-3-alquilo C1-3 ó omega-hidroxialquilo C1-3 y R6, R7,R8 también son, de modo independiente entre sí, halógeno; R11 es R15-O-, R15-O-CO, R16R17N-, R18R19NCO- ó Cy-; R12 tiene uno de los significados indicados para R20; R13 tiene uno de los significados indicados para R17; R14 es halógeno, alquilo C1-6, R15-O-, R15-O-CO-, R16R17N-, R18R19N-CO-, R15-O-alquilo C1-3, R15-O-CO-alquilo C1-3, R16R17N-alquilo C1-3, R18R19N-CO-alquilo C1-3 ó Cy-alquilo C1-3; R15 es H, alquilo C1-4, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, fenilo, fenil-alquilo C1-3 o piridinilo; R16 es H, alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, cicloalquenilo C4-7, cicloalquenil C4-7-alquilo C1-3, omega-hidroxialquilo C2-3, omega-(alcoxi C1-3)-alquilo C2-3, aminoalquilo C1-6, alquil C1-3-amino-alquilo C1-6 ó di-(alquil C1-3)-amino-alquilo C1-6; R17 tiene uno de los significados indicados para R16 o es fenilo, fenil-alquilo C1-3, piridinilo, dioxolan-2-ilo, alquilcarbonilo C1-3, hidroxicarbonil-alquilo C1-3, alcoxicarbonilo C1-4, alquil C1-3-carbonilamino-alquilo C2-3, alquilsulfonilo C1-3 ó alquil C1-3-sulfonilamino-alquilo C2-3; R18, R19 son, de modo independiente entre sí, H ó alquilo C1-6; R20 es halógeno, hidroxi, ciano, alquilo C1-4, cicloalquilo C3-7, hidroxialquilo C1-3, R22-alquilo C1-3 ó tiene uno de los significados indicados para R22; R21 es alquilo C1-3, omega-hidroxi-alquilo C2-3, fenilo, fenil-alquilo C1-3, alquilcarbonilo C1-3, carboxi, alcoxicarbonilo C1-4, alquilsulfonilo C1-3, fenilcarbonilo o fenil-alquil-carbonilo C1-3; R22 es piridinilo, fenilo, fenil-alcoxi C1-3, alcoxi C1-3, alquiltio C1-3, carboxi, H-CO-, alquilcarbonilo C1-3, alcoxicarbonilo C1-4, aminocarbonilo, alquilaminocarbonilo C1-3, di-(alquil C1-3)-aminocarbonilo, alquilsulfonilo C1-3, alquilsulfinilo C1-3, alquilsulfonilamino C1-3, amino, alquilamino C1-3, di-(alquil C1-3)-amino, fenil-alquilamino C1-3, ó N-(alquil C1-3)-fenil-alquilamino C1-3, acetilamino, propionilamino, fenilcarbonilo, fenilcarbonilamino, fenilcarbonilmetilamino, hidroxialquilaminocarbonilo, (4-morfolinil)carbonilo, (1-pirrolidinil)-carbonilo, (1-piperidinil)-carbonilo, (hexahidro-1-azepinil)carbonilo, (4-metil-1-piperazinil)carbonilo, metilendioxi, aminocarbonilamino o alquilaminocarbonilamino, donde en los grupo y radicales A, B, W, X, Y, Z, R1 a R9 y R11 a R22, uno o varios átomos de C pueden estar mono o polisustituidos con F y/o uno o dos átomos de C pueden estar, de modo independiente entre sí, monosustituidos con Cl ó Br, y/o uno o varios anillos fenilo presentan, de modo independiente entre sí, adicionalmente uno, dos o tres sustituyentes seleccionados del grupo F, Cl, Br, I, alquilo C1-4, alcoxi C1-4, difluorometil-, trifluorometil-, hidroxi-, amino, alquilamino C1-3, di-(alquil C1-3)-amino, acetilamino, aminocarbonilo, CN, difluorom
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ARP030103034A AR043046A1 (es) | 2002-08-24 | 2003-08-22 | Compuestos de amida de acido carboxilico con efecto antagonico de la hcm, medicamentos que contienen estos compuestos y procedimientos para su preparacion |
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EP (1) | EP1534689A1 (es) |
JP (1) | JP2006507246A (es) |
KR (1) | KR20050040928A (es) |
CN (1) | CN1678591A (es) |
AR (1) | AR043046A1 (es) |
AU (1) | AU2003258620A1 (es) |
BR (1) | BR0313790A (es) |
CA (1) | CA2496563A1 (es) |
DE (1) | DE10238865A1 (es) |
EA (1) | EA012834B1 (es) |
EC (1) | ECSP055615A (es) |
HR (1) | HRP20050179A2 (es) |
MX (1) | MXPA05002158A (es) |
NO (1) | NO20050068L (es) |
PE (1) | PE20040974A1 (es) |
PL (1) | PL375344A1 (es) |
RS (1) | RS20050173A (es) |
TW (1) | TW200413332A (es) |
UA (1) | UA82853C2 (es) |
WO (1) | WO2004024702A1 (es) |
ZA (1) | ZA200500086B (es) |
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WO2004072018A1 (ja) | 2003-02-12 | 2004-08-26 | Takeda Pharmaceutical Company Limited | アミン誘導体 |
JP2007508303A (ja) | 2003-10-01 | 2007-04-05 | ザ プロクター アンド ギャンブル カンパニー | メラニン凝集ホルモン拮抗物質 |
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US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
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DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
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CA2626220A1 (en) | 2005-12-21 | 2007-06-28 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
TW200804347A (en) | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
EP1987006B1 (en) | 2006-02-15 | 2011-01-12 | Sanofi-Aventis | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
JP5175228B2 (ja) * | 2006-02-15 | 2013-04-03 | サノフイ | 新規なアザシクリル置換アリールジヒドロイソキノリノン、それらの製造方法及び薬剤としてそれらの使用 |
AU2007214710A1 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
CA2636605A1 (en) * | 2006-02-15 | 2007-08-23 | Lothar Schwink | Novel azacycly-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
EP2041071B1 (en) | 2006-06-29 | 2014-06-18 | Kinex Pharmaceuticals, LLC | Biaryl compositions and methods for modulating a kinase cascade |
TWI398440B (zh) * | 2006-06-29 | 2013-06-11 | Kinex Pharmaceuticals Llc | 雙芳基組成物與調節激酶級聯之方法 |
AU2007281591A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica, N.V. | Urotensin II receptor antagonists |
AU2007287601B2 (en) | 2006-08-25 | 2012-12-20 | Boehringer Ingelheim International Gmbh | New pyridone derivatives with MCH antagonistic activity and medicaments comprising these compounds |
JP5290192B2 (ja) | 2006-12-05 | 2013-09-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Mch−1に媒介される疾患における使用のための新規な置換されたジアザ−スピロ−ピリジノン誘導体 |
JP2010512366A (ja) | 2006-12-11 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Mch拮抗活性を有する新規ピリダジン誘導体及びこれらの化合物を含む薬物 |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
AP2009004915A0 (en) * | 2007-01-03 | 2009-08-31 | Cortex Pharma Inc | 3-substituted-[1,2,3] benzotriazinone compounds for enhancing glutamatergic synaptic responses |
EP2124562B1 (en) | 2007-03-09 | 2016-04-20 | Second Genome, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101412682B (zh) * | 2007-10-19 | 2012-06-27 | 上海药明康德新药开发有限公司 | 芳基氨茴酸及其衍生物的合成方法 |
CN112079769A (zh) * | 2008-04-23 | 2020-12-15 | 里格尔药品股份有限公司 | 用于治疗代谢障碍的甲酰胺化合物 |
US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
ATE546448T1 (de) | 2008-08-02 | 2012-03-15 | Janssen Pharmaceutica Nv | Urotensin-ii-rezeptorantagonisten |
UY32443A (es) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos tetrahidronaftalenos, procesos para su preparación y uso de los mismos como medicamento. |
AR075401A1 (es) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
CA2796419C (en) | 2010-04-16 | 2018-11-06 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
PT2707361T (pt) | 2011-05-10 | 2017-11-28 | Gilead Sciences Inc | Compostos heterocíclicos fusionados como moduladores do canal de sódio |
TWI622583B (zh) | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
UY34194A (es) * | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
CN109999040A (zh) | 2012-08-30 | 2019-07-12 | 阿西纳斯公司 | 蛋白质酪氨酸激酶调节剂 |
FR3000491B1 (fr) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
CN110407824B (zh) * | 2019-08-08 | 2021-07-02 | 安徽医科大学 | 芳基甲酰胺类化合物及其制备方法、药物组合物及用途 |
US20220380314A1 (en) * | 2019-09-17 | 2022-12-01 | Bial - R&D Investments, S.A. | Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2386474A1 (en) * | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
AU2001256733A1 (en) * | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
JP2004504303A (ja) * | 2000-07-05 | 2004-02-12 | シナプティック・ファーマスーティカル・コーポレーション | 選択的メラニン凝集ホルモン−1(mch1)受容体アンタゴニストおよびその使用 |
US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
CN1273451C (zh) * | 2000-12-22 | 2006-09-06 | 先灵公司 | 哌啶mch拮抗剂及其治疗肥胖症的用途 |
GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-08-24 DE DE10238865A patent/DE10238865A1/de not_active Withdrawn
-
2003
- 2003-08-16 MX MXPA05002158A patent/MXPA05002158A/es unknown
- 2003-08-16 BR BR0313790-2A patent/BR0313790A/pt not_active Expired - Fee Related
- 2003-08-16 WO PCT/EP2003/009099 patent/WO2004024702A1/de active Application Filing
- 2003-08-16 KR KR1020057003110A patent/KR20050040928A/ko not_active Application Discontinuation
- 2003-08-16 EP EP03794886A patent/EP1534689A1/de not_active Withdrawn
- 2003-08-16 PL PL03375344A patent/PL375344A1/xx not_active Application Discontinuation
- 2003-08-16 UA UAA200502601A patent/UA82853C2/uk unknown
- 2003-08-16 RS YUP-2005/0173A patent/RS20050173A/sr unknown
- 2003-08-16 AU AU2003258620A patent/AU2003258620A1/en not_active Abandoned
- 2003-08-16 CN CNA038200767A patent/CN1678591A/zh active Pending
- 2003-08-16 CA CA002496563A patent/CA2496563A1/en not_active Abandoned
- 2003-08-16 EA EA200500301A patent/EA012834B1/ru not_active IP Right Cessation
- 2003-08-16 JP JP2004535098A patent/JP2006507246A/ja active Pending
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/es not_active Application Discontinuation
- 2003-08-22 TW TW092123197A patent/TW200413332A/zh unknown
- 2003-08-22 AR ARP030103034A patent/AR043046A1/es unknown
-
2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/xx unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/no not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/es unknown
- 2005-02-23 HR HR20050179A patent/HRP20050179A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20050068L (no) | 2005-03-04 |
CN1678591A (zh) | 2005-10-05 |
ECSP055615A (es) | 2005-05-30 |
MXPA05002158A (es) | 2005-05-23 |
RS20050173A (en) | 2007-09-21 |
PL375344A1 (en) | 2005-11-28 |
WO2004024702A1 (de) | 2004-03-25 |
KR20050040928A (ko) | 2005-05-03 |
EA012834B1 (ru) | 2009-12-30 |
BR0313790A (pt) | 2005-07-12 |
TW200413332A (en) | 2004-08-01 |
PE20040974A1 (es) | 2005-01-12 |
EA200500301A1 (ru) | 2006-02-24 |
AU2003258620A1 (en) | 2004-04-30 |
ZA200500086B (en) | 2006-07-26 |
HRP20050179A2 (en) | 2006-05-31 |
UA82853C2 (en) | 2008-05-26 |
CA2496563A1 (en) | 2004-03-25 |
JP2006507246A (ja) | 2006-03-02 |
DE10238865A1 (de) | 2004-03-11 |
EP1534689A1 (de) | 2005-06-01 |
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